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Précis of The neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system

  • Jeffrey A. Gray (a1)

A model of the neuropsychology of anxiety is proposed. The model is based in the first instance upon an analysis of the behavioural effects of the antianxiety drugs (benzodiazepines, barbiturates, and alcohol) in animals. From such psychopharmacologi-cal experiments the concept of a “behavioural inhibition system” (BIS) has been developed. This system responds to novel stimuli or to those associated with punishment or nonreward by inhibiting ongoing behaviour and increasing arousal and attention to the environment. It is activity in the BIS that constitutes anxiety and that is reduced by antianxiety drugs. The effects of the antianxiety drugs in the brain also suggest hypotheses concerning the neural substrate of anxiety. Although the benzodiazepines and barbiturates facilitate the effects of γ-aminobutyrate, this is insufficient to explain their highly specific behavioural effects. Because of similarities between the behavioural effects of certain lesions and those of the antianxiety drugs, it is proposed that these drugs reduce anxiety by impairing the functioning of a widespread neural system including the septo-hippocampal system (SHS), the Papez circuit, the prefrontal cortex, and ascending monoaminergic and cholinergic pathways which innervate these forebrain structures. Analysis of the functions of this system (based on anatomical, physiological, and behavioural data) suggests that it acts as a comparator: it compares predicted to actual sensory events and activates the outputs of the BIS when there is a mismatch or when the predicted event is aversive. Suggestions are made as to the functions of particular pathways within this overall brain system. The resulting theory is applied to the symptoms and treatment of anxiety in man, its relations to depression, and the personality of individuals who are susceptible to anxiety or depression.

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D. E. Broadbent (1958) Perception and communication. New York: Pergamon Press. [STM]

D. de Wied , Tj. B. van Wimersma Greidanus , B. Bohus , I. Urban & W. H. Gispen (1976) Vasopressin and memory consolidation. In: Perspectives in brain research, ed. M. A. Corner & D. F. Swaab . Progress in Brain Research, vol. 45, pp. 181–94. Amsterdam: Elsevier. [BB]

K. Elliott & J. Whelan , eds. (1978) Functions of the septo-hippocampal system. Ciba Foundation Symposium 58 (n.s.). Amsterdam: Elsevier. [AC, tarJAG]

J. A. Gray (1964) Strength of the nervous system and levels of arousal. In: Povlov's typology, ed. J. A. Gray , pp. 289366. New York: Macmillan. [MZ]

J. A. Gray (1977) Drug effects on fear and frustration: Possible limbic site of action of minor tranquillizers. In: Handbook of psychopharmacology: 8. Drugs, neurotransmitters and behaviour, ed. L. L. Iversen , S. D. Iversen & S. H. Snyder , pp. 433529. New York: Plenum Press. [tarJAG, JCL]

J. A. Gray (1981) A critique of Eysenck's theory of personality. In: A model for personality, ed. H. J. Eysenck , pp. 246–76. New York: Springer. [taJAG]

R. L. Isaacson (1974) The limbic system. New York: Plenum Press. [KHP]

R. L. Isaacson & K. H. Pribram , eds. (1975) The hippocampus, vols. 1 & 2. New York: Plenum Press. [rJAG, KHP]

L. L. Iversen & F. Schon (1973) The use of radioautographic techniques for the identification and mapping of transmitter-specific neurons in CNS. In: New concepts of transmitter regulation, ed. A. Mandell & D. Segal , pp. 153–93. New York: Plenum Press. [taJAG]

S. D. Iversen (1977) Brain dopamine systems and behavior. In: Handbook of psychophannacology: 8, Drugs, Neurotransmitters and Behavior, ed. L. L. Iversen , S. D. Iversen & S. H. Snyder , pp. 333–84. New York: Plenum Press. [rJAC]

D. P. Kimble (1975) Choice behavior in rats with hippocampal lesions. In: The hippocampus: 2. Neurophysiology and behavior, ed. R. L. Isaacson & K. H. Pribram , pp. 309–26. New York: Plenum Press. [tarJAG, KHP]

W. Lyons (1980) Emotion. Cambridge: Cambridge University Press. [WL]

J. B. Ranck Jr., (1975) Behavioral correlates and firing repertoires of neuron: in the dorsal hippocampal formation and septum of unrestrained rats. In: The hippocampus: 2. Neurophysiology and behavior, ed. R. L. Isaacson & K. H. Pribram , pp. 207–44. New York: Plenum Press. [TER]

D. E. Redmond , Y. H. Huang , J. Baulu & M. S. Gold (1979) Evidence for the involvement of a brain norepinephrine system in anxiety. In Catecholamines: Basic and clinical frontiers, ed. E. Usdin , I. Kopin & J. Barchas , pp. 1693–95. New York: Pergamon Press. [MSG]

J. Seggie & G. M. Brown (1976) The effects of ablation of the septal nuclei in the rat on circadian variation and stress response pattern of corticosterone, growth hormone and prolactin. In: The septal nuclei, ed. J. F. De France , pp. 335–44. New York: Plenum Press. [HU]

J. T. Spence & K. W. Spence (1966) The motivational components of manifest anxiety: Drive and drive stimuli. In: Anxiety and behavior, ed. C. D. Spielberger , pp. 291326. London: Academic Press. [WR]

C. H. Vanderwolf , R. Kramis , L. A. Gillespie & B. H. Bland (1975) Hippocampal rhythmic slow activity and neocortical low-voltage fast activity: Relations to behavior. In: The hippocampus: 2. Neurophysiology and behavior, ed. R. L. Isaacson & K. H. Pribram , pp. 101–27. New York: Plenum Press. [rJAG,. TER]

H. M. Van Praag (1978) Amine hypotheses of affective disorders. In: Handbook of psychopharmacology: 13. Biology of mood and antianxiety drugs, ed. L. L. Iversen , S. D. Iversen & S. H. Snyder , pp. 187297. New York: Plenum Press. [taJAG]

D. M. Warburton (1977) Stimulus selection and behavioral inhibition. In: Handbook of psychopharmacology: 8. Drugs, neurotransmitters and behavior, ed. L. L. Iversen , S. D. Iversen & S. H. Snyder , pp. 385431. New York: Plenum Press. [taJAG]

L. Weiskrantz & E. K. Warrington (1975) The problem of the amnesic syndrome in man and animals. In: The hippocampus: 2. Neurophysiology and behavior, ed. R. L. Isaacson & K. H. Pribram , pp. 411–28. New York: Plenum Press, [taJAG]

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Behavioral and Brain Sciences
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  • EISSN: 1469-1825
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