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6 - Principles of Embolization

from PART II - PRINCIPLES OF IMAGE-GUIDED THERAPIES

Published online by Cambridge University Press:  18 May 2010

By
Jae Hyung Park  and
Jin Wook Chung
Edited by
Jean-François H. Geschwind  and
Michael C. Soulen
Jae Hyung Park
Affiliation:
Professor, Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
Jin Wook Chung
Affiliation:
Associate Professor, Department of Radiology, Seoul National University Hospital, Seoul, Korea
Jean-François H. Geschwind
Affiliation:
The Johns Hopkins University School of Medicine
Michael C. Soulen
Affiliation:
University of Pennsylvania School of Medicine
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Summary

EMBOLOTHERAPY

General Indications

The percutaneous angiographic technique was first introduced by Seldinger (1), and modern embolotherapy was first attempted by Rösch (2) in 1972 to control duodenal bleeding. The term embolization refers to the induction of vascular occlusion by introducing an embolic agent into a vessel through a selectively placed catheter for therapeutic purposes.

The indications of embolotherapy are various, and include bleeding control, tumor devascularization, arteriovenous fistula and malformations, aneurysms, organ or tissue ablation, varicocele, blood flow redistribution and perigraft leakage. Tumors indicated for devascularization by embolotherapy are renal cell carcinoma (3, 4), angiomyolipoma (5), hepatic tumors (6, 7), bone and soft tissue tumors (8) and uterine fibroids (9). Liver tumor transcatheter arterial embolization (TAE) was first reported by Doyon et al. (10) and chemoembolization using Gelfoam and anti-cancer drugs was reported by Yamada et al. (7).

Recently, catheters with hydrophilic coatings and microcatheter systems have been developed, and currently, the precise and safe delivery of embolic materials is possible to any body location using blood vessels. The embolization process involves the precise localization of a target lesion, the selection of ideal embolic materials, complete embolization of the target lesion and preservation of non-targeted regions. For effective embolization, the selective and superselective techniques are important in terms of inducing complete embolization, and for preserving normal parenchyma and target organ function.

Type
Chapter
Information
Interventional Oncology
Principles and Practice
 , pp. 67 - 77
Publisher: Cambridge University Press
Print publication year: 2008

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  • Principles of Embolization
    • By Jae Hyung Park, Professor, Department of Radiology, Seoul National University College of Medicine, Seoul, Korea, Jin Wook Chung, Associate Professor, Department of Radiology, Seoul National University Hospital, Seoul, Korea
  • Edited by Jean-François H. Geschwind, The Johns Hopkins University School of Medicine, Michael C. Soulen, University of Pennsylvania School of Medicine
  • Book: Interventional Oncology
  • Online publication: 18 May 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511722226.007
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  • Principles of Embolization
    • By Jae Hyung Park, Professor, Department of Radiology, Seoul National University College of Medicine, Seoul, Korea, Jin Wook Chung, Associate Professor, Department of Radiology, Seoul National University Hospital, Seoul, Korea
  • Edited by Jean-François H. Geschwind, The Johns Hopkins University School of Medicine, Michael C. Soulen, University of Pennsylvania School of Medicine
  • Book: Interventional Oncology
  • Online publication: 18 May 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511722226.007
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  • Principles of Embolization
    • By Jae Hyung Park, Professor, Department of Radiology, Seoul National University College of Medicine, Seoul, Korea, Jin Wook Chung, Associate Professor, Department of Radiology, Seoul National University Hospital, Seoul, Korea
  • Edited by Jean-François H. Geschwind, The Johns Hopkins University School of Medicine, Michael C. Soulen, University of Pennsylvania School of Medicine
  • Book: Interventional Oncology
  • Online publication: 18 May 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511722226.007
Available formats
×