Book contents
- Hormones, Cognition and Dementia
- Hormones, Cognition and Dementia
- Copyright page
- Contents
- Contributors
- Preface
- Section 1 Estrogens and cognition: perspectives and opportunities in the wake of the Women's Health Initiative Memory Study
- Section 2 Varieties of estrogenic therapy
- Section 3 Potential modulators and modifiers of estrogenic effects
- Chapter 11 Progesterone regulation of neuroprotective estrogen actions
- Chapter 12 Clinical data of estrogen's effects in the central nervous system: estrogen and mood
- Chapter 13 Different forms of soy processing may determine the positive or negative impact on cognitive function of Indonesian elderly
- Chapter 14 Hypothalamus-pituitary-adrenal axis activity in aging women: its impact on the brain and the potential influence of estradiol
- Section 4 Possible genetic factors related to hormone treatment effects
- Section 5 Testosterone, estradiol and men, and sex hormone binding globulin
- Section 6 Gonadotropin effects
- Index
- Plate Section
Chapter 14 - Hypothalamus-pituitary-adrenal axis activity in aging women: its impact on the brain and the potential influence of estradiol
from Section 3 - Potential modulators and modifiers of estrogenic effects
Published online by Cambridge University Press: 06 July 2010
- Hormones, Cognition and Dementia
- Hormones, Cognition and Dementia
- Copyright page
- Contents
- Contributors
- Preface
- Section 1 Estrogens and cognition: perspectives and opportunities in the wake of the Women's Health Initiative Memory Study
- Section 2 Varieties of estrogenic therapy
- Section 3 Potential modulators and modifiers of estrogenic effects
- Chapter 11 Progesterone regulation of neuroprotective estrogen actions
- Chapter 12 Clinical data of estrogen's effects in the central nervous system: estrogen and mood
- Chapter 13 Different forms of soy processing may determine the positive or negative impact on cognitive function of Indonesian elderly
- Chapter 14 Hypothalamus-pituitary-adrenal axis activity in aging women: its impact on the brain and the potential influence of estradiol
- Section 4 Possible genetic factors related to hormone treatment effects
- Section 5 Testosterone, estradiol and men, and sex hormone binding globulin
- Section 6 Gonadotropin effects
- Index
- Plate Section
Summary
Acute and chronic stress have well documented effects on memory consolidation and retrieval. As we age, the ability of the brain to cope with stress is often diminished, even as the presence of physical and emotional stressors increase. In this chapter, Wolf summarizes the latest evidence pertaining to effects of stress hormones, particularly cortisol, on memory, as well as evidence that activity of the hypothalamus-pituitary-adrenal (HPA) axis increases with age. Indications that women in particular are likely to experience chronically elevated levels of cortisol with advanced age is discussed, as well as the possibility that estrogens provide neuroprotection from chronically elevated stress hormones. Based on these data, the author proposes that the loss of estrogens may contribute significantly to increased HPA activity in postmenopausal women, and confer greater susceptibility to the negative effects of chronically elevated stress hormones on memory.
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- Information
- Hormones, Cognition and DementiaState of the Art and Emergent Therapeutic Strategies, pp. 133 - 142Publisher: Cambridge University PressPrint publication year: 2009