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    Benes, Sharon E. Robinson, Peter H. and Cun, Grace S. 2015. Depletion of selenium in blood, liver and muscle from beef heifers previously fed forages containing high levels of selenium. Science of The Total Environment, Vol. 536, p. 603.


    2012. Trace Minerals and Livestock: Not Too Much Not Too Little. ISRN Veterinary Science, Vol. 2012, p. 1.


    Pedrero, Zoyne Murillo, Sara Cámara, Carmen Schram, E. Luten, J. B. Feldmann, Ingo Jakubowski, Nobert and Madrid, Yolanda 2011. Selenium speciation in different organs of African catfish (Clarias gariepinus) enriched through a selenium-enriched garlic based diet. J. Anal. At. Spectrom., Vol. 26, Issue. 1, p. 116.


    Stockdale, C.R. and Gill, H.S. 2011. Effect of duration and level of supplementation of diets of lactating dairy cows with selenized yeast on selenium concentrations in milk and blood after the withdrawal of supplementation. Journal of Dairy Science, Vol. 94, Issue. 5, p. 2351.


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Selenium persistency and speciation in the tissues of lambs following the withdrawal of dietary high-dose selenium-enriched yeast

  • D. T. Juniper (a1), R. H. Phipps (a1), E. Ramos-Morales (a1) and G. Bertin (a2)
  • DOI: http://dx.doi.org/10.1017/S1751731107001395
  • Published online: 01 March 2008
Abstract

The objective was to determine the concentration of total selenium (Se) and the proportion of total Se comprised as selenomethionine (SeMet) and selenocysteine (SeCys) in post mortem tissues of lambs in the 6 weeks period following the withdrawal of a diet containing high-dose selenised yeast (HSY), derived from a specific strain of Saccharomyces cerevisae CNCM (Collection Nationale de Culture de Micro-organism) I-3060. Thirty Texel × Suffolk lambs used in this study had previously received diets (91 days) containing either HSY (6.30 mg Se per kg dry matter (DM)) or an unsupplemented control (C; 0.13 mg Se per kg DM). Following the period of supplementation, all lambs were then offered a complete pelleted diet, without additional Se (0.15 mg Se per kg DM), for 42 days. At enrolment and 21 and 42 days later, five lambs from each treatment were blood sampled, euthanased and samples of heart, liver, kidney and skeletal muscle (longissimus dorsi and psoas major) tissue were retained. Total Se concentration in whole blood and tissues was significantly (P < 0.001) higher in HSY lambs at all time points that had previously received long-term exposure to high dietary concentrations of SY. The distribution of total Se and the proportions of total Se comprised as SeMet and SeCys differed between tissues, treatment and time points. Total Se was greatest in HSY liver and kidney (22.64 and 18.96 mg Se per kg DM, respectively) and SeCys comprised the greatest proportion of total Se. Conversely, cardiac and skeletal muscle (longissimus dorsi and psoas major) tissues had lower total Se concentration (10.80, 7.02 and 7.82 mg Se per kg DM, respectively) and SeMet was the predominant selenised amino acid. Rates of Se clearance in HSY liver (307 μg Se per day) and kidney (238 μg Se per day) were higher compared with HSY cardiac tissue (120 μg Se per day) and skeletal muscle (20 μg Se per day). In conclusion, differences in Se clearance rates were different between tissue types, reflecting the relative metabolic activity of each tissue, and appear to be dependent on the proportions of total Se comprised as either SeMet or SeCys.

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E-mail: d.t.juniper@rdg.ac.uk
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LA Cristaldi , LR McDowell , CD Buergelt , PA Davis , NS Wilkinson , FG Martin 2005. Tolerance of inorganic selenium in wether sheep. Small Ruminant Research 56, 205213.

PA Davis , LR McDowell , NS Wilkinson , CD Buergelt , R Van Alstyne , RN Weldon , TT Marshall 2006. Tolerance of inorganic selenium by range-type ewes during gestation and lactation. Journal of Animal Science 84, 660668.

DT Juniper , RH Phipps , AK Jones , G Bertin 2006. Selenium supplementation of lactating dairy cows: Effect on selenium concentration in blood, milk, urine and feces. Journal of Dairy Science 89, 35443551.

TL Lawler , JB Taylor , JW Finley , JS Caton 2004. Effect of supranutritional and organically bound selenium on performance carcass characteristics and selenium distribution in finishing beef steers. Journal of Animal Science 82, 14881493.

JC MacRae , DG Armstrong 1968. Enzyme method for determination of α-linked glucose polymers in biological materials. Journal of the Science and Food Agriculture 19, 578581.

O Palacios , JR Encinar , G Bertin , P Lobinski 2005. Analysis of the selenium species distribution in cow blood by size exclusion liquid chromatography – inductively coupled plasma collision cell mass spectrometry (SEC-ICPccMS). Analytical and Bioanalytical Chemistry 383, 516522.

S Qin , J Gao , K Huang 2007. Effects of different selenium sources on tissue selenium concentrations, blood GSH-Px activities and plasma interleukin levels in finishing lambs. Biological Trace Element Research 116, 91102.

KT Suzuki , Y Ogra 2002. Metabolic pathway for selenium in the body: speciation by HPLC-ICP MS with enriched Se. Food Additives and Contaminants 19, 974983.

JB Taylor 2005. Time-dependent influence of supranutritional organically bound selenium on selenium accumulation in growing whether lambs. Journal of Animal Science 83, 11861193.

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