Book contents
- Stories of Stroke
- Stories of Stroke
- Copyright page
- Contents
- Contributors
- Why This Book Needed to Be Written
- Preface
- Part I Early Recognition
- Part II Basic Knowledge, Sixteenth to Early Twentieth Centuries
- Part III Modern Era, Mid-Twentieth Century to the Present
- Types of Stroke
- Some Key Physicians
- Imaging
- Care
- Treatment
- Chapter Forty Three Clinical Stroke Trials
- Chapter Forty Four Heparin
- Chapter Forty Five Warfarin
- Chapter Forty Six Direct Oral Anticoagulants
- Chapter Forty Seven Aspirin
- Chapter Forty Eight Other Antiplatelets
- Chapter Forty Nine Other Medical Treatments
- Chapter Fifty Neuroprotection
- Chapter Fifty One Thrombolysis
- Chapter Fifty Two Treatment of Cerebral Venous Thrombosis
- Chapter Fifty three Recovery and Rehabilitation
- Chapter Fifty Four Carotid Artery Surgery
- Chapter Fifty Five Angioplasty and Stenting
- Chapter Fifty Six Endovascular Treatment of Acute Ischemic Stroke
- Chapter Fifty Seven Brain Aneurysm Treatment
- Chapter Fifty Eight Medical and Surgical Treatments of Intracerebral Hemorrhage
- Chapter Fifty Nine Treatment of Vascular Malformations
- Part IV Stroke Literature, Organizations, and Patients
- Index
- References
Chapter Forty Five - Warfarin
from Treatment
Published online by Cambridge University Press: 13 December 2022
- Stories of Stroke
- Stories of Stroke
- Copyright page
- Contents
- Contributors
- Why This Book Needed to Be Written
- Preface
- Part I Early Recognition
- Part II Basic Knowledge, Sixteenth to Early Twentieth Centuries
- Part III Modern Era, Mid-Twentieth Century to the Present
- Types of Stroke
- Some Key Physicians
- Imaging
- Care
- Treatment
- Chapter Forty Three Clinical Stroke Trials
- Chapter Forty Four Heparin
- Chapter Forty Five Warfarin
- Chapter Forty Six Direct Oral Anticoagulants
- Chapter Forty Seven Aspirin
- Chapter Forty Eight Other Antiplatelets
- Chapter Forty Nine Other Medical Treatments
- Chapter Fifty Neuroprotection
- Chapter Fifty One Thrombolysis
- Chapter Fifty Two Treatment of Cerebral Venous Thrombosis
- Chapter Fifty three Recovery and Rehabilitation
- Chapter Fifty Four Carotid Artery Surgery
- Chapter Fifty Five Angioplasty and Stenting
- Chapter Fifty Six Endovascular Treatment of Acute Ischemic Stroke
- Chapter Fifty Seven Brain Aneurysm Treatment
- Chapter Fifty Eight Medical and Surgical Treatments of Intracerebral Hemorrhage
- Chapter Fifty Nine Treatment of Vascular Malformations
- Part IV Stroke Literature, Organizations, and Patients
- Index
- References
Summary
The discovery of warfarin is an example of Pasteur’s famous quote: “Chance favors the prepared mind.” During the 1920s, in the northern United States and Canada, the livelihood of ranchers declined when cattle started dying. Cows bled to death following minor procedures such as dehorning or castration, and even spontaneously. Herds were decimated. There was no identifiable pathogen or nutritional deficiency. The mystery drew the attention of a Canadian veterinary pathologist, Frank Schofield, who noted that all the affected cattle had eaten moldy silage from sweet clover plants. Sweet clover was a popular source of fodder since it grew in poor soil and was a great source of protein. In damp weather, the silage became infected with molds of Penicillium nigricans and P. jensi. Schofield separated good clover hay stalks from spoiled ones and fed them to two different rabbits. The rabbit that consumed the spoiled hay died. Schofield had discovered the anticoagulant properties of spoiled sweet clover hay. The hemorrhagic disease of cattle became known as “sweet clover disease” [1–5].
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- Information
- Stories of StrokeKey Individuals and the Evolution of Ideas, pp. 434 - 441Publisher: Cambridge University PressPrint publication year: 2022