Article contents
High mental disorder rates are based on invalid measures: Questions about the claimed ubiquity of mutation-induced dysfunction
Published online by Cambridge University Press: 09 November 2006
Abstract:
Three reservations about Keller & Miller's (K&M's) argument are explored: Serious validity problems afflict epidemiological criteria discriminating disorders from non-disorders, so high rates may be misleading. Normal variation need not be mild disorder, contrary to a possible interpretation of K&M's article. And, rather than mutation-selection balance, true disorders may result from unselected combinations of normal variants over many loci.
- Type
- Open Peer Commentary
- Information
- Copyright
- Copyright © Cambridge University Press 2006
- 2
- Cited by