Book contents
- Frontmatter
- Dedication
- Contents
- List of Contributors
- Preface
- Part I Clinical syndromes: general
- Part II Clinical syndromes: head and neck
- Part III Clinical syndromes: eye
- Part IV Clinical syndromes: skin and lymph nodes
- Part V Clinical syndromes: respiratory tract
- Part VI Clinical syndromes: heart and blood vessels
- Part VII Clinical syndromes: gastrointestinal tract, liver, and abdomen
- Part VIII Clinical syndromes: genitourinary tract
- Part IX Clinical syndromes: musculoskeletal system
- Part X Clinical syndromes: neurologic system
- Part XI The susceptible host
- Part XII HIV
- Part XIII Nosocomial infection
- Part XIV Infections related to surgery and trauma
- Part XV Prevention of infection
- Part XVI Travel and recreation
- Part XVII Bioterrorism
- Part XVIII Specific organisms: bacteria
- 123 Actinomycosis
- 124 Anaerobic infections
- 125 Anthrax and other Bacillus species
- 126 Bartonella bacilliformis
- 127 Cat scratch disease and other Bartonella infections
- 128 Bordetella
- 129 Branhamella–Moraxella
- 130 Brucellosis
- 131 Campylobacter
- 132 Clostridium
- 133 Corynebacteria
- 134 Enterobacteriaceae
- 135 Enterococcus
- 136 Erysipelothrix
- 137 HACEK
- 138 Helicobacter pylori
- 139 Gonococcus: Neisseria gonorrhoeae
- 140 Haemophilus
- 141 Legionellosis
- 142 Leprosy
- 143 Meningococcus and miscellaneous neisseriae
- 144 Listeria
- 145 Nocardia
- 146 Pasteurella multocida
- 147 Pneumococcus
- 148 Pseudomonas, Stenotrophomonas, and Burkholderia
- 149 Rat-bite fevers
- 150 Salmonella
- 151 Staphylococcus
- 152 Streptococcus groups A, B, C, D, and G
- 153 Viridans streptococci
- 154 Poststreptococcal immunologic complications
- 155 Shigella
- 156 Tularemia
- 157 Tuberculosis
- 158 Nontuberculous mycobacteria
- 159 Vibrios
- 160 Yersinia
- 161 Miscellaneous gram-positive organisms
- 162 Miscellaneous gram-negative organisms
- Part XIX Specific organisms: spirochetes
- Part XX Specific organisms: Mycoplasma and Chlamydia
- Part XXI Specific organisms: Rickettsia, Ehrlichia, and Anaplasma
- Part XXII Specific organisms: fungi
- Part XXIII Specific organisms: viruses
- Part XXIV Specific organisms: parasites
- Part XXV Antimicrobial therapy: general considerations
- Index
- References
158 - Nontuberculous mycobacteria
from Part XVIII - Specific organisms: bacteria
Published online by Cambridge University Press: 05 April 2015
- Frontmatter
- Dedication
- Contents
- List of Contributors
- Preface
- Part I Clinical syndromes: general
- Part II Clinical syndromes: head and neck
- Part III Clinical syndromes: eye
- Part IV Clinical syndromes: skin and lymph nodes
- Part V Clinical syndromes: respiratory tract
- Part VI Clinical syndromes: heart and blood vessels
- Part VII Clinical syndromes: gastrointestinal tract, liver, and abdomen
- Part VIII Clinical syndromes: genitourinary tract
- Part IX Clinical syndromes: musculoskeletal system
- Part X Clinical syndromes: neurologic system
- Part XI The susceptible host
- Part XII HIV
- Part XIII Nosocomial infection
- Part XIV Infections related to surgery and trauma
- Part XV Prevention of infection
- Part XVI Travel and recreation
- Part XVII Bioterrorism
- Part XVIII Specific organisms: bacteria
- 123 Actinomycosis
- 124 Anaerobic infections
- 125 Anthrax and other Bacillus species
- 126 Bartonella bacilliformis
- 127 Cat scratch disease and other Bartonella infections
- 128 Bordetella
- 129 Branhamella–Moraxella
- 130 Brucellosis
- 131 Campylobacter
- 132 Clostridium
- 133 Corynebacteria
- 134 Enterobacteriaceae
- 135 Enterococcus
- 136 Erysipelothrix
- 137 HACEK
- 138 Helicobacter pylori
- 139 Gonococcus: Neisseria gonorrhoeae
- 140 Haemophilus
- 141 Legionellosis
- 142 Leprosy
- 143 Meningococcus and miscellaneous neisseriae
- 144 Listeria
- 145 Nocardia
- 146 Pasteurella multocida
- 147 Pneumococcus
- 148 Pseudomonas, Stenotrophomonas, and Burkholderia
- 149 Rat-bite fevers
- 150 Salmonella
- 151 Staphylococcus
- 152 Streptococcus groups A, B, C, D, and G
- 153 Viridans streptococci
- 154 Poststreptococcal immunologic complications
- 155 Shigella
- 156 Tularemia
- 157 Tuberculosis
- 158 Nontuberculous mycobacteria
- 159 Vibrios
- 160 Yersinia
- 161 Miscellaneous gram-positive organisms
- 162 Miscellaneous gram-negative organisms
- Part XIX Specific organisms: spirochetes
- Part XX Specific organisms: Mycoplasma and Chlamydia
- Part XXI Specific organisms: Rickettsia, Ehrlichia, and Anaplasma
- Part XXII Specific organisms: fungi
- Part XXIII Specific organisms: viruses
- Part XXIV Specific organisms: parasites
- Part XXV Antimicrobial therapy: general considerations
- Index
- References
Summary
Introduction
The nontuberculous mycobacteria (NTM) are ubiquitous in the environment; so much so that some experts feel they should be referred to as “environmental mycobacteria.” While there are almost 150 identified NTM species, the most common NTM associated with human disease in the United States are Mycobacterium avium complex (MAC), Mycobacterium kansasii, Mycobacterium fortuitum and Mycobacterium abscessus. Many other NTM species can cause human disease but are generally rarely encountered clinically, while a few NTM species, most notably Mycobacterium gordonae, are frequently isolated as specimen contaminants and almost never cause disease.
Infection is thought to occur from environmental exposure to the NTM with three potential portals of entry; the respiratory tract, the gastrointestinal tract, and direct inoculation of the skin and soft tissues. There had been no documented occurrences of either human-to-human or animal-to-human transmission until recent reports of the transmissibility between patients in several cystic fibrosis (CF) clinics.
The most common clinical manifestation of NTM infection in the immunocompetent host is chronic pulmonary disease. Symptoms are usually insidious in onset and variably include cough, sputum production, fatigue, weight loss, weakness, hemoptysis, and night sweats. MAC is the most common respiratory pathogen. Patients with MAC lung disease are divided between two groups. The first are primarily female patients without a history of smoking or pre-existing lung disease who have noncavitary disease characterized by nodular densities and bronchiectasis, usually in the right middle lobe and lingula. The second group are primarily male patients with pre-existing lung disease, most often chronic obstructive lung disease, and cavitary abnormalities radiographically, similar to tuberculosis.
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- Clinical Infectious Disease , pp. 1020 - 1029Publisher: Cambridge University PressPrint publication year: 2015