Interventional Oncology: Principles and Practice

doi:10.1017/CBO9780511722226

Interventional oncology has joined surgical, radiation, and medical oncology as the fourth pillar of cancer care. Advances in imaging and image guidance for the detection, characterization, targeting, and therapy of cancer now allow for minimally invasive image-guided treatment of many solid tumors without the morbidity of open surgery or the toxicity of chemotherapy and radiation. The editors have brought together the accrued experience of pioneers and leaders in image-guided cancer therapy from around the globe to create the first comprehensive text for this emerging field. Covering the biology, techniques, clinical applications, and outcomes of interventional oncologic procedures for the treatment and palliation of solid tumors throughout the body, this practical reference will be indispensable for physicians across specialties who seek to provide collaborative, leading-edge care to cancer patients.

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Contents

Frontmatter
pp i-iv
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Contents
pp v-viii
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FOREWORD
pp ix-xii
- By Daniel Haller MD, Hospital of the University of Pennsylvania
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ACKNOWLEDGMENTS
pp xiii-xiv
- By Jean-Francois H. Geschwind MD, Director of Cardiovascular and Interventional Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, Michael C. Soulen, Professor of Radiology and Surgery, University of Pennsylvania, Philadelphia
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CONTRIBUTORS
pp xv-xx
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PART I - PRINCIPLES OF ONCOLOGY
pp 1-2
- By Jean-Francois H. Geschwind, Director of Cardiovascular and Interventional Radiology, Johns Hopkins University School of Medicine, Michael C. Soulen, Professor of Radiology and Surgery, University of Pennsylvania
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1 - Biology of Cancer
pp 3-22
- By Sydney M. Evans, Professor of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, Robert Bristow, Associate Professor, Department of Radiation Oncology and Medical Biophysics, Princess Margaret Hospital, Toronto, Ontario, Canada, Robert Gatenby, Professor of Radiology and Applied Mathematics, University of Arizona, Tucson, AZ, Mary J. Hendrix, Professor, Northwestern University Feinberg School of Medicine, Chicago, IL, Richard Hill, Professor, Department of Medical Biophysics and Radiation Oncology, University of Toronto, Princess Margaret Hospital, Toronto, Ontario, Canada, William M.-F. Lee, Associate Professor of Medicine, Department of Medicine, Hematology/Oncology Division, University of Pennsylvania, Philadelphia, PA
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2 - Evaluation of the Cancer Patient
pp 23-27
- By Anjali Avadhani, Instructor, Division of Medical Oncology, University of Pennsylvania, Philadelphia, PA, Catherine M. Tuite, Assistant Professor of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA, Weijing Sun, Associate Professor of Medicine, Director of Gastrointestinal Medical Oncology Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
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3 - Principles of Chemotherapy
pp 28-37
- By Rowena Schwartz, Director of Oncology Pharmacy, Johns Hopkins University School of Medicine, Baltimore, MD, Tiffany V. Goolsby, Clinical Pharmacist, Johns Hopkins Pharmacy, Baltimore, MD, Wells A. Messersmith, Assistant Professor, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD
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4 - Pharmacologic Principles of Regional Therapy in the Treatment of Liver Metastases or Primary Liver Tumors
pp 38-52
- By Fidel David Huitzil Melendez, Gastrointestinal Oncology Fellow, Memorial Sloan-Kettering Cancer Center New York, NY, Nancy Kemeny, Professor of Medicine, Weill Medical College of Cornell University New York, NY
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PART II - PRINCIPLES OF IMAGE-GUIDED THERAPIES
pp 53-54
- By Jean-Francois H. Geschwind, Director of Cardiovascular and Interventional Radiology, Johns Hopkins University School of Medicine, Michael C. Soulen, Professor of Radiology and Surgery, University of Pennsylvania
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5 - Image-guided Interventions: Fundamentals of Radiofrequency Tumor Ablation
pp 55-66
- By Andrew Hines-Peralta, Radiologist, Beth Israel Deaconess Medical Center Department of Radiology Boston, MA, S. Nahum Goldberg, Professor in Radiology, Department of Radiology Beth Israel Deaconess Medical Center Boston, MA
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6 - Principles of Embolization
pp 67-77
- By Jae Hyung Park, Professor, Department of Radiology, Seoul National University College of Medicine, Seoul, Korea, Jin Wook Chung, Associate Professor, Department of Radiology, Seoul National University Hospital, Seoul, Korea
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7 - Imaging in Interventional Oncology: Role of Image Guidance
pp 78-85
- By Stephen B. Solomon, Associate Attending Physician, Co-Director, Center for Image-guided Intervention, Memorial Sloan-Kettering Cancer Center, New York, NY
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8 - Assessment of Tumor Response on Magnetic Resonance Imaging after Locoregional Therapy
pp 86-98
- By Manon Buijs, Postdoctoral Research Fellow, Interventional Radiology Division, Johns Hopkins University School of Medicine, Baltimore, MD, Josephina A. Vossen, Postdoctoral Research Fellow, Interventional Radiology Division, Johns Hopkins University School of Medicine, Baltimore, MD, Jean-Francois H. Geschwind, Director of Cardiovascular and Interventional Radiology, Johns Hopkins University School of Medicine, Ihab R. Kamel, Associate Professor of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD
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PART III - ORGAN-SPECIFIC CANCERS
pp 99-100
- By Jean-Francois H. Geschwind, Director of Cardiovascular and Interventional Radiology, Johns Hopkins University School of Medicine, Michael C. Soulen, Professor of Radiology and Surgery, University of Pennsylvania
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9 - Hepatocellular Carcinoma: Epidemiology, Pathology, Diagnosis and Screening
pp 101-106
- By Philip Johnson, Professor of Oncology and Translational Research, Institute for Cancer Studies University of Birmingham Birmingham, UK
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10 - Staging Systems for Hepatocellular Carcinoma
pp 107-114
- By Debashish Bose, Assistant Professor, Department of Surgery Johns Hopkins University School of Medicine Baltimore, MD, Timothy M. Pawlik, Assistant Professor, Department of Surgery Johns Hopkins University School of Medicine Baltimore, MD
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11 - Hepatocellular Carcinoma: Medical Management
pp 115-120
- By Philip Johnson, Professor of Oncology and Translational Research Director of the Clinical Trials Unit Cancer Research, UK Institute for Cancer Studies University of Birmingham Birmingham, UK, Daniel Palmer, Clinician Scientist Cancer Research, UK Institute for Cancer Studies University of Birmingham Birmingham, UK
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12 - Surgical Management (Resection)
pp 121-134
- By Brian D. Badgwell, Surgical Oncology Fellow, Department of Surgical Oncology M.D. Anderson Cancer Center University of Texas Houston, TX, Dario Ribero, Clinical Fellow, M.D. Anderson Cancer Center University of Texas Houston, TX, Jean-Nicolas Vauthey, Professor of Surgery and Chief of the Liver Service, Department of Surgical Oncology M.D. Anderson Cancer Center University of Texas Houston, TX
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13 - Liver Transplantation for Hepatocellular Carcinoma
pp 135-144
- By James P. Hamilton, Assistant Professor, Department of Gastroenterology Johns Hopkins University School of Medicine Baltimore, MD, Paul J. Thuluvath, Associate Professor, Department of Medicine Johns Hopkins University School of Medicine Baltimore, MD
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14 - Image-guided Ablation of Hepatocellular Carcinoma
pp 145-159
- By Riccardo Lencioni, Professor, Division of Diagnostic and Interventional Radiology University of Pisa Pisa, Italy, Laura Crocetti, Assistant Professor, Radiology University of Pisa Pisa, Italy, Clotilde Della Pina, Professor, Radiology Division of Diagnostic and Interventional Radiology University of Pisa Pisa, Italy, Dania Cioni, Professor, Division of Diagnostic and Interventional Radiology University of Pisa Pisa, Italy
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15 - Embolization of Liver Tumors: Anatomy
pp 160-191
- By Jin Wook Chung, Associate Professor, Department of Radiology Seoul National University Hospital Seoul, Korea, Jae Hyung Park, Professor, Department of Radiology Seoul National University College of Medicine Seoul, Korea
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16 - Transcatheter Arterial Chemoembolization: Technique and Future Potential
pp 192-201
- By Eleni Liapi, Postdoctoral Research Fellow, Department of Radiology and Radiological Science Division of Cardiovascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore, MD, Christos S. Georgiades, Assistant Professor, Department of Radiology and Radiological Science Division of Cardiovascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore, MD, Kelvin Hong, Assistant Professor, Department of Radiology and Radiological Science Division of Cardiovascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore, MD, Jean-Francois H. Geschwind, Professor of Radiology, Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore, MD
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17 - New Concepts in Targeting and Imaging Liver Cancer
pp 202-212
- By Eleni Liapi, Postdoctoral Research Fellow, Department of Radiology and Radiological Science Division of Cardiovascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore, MD, Christos S. Georgiades, Assistant Professor, Department of Radiology and Radiological Science Division of Cardiovascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore, MD, Kelvin Hong, Assistant Professor, Department of Radiology and Radiological Science Division of Cardiovascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore, MD, Jean-Francois H. Geschwind, Professor of Radiology, Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore, MD
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18 - Intrahepatic Cholangiocarcinoma
pp 213-221
- By Christos S. Georgiades, Assistant Professor, Department of Radiology and Radiological Science Division of Cardiovascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore, MD, Kelvin Hong, Assistant Professor, Department of Radiology and Radiological Science Division of Cardiovascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore, MD, Jean-Francois H. Geschwind, Professor of Radiology, Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore, MD
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19 - Medical Management of Colorectal Liver Metastasis
pp 222-242
- By Wen W. Ma, Clinical Fellow Gastrointestinal Oncology Program, Division of Medical Oncology Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine Baltimore, MD, Wells A. Messersmith, Assistant Professor Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine Baltimore, MD
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20 - Surgical Resection of Hepatic Metastases
pp 243-248
- By Michael A. Choti, Professor of Radiology and Surgery Division of Interventional Radiology, University of Pennsylvania Philadelphia, PA
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21 - Clinical Management of Patients with Colorectal Liver Metastasis Using Hepatic Arterial Infusion
pp 249-263
- By Fidel David Huitzil Melendez, Gastrointestinal Oncology Fellow Memorial Sloan-Kettering Cancer Center, New York, NY, Nancy Kemeny, Attending Physician Memorial Sloan-Kettering Cancer Center Professor of Medicine, Weill Medical College of Cornell University New York, NY
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22 - Colorectal Metastases: Ablation
pp 264-272
- By Luigi Solbiati, Chairman, Department of Diagnostic Imaging Department of Radiology General Hospital Busto Arsizio, Italy
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Principles and Practice

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