Cell Biology: Creating Structure and Function

doi:10.1017/9781009597852.013

Chapter 7 - Cell Biology: Creating Structure and Function

from Section III - Areas of Biological and Technical Advances Driving Neurosurgical Innovation

Published online by Cambridge University Press: aN Invalid Date NaN

Yuliya Lakhina and

Edited by

Rohan Ramakrishna and

Michael L. J. Apuzzo

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Benjamin Hartley: Affiliation:
Weill Cornell Medical Center
Philip E. Stieg: Affiliation:
Weill Cornell Medical College
Rohan Ramakrishna: Affiliation:
Weill Cornell Medical College
Michael L. J. Apuzzo: Affiliation:
Adjunct of Yale Medical School and Weill Cornell Medical College

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Summary

The unique characteristics of the cells that allow them to communicate with each other, influence their life cycle, and function by themselves have opened a magic world of precise stem cell treatment. This chapter will review the history of neural transplantation from M.L. Apuzzo’s pioneering stereotactic implantation of adrenal medulla autografts for Parkinson’s disease treatment to S. Yamanaka’s groundbreaking development of induced pluripotent stem cells. Employing cells as a therapeutic option for repairing the nervous system remains challenging. It is marked by considerations of government policy regarding embyos and fetal tissue, continuous improvement in the cell sourcing and stem cell quality, diverse expert perspectives, and the consistent upgrading of the delivery methods by experienced neurosurgeons. The authors highlight the challenges and outcomes of clinical trials for neurodegenerative diseases, stroke, and spinal cord trauma, emphasizing the safety of stem cell therapy and the limited efficacy in some cases. This chapter is a comprehensive overview of the potential and challenges of stem cell transplantation for neurological disorders, highlighting the need for further research and policy application to realize its full potential.

Keywords

Cell biology Regenerative medicine Bioengineering Stem cells Transplantation Neurodegenerative Diseases Clinical trials Medical device

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Type: Chapter
Information: Neurosurgery
Beyond the Cutting Edge
, pp. 121 - 167

DOI: https://doi.org/10.1017/9781009597852.013 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2025

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