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7 - Gene–Lifestyle Interactions in Longevity

from Part I - Biomedical Aspects

Published online by Cambridge University Press:  10 January 2019

By
Rune Lindahl-Jacobsen  and
Kaare Christensen
Edited by
Rocío Fernández-Ballesteros ,
Athanase Benetos  and
Jean-Marie Robine
Rocío Fernández-Ballesteros
Affiliation:
Universidad Autónoma de Madrid
Athanase Benetos
Affiliation:
Université de Lorraine and Institut national de la santé et de la recherche médicale (INSERM) Nancy
Jean-Marie Robine
Affiliation:
INSERM
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Summary

Individuals exposed to the same environmental factor show variation in responses and health outcomes. Such observations could be caused by chance or by gene-environment interactions – where gene variants modulate the effect of environmental factors on morbidity, aging and mortality or vice-versa. Twin and family studies have shown that lifespan is moderately heritable and that the chance of survival at the highest ages might be increasingly influenced by genetic factors. However, only for two genes, common variants have consistently been associated with longevity: the Apolipoprotein E gene and, to a lesser extent, FOXO. In this chapter, we review current knowledge on the association between Apolipoprotein E variants and mortality and summarize current evidence for interactions between lifestyle and Apolipoprotein E gene variants in morbidity, aging and longevity.
Type
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Information
The Cambridge Handbook of Successful Aging , pp. 91 - 109
Publisher: Cambridge University Press
Print publication year: 2019

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To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

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Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

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