Skip to main content Accessibility help
×
Hostname: page-component-848d4c4894-ndmmz Total loading time: 0 Render date: 2024-05-12T04:50:33.543Z Has data issue: false hasContentIssue false

Chapter 15 - Wernicke Disease

Published online by Cambridge University Press:  27 July 2023

Robert Laureno
Affiliation:
Georgetown University, Washington DC
Get access

Summary

In the era of MRI we have advanced our knowledge of the topography of Wernicke disease. We have learned that cortical and striatal lesions can occur. Clinical observations have revealed that hearing loss can occur, sometimes with the MRI correlate of involvement of the inferior colliculi. Vestibular signs have been correlated with involvement of the vestibular nuclei. Previously unpublished data show a high incidence of the midline cerebellar lesion in oropharyngeal cancer. Ideas about proper thiamine dosing are discussed.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2023

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Victor, M., Adams, R. D., Collins, G. H.. The Wernicke-Korsakoff syndrome. A clinical and pathological study of 245 patients, 82 with post-mortem examinations. Contemp Neurol Ser 1971; 7: 1206.Google ScholarPubMed
Zuccoli, G., Pipitone, N.. Neuroimaging findings in acute Wernicke’s encephalopathy: review of the literature. AJR Am J Roentgenol 2009; 192: 501508.CrossRefGoogle ScholarPubMed
Eren, O. E., Schöberl, F., Campana, M. et al. A unique MRI-pattern in alcohol-associated Wernicke encephalopathy. Acta Neurol Belg 2020; 120: 14391441.CrossRefGoogle ScholarPubMed
Rinehart, J. F., Friedman, M., Greenberg, L. D.. Effect of experimental thiamine deficiency on the nervous system of the rhesus monkey. Arch Pathol (Chic) 1949; 48: 129139.Google ScholarPubMed
Santos Andrade, C., Tavares Lucato, L., da Graca Morais Martin, M. et al. Non-alcoholic Wernicke’s encephalopathy: broadening the clinicoradiological spectrum. Br J Radiol 2010; 83: 437446.CrossRefGoogle ScholarPubMed
Wu, L., Jin, D., Sun, X. et al. Cortical damage in Wernicke’s encephalopathy with good prognosis: a report of two cases and literature review. Metab Brain Dis 2017; 32: 377384.CrossRefGoogle ScholarPubMed
Lapergue, B., Klein, I., Olivot, J. M. et al. Diffusion weighted imaging of cerebellar lesions in Wernicke’s encephalopathy. J Neuroradiol 2006; 33: 126128.CrossRefGoogle ScholarPubMed
Zuccoli, G., Siddiqui, N., Rizzi, R. et al. Neurological picture. Pendular nystagmus showing involvement of the floccular lobes in an atypical case of Wernicke encephalopathy: MRI findings. J Neurol Neurosurg Psychiatry 2010; 81: 858.CrossRefGoogle Scholar
Victor, M., Laureno, R.. Neurologic complications of alcohol abuse: epidemiologic aspects. Adv Neurol 1978; 19: 603617.Google ScholarPubMed
Laureno, R.. Nutritional cerebellar degeneration with comments on its relationship to Wernicke disease and alcoholism. In: Subramony, S. H., Dürr, A, eds. Handbook of Clinical Neurology, Ataxic Disorders. Amsterdam, Elsevier, 2011; 103: 175188.Google Scholar
Victor, M., Adams, R. D., Collins, G. H.. The Wernicke-Korsakoff Syndrome and Related Neurological Disorders Due to Alcoholism and Malnutrition. Philadelphia, F.A. Davis, 1989.Google Scholar
Kattah, J. C., Dhanani, S. S., Pula, J. H. et al. Vestibular signs of thiamine deficiency during the early phase of suspected Wernicke encephalopathy. Neurol Clin Pract 2013; 3: 460468.CrossRefGoogle ScholarPubMed
Walker, M. A., Zepeda, R., Afari, H. A. et al. Hearing loss in Wernicke encephalopathy. Neurol Clin Pract 2014; 4: 511515.CrossRefGoogle ScholarPubMed
Tallaksen, C. M., Sande, A., Bohmer, T. et al. Kinetics of thiamin and thiamin phosphate esters in human blood, plasma and urine after 50 mg intravenously or orally. Eur J Clin Pharmacol 1993; 44: 7378.CrossRefGoogle ScholarPubMed
Thomson, A. D., Ryle, P. R., Shaw, G. K.. Ethanol, thiamine and brain damage. Alcohol and Alcoholism 1983; 18: 2743.Google Scholar
Chataway, J., Hardman, E.. Thiamine in Wernicke’s syndrome – how much and how long? Postgrad Med J 1995; 71: 249.Google Scholar
Galvin, R., Brathen, G., Ivashynka, A. et al. EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy. Eur J Neurol 2010; 17: 14081418.CrossRefGoogle ScholarPubMed
Day, E., Bentham, P. W., Callaghan, R. et al. Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol. Cochrane Database Syst Rev 2013; 7: CD004033.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

  • Wernicke Disease
  • Robert Laureno, Georgetown University, Washington DC
  • Book: Insights into Clinical Neurology
  • Online publication: 27 July 2023
  • Chapter DOI: https://doi.org/10.1017/9781009234986.016
Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

  • Wernicke Disease
  • Robert Laureno, Georgetown University, Washington DC
  • Book: Insights into Clinical Neurology
  • Online publication: 27 July 2023
  • Chapter DOI: https://doi.org/10.1017/9781009234986.016
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Wernicke Disease
  • Robert Laureno, Georgetown University, Washington DC
  • Book: Insights into Clinical Neurology
  • Online publication: 27 July 2023
  • Chapter DOI: https://doi.org/10.1017/9781009234986.016
Available formats
×