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Genetic variability of the major histocompatibility complex (MHC) class II (DRB3) in South African and Namibian beef cattle breeds

  • L. Haikukutu (a1), T. O. Itenge (a1), L. Bosman (a2), C. Visser (a2) and E. van Marle-Köster (a2)...


The major histocompatibility complex region has been implicated in explaining some of the variation observed in adaptability and tick susceptibility of cattle. The bovine leukocyte antigen region of 192 cattle representing indigenous, composite and exotic breeds used in commercial beef production in Namibia and South Africa was investigated using four microsatellite markers. Ticks counted under the tail were taken as an indicator of tick susceptibility. Tick scores of all but one population was low (11 to 20 ticks), with only the South African Bonsmara population having an average score of 31 to 40 ticks per animal. The observed variation based on four microsatellite markers ranged from 5.5 alleles in Namibian Afrikaner to 7.7 alleles in South African Nguni and Bonsmara cattle. Unbiased heterozygosity values ranged from 0.66 (Namibian Afrikaner) to 0.76 (South African Bonsmara). Structure analyses grouped the five populations into three indistinct clusters with limited genetic variation between the populations.


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Duangjinda, M, Jindatajak, Y, Tipvong, W, Sriwarothai, J, Pattarajinda, V, Katawatin, S and Boonkum, W 2013. Association of BoLA-DRB3 alleles with tick-borne disease tolerance in dairy cattle in a tropical environment. Veterinary Parasitology 196, 314320.
Falush, D, Stephens, M and Pritchard, JK 2003. Inference of population structure: extensions to linked loci and correlated allele frequencies. Genetics 164, 15671587.
Machado, MA, Azevedo, AL, Teodoro, RL, Pires, MA, Peixoto, MG, de Freitas, C, Prata, MC, Furlong, J, da Silva, MV, Guimarães, SE and Regitano, LC 2010. Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus). BMC Genomics 11, 14712164.
Mapholi, NO, Maiwashe, A, Matika, O, Riggio, V, Bishop, SC, MacNeil, MD, Banga, C, Taylor, JF and Dzama, K 2016. Genome-wide association study of tick resistance in South African Nguni cattle. Ticks and Tick-borne Diseases 7, 487497.
Mapholi, NO, Marufu, MC, Maiwashe, A, Banga, CB, Muchenje, V, MacNeil, MD, Chimonyo, M and Dzama, K 2014. Towards a genomics approach to tick (Acari: Ixodidae) control in cattle: a review. Ticks and Tick-borne Diseases 5, 475483.
Marufu, MC, Chimonyo, M, Mans, BJ and Dzama, K 2013. Cutaneous hypersensitivity response to Rhipicephalus tick larval antigens in pre-sensitized cattle. Ticks and Tick-borne Diseases 4, 311316.
Muchenje, V, Dzama, K, Chimonyo, M, Raats, JG and Strydom, PE 2008. Tick susceptibility and its effects on growth performance and carcass characteristics of Nguni, Bonsmara and Angus steers raised on natural pasture. Animal 2, 298304.
Park, SDE 2001. Trypanotolerance in West African cattle and the population genetic effects of selection. PhD thesis, University of Dublin, Dublin.
Pritchard, JK, Stephens, M and Donnelly, P 2000. Inference of population structure using multilocus genotype data. Genetics 155, 945959.
Rothschild, MF, Skow, L and Lamont, SJ 2000. The major histocompatibility complex and its role in disease resistance and immune responsiveness. In Breeding for disease resistance in farm animals (ed. SC Bishop), pp. 73–105. CAB International, Wallingford, UK.
Untalan, PM, Pruett, JH and Steelman, DC 2007. Association of the leukocyte antigen major histocompatibility complex class II DRB3 *4401 allele with host resistance to the Lone Star tick, Amblyomma americanum . Veterinary Parasitology 145, 190195.
Wang, MD, Dzama, K, Hefer, CA and Muchadeyi, FC 2015. Genomic population structure and prevalence of copy number variations in South African Nguni cattle. BMC Genomics 16, 894.
Xu, A 2011. Polymorphism of bovine MHC class II genes: association with persistent lymphocytosis caused by bovine leukemia virus. PhD thesis, University of Illinois at Urbana-Champaign, Champaign, IL, USA.



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