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Biochemical, nutritional and genetic effects on boar taint in entire male pigs

  • G. Zamaratskaia (a1) and E. J. Squires (a2)
  • DOI:
  • Published online: 17 December 2008

Pork odour is to a great extent affected by the presence of malodorous compounds, mainly androstenone and skatole. The present review outlines the current state of knowledge about factors involved in the regulation of androstenone and skatole in entire male pigs. Androstenone is a pheromonal steroid synthesised in the testes and metabolised in the liver. Part of androstenone accumulates in adipose tissue causing a urine-like odour. Skatole is produced in the large intestine by bacterial degradation of tryptophan and metabolised by hepatic cytochrome P450 enzymes and sulphotransferase. The un-metabolised part accumulates in adipose tissue, causing faecal-like odour. Androstenone levels are mostly determined by genetic factors and stage of puberty, whereas skatole levels in addition to genetic background and hormonal status of the pigs are also controlled by nutritional and environmental factors. To reduce the risk of tainted carcasses entering the market, male pigs are surgically castrated in many countries. However, entire males compared to castrates have superior production characteristics: higher growth rate, better feed efficiency and leaner carcasses. Additionally, animal welfare aspects are currently of particular importance in light of increasing consumers’ concerns. Nutrition, hormonal status, genetic influence on boar taint compounds and the methods to develop genetic markers are discussed. Boar taint due to high levels of skatole and androstenone is moderately heritable and not all market weight entire males have boar taint; it should thus be possible to select for pigs that do not have boar taint. In these studies, it is critical to assess the steroidogenic potential of the pigs in order to separate late-maturing pigs from those with a low genetic potential for boar taint. A number of candidate genes for boar taint have been identified and work is continuing to develop genetic markers for low boar taint. More research is needed to clarify the factors involved in the development of boar taint and to develop additional methods to prevent the accumulation of high concentrations of skatole and androstenone in fat. This review proposes those areas requiring further research.

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I Aldal , O Andresen , AK Egeli , J-E Haugen , A Grodum , O Fjetland , JLH Eikaas 2005. Levels of androstenone and skatole and the occurrence of boar taint in fat from young boars. Livestock Production Science 95, 121129.

M Angels Rius , M Hortós , JA Garcia-Regueiro 2005. Influence of volatile compounds on the development of off-flavours in pig back fat samples classified with boar taint by a test panel. Meat Science 71, 595602.

J Babol , EJ Squires 1999. Liver metabolic activities of intact male pigs injected with skatole. Canadian Journal of Animal Science 79, 549552.

J Babol , G Zamaratskaia , RK Juneja , K Lundström 2004. The effect of age on distribution of skatole and indole levels in entire male pigs in four breeds: Yorkshire, Landrace, Hampshire and Duroc. Meat Science 67, 351358.

J Babol , EJ Squires 1995. Quality of meat from entire male pigs. Food Research International 28, 201212.

J Babol , EJ Squires , K Lundström 1998a. Hepatic metabolism of skatole in pigs by cytochrome P4502E1. Journal of Animal Science 76, 822828.

J Babol , EJ Squires , K Lundström 1998b. Relationship between oxidation and conjugation metabolism of skatole in pig liver and concentrations of skatole in fat. Journal of Animal Science 76, 829838.

C Baek , J Hansen-Møller , C Friiis , C Cornett , SH Hansen 1997. Identification of selected metabolites of skatole in plasma and urine from pigs. Journal of Agricultural and Food Chemistry 45, 23322340.

J Babol , EJ Squires , K Lundstrøm 1999. Relationship between metabolism of skatole and andtrostenone in intact male pigs. Journal of Animal Science 77, 8492.

S Bañón , C Andreu , J Laencina , M-D Garrido 2004. Fresh and eating pork quality from entire versus castrate heavy males. Food Quality and Preference 15, 293300.

M Bonneau 1982. Compounds responsible for boar taint, with special emphasis on androstenone: a review. Livestock Production Science 9, 687707.

M Bonneau 1987. Effects of age and live weight on fat 5 alpha-androstenone levels in young boars fed two planes of nutrition. Reproduction Nutrition Development 27, 413422.

M Bonneau 1998. Use of entire males for pig meat in the European Union. Meat Science 49, S257S272.

M Bonneau , P Russeil 1985. The size of cowper’s (bulbo-urethral) glands as an estimate of boar taint on the slaughter line. Livestock Production Science 13, 169178.

M Bonneau , J Carrié-Lemoine , A Prunier , DH Garnier , M Terqui 1987. Age-related changes in plasma LH and testosterone concentration profiles and fat androstenone content in the young boar. Animal Reproduction Science 15, 241258.

M Bonneau , M LeDenmat , JC Vaudelet , JR VelosoNunes , AB Mortensen , HP Mortensen 1992. Contributions of fat androstenone and skatole to boar taint: I. Sensory attributes of fat and pork meat. Livestock Production Science 32, 6380.

WD Booth 1987. Factors affecting the pheromone composition of voided boar saliva. Journal of Reproduction and Fertility 81, 427431.

JJ Brennan , PJ Shand , M Fenton , LL Nicholls , FX Aherne 1986. Androstenone, androstenol and odor intensity in backfat of 100- and 130-kg boars and gilts. Canadian Journal of Animal Science 66, 615624.

PJ Brophy , BD Gower 1972. 16-unsaturated C 19 3-oxo steroids as metabolic intermediates in boar testis. Biochemical Journal 128, 945952.

G Chen , G Zamaratskaia , A Madej , K Lundström 2006. Effect of hCG administration on the relationship between testicular steroids and indolic compounds in fat and plasma in entire male pigs. Meat Science 72, 339347.

G Chen , G Zamaratskaia , HK Andersson , K Lundström 2007. Effect of dietary supplement of raw potato starch and live weight on the levels of skatole, indole and androstenone measured by different methods. Food Chemistry 101, 439448.

G Chen , R-A Cue , K Lundström , JH Wood , O Doran 2008. Regulation of cytochrome P450 2A6 protein expression by skatole, indole and testicular steroids in primary cultured porcine hepatocytes. Drug Metabolism and Disposition 36, 5660.

R Claus , S Raab 1999. Influences on skatole formation from tryptophan in the pig colon. Advances in Experimental Medicine and Biology 467, 679684.

R Claus , B Hoffmann , H Karg 1971. Determination of 5-androst-16-en-3-one, a boar taint steroid in pigs, with reference to relationships to testosterone. Journal of Animal Science 33, 12931297.

R Claus , M Dehnhard , A Herzhog , H Bernal-Barragan , T Giménez 1993. Parallel measurements of indole and skatole (3-methylindole) in feces and blood plasma of pigs by HPLC. Livestock Production Science 34, 115126.

R Claus , U Weiler , A Herzog 1994. Physiological aspects of androstenone and skatole formation in the boars – a review with experimental data. Meat Science 38, 289305.

R Claus , D Losel , M Lacorn , J Mentschel , H Schenkel 2003. Effects of butyrate on apoptosis in the pig colon and its consequences for skatole formation and tissue accumulation. Journal of Animal Science 81, 239248.

R Claus , M Lacorn , K Danowski , MC Pearce , A Bauer 2007. Short-term endocrine and metabolic reactions before and after second immunization against GnRH in boars. Vaccine 25, 46894696.

GM Cooke , SE Ferguson , E Rytina , DB Gower 1983. Properties of porcine liver and testicular steroid sulphotransferases: reaction conditions and influence of naturally occurring steroids and steroid sulphates. Journal of Steroid Biochemistry 19, 11031109.

GM Cronin , FR Dunshea , KL Butler , I McCauley , JL Barnett , PH Hemsworth 2003. The effects of immuno- and surgical-castration on the behaviour and consequently growth of group-housed, male finisher pigs. Applied Animal Behaviour Science 81, 111126.

SM Davis , EJ Squires 1999. Association of cytochrome b5 with 16-androstene steroid synthesis in the testis and accumulation in the fat of male pigs. Journal of Animal Science 77, 12301235.

M Dehnhard , H Bernal-Barragan , R Claus 1991. Rapid and accurate high-performance liquid chromatographic method for the determination of 3-methylindole (skatole) in faeces of various species. Journal of Chromatography 566, 101107.

GJ Diaz , EJ Squires 2000a. Metabolism of 3-methylindole by porcine liver microsomes: responsible cytochrome P450 enzymes. Toxicological Sciences 55, 284292.

GJ Diaz , EJ Squires 2000b. Role of aldehyde oxidase in the hepatic in vitro metabolism of 3-methylindole in pigs. Journal of Agricultural and Food Chemistry 48, 833837.

GJ Diaz , EJ Squires 2003. Phase II in vitro metabolism of 3-methylindole metabolites in porcine liver. Xenobiotica 33, 485498.

E Doran , FM Whittington , JD Wood , JD McGivan 2002a. The relationship between adipose tissue skatole levels, rates of hepatic microsomal skatole metabolism and hepatic cytochrome P450IIE1 expression in two breeds of pig. Animal Science 74, 461468.

E Doran , FW Whittington , JD Wood , JD McGivan 2002b. Cytochrome P450IIE1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes. Chemico-Biological Interactions 140, 8192.

E Doran , FM Whittington , JD Wood , JD McGivan 2004. Characterization of androstenone metabolism in pig liver microsomes. Chemico-Biological Interactions 147, 141149.

AJ Draper , A Madan , A Parkinson 1997. Inhibition of coumarin 7-hydroxylase activity in human liver microsomes. Archives of Biochemistry and Biophysics 341, 4761.

I Dufort , P Soucy , L Lacoste , V Luu-The 2001. Comparative biosynthetic pathway of androstenol and androgens. Journal of Steroid Biochemistry and Molecular Biology 77, 223227.

FR Dunshea , C Colantoni , K Howard , I McCauley , P Jackson , KA Long , S Lopaticki , EA Nugent , JA Simons , J Walker , DP Hennessy 2001. Vaccination of boars with a GnRH vaccine (Improvac) eliminates boar taint and increases growth performance. Journal of Animal Science 79, 25242535.

S Einarsson 2006. Vaccination against GnRH: pros and cons. Acta Veterinaria Scandinavica 48 (suppl. 1), S10.

DE Fish , GM Cooke , DB Gower 1980. Investigation into the sulphoconjugation of 5 alpha-androst-16-en-3 beta-ol by porcine liver. FEBS Letters 117, 2832.

JA García-Regueiro , I Diaz 1989. Evaluation of the contribution of skatole, indole, androstenone and androstenols to boar-taint in back fat of pigs by HPLC and capillary gas chromatography (CGC). Meat Science 25, 307316.

M Gillberg , MT Skaanild , C Friis 2006. Regulation of gender-dependent CYP2A expression in pigs: involvement of androgens and CAR. Basic and Clinical Pharmacology and Toxicology 98, 480487.

DB Gower 1972. 16-Unsaturated C 19 steroids. A review of their chemistry, biochemistry and possible physiological role. Journal of Steroid Biochemistry 3, 45103.

LL Hansen , H Mejer , SM Thamsborg , DV Byrne , A Roepstorff , AH Karlsson , J Hansen-Møller , MT Jensen , M Tuomola 2006. Influence of chicory roots (Cichorium Intybus L.) on boar taint in entire male and female pigs. Animal Science 82, 359368.

M Hilbe , P Jaros , F Ehrensperger , K Zlinszky , F Janett , M Hässig , R Thun 2006. Histomorphological and immunohistochemical findings in testes, bulbourethral glands and brain of immunologically castrated male piglets. Schweizer Archiv für Tierheilkunde 148, 599608.

P Jaros , E Bürgi , KDC Stärk , R Claus , D Hennessy , R Thun 2005. Effect of active immunization against GnRH on androstenone concentration, growth performance and carcass quality in intact male pigs. Livestock Production Science 92, 3138.

MT Jensen , LL Hansen 2006. Feeding with chicory roots reduces the amount of odorous compounds in colon and rectal contents of pigs. Animal Science 82, 369376.

A Knarreborg , J Beck , MT Jensen , A Laue , N Agergaard , BB Jensen 2002. Effect of non-starch polysaccharides on production and absorption of indolic compounds in entire male pigs. Animal Science 74, 445453.

TK Kwan , C Orengo , DB Gower 1985. Biosynthesis of androgens and pheromonal steroids in neonatal porcine testicular preparations. FEBS Letters 183, 359364.

F Lanthier , Y Lou , MA Terner , EJ Squires 2006. Characterizing developmental changes in plasma and tissue skatole concentrations in the prepubescent intact male pig. Journal of Animal Science 84, 16991708.

F Lanthier , Y Lou , EJ Squires 2007. Skatole metabolism in the intact pre-pubescent male pig: the relationship between hepatic enzyme activity and skatole concentrations in plasma and fat. Livestock Science 106, 145153.

GJ Lee , AL Archibald , AS Law , S Lloyd , J Wood , CS Haley 2005. Detection of quantitative trait loci for androstenone, skatole and boar taint between large white and Meishan pigs. Animal Genetics 36, 1422.

Z Lin , Y Lou , EJ Squires 2004a. Molecular cloning, expression and functional characterization of cytochrome P450 2A6 gene in pig liver. Animal Genetics 35, 314316.

Z Lin , Y Lou , EJ Squires 2004b. Molecular cloning and functional analysis of porcine SULT1A1 gene and its variant: a single mutation in SULT1A1 causes a significant decrease in sulfation activity. Mammalian Genome 15, 218226.

ZH Lin , YP Lou , J Peacock , EJ Squires 2005. A novel polymorphism in the 5′ untranslated region of the porcine cytochrome b5 (CYB5) gene is associated with decreased fat androstenone level. Mammalian Genome 16, 367373.

Z Lin , Y Lou , EJ Squires 2006. Functional polymorphism in porcine CYP2E1 gene: Its association with skatole levels. Journal of Steroid Biochemistry and Molecular Biology 99, 231237.

WJ Meadus , JI Mason , EJ Squires 1993. Cytochrome P450c17 from porcine and bovine adrenal catalyses the formation of 5,16 androstadien-3β-ol from pregnenolone in the presence of cytochrome b5. Journal of Steroid Biochemistry and Molecular Biology 46, 565572.

J Mentschel , R Claus 2003. Increased butyrate formation in the pig colon by feeding raw potato starch leads to a reduction of colonocyte apoptosis and a shift to the stem cell compartment. Metabolism 52, 14001405.

C Metz , K Hohl , S Waidelich , W Drochner , R Claus 2002. Active immunization of boars against GnRH at an early age: consequences for testicular function, boar taint accumulation and N-retention. Livestock Production Science 74, 147157.

M Moe , E Grindflek , O Doran 2007a. Expression of 3beta-hydroxysteroid dehydrogenase, cytochrome P450-c17, and sulfotransferase 2B1 proteins in liver and testis of pigs of two breeds: relationship with adipose tissue androstenone concentration. Journal of Animal Science 85, 29242931.

M Moe , T Meuwissen , S Lien , C Bendixen , X Wang , LN Conley , I Berget , H Tajet , E Grindflek 2007b. Gene expression profiles in testis of pigs with extreme high and low levels of androstenone. BMC Genomics 8, 405.

HM Mutembei , S Pesch , G Schuler , B Hoffmann 2005. Expression of oestrogen receptor and ß and of aromatase in the testis of immature and mature boars. Reproduction in Domestic Animals 40, 228236.

SI Nicolau-Solano , FM Whittington , JD Wood , O Doran 2007. Relationship between carcass weight, adipose tissue androstenone level and expression of the hepatic 3β-hydroxysteroid dehydrogenase in entire commercial pigs. Animal 1, 10531059.

WT Oliver , I McCauley , RJ Harrell , D Suster , DJ Kerton , FR Dunshea 2003. A gonadotropin-releasing factor vaccine (Improvac) and porcine somatotropin have synergistic and additive effects on growth performance in group-housed boars and gilts. Journal of Animal Science 81, 19591966.

RLS Patterson 1967. A possible contribution of phenolic components to boar odour. Journal of the Science of Food Agriculture 18, 810.

RLS Patterson 1968. 5α-androst-16-ene-3-one: compound responsible for taint in boar fat. Journal of the Science of Food Agriculture 19, 3138.

J Peacock , Y Lou , K Lundström , EJ Squires 2007. The effect of a ca. −8G>T polymorphism on the expression of cytochrome b5A and boar taint in pigs. Animal Genetics 39, 1521.

R Quintanilla , O Demeure , JP Bidanel , D Milan , N Iannuccelli , Y Amigues , J Gruand , C Renard , C Chevalet , M Bonneau 2003. Detection of quantitative trait loci for fat androstenone levels in pigs. Journal of Animal Science 81, 385394.

JI Raeside , RL Renaud 1983. Estrogen and androgen production by purified Leydig cells of mature boars. Biology of Reproduction 28, 727733.

MA Rius Sole , JA García-Regueiro 2001. Role of 4-phenyl-3-buten-2-one in boar taint: identification of new compounds related to sensorial descriptors in pig fat. Journal of Agricultural and Food Chemistry 49, 53035309.

A Robic , C Larzul , M Bonneau 2008. Genetic and metabolic aspects of androstenone and skatole deposition in pig adipose tissue: a review. Genetics Selection Evolution 40, 129143.

YA Saat , DB Gower , FA Harrison , RB Heap 1974. Studies on the metabolism of 5alpha-androst-16-en-3-one in boar tests in vivo. Biochemical Journal 144, 347352.

P Sellier , P Le Roy , MN Foilloux , J Gruand , M Bonneau 2000. Responses to restricted index selection and genetic parameters for fat androstenone level and sexual maturity status of young boars. Livestock Production Science 63, 265274.

PA Sinclair , EJ Squires , JI Raeside 2001. Early postnatal plasma concentrations of testicular hormones, pubertal development and carcass leanness as potential indicators of boar taint in market weight intact male pigs. Journal of Animal Science 79, 18681876.

PA Sinclair , EJ Squires 2005. Testicular sulfoconjugation of the 16-androstene steroids by hydroxysteroid sulfotransferase: its effect on the concentrations of 5alpha-androstenone in plasma and fat of the mature domestic boar. Journal of Animal Science 83, 358365.

PA Sinclair , EJ Squires , JI Raeside , R Renaud 2005a. Synthesis of free and sulphoconjugated 16-androstene steroids by the Leydig cells of the mature domestic boar. Journal of Steroid Biochemistry and Molecular Biology 96, 217228.

PA Sinclair , S Hancock , WJ Gilmore , EJ Squires 2005b. Metabolism of the 16-androstene steroids in primary cultured porcine hepatocytes. Journal of Steroid Biochemistry and Molecular Biology 96, 7987.

PA Sinclair , WJ Gilmore , Z Lin , Y Lou , EJ Squires 2006. Molecular cloning and regulation of porcine SULT2A1: relationship between SULT2A1 expression and sulfoconjugation of androstenone. Journal of Molecular Endocrinology 36, 301311.

TM Skinner , E Doran , JD McGivan , CS Haley , AL Archibald 2005. Cloning and mapping of the porcine cytochrome-P450 2E1 gene and its association with skatole levels in the domestic pig. Animal Genetics 36, 417422.

TM Skinner , JA Anderson , CS Haley , AL Archibald 2006. Assessment of SULT2A1, CYP2A6 and CYPC18 as candidate genes for elevated backfat skatole levels in commercial and experimental pig populations. Animal Genetics 37, 521522.

EJ Squires , K Lundström 1997. Relationship between cytochrome P450IIE1 in liver and levels of skatole and its metabolites in intact male pigs. Journal of Animal Science 75, 25062511.

JD Stewart , Y Lou , EJ Squires , PM Coussens 2005. Using human microarrays to identify differentially expressed genes associated with increased steroidogenesis in boars. Animal Biotechnology 16, 139151.

WS Tambyrajah , E Doran , JD Wood , JD McGivan 2004. The pig CYP2E1 promoter is activated by COUP-TF1 and HNF-1 and is inhibited by androstenone. Archives of Biochemistry and Biophysics 431, 252260.

MA Terner , WJ Gilmore , Y Lou , EJ Squires 2006. The role of CYP2A and CYP2E1 in the metabolism of 3-methylindole in primary cultured porcine hepatocytes. Drug Metabolism and Disposition 34, 848854.

M Tuomola , R Harpio , P Knuuttila , H Mikola , T Lövgren 1997. Time-resolved fluoroimmunoassay for the measurement of androstenone in porcine serum and fat samples. Journal of Agricultural and Food Chemistry 45, 35293534.

MJ Van Oeckel , N Warnants , M De Paepe , M Casteels , ChV Boucqué 1998. Effect of fibre-rich diets on the backfat skatole content of entire male pigs. Livestock Production Science 56, 173180.

L Varona , O Vidal , R Quintanilla , M Gil , A Sanchez , JM Folch , M Hortos , MA Rius , M Amills , JL Noguera 2005. Baysean analysis of quantitative trait loci for boar taint in a Landrace population. Journal of Animal Science 83, 301307.

P Walstra , C Claudi-Magnussen , P Chevillon , G von Seth , A Diestre , KR Matthews , DB Homer , M Bonneau 1999. An international study on the importance of androstenone and skatole for boar taint: levels of androstenone and skatole by country and season. Livestock Production Science 62, 1528.

FM Whittington , GR Nute , SI Hughes , JD McGivan , IJ Lean , JD Wood , E Doran 2004. Relationships between skatole and androstenone accumulation, and cytochrome P4502E1 expression in Meishan × Large White pigs. Meat Science 67, 569576.

H Willeke , R Claus , E Müller , F Pirchner , H Karg 1987. Selection for high and low level of 5 α-androst-16-en-3-one in boars. I. Direct and correlated response of endocrinological traits. Journal of Animal Breeding and Genetics 104, 6473.

JD Wood , PJ Buxton , FM Whittington , M Enser 1986. The chemical composition of fat tissues in the pig: effects of castration and feeding treatment. Livestock Production Science 15, 7382.

J Xue , GD Dial , EE Holton , Z Vickers , EJ Squires , Y Lou , D Godbout , N Morel 1996. Breed differences in boar taint: relationship between tissue levels of boar taint compounds and sensory analysis of taint. Journal of Animal Science 74, 21702177.

G Zamaratskaia , J Babol , H Andersson , K Lundström 2004a. Plasma skatole and androstenone levels in entire male pigs and relationship between boar taint compounds, sex steroids and thyroxine at various ages. Livestock Production Science 87, 9198.

G Zamaratskaia , J Babol , A Madej , EJ Squires , K Lundström 2004b. Age-related variation of plasma concentrations of skatole in relation to androstenone, sex hormones, triiodothyronine and IGF-1 in six entire male pigs. Reproduction in Domestic Animals 39, 168172.

G Zamaratskaia , EJ Squires , J Babol , HK Andersson , K Andersson , K Lundström 2005a. Relationship between the activities of cytochromes P4502E1 and P4502A6 and skatole content in fat in entire male pigs fed with and without raw potato starch. Livestock Production Science 95, 8388.

G Zamaratskaia , J Babol , HK Andersson , K Andersson , K Lundström 2005b. Effect of live weight and dietary supplement of raw potato starch on the levels of skatole, androstenone, testosterone and oestrone sulphate in entire male pigs. Livestock Production Science 93, 235243.

G Zamaratskaia , A Madej , J Babol , EJ Squires , K Lundström 2005c. Free oestrone in adipose tissue and its relation to androstenone and skatole in entire male pigs. Reproduction in Domestic Animals 40, 156160.

G Zamaratskaia , L Rydhmer , G Chen , A Madej , HK Andersson , K Lundström 2005d. Boar taint is related to endocrine and anatomical changes at puberty but not to aggressive behaviour in entire male pigs. Reproduction in Domestic Animals 40, 500506.

G Zamaratskaia , G Chen , K Lundström 2006. Effects of sex, weight, diet and hCG administration on levels of skatole and indole in the liver and hepatic activities of cytochromes P4502E1 and P4502A6 in pigs. Meat Science 72, 331338.

G Zamaratskaia , Y Lou , G Chen , Ø Andresen , K Lundström , EJ Squires 2007a. Effect of hCG stimulation on plasma androstenone concentrations and cytochrome b5 (CYB5) levels in testicular tissue. Reproduction in Domestic Animals 42, 105108.

G Zamaratskaia , WJ Gilmore , K Lundström , EJ Squires 2007b. Effect of testicular steroids on catalytic activities of cytochrome P450 enzymes in porcine liver microsomes. Food and Chemical Toxicology 45, 676681.

G Zamaratskaia , I Oskam , E Ropstad , H Tajet , Ø Andresen 2008a. Effect of hCG stimulation on hepatic activities of cytochrome P4502E1 and P4502A in entire male pigs. Reproduction in Domestic Animals 43, 147152.

G Zamaratskaia , HK Andersson , G Chen , K Andersson , A Madej , K Lundström 2008b. Effect of a gonadotropin-releasing hormone vaccine (ImprovacTM) on steroid hormones, boar taint and performance in entire male pigs. Reproduction in Domestic Animals (doi:10.1111/j.1439-0531.2007.00914.x).

G Zamaratskaia , L Rydhmer , HK Andersson , G Chen , S Lowagie , K Andersson , K Lundström 2008c. Long-term effect of vaccination against gonadotropin-releasing hormone, using ImprovacTM mark, on hormonal profile and behaviour of male pigs. Animal Reproduction Science (doi:10.1016/j.anireprosci.2007.07.001).

G Zamaratskaia , Y Lou , J Peacock , L Rydhmer , HK Andersson , RK Juneja , G Chen , K Lundström , EJ Squires 2008d. Effect of polymorphism in the porcine cytochrome b5 (CYB5A) gene on androstenone and skatole concentrations and sexual development in Swedish swine populations. Animal 2, 190196.

TC Rideout , MZ Fan , JP Cant , C Wagner-Riddle P Stonehouse 2004. Excretion of major odor-causing and acidifying compounds in response to dietary supplementation of chicory inulin in growing pigs. Journal of Animal Science 82, 16781684.

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  • ISSN: 1751-7311
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