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Genopolitics and the Science of Genetics

  • EVAN CHARNEY (a1) and WILLIAM ENGLISH (a2)
Abstract

In an earlier article we challenged the findings of Fowler and Dawes (FD) that two genes predict voter turnout as part of a more general critique of “genopolitics.” FD now acknowledge that their finding of a “significant” direct association between MAOA and voting was incorrect, but claim to have replicated their finding of an “indirect” association between 5HTT, self-reported church attendance, and self-reported voting. We show that this finding is likely driven by population stratification and omitted variable bias. We then explain why, from the standpoints of genetics, neuroscience, and evolutionary biology, genopolitics is a fundamentally misguided undertaking; we also respond to FD's charge that some of our previous statements concerning genetics are “highly misleading,” “extremely disingenuous,” and “even incorrect.” We show that their criticisms demonstrate a lack of awareness of some basic principles in genetics and of discoveries in molecular genetics over the past 50 years.

Copyright
Corresponding author
Evan Charney is Faculty Fellow, Duke Institute for Brain Sciences; Faculty Researcher, Duke Institute for Genome Science and Policy; and Associate Professor of the Practice of Public Policy and Political Science, Duke University, Rubenstein 250, Durham, NC 27708 (echar@duke.edu).
William English is a Lab Fellow, Edmond J. Safra Center for Ethics, Harvard University, 124 Mount Auburn Street, Cambridge, MA 02138 (wenglish@ethics.harvard.edu).
References
Hide All
Alford, J. R., Funk, C. L., and Hibbing, J. R.. 2005. “Are Political Orientations Genetically Transmitted?American Political Science Review 99 (2): 153–67.
Allis, C. D., Jenuwein, T., and Reinberg, D.. 2007. Epigenetics. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
Baillie, J. K., Barnett, M. W., Upton, K. R., Gerhardt, D. J., Richmond, T. A., De Sapio, F., Brennan, P. M., et al. 2011. “Somatic Retrotransposition Alters the Genetic Landscape of the Human Brain.” Nature 479 (7374): 534–37.
Bartels, L. M. 2000. “Partisanship and Voting Behavior, 1952–1996.” American Journal of Political Science 44 (1): 3550.
Bird, A. 2007. “Perceptions of Epigenetics.” Nature 447 (7143): 396–98.
Bouaziz, M., Ambroise, C., and Guedj, M.. 2011. “Accounting for Population Stratification in Practice: A Comparison of the Main Strategies Dedicated to Genome-Wide Association Studies.” PLoS ONE 6 (12): e28845.
Bradshaw, M., and Ellison, C. G.. 2008. “Do Genetic Factors Influence Religious Life? Findings from a Behavior Genetic Analysis of Twin Siblings.” Journal for the Scientific Study of Religion 47 (4): 529–44.
Brooks, C., and Brady, D.. 1999. “Income, Economic Voting, and Long-Term Political Change in the U.S., 1952–1996.” Social Forces 77 (4): 1339–74.
Champagne, F. A. 2010. “Epigenetic Influence of Social Experiences across the Lifespan.” Developmental Psychobiology 52 (4): 299311.
Charney, E. 2012. “Behavior Genetics and Postgenomics.” Behavioral and Brain Sciences 35 (5): 331–58.
Charney, E., and English, W.. 2012. “Candidate Genes and Political Behavior.” American Political Science Review 106 (1): 134.
Chatters, L. M., Taylor, R. J., Jackson, J. S., and Lincoln, K. D.. 2008. “Race and Ethnic Differences in Religious Involvement: African Americans, Caribbean Blacks and Non-Hispanic Whites.” Ethnic and Racial Studies 32 (7): 1143–63.
Chialvo, D. R. 2010. “Emergent Complex Neural Dynamics.” Nature Physics 6 (10): 744–50.
Clayton-Smith, J, and Laan, L.. 2003. “Angelman Syndrome: A Review of the Clinical and Genetic Aspects.” Journal of Medical Genetics 40 (2): 8795.
Coufal, N. G., Gage, F. H., Garcia-Perez, J. L., Lovci, M. T., Moran, J. V., Morell, M., Mu, Y., Shea, K. S., Peng, G. E., and Yeo, G. W.. 2009. “L1 Retrotransposition in Human Neural Progenitor Cells.” Nature 460: 1127–31.
De, S. 2011. “Somatic Mosaicism in Healthy Human Tissues.” Trends in Genetics 27 (6): 217–23.
Dear, P. H. 2009. “Copy-number Variation: The End of the Human Genome?Trends in Biotechnology 27 (8): 448–54.
Delhanty, J. D. 2011. “Inherited Aneuploidy: Germline Mosaicism.” Cytogenetic Genome Research 133 (2–4): 136–40.
DeLorenzo, R. J., Hauser, W. A., Towne, A. R., Boggs, J. G., Pellock, J. M., Penberthy, L., Garnett, L., Fortner, C. A., and Ko, D.. 1996. “A Prospective, Population-based Epidemiologic Study of Status Epilepticus in Richmond, Virginia.” Neurology 46 (4): 1029–35.
Devlin, B., Bacanu, S. A., and Roeder, K.. 2004. “Genomic Control to the Extreme.” Nature Genetics 36 (11):1129–30; author reply, 31.
de Vries, J., de Graaf, N. D., and Eisinga, R.. 2009. “Biases in the Effects of Family Background Characteristics on Voting Preference: The Dutch Case.” Electoral Studies 28 (2): 204–17.
Droste, F., Do, A., and Gross, T.. 2013. “Analytical Investigation of Self-Organized Criticality in Neural Networks.” Journal of The Royal Society Interface 10 (78): 18.
Edwards, A., Rollmann, S. M., Morgan, T. J., and Mackay, T. F. C.. 2006. “Quantitative Genomics of Aggressive Behavior in Drosophila melanogaster .” PLoS Genetics 2 (9): 1386–95.
Eguíluz, V. M., Chialvo, D. R., Cecchi, G. A., Baliki, M., and Apkarian, A. V.. 2005. “Scale-Free Brain Functional Networks.” Physical Review Letters 94 (1): 14.
Fagiolini, M., Jensen, C. L., and Champagne, F. A.. 2009. “Epigenetic Influences on Brain Development and Plasticity.” Current Opinion in Neurobiology 19 (2): 207–12.
Faulkner, G. J. 2011. “Retrotransposons: Mobile and Mutagenic from Conception to Death.” FEBS Letters 585 (11): 1589–94.
Fontdevila, A. 2011. The Dynamic Genome: A Darwinian Approach. New York: Oxford University Press.
Fowler, J. H., and Dawes, C. T.. 2008. “Two Genes Predict Voter Turnout.” Journal of Politics 70 (03): 579–94.
Frisco, M. L., Muller, C., and Dodson, K.. 2004. “Participation in Voluntary Youth-serving Associations and Early Adult Voting Behavior.” Social Science Quarterly 85 (3): 660–76.
“From Gene to Protein: Gene Expression Quantification Offers New Insights.” 2011. PHYSorg.com. http://phys.org/news/2011-05-gene-protein-quantification-insights.html.
Garland, T., Jr, , and Kelly, S. A.. 2006. “Phenotypic Plasticity and Experimental Evolution.” Journal of Experimental Biology 209 (12): 2344–61.
Gelernter, J., Goldman, D., and Risch, N.. 1993. “The A1 Allele at the D2 Dopamine Receptor Gene and Alcoholism: A Reappraisal.” Journal of the American Medical Association 269 (13): 1673–67.
Hao, K., Chudin, E., Greenawalt, D., and Schadt, E. E.. 2010. “Magnitude of Stratification in Human Populations and Impacts on Genome Wide Association Studies.” PLoS ONE 5 (1): e8695.
Hart, D., Donnelly, T. M., Youniss, J., and Atkins, R.. 2007. “High School Community Service as a Predictor of Adult Voting and Volunteering.” American Educational Research Journal 44 (1): 197219.
He, B. J., Zempel, J. M., Snyder, A. Z., and Raichle, M. E.. 2010. “The Temporal Structures and Functional Significance of Scale-free Brain Activity.” Neuron 66 (3): 353–69.
Helgason, A., Yngvadottir, B., Hrafnkelsson, B., Gulcher, J., and Stefansson, K.. 2005. “An Icelandic Example of the Impact of Population Structure on Association Studies.” Nature Genetics 37 (1): 9095.
Iourov, I. Y., Vorsanova, S. G., and Yurov, Y. B.. 2006. “Chromosomal Variation in Mammalian Neuronal Cells: Known Facts and Attractive Hypotheses.” International Review of Cytology 249: 143–91.
Iskow, R. C., McCabe, M. T., Mills, R. E., Torene, S., Pittard, W. S., Neuwald, A. F., Van Meir, E. G., Vertino, P. M., and Devine, S. E.. 2010. “Natural Mutagenesis of Human Genomes by Endogenous Retrotransposons.” Cell 141 (7): 1253–61.
Julio, J. R. 2009. “Attitude-dependent Altruism, Turnout and Voting.” Public Choice 140 (12): 223–44.
Kaushal, D., Contos, J. J. A., Treuner, K., Yang, A. H., Kingsbury, M. A., Rehen, S. K., McConnell, M. J., et al. 2003. “Alteration of Gene Expression by Chromosome Loss in the Postnatal Mouse Brain.” Journal of Neuroscience 23 (13): 5599–606.
Khavari, D. A., Sen, G. L., and Rinn, J. L.. 2010. “DNA Methylation and Epigenetic Control of Cellular Differentiation.” Cell Cycle 9 (19): 3880–83.
Kingsbury, M. A. 2005. “Aneuploid Neurons Are Functionally Active and Integrated unto Brain Circuitry.” Proceedings of the National Acadamy of Sciences USA 102: 6143–47.
Knip, M., Veijola, R., Virtanen, S. M., Hyoty, H., Vaarala, O., and Akerblom, H. K.. 2012. “Environmental Triggers and Determinants of Type 1 Diabetes.” Diabetes 54 (Suppl 2): S12536.
Lopez, M., and Moore, K.. 2006. “Participation in Sports and Civic Engagement.” CIRCLE: The Center for Information & Research on Civic Learning & Engagement. http://www.civicyouth.org/PopUps/FactSheets/FS_06_Sports_and_Civic_Engagement.pdf.
Lotrich, F. E., Pollock, B. G., and Ferrell, R. E.. 2003. “Serotonin Transporter Promoter Polymorphism in African Americans: Allele Frequencies and Implications for Treatment.” American Journal of Pharmacogenomics 3 (2): 145–47.
Maddox, K. B. 2004. “Perspectives on Racial Phenotypicality Bias.” Personality and Social Psychology Review 8 (4): 383401.
Marler, P. L., and Hadaway, C. K.. 1999. “Testing the Attendance Gap in a Conservative Church.” Sociology of Religion 60 (2): 175–86.
McDermott, R., Tingley, D., Cowden, J., Frazzetto, G., and Johnson, D. D. P.. 2009. “Monoamine Oxidase A Gene (MAOA) Predicts Behavioral Aggression Following Provocation.” Proceedings of the National Academy of Sciences USA 106 (7): 2118–23.
McNulty, J. E., Dowling, C. M., and Ariotti, M. H.. 2009. “Driving Saints to Sin: How Increasing the Difficulty of Voting Dissuades Even the Most Motivated Voters.” Political Analysis 17 (4): 435–55.
Muotri, A. R., Marchetto, M. C. N., Coufal, N. G., Oefner, R., Yeo, G., Nakashima, K., and Gage, F. H.. 2010. “L1 Retrotransposition in Neurons Is Modulated by MeCP2.” Nature 468 (7322): 443–46.
Mychasiuk, R., Zahir, S., Schmold, N., Ilnytskyy, S., Kovalchuk, O., and Gibb, R.. 2012. “Parental Enrichment and Offspring Development: Modifications to Brain, Behavior and the Epigenome.” Behavioral and Brain Research 228 (2): 294–98.
Nie, N. H., Junn, J., and Stehlik Barry, K.. 1996. Education and Democratic Citizenship in America. Chicago: University of Chicago Press.
Noskova, T., Pivac, N., Nedic, G., Kazantseva, A., and Seler, D. M.. 2008. “Ethnic Differences in the Serotonin Transporter Polymorphism (5-HTTLPR) in Several European Populations.” Progress in Neuro-Psychopharmacology: Biological Psychiatry 32 (7): 1735–39.
Notini, A. J., Craig, J. M., and White, S. J.. 2008. “Copy Number Variation and Mosaicism.” Cytogenetic and Genome Research 123 (14): 270–77.
Pigliucci, M., Murren, C. J., and Schlichting, C. D.. 2006. “Phenotypic Plasticity and Evolution by Genetic Assimilation.” Journal of Experimental Biology 209 (12): 2362–67.
Plenz, D. 2012. “Neuronal Avalanches and Coherence Potentials.” European Physical Journal Special Topics 205 (1): 259301.
Popper, K. R. 2002. The Logic of Scientific Discovery. London: Routledge.
Price, A. L., Helgason, A., Palsson, S., and Stefansson, K.. 2009. “The Impact of Divergence Time on the Nature of Population Structure: An Example from Iceland.” PLoS Genetics 5 (6): e1000505.
Price, A. L., Zaitlen, N. A., Reich, D., and Patterson, N.. 2010. “New Approaches to Population Stratification in Genome-wide Association Studies.” Nature Reviews Genetics 11 (7): 459–63.
Proekt, A., Banavar, J. R., Maritan, A., and Pfaff, D. W.. 2012. “Scale Invariance in the Dynamics of Spontaneous Behavior.” Proceedings of the National Academy of Sciences USA 109 (26): 10564–99.
Qureshi, I. A., and Mehler, M. F.. 2012. “Emerging Roles of Non-coding RNAs in Brain Evolution, Development, Plasticity and Disease.” Nature Reviews Neuroscience 13 (8): 528–41.
Redon, R., Ishikawa, S., Fitch, K. R., Feuk, L., Perry, G. H., and Andrews, T. D.. 2006. “Global Variation in Copy Number in the Human Genome.” Nature 444: 444–54.
Rehen, S. K. 2005. “Constitutional Aneuploidy in the Normal Human Brain.” Journal of Neuroscience 25: 2176–80.
Schwanhäusser, B., Busse, D., Li, N., Dittmar, G., Schuchhardt, J., Wolf, J., Chen, W., and Selbach, M.. 2011. “Global Quantification of Mammalian Gene Expression Control.” Nature 473 (7347): 337–42.
Sciamanna, I., Vitullo, P., Curatolo, A., and Spadafora, C.. 2009. “Retrotransposons, Reverse Transcriptase and the Genesis of New Genetic Information.” Gene 448 (2): 180–86.
Shew, W. L., and Plenz, D.. 2012. “The Functional Benefits of Criticality in the Cortex.” Neuroscientist 19 (1): 88100.
Singer, T., McConnell, M. J., Marchetto, M. C. N., Coufal, N. G., and Gage, F. H.. 2010. “LINE-1 Retrotransposons: Mediators of Somatic Variation in Neuronal Genomes?Trends in Neurosciences 33 (8): 345–54.
Skinner, Michael K. 2011. “Role of Epigenetics in Developmental Biology and Transgenerational Inheritance.” Birth Defects Research Part C: Embryo Today: Reviews 93 (1): 5155. “Study Suggests Link between Oral Health and Ethnicity.” 2007. British Dentistry Journal 202 (9): 514–15.
Theodore, W. H., Spencer, S. S., Wiebe, S., Langfitt, J. T., Ali, A., Shafer, P. O., Berg, A. T., and Vickrey, B. G.. 2006. “Epilepsy in North America: A Report Prepared under the Auspices of the Global Campaign against Epilepsy, the International Bureau for Epilepsy, the International League against Epilepsy, and the World Health Organization.” Epilepsia 47 (10): 1700–22.
Thomas, D. C., and Witte, J. S.. 2002. “Point: Population Stratification: A Problem for Case-Control Studies of Candidate-Gene Associations?Cancer Epidemiology, Biomarkers & Prevention 11 (6): 505–12.
Tom, W. S. 1998. “A Review of Church Attendance Measures.” American Sociological Review 63 (1): 131–36.
U.S. Census Bureau. 2012. “Voting-Age Population, Percent Reporting Registered, and Voted. 2012.” http://www.census.gov/compendia/statab/2012/tables/12s0399.pdf.
van den Oord, E. J. C. G., Verhulst, F. C., and Boomsma, D. I.. 1996. “A Genetic Study of Maternal and Paternal Ratings of Problem Behaviors in 3-year-old Twins.” Journal of Abnormal Psychology 105 (3): 349–57.
Vitullo, P., Sciamanna, I., Baiocchi, M., Sinibaldi-Vallebona, P., and Spadafora, C.. 2012. “LINE-1 Retrotransposon Copies Are Amplified during Murine Early Embryo Development.” Molecular Reproduction and Development 79 (2): 118–27.
West-Eberhard, M. J. 2003. Developmental Plasticity and Evolution. New York: Oxford University Press.
Westra, J. W., Rivera, R. R., Bushman, D. M., Yung, Y. C., Peterson, S. E., Barral, S., and Chun, J.. 2010. “Neuronal DNA Content Variation (DCV) with Regional and Individual Differences in the Human Brain.” Journal of Comparative Neurology 518 (19): 39814000.
Yashin, A. 2011. “Genetics of Exceptional Lifespan: Testing Mutation Accumulation Hypothesis of Aging Using GWAS” Rresented at Integrating Genetics and the Social Sciences conference, Boulder, CO.
Zhang, T. Y., and Meaney, M. J.. 2010. “Epigenetics and the Environmental Regulation of the Genome and Its Function.” Annual Review of Psychology 61 (1): 439–66.
Zwarts, L., Magwire, M. M., Carbone, M. A., Versteven, M., Herteleer, L., Anholt, R. R. H., Callaerts, P., and Mackay, T. F. C.. 2011. “Complex Genetic Architecture of Drosophila Aggressive Behavior.” Proceedings of the National Academy of Sciences USA 108 (41): 17070–75.
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American Political Science Review
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CHARNEY and WILLIAM ENGLISH
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