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Debate 43B - Is Radical Surgery or Parametrectomy Needed for Early-stage FIGO IA2 and Microscopic IB1 Cervical Cancer?

No

from Section V - Cervical Cancer

Published online by Cambridge University Press:  20 July 2023

Dennis S. Chi
Affiliation:
Memorial Sloan-Kettering Cancer Center, New York
Nisha Lakhi
Affiliation:
Richmond University Medical Center, Staten Island
Nicoletta Colombo
Affiliation:
University of Milan-Bicocca
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Summary

Although radical hysterectomy or radical trachelectomy with lymph node assessment are both considered a gold standard treatment for patients with cervical cancer stages IA2 and IB1, radical procedures (parametrectomy) are associated with an increased risk of morbidity and inferior quality of life as well as adverse obstetrical outcomes for radical trachelectomy. Moreover, prior studies demonstrated that in patients with favorable factors, such as: tumor size ≤2 cm, depth of stromal invasion <10 mm, and the absence of lymphovascular space, and negative pelvic nodes the risk of parametrial involvement is below 1%. The mounting evidence from retrospective and prospective studies (ConCerv trial) suggest that in those with a low risk of parametrial involvement simple surgery (conization, trachelectomy or hysterectomy) with lymph node assessment might be a safe alternative to the radical surgery (parametrectomy). It is expected that the results of two large prospective trials: GOG 278 and SHAPE will add to this debate in favor of “simple” surgery with lymph node assessment.

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Publisher: Cambridge University Press
Print publication year: 2023

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References

National Comprehensive Cancer Network. NCCN guidelines in oncology: cervical cancer. Available at: www.nccn.org/professionals/physician_gls/pdf/cervical.pdf. Retrieved September 11, 2020.Google Scholar
Covens, A, et al. How important is removal of the parametrium at surgery for carcinoma of the cervix? Gynecol Oncol 2002;84(1):145149. https://doi.org/10.1006/gyno.2001.6493CrossRefGoogle ScholarPubMed
Tseng, JH, et al. Less versus more radical surgery in stage IB1 cervical cancer: a population-based study of long-term survival. Gynecol Oncol 2018;150:4449.CrossRefGoogle ScholarPubMed
Sia, TY, et al. Trends in use and effect on survival of simple hysterectomy for early-stage cervical cancer. Obstet Gynecol 2019;134:11321143.CrossRefGoogle ScholarPubMed
Li, X, et al. Simple conization and pelvic lymphadenectomy in early-stage cervical cancer: a retrospective analysis and review of the literature. Gynecol Oncol 2020;158(2):231235. https://doi.org/10.1016/j.ygyno.2020.05.035CrossRefGoogle ScholarPubMed
Schmeler, K, et al. Concerv: a prospective trial of conservative surgery for low-risk early-stage cervical cancer Int J Gynecol Cancer 2019;29:A14A15.Google Scholar

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