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The neuropsychology of schizophrenia

  • J. A. Gray (a1), J. Feldon (a2), J. N. P. Rawlins (a3), D. R. Hemsley (a1) and A. D. Smith (a4)...
Abstract
Abstract

A model is proposed for integrating the neural and cognitive aspects of the positive symptoms of acute schizophrenia, using evidence from postmortem neuropathology and neurochemistry, clinical and preclinical studies of dopaminergic neurotransmission, anatomical connections between the limbic system and basal ganglia, attentional and other cognitive abnormalities underlying the positive symptoms of schizophrenia, specific animal models of some of these abnormalities, and previous attempts to model the cognitive functions of the septohippocampal system and the motor functions of the basal ganglia. Anatomically, the model emphasises the projections from the septohippocampal system, via the subiculum, and the amygdala to nucleus accumbens, and their interaction with the ascending dopaminergic projection to the accumbens. Psychologically, the model emphasises a failure in acute schizophrenia to integrate stored memories of past regularities of perceptual input with ongoing motor programs in the control of current perception. A number of recent experiments that offer support for the model are briefly described, including anatomical studies of limbic-striatal connections, studies in the rat of the effects of damage to these connections, and of the effects of amphetamine and neuroleptics, on the partial reinforcement extinction effect, latent inhibition and the Kamin blocking effect; and studies of the latter two phenomena in acute and chronic schizophrenics.

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Albin R. L., Young A. B. & Penny J. B. (1989) The functional anatomy of basal ganglia disorders. Trends in the Neurosciences 12:366–74. [IW]
Allen R. M. & Young S. J. (1978) Phencyclidine-induced psychosis. American Journal of Psychiatry 135:1081–84. [KLRJ]
Alpert M. & Rush M. (1983) Comparison of affects in Parkinson's disease and schizophrenia. Psychopharmacology Bulletin 196:118–20. [RS]
Altman J., Das G. D. & Anderson W. J. (1968) Effects of infantile handling on morphological development of the rat brain: An explanatory study. Developmental Psychology 1:1020. [rJAG]
Altschuler L. L., Conrad A., Kovelman J. A. & Scheibel A. (1987) Hippocampal pyramidal cell orientation in schizophrenia. Archives of General Psychiatry 44:1094–98. [LP, AR]
Alzheimer A. 1897) Beitrage zür pathologischen Anatomic der Hirnrinde und zür anatomischen Grundlage einiger Psychosen. Monatsschrift der Psychiatric und Neurologie 2:82119. [RS]
American Psychiatric Association (1980) Diagnostic and statistical manual of mental disorders (3rd ed.). American Psychiatric Association. [IJE]
Andreasen N. C. (1982) Negative symptoms in schizophrenia: Definition and reliability. Archives of General Psychiatry 39:784–88. [MS]
Andreasen N. C. (1985) Positive vs. negative schizophrenia: A critical evaluation. Schizophrenia Bulletin 11:380–89. [HES, RS]
Andreasen N. C. & Olsen S. (1982) Negative vs. positive schizophrenia. Archives of General Psychiatry 39:789–94. [PHV]
Angrist B., Rotrosen J. & Gershon S. (1980) Differential effects of amphetamine and neuroleptics vs. positive symptoms in schizophrenia. Psychopharmacology 72:1719. [RS]
Anscombe R. (1987) The disorder of consciousness in schizophrenia. Schizophrenia Bulletin 13:241–60. [aJAG]
Archer T., Mohammed A. K. & Jarbe T. U. C. (1986) Context–dependent latent inhibition in taste aversion learning. Scandinavian Journal of Psychology 27:277–84. [REL]
Asarnow R. F., Granholm E. & Sherman T. (in press) Span of apprehension in schizophrenia. In: Handbook of schizophrenia, vol. 5: Neuropsychology, psychophysiology, and information processing, ed. Steinhauer S.Gruzelier J. H. & Zubin J.. Elsevier Science Publishers. [KHN, IJE]
Baker A. G. & Mercier P. (1982) Extinction of the context and latent inhibition. Learning and Motivation 13:391416. [REL]
Baker N. J., Staunton M., Adler L. E., Gerhardt G. A., Drebing C., Waldo M., Nagamoto H. & Freedman R. (1990) Sensory gating deficits in psychiatric patients: relation to catecholamine metabolites in different diagnostic groups. Biological Psychiatry 27:519–28. [RDO]
Balaz A. M., Capra S., Kasprow W. J. & Miller R. R. (1982) Latent inhibition of the conditioning context: Further evidence of contextual potentiation of retrieval in the absence of appreciable context–US associations. Animal Learning and Behavior 10:242–48. [REL]
Balogh R. D. & Merritt D. W. (1989) Backward masking spatial frequency effects among hypothetically schizotypal individuals. Schizophrenia Bulletin 15:573583. [RDO]
Baron M. (1986) Genetics of schizophrenia: I. Familial patterns and mode of inheritance. Biological Psychiatry 21:1051–66. [WEC]
Baruch I. (1988) Differential performance of acute and chronic schizophrenics in a latent inhibition task and its relevance for the dopamine hypothesis and the dimensional view of psychosis. Ph.D. thesis, University of London. [aJAG]
Baruch I., Hemsley D. R. & Gray J. A. (1988a) Differential performance of acute and chronic schizophrenics in a latent inhibition task. Journal of Nervous and Mental Disease 176:598606. [arJAG, KHN, GGD, REL, LJI, REH, PHV]
Baruch I., Hemsley D. R. & Gray J. A. (1988b) Latent inhibition and “psychotic proneness” in normal subjects. Personality and Individual Differences 9:777–84. [arJAG, REL, PHV]
Baxter L. R., Phelps M. E., Mazziotta J. C., Guze B. H., Schwartz J. M. & Selin C. E. (1987) Local cerebral glucose metabolic rates in obsessive-compulsive disorder. Archives of General Psychiatry 44:221–28. [NRS]
Beani L. & Bianchi C. (1973) Effect of amantidine on cerebral acetylcholine release and content in the guinea pig. Neuropharmacology 12:283–89. [MS]
Beckmann H. (1991) Schizophrenia and the limbic system. In: Schizophrenia and youth, eds. Eggers C., Springer–Verlag in press.
Beckmann H., Gattaz W. F. & Jakob H. (1987) Biochemical and neuropathological indices for the aetiology of schizophrenia. In: Search for the causes of schizophrenia, ed. Haffher H.Gattaz W. F. & Janzarik W.. Springer-Verlag. [aJAG]
Beech A., Powell T., McWilliam J. & Claridge G. (1989) Evidence of reduced “cognitive inhibition” in schizophrenia. British Journal of Clinical Psychology 28:109–17. [aJAG]
Begleiter H., Porjesz B. & Chou G. L. (1981) Auditory brainstem potentials in chronic alcoholics. Science 211:1064–66. [TP]
Bell D. S. (1965) Comparison of amphetamine psychosis and schizophrenia. British Journal of Psychiatry 111:701–07. [JHW]
Bellissimo A. & Steffy R. A. (1972) Redundancy-associated deficit in schizophrenic reaction time performance. Journal of Abnormal Psychology 80:299397. [IJE]
Benes F. M. (1989) Myelination of cortical-hippocampal relays during late adolescence. Schizophrenia Bulletin 15:585–93. [rJAG, LP, RDO]
Beninger R. J. (1983) The role of dopamine in locomotor activity and learning. Brain Research Reviews 6:173–96. [NAS]
Berger T. W. & Thompson R. F. (1978) Neuronal plasticity in the limbic system during classical conditioning of the rabbit nictitating membrane response. I. The hippocampus. Brain Research 145:323–46. [NAS]
Berman K. F. & Weinberger D. R. (1989) Schizophrenia: Brain structure and function. In: Comprehensive textbook of psychiatry 5, vol. 1, ed. Kaplan H.I. & Saddock B. J.. Williams & Wilkins. [KLRJ]
Bernstein A. S., Frith C. D., Gruzelier J. H., Patterson T., Straube E., Venables P. H. & Zahn T. P. (1982) An analysis of the skin conductance orienting response in samples of American, British, and German schizophrenics. Biological Psychology 14:155211. [HES, MED]
Bick P. A. & Kinsbourne M. (1987) Auditory hallucinations and subvocal speech in schizophrenic patients. The American Journal of Psychiatry 144:222–25. [TP]
Bird E., Spokes E. & Iversen L. (1980) Dopamine and noradrenaline in post mortem brain in Huntington's disease and schizophrenic illness. Acta Psychiatrica Scandinavica, Supplement 280:6373. [ARC]
Birchwood M., Hallett S. & Preston M. (1988) Schizophrenia: An integrated approach to research and treatment. Longman. [GC]
Bland B. H. (1986) The physiology and pharmacology of the hippocampal formation theta rhythms. Progress in Neurobiology 26:154. [JHW]
Bleuler E. (1934) Textbook of psychiatry. Macmillan. [AFO]
Bleuler E. (1950) Dementia praecox or the group of schizophrenias. International Universities Press. [AnC, IJE]
Bogerts B. (1989) The role of limbic and paralimbic pathology in the aetiology of schizophrenia. Psychiatry Research 29:255–56. [PHV]
Bogerts B., Meertz E. & Schonfeldt-Bausch R. (1985) Basal ganglia and limbic system pathology in schizophrenia: A morphometric study of brain volume and shrinkage. Archives of General Psychiatry 42:784–91. [aJAG, TP, RS]
Bouton M. E. & Swartzentruber D. (1986) Analysis of the associative and occasion setting properties of contexts participating in a Pavlovian discrimination. Journal of Experimental Psychology: Animal Behavior Processes 12:333–50. [REL]
Bowen W. D., Moses E. L., Tolentino P. J. & Walker J. M. (1990) Metabolites of haloperidol display preferential activity at sigma receptors compared to dopamine D-2 receptors. European Journal of Pharmacology 177:111–18. [KLRJ]
Bowers M. B. (1974) Central dopamine turnover in schizophrenic syndromes. Archives of General Psychiatry 31:5054. [RS]
Bracha H. S. (1987) Asymmetric rotational (circling) behavior, a dopaminerelated asymmetry: Preliminary findings in unmedicated and never-medicated schizophrenic patients. Biological Psychiatry 22:9951003. [rJAG, TSE]
Braff D. L. (1978) Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology 14:339–43. [HES]
Braff D. L. & Geyer M. A. (1990) Sensorimotor gating and schizophrenia: Human and animal model studies. Archives of General Psychiatry 47:181–88. [NRS]
Braff D. L. & Saccuzzo D. P. (1985) The time course of information-processing deficits in schizophrenia. American Journal of Psychiatry 142:170–74. [AFO]
Braff D. L., Butler R. W., Jenkins M. J. & Geyer M. A. (1989) Wisconsin card sorting in schizophrenia: Neurophysiological correlates. Proceedings of the American College of Neuropsychopharmacology 28:42. [NRS]
Brecher M., Porjesz B. & Begleiter H. (1987) The N2 component of the event-related potential in schizophrenic patients. EEG and Clinical Neurophysiology 66:369–75. [RDO]
Broadbent D. E. (1977) The hidden preattentive processes. American Psychologist 32:109–18. [aJAG]
Brown R., Colter N., Corsellis J. A. N., Crow T. J., Frith C. D., Jagoe R., Johnstone E. C. & Marsh L. (1986) Postmortem evidence of structural brain changes in schizophrenia. Differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorder. Archives of General Psychiatry 43:3642. [aJAG, AR]
Brozowski T. J., Brown R. M., Rosvold H. E. & Goldman P. S. (1979) Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. Science 205:929–32. [aJAG]
Brunner R. L., Haggbloom S. J. & Gazzara R. A. (1974) Effects of hippocampal X-ir radiation-produced granule–cell agenesis on instrumental runaway performance in rats. Physiology & Behaviour 13:485–94. [rJAG]
Bruton C. J., Crow T. J., Frith C. D., Johnstone E. C., Owens D. C. & Roberts G. W. (1990) Schizophrenia and the brain. Psychological Medicine 20:285304. [LP]
Bunney B. S. (1984) Antipsychotic drug effects on the electrical activity of dopamine neurons. Trends in Neuroscience 7:212–15. [REH]
Burton H. A. & Toga A. W. (1982) Successive discrimination performance improves with increasing numbers of stimulus preexposures in septal rats. Behavioral and Neural Biology 34:141–51. [RDO]
Buscaino V. M. (1920) Le cause anatoma-pathologiche della manifestatione schizophrenica della demenza precoce. Ric Pathologia Nervus Mental 25:193226. [RS]
Cador M., Robbins T. W. & Everitt B. J. (1989) Involvement of the amydgala in stimulus-reward associations: Interaction with the ventral striatum, Neuroscience 30:7786. [ARC]
Cain S. & Routtenberg A. (1983) Neonatal handling selectively alters the phosphorylation of A 47.000 mol. wt. protein in male rat hippocampus. Brain Research 267:192–95. [rJAG]
Cannon T. D. (in press) Genetic and perinatal sources of structural brain abnormalities in schizophrenia. In: Fetal neural development and adult schizophrenia, ed. Mednick S. A., Cannon T. D., Barr C. E. & Lyon M.. Cambridge University Press. [AR]
Cannon T. D., Mednick S. A. & Parnas J. (1990) Antecedents of predominantly negative and predominantly positive symptoms in a high risk population. Archives of General Psychiatry. 47:622–32. [rJAG, AR]
Carlsson A. (1988) The current status of the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 1:179203. [aJAG, KLRJ, NRS, AC]
Carlsson M. & Carlsson A. (1989a) The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine depleted mice. Journal of Neural Transmission 75:221–26. [AC]
Carlsson M. & Carlsson A. (1989b) Dramatic synergism between MK-801 and clonidine with respect to locomotor stimulatory effect in monoamine-depleted mice. Journal of Neural Transmission 77:6571. [AC]
Carlsson M. & Carlsson A. (1989c) Marked locomotor stimulation in monoamine-depleted mice following treatment with atropine in combination with clonidine. Journal of Neural Transmission (PD-Sect) 1:317–22. [AC]
Carlsson M. & Carlsson A. (1990) Interfering with glutamatergic neurotransmission by means of NMDA antagonist administration discloses the locomotor stimulatory potential of other transmitter systems. Pharmacology, Biochemistry, & Behavior 36:4550. [AC]
Carlsson M. & Carlsson A. (in press) Interactions between glutamatergic and monoaminergic systems within the basal ganglia – implications for schizophrenia and Parkinson's disease. Trends in Neurosciences. [AC]
Carpenter W. T., Strauss J. S. & Muleh S. (1973) Are there pathognomonic symptoms of schizophrenia? An empiric investigation of Schneider's first rank symptoms. Archives of General Psychiatry 28:847–52. [JHW]
Carpenter W. T. Jr., Kirkpatrick B. & Buchanan R. W. (1990) Conceptual approaches to the study of schizophrenia. In: Recent advances in schizophrenia, ed. Kales A.Stefanis C. N. & Talbott J. A.. Springer-Verlag. [MP]
Casamenti F., Cosi C. & Pepeu G. (1987) Effect of Dl and D2 dopaminergic agonists and antagonists on cortical acetylcholine release in vivo. In: Cellular and molecular basis of cholinergic functions, ed. Dowdall M. J. & Hawthorne J. N.. VCH Publishers. [MS]
Cassaday H. J., Hodges H. & Gray J. A. (in press) The effects of pharmacological and neurotoxic manipulation of serotonergic activity on latent inhibition in the rat: Implications for the neural basis of acute schizophrenia. Proceedings of Conference on Serotonin-System–Related Syndromes: Psychopathological and Therapeutic Links, Venice, March, 1990. Royal Society of Medicine, London. [arJAG]
Castle D. & Murray R. M. (1991) The neurodevelopmental basis of sex differences in schizophrenia. Psychological Medicine, in press [LP]
Caza P. A. (1984) Noradrenergic influences on blocking: Interactions with development. Pharmacology Biochemistry and Behavior 21:917. [RDO]
Ceci A., Smith M. & French E. D. (1988) Activation of the A 10 mesolimbic system by the sigma–receptor agonist (+)SKF10,047 can be blocked by rimcazole, a novel putative anti-psychotic. European Journal of Pharmacology 154:5357. [KLRJ]
Chandler M. (1989) Doubt and developing theories of mind. In: Developing theories of mind, ed. Astington J. W., Harris P. & Olson D. R.. Cambridge University Press. [LP]
Chapman L. J. & Chapman J. P. (1978) The measurement of differential deficits. Journal of Psychiatric Research 14:303–11. [rJAG]
Chapman L. J., Chapman J. P. & Miller G. A. (1964) A theory of verbal behavior in schizophrenia. In: Progress in experimental personality research, vol. 1, ed. Maher B. A.. Academic Press. [KS]
Cheramy A., Romo R., Godeheu G., Baruch P. & Glowinski J. (1986) In vivo presynaptic control of dopamine release in the cat caudate nucleus, II. Facilitatory or inhibitory influence of L-glutamate. Neuroscience 19:1081–90. [aJAG, KLRJ, IW]
Chesselet M.-F. (1984) Presynaptic regulation of neurotransmitter release in the brain; Facts and hypotheses. Neuroscience 12:347–75. [aJAG]
Chiarenza G. A., Papakostopoulos D., Dini M. & Cazzullo C. L. (1985) Neurophysiological correlates of psychomotor activity in chronic schizophrenics. Electroencephalography and Clinical Neurophysiology 61:218–28. [GGD]
Christison G. W., Casanova M. F., Weinberger D. R., Rawlins R. & Kleinman J. E. (1989) A quantitative investigation of hippocampal pyramidal cell size, shape and variability of orientation in schizophrenia. Archives of General Psychiatry 46:1027–34. [aJAG]
Claridge G. (1978) Animal models of schizophrenia: The case for LSD25. Schizophrenia Bulletin 4:186209. [aJAG, GC]
Claridge G. & Broks P. (1984) Schizotypy and hemisphere function-I. Theoretical considerations and the measurement of schizotypy. Personality and Individual Differences 5:615–32. [rJAG, PHV]
Claridge G. S., Clark K. H. & Beech A. R. (submitted) Lateralisation of the “negative priming” effect: Relationships with schizotypy and with gender. [GC]
Cleghorn J. M. & Albert M. L. (1990) Modular disjunction in schizophrenia: A framework for a pathological psychophysiology. In: Recent advances in schizophrenia, ed. Kales A.Stefanis C. N. & Talbott J. A.. Springer-Verlag. [MP]
Cleghorn J. M., Kaplan R. D., Szechtman B., Szechtman H. & Brown C. M. (1990) Neuroleptic drug effects on cognitive function in schizophrenia. Schizophrenia Research 3:211–19. [MP]
Cleghorn J. M., Garnett E. S., Nahmias C., Firnau G., Brown G. M., Kaplan R., Szechtman H. & Szechtman B. (1989) Increased frontal and reduced parietal glucose metabolism in acute untreated schizophrenia. Psychiatry Research 28:119–33. [AR]
Colle L. M. & Wise R. A. (1988) Effects of nucleus accumbens amphetamine on lateral hypothalamic brain stimulation reward. Brain Research 459:361–68. [NAS]
Conrad A. J. & Scheibel A. B. (1987) Schizophrenia and the hippocampus: The embryological hypothesis extended. Schizophrenia Bulletin 13:577–87. [TP]
Contreras P. C., Quirion R., Gehlert D. R., Contreras M. L. & O'Donohue T. L. (1987) Autoradiographic distribution of non-dopaminergic binding sites labelled by [ *3H] haloperidol in rat brain. Neuroscience Letters 75:133–40. [KLRJ]
Contreras P. C., Dimaggio D. A. & O'Donohue T. L. (1987) An endogenous ligand for the sigma opioid binding site. Synapse 1:5761. [KLRJ]
Cools A. R. (1980) Role of the neostriatal dopaminergic activity in sequencing and selecting behavioural strategies: Facilitation of processes involved in selecting the best strategy in a stressful situation. Behavioral Brain Research 1:361–78. [ARC]
Cools A. R. (in press), Role of neostriatal and mesostriatal or mesolimbic dopaminergic fibres in Parkinson's disease with and without dementia: Prospects, concepts and facts, Japanese Journal of Psychopharmacology [ARC]
Cools A. R., Brachten R., Heeren D., Willemen A. & Ellenbroek B. (1990) Search after neurobiological profile of individual-specific features of Wistar rats. Brain Research Bulletin 24:4969. [ARC]
Cools A. R., van den Bos R., Ploeger G. & Ellenbroek B. (in press) Gating function of noradrenaline in the ventral striatum: Its role in behavioural responses to environmental and pharmacological challenges. In: The mesolimbic dopamine system: From motivation to action, eds. Willner P., Scheel–Krüger J.. John Wiley & Sons Limited. [ARC]
Crider A., Blockel L. & Solomon P. R. (1986) A selective attention deficit in the rat following induced dopamine receptor supersensitivity. Behavioral Neuroscience 100:315–19. [AnC, RDO]
Crider A., Solomon P. R. & McMahon M. A. (1982) Disruption of selective attention in the rat following d–amphetamine administration: Relationship to schizophrenic attention disorder. Biological Psychiatry 17:351–61. [aJAG, AnC]
Cromwell R. L. (1968) Stimulus redundancy and schizophrenia. Journal of Nervous and Mental Disease 146:360–75. [IJE]
Cromwell R. L. (1984) Preemptive thinking and schizophrenia research. In: Nebraska symposium on motivation, ed. Spaulding W. D. & Cole J. K.. University of Nebraska Press. [IJE]
Cromwell R. L. (1987) An argument concerning schizophrenia: The left hemisphere drains the swamp. In: Individual differences in hemispheric specialization, ed. Glass A.. Spectrum Press. [IJE]
Cromwell R. L. & Dokecki P. R. (1968) Schizophrenic language: A disattention interpretation. In: Developments in applied psycholinguistic research, ed. Rosenberg S. & Koplin J. H.. Macmillan. [IJE]
Cromwell R. L. & Spaulding W. (1978) How schizophrenics handle information. In: Phenomenology and treatment of schizophrenia, ed. Fann W. E., Karacan I., Pokorny A. D., & Williams R. L.. Spectrum Press. [KHN]
Crosson B. (1984) Role of the dominant thalamus in language: A review. Psychological Bulletin 96:491517. [TP]
Crosson B. (1985) Subcortical function in language: A working model. Brain and Language 25:257–92. [NRS]
Crosson B. & Hughes C. W. (1987) Role of the thalamus in language: Is it related to schizophrenic thought disorder? Schizophrenia Bulletin 13:605–21. [TP]
Crow T. J. (1980a) Molecular pathology of schizophrenia: More than one disease process? British Medical Journal 280:6668. [RS]
Crosson B. (1980b) Positive and negative schizophrenic symptoms and the role of dopamine. British Journal of Psychiatry 137:383–86. [aJAG, PHV]
Crosson B. (1985) The two-syndrome concept: Origin and current status. Schizophrenia Bulletin 11:471–86. [MS, LP]
Crosson B. (1990) The continuum of psychosis and its genetic origins. British Journal of Psychiatry 156:788–97. [GC]
Crosson B. (in press) Temporal lobe asymmetries as the key to the aetiology of schizophrenia. Schizophrenia Bulletin. [rJAG, AR]
Crow T. J., Ball J., Bloom S. R., Brown R., Bruton C. J., Colter N., Frith C. D., Johnstone E. C., Owens D. G. C. & Roberts G. W. (1989) Schizophrenia as an anomaly of the development of cerebral asymmetry. Archives of General Psychiatry 46:1145–50. [AR]
Crusio W. E., Genthner-Grimm G. & Schwegler H. (1986) A quantitative-genetic analysis of hippocampal variation in the mouse. Journal of Neurogenetics 3:203–14. [WEC]
Crusio W. E., Schwegler H. & Lipp H. P. (1987) Radial maze performance and structural variation of the hippocampus in mice: A correlation with mossy fibre distribution. Brain Research 425:182–85. [rJAG, WEC]
Csernansky J. G., Gsernansky C. A., Bonnet K. A. & Hollister L. E. (1985) Dopaminergic supersensitivity follows ferric chloride–induced limbic seizures. Biological Psychiatry 20:723–33. [RDO]
Cummings J. L. & Benson D. F. (1987) The role of the nucleus basalis of Meynert in dementia: A review and reconsideration. Alzheimer's Disease and Associated Disorders 3:128–45. [MS]
Cutting J. (1985) The psychology of schizophrenia. Churchill Livingstone. [ajAG]
Daun I., Channon S., Polkey C. E. & Gray J. A. (in press) Classical conditioning after temporal lobe lesions in man: Impairment in conditional discrimination. Behavioral Neuroscience. [rJAG]
Davila R., Manero E., Zumarrage M., Andia I., Schweitzer J. W. & Friedhoff A. J. (1988) Plasma homovanillic acid as a predictor of response to neuroleptics. Archives of General Psychiatry 45:564–67. [GGD]
Davis J. M., Dysken M. W., Haberman S. J., Javaid J. I., Chang S. S. & Killian G. A. (1980) Use of survival curves in analysis of antipsychotic relapse studies. Advances in Biochemical Psychopharmacology 24:471–81. [GGD]
Davison K. (1983) Schizophrenia–like psychoses associated with organic cerebral disorders: A review. Psychiatric Developments 1:134. [JHW]
Dawson M. E. (1990) Psychophysiology at the interface of clinical science, cognitive science, and neuroscience. Psychophysiology 27:243–55. [MED]
Dawson M. E., & Nuechterlein K. H. (1984) Psychophysiological dysfunctions in the developmental course of schizophrenic disorders. Schizophrenia Bulletin 10:204–32. [GC, MED]
De Lisi L. E., Dauphinais D. & Gershan E. S. (1988) Perinatal complications and reduced size of brain limbic structures in familial schizophrenia. Schizophrenia Bulletin 14(2):185–91. [rJAG]
DeAmicis L. A. & Cromwell R. L. (1979) Reaction time crossover in process schizophrenic patients, their relatives, and control subjects. Journal of Nervous and Mental Disease 167:593600. [IJE]
Deakin J. F. W., Slater P., Simpson M. D. C., Gilchrist A. C., Skan W. J., Royston M. C., Reynolds G. P. & Cross A. J. (1989) Front cortical and left temporal glutamatergic dysfunction in schizophrenia. Journal of Neurochemistry 52:1781–86. [rJAG]
Dean P. & Redgrave P. (1984) Superior colliculus and visual neglect in rat and hamster. III. Functional implications. Brain Research Reviews 8:155–63. [aJAG]
Depue R. A. & Woodburn L. (1975) Disappearance of paranoid symptoms with chronicity. Journal of Abnormal Psychology 84:8486. [aJAG]
Dickinson A. (1980) Contemporary animal learning theory. Cambridge University Press. [aJAG]
Dodd J. & Kelly J. S. (1981) The actions of cholecystokinin and related peptides on pyramidal neurones of the mammalian hippocampus. Brain Research 205:337–50. [aJAG]
Domino E. P. & Luby E. D. (1981) Abnormal mental states induced by phencyclidine as a model of schizophrenia. In: PCP(Phencyclidine): historical and current perspectives. NPP Books. [KLRJ]
Donchin E. & Coles M. G. H. (1988) Is the P300 component a manifestation of context updating? Behavioral and Brain Sciences 11:357–74. [PHV]
Downes L. P., Lewis P. E. & Stone M. A. (1986) A comparison of the binding of sigma opioids and phencyclidine, and the interaction with antipsychotic drugs in rat brain membranes. British Journal of Pharmacology 88:231–37. [KLRJ]
Duchen M. R., Burton N. R. & Biscoe T. J. (1985) An intracellular study of the interactions of N-methyl-DL-aspartate with ketamine in the mouse hippocampal slice. Brain Research 342:149–53. [REH]
Duncan C. C., Morihisa J. M., Fawcett R. W. & Kirch D. G. (1987) P300 in schizophrenia: State or trait marker? Psychopharmacology Bulletin 23:497501. [GGD]
Dunne M. P. & Hartley M. R. (1986) Scopolamine and the control of attention in humans. Psychopharmacology 89:9497. [JHW]
Dworkin R. H., Lenzenweger M. F., Moldin S. O., Skillings G. F. & Levick S. E. (1988) A multidimensional approach to the genetics of schizophrenia. American Journal of Psychiatry 145:1077–83. [WEC]
Early T. S., Posner M. I., Reiman E. M. & Raichle M. E. (1989a) Hyperactivity of the left striato-pallidal projection. Part I: Lower level theory. Psychiatric Developments 2:85108. [TSE]
Early T. S., Posner M. I., Reiman E. M., & Raichle M. E. (1989b) Left striato-pallidal hyperactivity in schizophrenia. Part II: Phenomenology and thought disorder. Psychiatric Developments 2:109121. [TSE]
Early T. S., Reiman E. M., Raichle M. E. & Spitznagel E. L. (1987) Left globus pallidus abnormality in never-medicated patients with schizophrenia. Proceedings of the National Academy of Sciences of the United States of America 84. [TP]
Einhorn H. J. & Hogarth R. M. (1980) Judging probable cause. Psychological Bulletin 99:319. [aJAG]
Elkins I. J. (1989) Span of apprehension in schizophrenic patients as a function of distractor masking and laterality. Master's thesis, University of Kansas. [IJE]
Ellenbroek B. & Cools A. R. (in press) Animal models with construct validity for schizophrenia, Behavioral Pharmacology. [ARC]
Ellinwood E. H., Stripling J. S. & Kilbey M. M. (1977) Chronic changes with amphetamine intoxication: Underlying processes. In: Neuroregulators and psychiatric disorders, ed. Usdin E.Hamburg D. A. & Barchas J.. Oxford University Press. [GGD]
Eriksen B. A. & Eriksen C. W. (1974) Effects of noise letters upon identification of a target letter in a nonsearch task. Perception and Psychophysics 6:143–49. [rJAG]
Etienne P. & Baudry M. (1987) Calcium dependent aspects of synaptic plasticity, excitatory amino acid neurotransmissions, brain aging, and schizophrenia: A unifying hypothesis. Neurobiology of Ageing 8:362–66. [KLRJ]
Evenden J. L. & Robbins T. W. (1983) Increased response switching, perseveration, and perseverative switching following d-amphetamine in the rat. Psychopharmacology 80:6773. [AnC]
Everitt B. J., Cador M. & Robbins T. W. (1989) Interactions between the amygdala and ventral striatum in stimulus-reward associations: Studies using a second-order schedule of sexual reinforcement. Neuroscience 30:6375. [ARC]
Eysenck H. J. (1967) The biological basis of personality. Charles C. Thomas. [GC]
Eysenck H. J. & Eysenck S. B. G. (1975a) Manual of the Eysenck personality questionnaire. Hodder & Stoughton. [rJAG]
Eysenck H. J. & Eysenck S. B. G. (1975b) Psychoticism as a dimension of personality. Hodder & Stoughton. [PHV]
Eysenck M. W. (1982) Attention and arousal: Cognition and performance. Springer Verlag. [aJAG]
Falkai P. & Bogerts B. (1986) Cell loss in the hippocampus of schizophrenics. European Archives of Psychiatry and Neurological Sciences 236:154–61. [aJAG]
Falkai P., Bogerts B., Roberts T. W. & Crow T. J. (1988a) Measurement of the alpha cell migration in the entorhinal region: A marker for developmental disturbances in schizophrenia? Schizophrenia Research 1:157–58. [AR]
Falkai P., Bogerts B. & Rozumek M. (1988b) Limbic pathology in schizophrenia: The entorhinal region – a morphometric study. Biological Psychiatry 24:515–21. [RDO]
Farah M. (1989) The neural basis of mental imagery. Trends in Neurosciences 12:395–99. [DH]
Faraone S. V. & Tsuang M. T. (1985) Quantitative models of the genetic transmission of schizophrenia. Psychological Bulletin 98:4166. [WEC]
Farde L.Hall H., Ehrin E. & Sedvall G. (1986) Quantitative analysis of dopamine D*2 receptor binding in the living human brain by positron emission tomography. Science 231:258–61. [REH]
Farde L., Wiesel F. A., Hall H., Halldin C., Stone-Elder S. & Sedvall G. (1987) No D2 receptor increase in PET study of schizophrenia. Archives of Psychiatry 44:671–72. [aJAG]
Farde L., Wiesel F. A., Stone-Elander S. S., Halldin C., Nordstrom A. L., Hall H. & Sedvall G. (1990) D2 dopamine receptors in neurolepticnaive schizophrenic patients. Archives of General Psychiatry 47:213–19. [JRS, TSE, REH, LP]
Farley I., Price K., McCulloch E., Deck J., Hordynski W. & Hornykiewicz O. (1978) Norepinephrine in chronic paranoid schizophrenia: Above-normal in limbic forebrain. Science 200:456–58. [ARC]
Feldon J. & Gray J. A. (1979) Effects of medial and lateral septal lesions on the partial reinforcement extinction effect at short inter-trial intervals. Quarterly Journal of Experimental Psychology 31:675–90. [aJAG]
Feldon J. & Weiner I. (1988) Long-term attentional deficit in nonhandled males: Possible involvement of the dopaminergic system. Psychopharmacology 95:231–36. [aJAG]
Feldon J. & Weiner I. (in press a) An animal model of attention deficit. In: Neuromethods, vol. 20: Animal models in psychiatry, ed. Boulton A. A., Baker G. B. & Martin-Iversen M. T.Humana Press. [rJAG]
Feldon J. & Weiner I. (in press b) Amphetamine and the multi-trial partial reinforcement extinction effect (PREE) in an operant chamber: Procedural modifications which lead to the attenuation of the PREE. Pharmacology, Biochemistry and Behavior. [rJAG]
Feldon J., Avnimelech-Gigus N. & Weiner I. (1990) The effects of pre- and post-weaning rearing conditions on latent inhibition and partial reinforcement extinction effect in male rats. Behavioral and Neural Biology 53:181204. [rJAG]
Feldon J., Bercovitz H. & Weiner I. (1989) The effects of amphetamine on a multitrial partial reinforcement extinction effect (PREE) in a runway. Pharmacology, Biochemistry, and Behavior 32:6569. [rJAG, IW]
Feldon J., Katz Y. & Weiner I. (1988) The effects of haloperidol on the partial reinforcement extinction effect (PREE): Implications for neuroleptic drug action on reinforcement and nonreinforcement. Psychopharmacology 95:528–33. [aJAG]
Fisher W., Kerbeshian J. & Burd L. (1986) A treatable language disorder: Pharmacological treatment of pervasive developmental disorder. Developmental and Behavioral Pediatrics 7:7376. [NRS]
Fisman M. (1975) The brain stem in psychosis. British Journal of Psychiatry 126:414–22. [RS]
Fleischhacker W. W., Barnas C., Stuppack C., Unterweger B. & Hinterhuber H. (1987) Zotepine in the treatment of negative symptoms in chronic schizophrenia. Pharmacopsychiatry 20:5860. [MS]
Frecska E., Perenyl A., Bagdy G. & Reval K. (1985) CSF dopamine turnover and positive schizophrenic symptoms after withdrawal of longterm neuroleptic treatment. Psychiatry Research 16:221–26. [RS]
Freedman R. L., Adler L. E., Gerhardt G. A., Waldo M., Baker N., Rose G. M., Drebing C., Nagamoto H., Bickford-Wimer P. & Franks R. (1987) Neurobiological studies of sensory gating in schizophrenia. Schizophrenia Bulletin 13:669–78. [AFO]
Freeman A. S. & Bunney B. S. (1984) The effects of phencyclidine and N– allylnormetazocine on midbrain dopamine neuronal activity. European Journal of Pharmacology 104:287. [KLRJ]
Freeman T. &; Gathercole C. E. (1966) Perseveration – the clinical symptoms – in chronic schizophrenic and organic dementia. British Journal of Psychiatry 112:2732. [AnC]
Freund T. F., Powell J. F. & Smith A. D. (1984) Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines. Neuroscience 13:11891214. [aJAG]
Frith C. D. (1979) Consciousness, information processing, and schizophrenia. British Journal of Psychiatry 134:225–35. [aJAG, REL, KHN]
Freund T. F., Powell J. F. & Smith A. D. (1987) The positive and negative sumptoms of schizophrenia reflect impairments in the perception and initiation of action. Psychological Medicine 17:631–48. [arJAG, IJE, NRS]
Frith C. D. & Done D. J. (1988) Towards a neuropsychology of schizophrenia. British Journal of Psychiatry 153:437–43. [arJAG, AFO, CF]
Frith C. D. & Done D. J. (1989) Experiences of alien control in schizophrenia reflect a disorder in the central monitoring of action. Psychological Medicine 19:359–63. [aJAG]
Frith C. D. & Frith U. (in press) Elective affinities in schizophrenia and childhood autism. In: Social psychiatry: Theory, methodology, and practice, ed. Bebbington P.. Transaction. [CF]
Frith C. D., Stevens M., Johnstone E. C. & Crow T. J. (1988) Acute schizophrenic patients fail to modulate their level of attention. Journal of Psychophysiology 2:195200. [CF]
Gallagher M., Meagher M. W. & Bostock E. (1987) Effects of opiate manipulations on latent inhibition in rabbits: Sensitivity of the medial septal region to intracranial treatments. Behavioral Neuroscience 101:315–24. [RDO]
Garrud P., Rawlins J. N. P., Mackintosh N. J., Goodall G., Cotton M. M. & Feldon J. (1984) Successful overshadowing and blocking in hippocampectomized rats. Behavioural Brain Research 12:3953. [RDO]
Gay N., Cottraux J. A., Denoroy L., Tommasi M. & Copp N. (1989) Possible increase of dopamine beta-hydroxylase activity in the locus ceruleus of paranoid schizophrenic patients: A preliminary post-mortem study. Psychiatry Research 27:3138. [RS]
George L. &: Neufeld R. W. J. (1985) Cognition and symptomatology in schizophrenia. Schizophrenia Bulletin 11:264–85. [aJAG, KLRJ]
Geyer M. A. & Braff D. L. (1987) Startle habituation and sensorimotor gating in schizophrenia and related animal models. Schizophrenia Bulletin 13:643–68. [AFO]
Geyer M. A., Russo P. V., Segal D. S. & Kuczenski R. (1987) Effects of apomorphine and amphetamine on patterns of locomotor and investigatory behavior in rats. Pharmacology, Biochemistry, and. Behavior 28:393–99. [IW]
Ginton A., Urea G. & Lubow R. E. (1975) The effects of preexposure to a non-attended stimulus on subsequent learning: Latent inhibition in adults. Bulletin of the Psychonomic Society 5:58. [REL]
Glowinski J., Besson M. J. & Cheramy A. (1984) Role of the thalamus in the bilateral regulation of dopaminergic and GABAergic neurons in the basal ganglia. In: Functions of the basal ganglia. Ciba Foundation Symposium 107, ed. Evered D. & O'Connor M.. Ciba Foundation. [aJAG]
Gluck M. A. &: Thompson R. F. (1987) Modeling the neural substrate of associative learning and memory: A computational approach. Psychological Review 94:176–91. [JG]
Gold J. M. & Hurt S. W. (1990) The effects of haloperidol on thought disorder and IQ in schizophrenia. Journal of Personality Assessment 54:390400. [JRS]
Goldberg E. & Bilder R. (1987) Frontal lobes and hierarchic organization of neurocognitive control. In: Frontal lobes revisited, ed. Perecman E.. IRBN Press. [EG]
Goldberg E. & Costa L. D. (1981) Hemisphere differences in the acquisition and use of descriptive systems. Brain and Language 14:144–73. [EG]
Goldberg E. (1985) Akinesia, tardive dysmentia, and frontal lobe disorder in schizophrenia. Schizophrenia Bulletin 11:255–63. [rJAG, EG]
Goldberg E. (1989) The gradiental approach to neocortical functionai organization. Journal of Clinical and Experimental Neuropsychology 11:489517. [EG]
Goldberg E. (1990) Associative agnosias and the functions of the left hemisphere. Journal of Clinical and Experimental Neuropsychology 12:467–84. [EG]
Goldberg G. (1985) Supplementary motor area structure and function: Review and hypotheses. Behavioral and Brain Sciences 8:189230. [REH]
Goldberg T. E., Weinberger D. R., Pishkin N. H., Berman K. F. & Podd M. H. (1990) Recall memory deficit in schizophrenia: A possible manifestation of prefrontal dysfunction. Schizophrenia Research 2:251–57. [MP]
Gottesman I. I. & Shields J. (1982) Schizophrenia: The epigenetic puzzle. Cambridge University Press. [IJE, WEC]
Grace A. A. & Bunney B. S. (1986) Induction of depolarization block in. midbrain dopamine neurons by repeated administration of haloperidol: Analysis using in vivo intracellular recording. Journal of Pharmacology and Experimental Therapeutics 238:10921100. [GGD]
Gray J. A. (1975) Elements of a two-process theory of learning. Academic Press. [aJAG]
Gray J. A. (1982a) The neuropsychology of anxiety: An enquiry into the function of the septo-hippocampal system. Oxford University Press. [arJAG, IW, NAS, NRS, JHW, GC]
Gray J. A. (1982b) Précis of “The Neuropsychology of Anxiety: An enquiry into the functions of the septo-hippocampal system.” Behavioral and Brain Sciences 5:469–84. [aJAG, NRS]
Gray J. A. (1987) The neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system. Oxford University Press, paperback edition. [aJAG]
Gray J. A. & Baruch I. (1987) Don't leave the “psych” out of neuropsychology. Peer commentary on N. R. Swerdlow & G. F. Koob: “Dopamine, Schizophrenia, Mania and Depression: Toward a Unified Hypothesis of Cortico-striato-pallido-thalamic Function.” Behavioral and Brain Sciences 10:215–17. [arJAG, NRS]
Graybiel A. M.Besson M. J. & Weber E. (1989) Neuroleptic-sensitive binding sites in the nigrostriatal system: Evidence for differential distribution of sigma sites in the substantia nigra pars compacta of the cat. Journal of Neuroscience 9:326–38. [KLRJ]
Grillon C., Courchesne E., Ameli R., Geyer M. A. & Braff D. L. (1990) Increased distractibility in schizophrenic patients: electrophysiologic and behavioral evidence. Archives of General Psychiatry 47:171–79. [RDO]
Grinspoon L. & Bakalar S. B. (1981) Psychedelic drugs reconsidered. Basic Books. [KLRJ]
Groves P. M. (1983) A theory of the functional organization of the neostriatum and the neostriatal control of voluntary movement. Brain Research Reviews 5:109–32. [aJAG]
Gruzelier J. H. (1984) Hemispheric imbalances in schizophrenia. International Journal of Psychophysiology 1:227–40. [IJE]
Gruzelier J. H. & Venables P. H. (1972) Skin conductance orienting activity in a heterogeneous sample of schizophrenics. Journal of Nervous and Mental Disease 155:277–87. [GC]
Gruzelier J., Seymour K., Wilson L., Jolley A. & Hirsch S. (1988) Impairments on neuropsychologic tests of hippocampal functions and word fluency in remitting schizophrenia and affective disorder. Archives of General Psychiatry 45:623–29. [aJAG]
Gundlach A. L., Largent B. L. & Snyder S. H. (1986) Autoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)*3H–3–(3–hydroxyphenyl)–N–(l–propyl)–piperidine. Journal of Neuroscience 6:1757–70. [KLRJ]
Hackley S. A., Woldorff M. & Hillyard S. A. (1987) Combined use of microreflexes and event–related brain potentials as measures of auditory selective attention. Psychophysiology 24:632–47. [RDO]
Gundlach A. L., Largent B. L. & Snyder S. H. (1986) Autoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)*3H–3–(3–hydroxyphenyl)–N–(l-propyl)–piperidine. Journal of Neuroscience 6:1757–70. [KLRJ]
Hackley S. A., Woldorff M. & Hillyard S. A. (1987) Combined use of microreflexes and event-related brain potentials as measures of auditory selective attention. Psychophysiology 24:632–47. [RDO]
Haigler H. J. & Aghajanian G. K. (1974) Peripheral serotonin antagonists: Failure to antagonise serotonin in brain areas receiving a prominent serotonergic input. Journal of Neural Transmission 35:257–73. [aJAG]
Halgren E., Squires N. K., Wilson C. L., Rohrbaugh J. W., Babb T. L. & Crandall P. H. (1980) Endogenous potentials generated in the human hippocampal formation by infrequent events. Science 210:803–5. [rJAG, PHV]
Hall G. & Channell S. (1985a) Differential effects of contextual change on latent inhibition and on the habituation of an orienting response. Journal of Experimental Psychology: Animal Behavior Processes 11:470–81. [rJAG, JG]
Hall G. & Channell S. (1985b) Latent inhibition and conditioning after preexposure to the training context. Learning, and Motivation 16:381–97. [REL]
Hall G. & Channell S. (1986) Context specificity of latent inhibition in taste aversion learning. Quarterly Journal of Experimental Psychology 38B:121–39. [REL]
Hall G. & Honey R. C. (1987) Contextual effects in conditioning, latent inhibition and habituation: Associative and retrieval functions of contextual cues. Journal of Experimental Psychology: Animal Behaviour Processes 15:232–41. [CF]
Hall G. & Minor H. (1984) A search for context-stimulus associations in latent inhibition. Quarterly Journal of Experimental Psychology 36B:145–69. [REL]
Harrow M. & Quinlan D. (1985) Disordered thinking and schizophrenic psychopathology. Gardner Press. [MH]
Harrow M., Lanin-Kettering I. & Miller J. G. (1989) Impaired perspective and thought pathology in schizophrenic and psychotic disorders. Schizophrenia Bulletin 15:605–23. [MH]
Harrow M., Rattenbury F. & Stoll F. (1988) Schizophrenic delusions. In: Delusional beliefs: Interdisciplinary perspectives, ed. Öltmanns T. F. & Maher B. A.. John Wiley & Sons. [MH]
Hawkings R. D. & Kandel E. R. (1984) Is there a cell-biological alphabet for simple forms of learning? Psychological Review 91:375–91. [JG]
Hawton K., Shepstone B., Soper N. & Reznek L. (1990) Single-photon emission computerised tomography (SPECT) in schizophrenia. British Journal of Psychiatry 156:425–27. [RDO]
Hazlett E. A., Dawson M. E., Buchsbaum M. S. & Nuechterlein K. H. (submitted) Reduced frontal and hippocampal glucose metabolism in electrodermal nonresponder schizophrenics assessed by PET: A pilot study. [MED]
Heath R. G. (1954) Studies in schizophrenia. Harvard University Press. [JRS]
Heath R. G. & Walker C. F. (1985) Correlation of deep and surface electroencephalograms with psychosis in schizophrenics: A report of two cases. Biological Psychiatry 20:669–74. [rJAG, JHW]
Heath R. G., McCarron K. L. & O'Neil C. E. (1989) Antiseptal brain antibody in IgG of schizophrenic patients. Biological Psychiatry 25:725–33. [WEC]
Hemsley D. R. (1977) What have cognitive deficits to do with schizophrenic symptoms? British Journal of Psychiatry 130:167–73. [aJAG]
Hemsley D. R. (1982) Cognitive impairment in schizophrenia. In: The pathology and psychology of cognition, ed. Burton A.. Methuen. [aJAG]
Hemsley D. R. (1987a) An experimental psychological model for schizophrenia. In: Search for the causes of schizophrenia, ed. Hamer H., Gattaz W. F. & Janzavik W.. Springer Verlag. [arJAG, MP, IJE, KLRJ, JG]
Hemsley D. R. (1987b) Hallucinations: Unintended or unexpected? Behavioral and Brain Sciences 10:532–33. [REH]
Hestenes D. (1990) A neural network theory of manic-depressive illness. In: Motivation, emotion and goal direction in neural networks, eds. Levine D. S. and Leven S. J.. Lawrence Erlbaum. [DH]
Hillyard S. A., Picton T. W. & Regan D. (1978) Sensation, perception and attention: Analysis using ERPs. In: Event-related brain potentials in man, ed. Callaway E., Tueting P. & Koslow S. H.. Academic Press. [RDO]
Hoffman R. E. (1986) Verbal hallucinations and language production processes in schizophrenia. Behavioral and Brain Sciences 9:503–48. [aJAG, REH, AFO]
Hoffman R. E. (1987) Cognitive models of verbal hallucinations in schizophrenia. Behavioral and Brain Sciences 10:534–37. [REH]
Hoffman R. E. & Dobscha S. B. (1989) Cortical pruning and the development of schizophrenia: A computer model. Schizophrenia Bulletin 15:477–90. [REH]
Hoffman W. F., Labs S. M. & Casey D. E. (1987) Neuroleptic induced Parkinsonism in older schizophrenics. Biological Psychiatry 22:427–39. [RS]
Hogarty G. E. & Ulrich R. F. (1977) Temporal effects of drug and placebo in delaying relapse in schizophrenic outpatients. Archives of General Psychiatry 34:297313. [GGD]
Holzman P. S. (1987) Recent studies of psychophysiology in schizophrenia. Schizophrenia Bulletin 13:4975. [aJAG, MED, KHN]
Hopf A. (1952) Uber histopathologische Veranderungen in Pallidum und Striatum bei Schizophrenic. Proceedings of the International Congress of Neuropathology, vol. 3, Turin, Italy. Rosenberg & Sellinger. [RS]
Horvath T. B., Siever L. J., Mohs R. C. & Davis K. (1989) Organic mental syndromes and disorders. In: Comprehensive textbook of psychiatry, eds. Kaplan H. I. and Sadcock B. J., Williams & Wilkins. [JHW]
Houston J. P., Maas J. W., Bowden C. L., Contreras S. A., Melntyre K. L. & Javors M. A. (1986) Cerebrospinal fluid HVA, central brain atrophy, and clinical state in schizophrenia. Psychiatry Research 19:207–14. [RS]
Iacono W. G. (1988) Eye movement abnormalities in schizophrenic and affective disorders. In: Neuropsychology of eye movements, ed. Johnston C. W. & Pirozzolo F. J.. Lawrence Erlbaum. [aJAG]
Imperato A., Alivernini L., Scrocco M. G., Bacchi S., & Angelucci L. (1990) Excitatory aminoacids on dopaminergic and cholinergic transmission: Potential therapeutic applications. Neurochemistry International 16, Supplement 1:44. [AC]
Imperato A., Mulas A. & Di Chiara G. (1986) Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats. European Journal of Pharmacology 132:337–38. [rJAG]
Ingham C. A., Bolam J. P. & Smith A. D. (1988) GABA-immunoreactive synaptic boutons in the rat basal forebrain: Comparisons of neurons that project to the neocortex with pal lidos ubthalamic neurons. Journal of Comparative Neurology 273:263–82. [MS]
Ingraham L. J. & Kety S. S. (1988) Schizophrenia spectrum disorders. In: Handbook of schizophrenia: Nosology, epidemiology and genetics, vol. 3, eds. Tsuang M. T. & Simpson J. C.. Elsevier Science Publishers. [LJI]
Isaacson R. L. (1980) A perspective for the interpretation of limbic system function. Physiological Psychology 8:183–88. [aJAG]
Isaacson R. L. (1984) Hippocampal damage: Effects on dopaminergic systems of the basal ganglia. International Beview of Neurobiology. [TSE]
Itzhak Y. & Alerhand S. (1989) Differential regulation of sigma and PCP receptors after chronic administration of haloperidol and phencyclidine in mice. The Federation of American Societies of Experimental Biology Journal 3:1868–72. [KLRJ]
Iversen S. D. (1977) Striatal function and stereotyped behaviour. In: Psychobiology of the striatum, ed. Cools A. R., Lohman A. H. M. & van der Berken J. H. L.. North-Holland Publishing Co. [aJAG]
Jackson H. F. (1990) Are there biological markers of schizophrenia? In: Reconstructing schizophrenia, ed. Bentall R. P.. Routledge. [GC]
Jaffe J. H. (1989) Psychoactive substance abuse disorders. Ch. 13 in Comprehensive Textbook of Psychiatry 5th Edition, eds. Kaplan H. I. and Sadcock B. J., Williams and Wilkins. [JHW]
Jakob H. & Beckmann H. (1986) Prenatal development disturbances in the limbic allocortex in schizophrenics. Journal of Neural Transmission 65:303–26. [LP, TP, AR]
Jansen K. L. R. (1989) Near death experience and the NMDA receptor. British Medical Journal 298:1708. [KLRJ]
Jansen K. L. R. (1990) Neuroscience and the near-death experience: Roles for the NMDA– PCP receptor, the sigma receptor, and the endopsychosins. Medical Hypotheses 31:2529. [KLRJ]
Jansen K. L. R., Dragunow M. & Faull R. L. M. (1989a) [*3H] glycine binding sites, NMDA and PCP receptors similar distributions in the human hippocampus: An autoradiographic study. Brain Research 482:174–78. [rJAG, KLRJ]
Jansen K. L. R., Dragunow M. & Faull R. L. M. (1989b) Excitatory amino acid receptors in the human cerebral cortex: A quantitative autoradiographic study comparing the distributions of [*3H] TCP, [*3H] glycine, L–[*3H] glutamate, [*3H] AMPA and [*3H] kainic acid binding sites. Neuroscience 32:587607. [rJAG, KLRJ]
Jansen K. L. R., Dragunow M. & Faull R. L. M. (1990) Sigma receptors are highly concentrated in the rat pineal gland. Brain Research 507:158–60. [KLRJ]
Jarrard L. E., Feldon J., Rawlins J. N. P., Sinden J. D. & Gray J. A. (1986) The effects of intrahippocampal ibotenate on resistance to extinction after continuous or partial reinforcement. Experimental Brain Research 61:519–30. [aJAG]
Jeste D. V. & Lohr J. B. (1989) Hippocampal pathologic findings in schizophrenia. Archives of General Psychiatry 46:1019–24. [aJAG]
Johnson F. H. (1978) The anatomy of hallucinations. Nelson-Hall. [AFO]
Jones E. G. (1985) The thalamus. Plenum Press. [AFO]
Jones S. H. (1989) The Kamin blocking effect, incidental learning and choice reaction time in acute and chronic schizophrenia. Ph.D. thesis, University of London. [arJAG]
Jones S. H., Hemsley D. R. & Gray J. A. (1990) The Kamin blocking effect, incidental learning and psychoticism. British Journal of Psychology 81:95109. [arJAG, PHV]
Joseph M. H., Young A. M. J. & Gray J. A. (in press) Insights into behavioural functions of dopamine systems using in vivo voltammetry and dialysis. Journal of Psychopharmacology. [rJAG]
Joseph M. H., Frith C. D. & Waddington J. L. (1979) Dopaminergic mechanisms and cognitive deficit in schizophrenia: A neurobiological model. Psychopharmacology 63:273–80. [aJAG]
Kaku T., Momotani Y. & Higashi Y. (1986) Study of movement-related cortical potential in chronic schizophrenics. Japanese Journal of Psychiatry and Neurology 40:533. [GGD]
Kamer R. S., Turi A. R., Solomon P. R. & Kaplan L. J. (1981) Increased mesolimbic dopamine binding following chronic haloperidol treatment. Psychopharmacologia 72:261–63. [RDO]
Kamin L. J. (1968) “Attention-like” processes in classical conditioning. In: Miami symposium on the prediction of behavior, ed. Jones M. R.. University of Miami Press. [aJAG]
Kar B. C. (1967) Muller-Lyer illusion in schizophrenics as a function of field distraction and exposure time. Master's thesis, George Peabody College for Teachers, Nashville, TN. [IJE]
Karlsson J. L. (1978) Inheritance of creative intelligence. Nelson-Hall. [GC]
Kay S. R. & Sevy S. (in press) Pyramidal model of schizophrenia. Schizophrenia Bulletin. [RS]
Kay S. R. & Singh M. M. (1989) The positive-negative distinction in drug-free schizophrenic patients: Stability, response to neuroleptics, and prognostic significance. Archives of General Psychiatry 46:711–18. [RS]
Kay S. R., Fiszbein A. & Opler L. A. (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin 13:261–75. [RS]
Kaye H. & Pearce J. M. (1987) Hippocampal lesions attenuate latent inhibition and the decline of the orienting response in rats. Quarterly Journal of Experimental Psychology 39B:107–25. [aJAG, PHV]
Kelley A. E. & Domesick V. B. (1982) The distribution of the projection from the hippocampal formation to the nucleus accumbens in the rat. An anterograde– and retrograde-horseradish peroxidase study. Neuroscience 7:2321–35. [aJAG]
Kelly P. K., Seviour P. W. & Iversen S. D. (1975) Amphetamine and apomorphine responses in the rat following 6–OHDA lesions of the nucleus accumbens septi and corpus striatum. Brain Research 94:507–22. [aJAG]
Kemp J. M. & Powell T. P. S. (1971) The termination of fibres from the cerebral cortex and thalamus upon dendritic spines in the caudate nucleus: A study with the Golgi method. Philosophical transactions of the Royal Society (London), Section B 262:429–39. [rJAG]
Kendler K. S. (1985) Diagnostic approaches to schizotypal personality disorder: A historical perspective. Schizophrenia Bulletin 11:538–53. [LJI]
Kennedy J. L., Giuffra L. A., Moises H. W., Cavalli-Sforza L. L., Pakstis A. J., Kidd J. R., Castiglione C. M., Sjogren B., Wetterberg L. & Kidd K. K. (1988) Evidence against linkage of schizophrenia to markers on chromosome 5 in northern Swedish pedigree. Nature 336:167–70. [WEC]
Kerwin R. W., Patel S., Meldrum B. S., Czudeck C. & Reynolds G. P. (1988) Asymmetrical loss of a glutamate receptor subtype in left hippocampus in postmortem schizophrenic brain. Lancet (i):583–84. [aJAG]
Ketchum J. S., Sidell F. R., Crowell E. B. Jr, Aghajanian G. K. & Hayes A. H. (1973) Atropine, scopolamine and ditran: Comparative pharmacology and antagonists in man. Psychopharmacologia 28:121–45. [JHW]
Kety S. S., Rosenthal D., Wender P. H., Schulsinger F. (1968) The types and prevalence of mental illness in the biological and adoptive families of adopted schizophrenics. Journal of Psychiatric Research 6, Supplement 1:345–62. [LJI]
Kim J. S., Kornhuber H. H., Kornhuber J. & Kornhuber M. E. (1986) Glutamic acid and the dopamine hypothesis of schizophrenia. In: Biological psychiatry (1985) ed. Chagass L.–H., Josiassen R. C., Bridger W. H., Weiss H. J., Stuff D. & Simpson G. S.. Elsevier. [KLRJ]
Klawans H. L. (1988) Psychiatric side effects during the treatment of Parkinson's disease. Journal of Neural Transmission 27, Supplement: 117–22. [RS]
Kleinman J. (1987) Postmortem studies in schizophrenia, International Journal of Neuroscience 32:640–41. [ARG]
Knight R. A. (1984) Converging models of cognitive deficit in schizophrenia. In: Theories of schizophrenia and psychosis, ed. Spaulding W. & Cole J. K.. University of Nebraska Press. [aJAG, IJE]
Knight R. A., Elliott D. S., Roff J. D. & Watson C. G. (1986) Concurrent and predictive validity of components of disordered thinking in schizophrenia. Schizophrenia Bulletin 12:427–46. [aJAG]
Koh S. D. (1978) Remembering of verbal materials in schizophrenic young adults. In: Language and cognition in schizophrenia, ed. Schwartz S.. Erlbaum. [JRS]
Kohler C. & Chan-Palay V. (1988) Cholecystokinin-octapeptide (CCK–8) receptors in the hippocampal region: A comparative in vitro autoradiographic study in the rat, monkey, and the postmortem human brain. Neuroscience Letters 90:5156. [rJAG, LP]
Kokkinidis L. & Anisman H. (1981) Amphetamine psychosis and schizophrenia: A dual model. Neuroscience & Biobehavioral Reviews 5:449–61. [LJI]
Kolb B., & Whishaw I. Q. (1983) Performance of schizophrenic patients on tests sensitive to left or right frontal, temporal, or parietal function in neurological patients. Journal of Nervous and Mental Disease 171:435–43. [MED]
Kopstein J. H. & Neale J. M. (1972) A multivariate study of attention dysfunction in schizophrenia. Journal of Abnormal Psychology 80:294–98. [JRS]
Kornhuber J. & Kornhuber M. E. (1986) Presynaptic dopaminergic modulation of cortical input to the striatum. Life Sciences 39:669–74. [KLRJ]
Kornhuber J., Mack-Burkhardt F., Riederer P., Hebenstriet G. F., Reynolds G. P., Andrews H. B. & Beckmann H. (1989) [*3H] MK–801 binding sites in postmortem brain regions of schizophrenic patients. Journal of Neural Transmission 77:231–36. [KLRJ]
Kornhuber J., Riederer P., Reynolds G. P., Beckmann H., Jellinger K., & Gabriel E. (1989) 3H-spiperone binding sites in post-mortem brains from schizophrenic patients: Relationship to neuroleptic drug treatment, abnormal movements, and positive symptoms. Journal of Neural Transmission 75:110. [JRS]
Kovelman J. A. & Scheibel A. B. (1984) A neuro-histological correlate of schizophrenia. Biological Psychiatry 19:1601–21. [AR]
Kraepelin E. (1919) Dementia praecox. (Trans. Barclay E. & Barclay W..) Livingston. [aJAG]
Kraepelin E. (1971) Dementia praecox and paraphrenia. Krieger. [AnC]
Kuczenski R. (1983) Biochemical actions of amphetamine and other stimulants. In: Stimulants: Neurochemical, behavioral, and clinical perspectives, ed. Creese I.. Raven Press. [IW]
Largent B. L., Wikstrom H., Snowman A. M. & Snyder S. H. (1988) Novel antipsychotic drugs share high affinity for sigma receptors. European Journal of Pharmacology 155:345–47. [KLRJ]
Launay G. & Slade P. D. (1981) The measurement of hallucinatory predisposition in male and female prisoners. Personality and Individual Differences 2:221–34. [rJAG, PHV]
Leff J. (1987) A model of schizophrenic vulnerability to environmental factors. In: Search for the causes of schizophrenia, ed. Hafher H., Gattaz W. F. & Janzarik W.. Springer Verlag. [rJAG]
Leichnetz G. R. (1981) The prefrontal cortico-oculomotor trajectories in the monkey. A possible explanation for the effects of stimulation/lesion experiments on eye movement. Journal of the Neurological Sciences 49:387–96. [aJAG]
Leichnetz G. R., Spencer R. F., Hardy S. G. P. & Astruc J. (1981) The prefrontal corticotectal projection in the monkey: An anterograde and retrograde horseradish peroxidase study. Neuroscience 6:1023–41. [aJAG]
Lesch A. & Bogerts B. (1984) The diencephalon in schizophrenia: Evidence for reduced thickness of the periventricular grey matter. European Archives of Psychiatry and Neurological Sciences 234:212–19. [RS, AR]
Levin S. (1983) Smooth pursuit impairment in schizophrenia – What does it mean? Schizophrenia Bulletin 9:3744. [aJAG]
Levin S. (1984) Frontal lobe dysfunctions in schizophrenia I. Eye movement impairments. Journal of Psychiatric Research 18:2755. [aJAG, HES]
Levin S., Levin S.Lipton R. B. & Holzman P. S. (1981) Pursuit eye movements in psychopathology: Effects of target characteristics. Biological Psychiatry 16:255–67. [aJAG]
Levin S., Yurgelun-Todd D. & Craft S. (1989) Contributions of clinical neuropsychology to the study of schizophrenia. Journal of Abnormal Psychology 98:341–56. [JRS]
Levit R. A., Sutton S. & Zubin J. (1973) Evoked potential correlates of information processing in psychiatric patients. Psychological Medicine 3:487–94. [GGD]
Lewis S. W. & Mezey G. C. (1985) Clinical correlates of septum pellucidum cavities: An unusual association with psychosis. Psychological Medicine 15:4345. [rJAG, JHW]
Lewis S. W., Murray R. M. & Owen M. J. (1989) Obstetric complications in schizophrenia. Methodology and mechanisms. In: Schizophrenic-Scientific progress, ed. Schultz S. C. & Tamminga C. A.. Oxford University Press. [LP]
Lieberman J. A., Kinon B. J. & Loebel A. D. (1990) Dopaminergic mechanisms in idiopathic and drug-induced psychoses. Schizophrenia Bulletin 16:97110. [AnC]
Lindstrom L., Klockhoff I., Svedberg A. & Bergstrom K. (1987) Abnormal auditory brain-stem responses in hallucinating schizophrenic patients. The British Journal of Psychiatry 151:914. [TP]
Lipp H. P. & Schwegler H. (1983) Hippocampal mossy fibers and avoidance learning. In: Genetics of the brain, ed. Lieblich I., Elsevier Biomedical. [WEC]
Ljungberg T. & Enquist M. (1987) Disruptive effects of low doses of d-amphetamine on the ability of rats to organise behaviour into functional sequences. Psychopharmacology 93:146–51. [MHJ]
Loescher W. & Czuczwar S. J. (1986) Studies on the involvement of dopamine D-l and D–2 receptors in the anticonvulsant effect of dopamine agonists in various rodent models of epilepsy. European Journal of Pharmacology 128:5565. [RDO]
London E. D., Cascella N. G., Wong D. F., Phillips R. L., Dannals R. F., Links J. M., Herning R., Grayson R., Jaffe J. H. & Wagner H. N. (1990) Cocaine-induced reduction of glucose utilization in human brain: A study using positron emission tomography and [Fluorine 18] – fluorodeoxyglucose. Archives of General Psychiatry 47:567–74. [NRS]
Silva Lopes da, Arnolds F. H., D. E. A. T. & Neijt H. C. (1984) A functional link between the limbic cortex and ventral striatum: Physiology of the subiculum accumbens pathway. Experimental Brain Research 55:205–14. [aJAG]
Louilot A., LeMoal M. & Simon H. (1989) Opposite influences of dopaminergic pathways to the prefrontal cortex or the septum on the dopaminergic transmission in the nucleus accumbens. An in vivo voltammetric study. Neuroscience 29:4556. [TSE]
Louilot A., Simon H., Taghzouti K. & LeMoal M. (1985) Modulation of dopaminergic activity in the nucleus accumbens following facilitation or blockade of the dopaminergic transmission in the amygdala: A study by in vivo differential pulse voltammetry. Brain Research 346:141–45. [TSE]
Louw D., Sutherland G. R., Glavin G. B. & Girvin J. (1989) A study of monoamine metabolism in human epilepsy. Canadian Journal of Neurological Sciences 16:394–97. [RDO]
Lubow R. E. (1973) Latent inhibition. Psychological Bulletin 79:398407. [aJAG]
Lubow R. E. (1989) Latent inhibition and conditioned attention theory. Cambridge University Press. [arJAG, REL]
Lubow R. E., Lubow R. E.Riflcin B. & Alek M. (1976) The context effect: The relationship between stimulus preexposure and environmental preexposure determines subsequent learning. Journal of Experimental Psychology: Animal Behavior Processes 2:3847. [REL]
Lubow R. E., Werner I., Schlossberg A. & Baruch I. (1987) Latent inhibition and schizophrenia. Bulletin of the Psychonomic Society 25:464–67. [REL]
Lubow R. E., Weiner I. & Feldon J. (1982) An animal model of attention. In: Behavioural models and the analysis of drug action, ed. Speigelstein M. Y. & Levy A.. Elsevier. [aJAG, REL]
Lubow R. E., Zalstein N. & Zaks Y. (submitted) Latent inhibition in Iow– and high–“psychotic-prone” normal subjects. [REL]
Luria A. R. (1977) On quasiphasie speech disturbances in lesions of the deep structures of the brain. Brain and Language 4:432–59. [AFO]
Lynch J. C. (1987) Frontal eye field lesions in monkeys disrupt visual pursuit. Experimental Brain Research 68:437–41. [aJAG]
MacKay A. V. P. (1980) Positive and negative schizophrenic symptoms and the role of dopamine. Discussion. British Journal of Psychiatry 137:379–83. [RS]
MacLean P. D. (1986) Culminating developments in the evolution of the limbic system: The thalamocingulate division. In: The limbic system: Functional organization and clinical disorders, ed. Doane B. K. & K. E.Livingston. Raven Press. [rJAG, NRS]
Mackintosh N. J. (1983) Conditioning and associative learning. Oxford University Press. [aJAG, GC]
Magaro P. A. (1984) Psychosis and schizophrenia. In: Theories of schizophrenia and psychosis, ed. Spaulding W. D. & Cole J. K.. University of Nebraska Press. [aJAG]
Maher B. A. (1983) A tentative theory of schizophrenic utterance. In: Progress in experimental personality research, vol. 12, ed. Maher B. A. & Maher W. B.. Academic Press. [aJAG, TCM]
Manschreck T. C. (1986) Motor abnormalities in schizophrenia. In: Handbook of schizophrenia: The neurology of schizophrenia, vol. 1, ed. Nasrallah H. A. & Weinberger D. R.. Elsevier. [rJAG, AnC]
Manschreck T. C., Maher B. A. & Ader D. N. (1981) Formal thought disorder, the type-token ratio, and disturbed voluntary motor movements in schizophrenia. British Journal of Psychiatry 139:715. [aJAG]
Manschreck T. C., Maher B. A.Rucklos M. E. & Vereen D. R. (1982) Disturbed voluntary motor activity in schizophrenic disorders. Psychological Medicine 12:7384. [TCM, AnC]
Maragos W. F., Penney J. B. & Young A. B. (1988) Anatomic correlation of NMDA and *3–TCP-labeled receptors in rat brain. Journal of Neuroscience 8:493501. [REH]
Marie P. (1906) Révision de la question de l'aphasie: La troisième circonvolution frontale gauche ne joue aucun rôle spécial dans la function du langage. Semaine Médicale 26:241–47. [NRS]
Marien M., Brien J. & Jhamandas K. (1983) Regional release of (3H)dopamine from rat brain in vitro: Effects of opioids on release induced by potassium, nicotine, and L-glutamic acid. Canadian Journal of Physiology & Pharmacology 61:4360. [aJAG]
Markianos M., Rinieris P., Hatzmanolis J. & Stefanis C. (1990) Plasma dopamine-beta-hydroxylase in familial and sporadic paranoid schizophrenia. Biological Psychiatry 27:1176–78. [WEC]
Martinot J. L., Peron-Magnan P., Huret J. D., Mazoyer B., Baron J. C., Boulenger J. P., Loc'h C., Maziere B., Caillard V. & Loo H. (1990) Striatal D*2 dopaminergic receptors assessed with positron emission tomography and [76Br] Bromospiperone in untreated schizophrenic patients. American Journal of Psychiatry 147:4450. [REH]
Matthysse S. (1980) Nucleus accumbens and schizophrenia. In: The neurobiology of the nucleus accumbens, ed. Chronister R. B. & DeFrance j. F.. Haer Institute. [MP]
Matussek P. (1952) Studies in delusional perception. Psychiatric und Zeitschrift Neurologic 189:279318. (trans. 1987 in: The clinical roots of the schizophrenia concept, ed. Cutting J. & Shepherd M.. Cambridge University Press) [arJAG]
McGhie A. & Chapman J. (1961) Disorders of attention and perception in early schizophrenia. British Journal of Medical Psychology 34:103–16. [aJAG]
McKenna P. J. (1987) Pathology, phenomenology and the dopamine hypothesis of schizophrenia. British Journal of Psychiatry 151:288301. [aJAG]
McLardy T. (1974) Hippocampal zinc and structural deficit in brains from chronic alcoholics and some schizophrenics. Journal of Orthomolecular Psychiatry 4:3236. [AR]
McLaren I. P. L., Kaye H. & Mackintosh N. J. (1989) An associative theory of the representation of stimuli: Applications to perceptual learning and latent inhibition. In: Parallel distributed processing: Implications for psychology and neurobiology, ed. Morris R. G. M.. Oxford University Press. [rJAG, JG]
McLean S. & Weber E. (1988) Autoradiographic visualisation of haloperidol– sensitive sigma receptors in guinea-pig brain. Neuroscience 25:259–69. [KLRJ]
Meaney M. J., Aitken D. H., Bodnoff S. R., Iny L. F., Tatarewicz J. E. & Sapolsky R. M. (1985) Early postnatal handling alters glucocorticoid receptor concentrations in selected brain regions. Behavioral Neuroscience 99:765–70. [rJAG]
Medalia A., Gold J. -M. & Merriam A. (1988) The effects of neuroleptics on neuropsychological test results of schizophrenics. Archives of Clinical Neuropsychology 3:249–71. [JRS]
Mednick S. A. (1970) Breakdown in individuals at high risk for schizophrenia: Possible predispositional perinatal factors. Mental Hygiene 54:5063. [PHV]
Mednick S. A. (1974) Breakdown in individuals at high risk for schizophrenia: Possible predispositional perinatal factors. In: Genetics, environment, and psychopathology, ed. Mednick S. A., Schulsinger F., Higgins J. & Bell B.. North-Holland. [WEC]
Mednick S. A. & Schulsinger F. (1968) Some premorbid characteristics related to breakdown in children with schizophrenic mothers. Journal of Psychiatric Research 6:267–91. [rJAG, AR]
Mednick S. A. & Silverton L. (1987) High risk studies of the etiology of schizophrenia. In: Handbook of schizophrenia: Nosology, epidemiology and genetics, vol. 3, ed. Tsuang M. T. & Simpson J. C.. Elsevier. [AR]
Miller G. A., Galanter E. H. & Pribram K. H. (1960) Plans and the structure of behavior. Rinehart & Winston. [aJAG]
Miller J. (1987) Priming is not necessary for selective attention failures: Semantic effects of unattended, unprimed letters. Perception and Psychophysics 41:419–34. [rJAG]
Mirkin A. M. (1985) Bimodal electrodermal activity in schizophrenia. British Journal of Clinical Psychology 24:131–32. [rJAG]
Mishkin M., Ungerleider L. G. & Macko K. A. (1983) Object vision and spatial vision: Two cortical pathways. Trends in Neurosciences 6:414–17. [EG]
Mithani S., Martin-Iverson M. T., Phillips A. G., & Fibiger H. C. (1986) The effects of haloperidol on amphetamine– and methylphenidate–induced conditioned place preferences and locomotor activity. Psychopharmacology 90:247–52. [IW]
Mogenson G. J. & Nielsen M. (1984) A study of the contribution of hippocampal–accumbens–subpallidal projections to locomotor activity. Behavioral and Neural Biology 42:5260. [NRS]
Mogenson G. J., Swanson L. W. & Wu M. (1983) Neural projections from nucleus accumbens to globus pallidus, substantia innominata, and lateral preoptic–lateral hypothalamic area: An anatomical and electrophysiological investigation in the rat. Journal of Neuroscience 3:189202. [MS]
Mohammed A. K., Callenholm N. E. B., Jaerbe T. U. C., Swedberg M. D. B., Danysz W., Robbins T. W. & Archer T. (1986) Role of central noradrenaline neurons in the contextual control of latent inhibition in taste aversion learning. Behavioural Brain Research 21:109–18. [RDO]
Monaghan D. T.; Bridges R. J. & Cotman C. W. (1989) The excitatory amino acid receptors. Their classes, pharmacology, and distinct properties in the function of the central nervous system. Annual Review of Pharmacology and Toxicology 29:365402. [KLRJ]
Moore J. W. (1979) Information processing in space–time by the hippocampus. Physiological Psychology 7:224–32. [PHV]
Moore R. Y., Bjorklund A.& Stenevi U. (1971) Plastic changes in the adrenergic innervation of the rat septal area in response to denervation. Brain Research 33:1335. [JRS]
Mowrer R. R. (1987) Latent inhibition of contextual stimuli reduces the US preexposure effect. Psychological Record 37:239–46. [REL]
Murray R. M., Lewis S. W., & Reveley A. M. (1985) Towards an aetiological classification of schizophrenia. The Lancet i:1023–26. [LJI]
Murray R. M., Lewis S. W., Owen M. J. & Foerster A. (1988) The neurodevelopmental origins of dementia praecox. In: Schizophrenia: The major issues, ed. Bebbington P. & McGuffin P.. Heinmann. [arJAG, LP]
Nauta W. J. H. & Domesick V. B. (1984) Afferent and efferent relationships of the basal ganglia. In: Functions of the basal ganglia, ed. Evered D. & O'Connor M.. Ciba Foundation Symposium 107. Pitman. [aJAG]
Nicolle M. M., Barry C. C., Veronesi B.& Stanton M. E. (1989) Fornix transections disrupt the ontogeny of latent inhibition in the rat. Psychobiology 17:349–57. [RDO]
Nieto D.& Escobar A. (1972) Major psychoses. In: Pathology of the nervous system, ed. Minckler J.. McGraw–Hill. [RS]
Nishikawa T., Takashima M. & Toru M. (1983) Increased [^ F3H] kainic acid binding in the prefrontal cortex in schizophrenia. Neuroscience Letters 40:245–50. [aJAG]
Nolan J. D. (1968) Reversal and extra–dimensional shifts in abstract and concrete schizophrenics. Journal of Abnormal Psychology 73:330–35. [rJAG]
Nuechterlein K. H. (in press) Vigilance in schizophrenia and related disorders. In: Handbook of schizophrenia: Neuropsychology, psychophysiology, and information processing, vol. 5, ed. Steinhauer S., Gruzelier J. H. & Zubin J.. Elsevier Science Publishers. [KHN]
Nuechterlein K. H. & Dawson M. E. (1984a) A heuristic vulnerability/stress model of schizophrenic episodes. Schizophrenia Bulletin 10:300–12. [KHN]
Nuechterlein K. H. & Dawson M. E. (1984b) Information processing and attentional functioning in the developmental course of the schizophrenic disorder. Schizophrenia Bulletin 10:160203. [arJAG, JRS, IJE, KHN]
Oades R. D. (1985) The role of NA in tuning and DA in switching between signals in the CNS. Neuroscience & Biobehavioral Review 9:261–82. [aJAG, ARC]
Oades R. D. & Isaacson R. L. (1978) The development of food search behavior by rats: The effects of hippocampal damage and haloperidol. Behavioral Biology 24:327–37. [RDO]
Oades R. D., Rea M.or Taghzouti K. (1985) The modulation of selective processes in learning by neocortical and limbic dopamine. In: Brain plasticity, learning and memory, ed. Will B., Schmitt P. & Dalrymple– Alford J., Plenum Press. [RDO]
Oades R. D., Rivet, J–M., Taghzouti, K., Kharuoby, M., Simon H.& Le Moal M. (1987) Attentional blocking is delayed by depletion of septal dopamine but remains attenuated after frontal depletion. Brain Research 406:136–46. [RDO]
Öhman A. (1981) Electrodermal activity and vulnerability to schizophrenia: A review. Biological Psychology 12:87145. [MED]
Öhman A., Nordby H., & d'Elia G. (1986) Orienting and schizophrenia: Stimulus significance, attention, and distraction in a signaled reaction time task. Journal of Abnormal Psychology 95:326–34. [MED]
Ojemann G. A. (1975) Language and the thalamus: Object naming and recall during and after thalamic stimulation. Brain and Language 2:101–20. [AFO]
Ojemann G. A. (1976) Subcortical language mechanisms: In: Studies in neurolinguistics, vol. 1, ed. Whitaker H. & Whitaker H. A.. Academic Press. [AFO]
Ojemann G. A. (1983) Brain organization for language from the perspective of electrical stimulation mapping. Behavioral and Brain Sciences 6:189230. [AFO]
Ojemann G. A. & Ward A. A. (1971) Speech representation in ventrolateral thalamus. Brain 94:669–80. [AFO]
Oke A. F. & Adams R. N. (1987) Elevated thalamic dopamine: Possible link to sensory dysfunctions in schizophrenia. Schizophrenia Bulletin 13:589605. [AFO, TP]
Oke A. F., Adams R. N., Winblad B. & von Knorring L. (1988) Elevated dopamine/norepinephrine ratios in thalami of schizophrenic brains. Biological Psychiatry 24:7982. [AFO]
Olney J. W. (1989) Excitatory amino acids and neuropsychiatric disorders. Biological Psychiatry 26:505–25. [KLRJ]
Owen F., Cross A. J., Crow T. J., Longden A., Poulter M. & Riley G. J. (1978) Increased dopamine–receptor sensitivity in schizophrenia. Lancet ii:223–26. [aJAG]
Owens D. G. C., Johnstone E. C. & Frith C. D. (1982) Spontaneous involuntary disorders of movement: Their prevalence, severity and distribution in chronic schizophrenics with and without treatment with neuroleptics. Archives of General Psychiatry 39:452–61. [aJAG, MP, AnC]
Papez J. W. (1937) A proposed mechanism of emotion. Archives of Neurology and Psychiatry 38:725–43. [NRS]
Parish E. (1897) Hallucinations and illusions. Walter Scott. [AFO]
Patel S. & Slater P. (1988) Effects of GABA compounds injected into the subpallidal regions of rat brain on nucleus accumbens evoked hyperactivity. Behavioral Neuroscience 102:596600. [MS]
Patterson T. (1987) Studies toward the subcortical pathogenesis of schizophrenia. Schizophrenia Bulletin 13:555–76. [aJAG, TP]
Patterson, T., Spohn H. E. & Hayes K. (1987) Topographic evoked potentials during backward masking in schizophrenics, patient controls and normal controls. Progress in Neuro–Psychopharmacology & Biological Psychiatry 11:709–28. [TP]
Pavlov I. P. (1927) Conditioned reflexes. Oxford University Press. [MED]
Pay R. G. (1980a) Conative regulation of cortical activity by the reticular formation, hypothalamus, and thalamus. International Journal of Neuroscience 10:233–53. [TP]
Pay R. G. (1980b) Contextual organization of unitary information processes in the cortex by the thalamus and basal ganglia and the central control of attention. International Journal of Neuroscience 11:249–78. [TP]
Pay R. G. (1981) Control of complex conation and emotion in the neocortex by the limbic entorhinal, subicular, and cingulate cortices and the hypothalamus, mammilary body and thalamus. International Journal of Neuroscience 15:130. [TP]
Pay R. G. (1982) Behavioral steering in dual and social states of conation by the amygdala, hypothalamus, ventral striatum, and thalamus. International Journal of Neuroscience 16:140. [TP]
Pearce J. M. & Hall G. (1980) A model for Pavlovian learning: Variations in the effectiveness of conditioned but not unconditioned stimuli. Psychological Review 87:532–52. [rJAG, JG, NAS]
Penney J. B. & Young A. B. (1981) GABA as the pallidothalamic neurotransmitter. Implications for basal ganglia function. Brain Research 207:195–99. [aJAG]
Penney J. B. & Young A. B. (1983) Speculations on the functional anatomy of basal ganglia disorders. Annual Review of Neuroscience 6:7394. [NRS]
Penney J. B. & Young A. B. (1986) Striatal inhomogeneities and basal ganglia function. Movement Disorders 1:315. [AC]
Percheron G.; Francois C., Yelnik J. & Fenelon G. (1989) The primate nigro–striatal–pallido–nigral System. Not a mere loop. In: Neural mechanisms in disorders of movement, eds. Grossman A. R. & Sambrook M. A.. John Libby. [DH]
Perez M. M., Trimble M. R.; Murray N. N. F. & Reider I. (1985) Epileptic psychosis: An evaluation of PSE profiles. British Journal of Psychiatry 146:155–63. [JHW]
Petrides M. (1987) Conditional learning and the primate frontal cortex. In: The frontal lobes revisited, ed. Perecman E.. IRBN Press. [CF]
Pfefferbaum A., Ford J. M., White P. & Roth W. T. (1989) P3 in schizophrenia is affected by stimulus modality, response requirements, medication status and negative symptoms. Archives of General Psychiatry 46:1035–44. [PHV]
Pfohl B. & Winokur G. (1982) The evolution of symptoms in institutionalized hebephrenic/catatonic schizophrenics. British Journal of Psychiatry 141:567–72. [aJAG, RS]
Phillipson O. T. & Griffiths A. C. (1985) The topographical order of inputs to nucleus accumbens in the rat. Neuroscience 16:275–96. [aJAG]
Phillis J. W. & Kirkpatrick J. R. (1980) The actions of motilin, luteinizing hormone releasing hormone, cholecystokinin, somatostatin, vasoactive intestinal peptide, and other peptides on rat cerebral cortical neurons. Canadian Journal of Physiology and Pharmacology 58:612–23. [aJAG]
Pickar D. (1988) Perspectives on a time dependent model of neuroleptic action. Schizophrenia Bulletin 14:255–68. [rJAG]
Pickar D., Labarca R., Doran A. R., Wolkowitz O. M., Roy A., Breier A., Linnoila M. & Paul S. M. (1986) Longitudinal measurement of homovanillic acid levels in schizophrenic patients: Correlation with psychosis and response to neuroleptic treatment. Archives of General Psychiatry 43:669–76. [GGD]
Pogue-Geile M. F. & Harrow M. (1988) Negative symptoms in schizophrenia: Their longitudinal course and prognostic importance. Schizophrenia Bulletin 11:427–30. [aJAG]
Pogue–Geile M. F. & Oltmanns T. F. (1980) Sentence perception and distractibility in schizophrenic, manic, and depressed patients. Journal of Abnormal Psychology 89:115–24. [REL]
Pope S. E., Dean P. & Redgrave P. (1980) Dissociation of d–amphetamine–induced locomotor activity and stereotyped behaviour by lesions of the superior colliculus. Psychopharmacology 70:297302. [aJAG]
Posey B. T. & Losch M. E. (1983–84) Auditory hallucinations of hearing voices in 375 normal subjects. Imagination, Cognition, & Personality 3:99113. [MH]
Posner M. I. (1982) Cumulative development of attentional theory. American Psychology 37:168–79. [aJAG]
Posner M. I., Early T. S., Reiman E. M., Pardo P. J. & Dhawan M. (1988) Asymmetries in hemispheric control of attention in schizophrenia. Archives of General Psychiatry 45:814–21. [rJAG, IJE, TSE, GC]
Pritchard W. S. (1986) Cognitive event–related potential correlates of schizophrenia. Psychological Bulletin 100:4366. [PHV]
Prochazka A. (1989) Sensorimotor gain control: A basic strategy of motor systems?. Progress in Neurobiology 33:281307. [DH]
Puente G. P., Cannon D. S., Best M. R. & Carrell L. E. (1988) Occasion setting of fluid ingestion by contextual cues. Learning and Motivation 19:239–53. [REL]
Pycock C. J., Kerwin R. W. & Carter C. J. (1980) Effect of lesion of cortical dopamine terminals on subcortical dopamine in rats. Nature 286:7477. [aJAG]
Raine A., Harrison G., Reynolds G. P., Sheard C., Cooper J. E. & Medley I. (in press) Structural and functional characteristics of the corpus callosum in schizophrenics, psychiatric controls, and normal controls: An MRI and neuropsychological evaluation. Archives of General Psychiatry. [TDC]
Raisman G. (1969) Neuronal plasticity in the septal nuclei of the adult rat. Brain Research 14:2548. [JRS]
Rappaport J. L. & Wise S. P. (1988) Obsessive–compulsive disorder: Evidence for basal ganglia dysfunction. Psychopharmacology Bulletin 24:380–84. [NRS]
Rawlins J. N. P. (1985) Associations across time: The hippocampus as a temporary memory store. Behavioral and Brain Sciences 8:479528. [rJAG]
Rawlins J. N. P., Feldon J. & Gray J. A. (1980) The effects of hippocampectomy and of fimbria section upon the partial reinforcement extinction effect in rats. Experimental Brain Research 38:273–83. [arJAG]
Rawlins J. N. P., Feldon J., Tonkiss J. & Coffey P. J. (1989) The role of subicular output in the development of the partial reinforcement extinction effect. Experimental Brain Research 77:153–60. [arJAG]
Reisberg B. (1983) Alzheimer's disease. The standard reference. The Free Press. [MS]
Rescorla R. A. (1985) Facilitation and inhibition. In: Information processing in animals: Conditioned inhibition, ed. R R. R. & Spear N. E.. Erlbaum. [REL]
Rescorla R. A. (1986) Extinction and facilitation. Journal of Experimental Psychology: Animal Behavior Processes 12:1624. [REL]
Reynolds G. P. (1987) Postmortem neurochemical studies in schizophrenia. In: Search for the causes of schizophrenia, ed. Hafher H., Gattaz W. F. & Janzavik W.. Springer–Verlag. [aJAG]
Reynolds G. P. (1989) Beyond the dopamine hypothesis – the neurochemical pathology of schizophrenia. British Journal of Psychiatry 155:305–16. [MP]
Rickert E. J. & Lorden J. F. (1989) Forebrain monoamines and associative learning: III the US preexposure effect. Behavioural Brain Research 35:147–52. [RDO]
Rickert E. J., Lorden J. F., Dawson R. & Smyly E. (1981) Limbic lesions and the blocking effect. Physiology and Behavior 26:601–06. [RDO]
Ridley R. M. & Baker H. F. (1983) Is there a relationship between social isolation, cognitive inflexibility, and behavioural stereotypy? An analysis of the effects of amphetamine in the marmoset. In: Ethnopharmacology: Primate models of neuropsychiatry disorders, ed. Miczek Alan K. A.R. Liss. [AnC]
Ridley R. M., Aitken D. N. & Baker H. F. (1989) Learning about rules, but not about reward is impaired following lesions of the cholinergic projection to the hippocampus. Brain Research 502:306–18. [CF]
Ridley R. M., Baker H. F., & Haystead T. A. G. (1981) Perseverative behaviour after amphetamine: Dissociation of response tendency from reward association. Psychopharmacology 75:283–86. [rJAG, CF]
Riklan M. & Cooper R. S. (1975) Psychometric studies of verbal functions following thalamic lesions in humans. Brain and Language 2:4564. [AFO]
Robbins T. W. & Everitt B. J. (1982) Functional studies of the central catecholamines. International Review of Neurobiology 23:303–65. [aJAG, ARC]
Robbins T. W., Watson B. A., Gaskin M. & Ennis C. (1983) Contrasting interactions of pipradol, d–amphetamine, cocaine, cocaine analogues, apomorphine, and other drugs with conditioned reinforcement. Psychopharmacology 80:113–19. [IW]
Roberts G. W. (1990) Schizophrenia: The cellular biology of a functional psychosis. Trends in Neuroscience 13:207–11. [MS]
Roberts G. W., Ferrier I. N., Lee Y., Crow T. J., Johnstone E. C., Owens D. G. C., Bararese-Hamilton A. J., McGregor G., O'Shaughnessy D., Polak J. M. & Bloom S. R. (1983) Peptides, the limbic lobe and schizophrenia. Brain Research 288:199211. [arJAG, LP]
Robertson L. C. (1986) From gestalt to neo–gestalt. In Approaches to cognition: Contrast and controversies, ed. knapp T. J. & Robertson L. C.. L. Erlbaum. [RDO]
Robertson M. M. (1989) The Gilles de la Tourette syndrome: The current status. British Journal of Psychiatry 154:147–69. [NRS]
Rochester S. R. (1978) Are language disorders in acute schizophrenics actually information processing problems?. Journal of Psychiatric Research 14:275–83. [REL]
Rodnick E. H. & Shakow D. (1940) Set in the schizophrenic as measured by a composite reaction time index. American Journal of Psychiatry 97:214–25. [IJE]
Rolls E. T. (1986a) Information representation, processing and storage in the brain: Analysis at the single neuron level. In: Neural and molecular mechanisms of learning, ed. Ritter R. & Ritter S.. Springer– Verlag. [aJAG]
Rolls E. T. (1986b) A theory of emotion, and its application to understanding the neural basis of emotion. In: Emotions: Neural and chemical control, ed. Oomura Y.. Japan Scientific Societies Press Karger. [aJAG]
Rolls E. T. & Williams G. V. (1987) Sensory and movement related neuronal activity in different regions of the primate striatum. In: Basal ganglia and behavior: Sensory aspects and motor functioning, ed. Schneider J. S. & Kidsky T. I.. Hans Huber. [aJAG]
Romo R. et al. (1986) In vivo presynaptic control of dopamine release in the cat caudate nucleus – III. Further evidence for the implication of corticostriatal glutamatergic neurons. Neuroscience 19:1091–99. [aJAG]
Rosen W. G., Mohs R. C., Celeste A. J., Small N. S., Kendler K. S., Horvath T. B. & Davis K. L. (1984) Positive and negative symptoms in schizophrenia. Psychiatry Research 13:277–84. [MS]
Rund B. R. (1986) Verbal hallucinations and information processing. Behavioral and Brain Sciences 9:531–32. [aJAG]
Russell V. A., Allin R., Lamm M. C. L. & Taljaard J. J. F. (1989) Increased dopamine D2 receptor–mediated inhibition of [*14] acetylcholine release in the dorsomedial part of the nucleus accumbens. Neurochemical Research 14:877–81. [MS]
Sabatino M., Gravante G., Ferraro G., Savatteri V. & La Grutta V. (1988) Inhibitory control by substantia nigra of generalized epilepsy in the cat. Epilepsy Research 2:380–86. [RDO]
Saccuzzo D. P. & Braff D. L. (1981) Early information processing deficit in schizophrenia: New findings using subgroups & manic control subjects. Archives of General Psychiatry 38:175179. [RDO]
Salzinger K. (1957) Shift in judgment of weights as a function of anchoring stimuli and instructions in early schizophrenics and normals. Journal of Abnormal and Social Psychology 55:4349. [KS]
Salzinger K. (1971) The immediacy hypothesis and schizophrenia. In: The future of time: Man's temporal environment, ed. Yaker H. M., Osmond H. & Cheek F.. Doubleday. [IJE]
Salzinger K. (1984) The immediacy hypothesis in a theory of schizophrenia. In: Nebraska symposium on motivation: Theories of schizophrenia and psychosis. University of Nebraska Press. [KS]
Salzinger K.& Pisoni S. (1960) Reinforcement of verbal affect responses of normal subjects during the interview. Journal of Abnormal and Social Psychology 60:127–30. [KS]
Salzinger K., Portnoy S., Pisoni D. & Feldman R. S. (1970) The immediacy hypothesis and response–produced stimuli in schizophrenic speech. Journal of Abnormal and Social Psychology 76:258–64. [KS]
Sandyk R. & Kay S. R. (in press a) Negative schizophrenia: A variant of Parkinsonism. An integrated hypothesis of the pathophysiology of schizophrenia. International Journal of Neuroscience. [RS]
Sandyk R. & Kay S. R. (in press b) Third ventricular width and negative schizophrenia. International Journal of Neuroscience. [RS]
Sandyk R.& Kay S. R. (in press c) Negative schizophrenia as a variant of Parkinsonism. International Journal of Neuroscience. [RS]
Sandyk R.& Kay S. R. (in press d) Habituation of the glabellar tap reflex as a marker of negative schizophrenia. International Journal of Neuroscience. [RS]
Sarter M., Bruno J. P., & Dudchenck P. (1990) Activating the damaged basal forebrain cholinergic system: Tonic stimulation versus signal amplification. Psychopharmacology 101:117. [MS]
Schallert T., De Ryck M. & Teitelbaum P. (1980) Atropine stereotypy as a behavioral trap: A movement subsystem and electroencephalographic analysis. Journal of Comparative and Physiological Psychology 94:124. [JHW]
Schaltenbrand G. (1975) The effects on speech and language of stereotactical stimulation in the thalamus and corpus callosum. Brain and Language 2:7077. [AFO]
Schmajuk N. A. (1984) A model for the effects of hippocampal lesions on Pavlovian conditioning. Abstracts of the 14th annual meeting of the Society for Neuroscience 10:124. [NAS]
Schmajuk N. A. (1987) Animal models of schizophrenia: The hippocampally lesioned animal. Schizophrenia Bulletin 12:317–27. [aJAG, WEC, NAS, MP]
Schmajuk N. A. (1989) The hippocampus and the control of information storage in the brain. In: Dynamic interactions in neural networks: Models and data, ed. Arbib M. & Amari S. I.. Springer–Verlag. [NAS]
Schmajuk N. A. (1990) Role of the hippocampus in temporal and spatial navigation: An adaptive neural network. Behavioural Brain Research, in press. [NAS]
Schmajuk N. A. & Moore J. W. (1985) Real–time attentional models for classical conditioning and the hippocampus. Physiological Psychology 11:278–90. [NAS]
Schmajuk N. A. (1988) The hippocampus and the classically conditioned nictitating membrane response: A real–time attentional–associative model. Psychobiology 46:2035. [NAS]
Schmajuk N. A. & Tyberg M. (1990) The hippocampal lesion model of schizophrenia. In: Neuromethods: Animal models in psychiatry I, vol. 19, ed. Boulton A. A., Baker G. B. & Martin-Iverson M. T.. Humana Press. [NAS]
Schneider W.& Shiffrin R. M. (1977) Controlled and automatic human information processing: I. Detection, search and attention. Psychological Review 84:166. [arJAG]
Schwartz S. (1982) Is there a schizophrenic language?. Behavioral and Brain Sciences 5:579626. [aJAG]
Schwartz-Place E. J. & Gilmore G. C. (1980) Perceptual organization in schizophrenia. Journal of Abnormal Psychology 89:409–18. [JRS, RDO]
Schwegler H., Crusio W. E. & Brust I. (1990) Hippocampal mossy fibers and radial–maze learning in the mouse: A correlation with spatial working memory but not with non–spatial reference memory. Neuroscience 34:293–98. [rJAG, WEC]
Scoville W. B. & Milner B. (1957) Loss of recent memory after bilateral hippocampal lesions. Journal of Neurology, Neurosurgery and Psychiatry 20:1121. [MP]
Seagraves M. A. & Goldberg M. E. (1987) Functional properties of corticotectal neurons in the monkey's frontal eye field. Journal of Neurophysiology 58:13871419. [aJAG]
Seeman P., Ulpian C., Bergeron C., Riederer P., Jellinger K., Gabriel E., Reynolds G. P. & Tourtelotte W. W. (1984) Bimodal distribution of dopamine receptor densities in brains of schizophrenics. Science 225:728–31. [arJAG, MP]
Segal D. S. & Janowsky D. S. (1978) Psychostimulant–induced behavioral effects: Possible models of schizophrenia. In: Psychopharmacology: A generation of progress, ed. Liupton M. A., DiMascio A. & Killam K. F.. Raven Press. [AnC]
Shakow D. (1962) Segmental set: A theory of psychological deficit in schizophrenia. Archives of General Psychiatry 6:117. [HES]
Shakow D. (1963) Psychological deficit in schizophrenia. Behavioral Science 8:275305. [AnC, IJE]
Shakow D. (1977) Segmental set: The adaptive process in schizophrenia. American Psychologist 32:129–39. [AnC]
Shelton R. C. & Weinberger D. R. (1986) X–ray computerized tomography studies in schizophrenia: A review and synthesis. In: Handbook of schizophrenia: The neurology of Schizophrenia, Vol. 1, ed. Nasarallah H. A. & Weinberger D. R.. [AR]
Shenton M. E., Faux S. F., McCarley R. W., Ballinger R., Coleman M., Torello M. & Duffy F. H. (1989) Correlations between abnormal auditory P300 topography and positive symptoms in schizophrenia: A preliminary report. Biological Psychiatry 25:710–16. [GGD]
Shepherd M. (1987) Formulation of new research strategies in schizophrenia. In: Search for the causes of schizophrenia, ed. Hafner H., Gattaz W. F. & Janzavik W.. Springer Verlag. [aJAG]
Simon H., Taghzouti K., Gozlan H., Studler J. M., Louilot A., Hervé D., Glowinski J., Tassin J. P. & LeMoal M. (1988) Lesion of dopaminergic terminals in the amygdala produces enhanced locomotor response to D–amphetamine and opposite changes in dopaminergic activity in prefrontal cortex and nucleus accumbens. Brain Research 447:335–40. [TSE]
Slater, E., Beard A. W. & Glithero E. (1963) The schizophrenia–like psychoses of epilepsy. British Journal of Psychiatry 109:95150. [JHW]
Smith M., Wolf A. P., Brodie J. D., Arnett C. D., Barouche F., Shiue C. -Y., Fowler J. S., Russell J. A. G., MacGregor R. R., Wolkin A., Angrist B., Rotrosen J. & Peselow E. (1988) Serial [*18F] N–methylspiroperidol PET studies to measure change in antipsychotic drug D2 receptor occupancy in schizophrenic patients. Biological Psychiatry 23:653–63. [GGD]
Smolensky P. (1989) Connectionist modeling: Neural computation/mental connections. In: Neural connections, mental computation, ed. Nadet L., Cooper L. A., Culicover P. & Harnish R. M.. MIT Press. [DH]
Snyder S. H. (1972) Catecholamines in the brain as mediators of amphetamine psychosis. Archives of General Psychiatry 27:169–79. [LJI]
Snyder S. H. (1973) Amphetamine psychosis: A “model” schizophrenia mediated by catecholamines. American Journal of Psychiatry 130:6167. [GGD]
Snyder S. H. (1980) Phencyclidine. Nature 285:355–56. [KLRJ]
Solomon P. R. (1977) Role of the hippocampus in blocking and conditioned inhibition of the rabbit's nictating membrane response. Journal of Comparative and Physiological Psychology 91:407–17. [aJAG]
Solomon P. R. & Staton D. M. (1982) Differential effects of microinjections of d–amphetamine into the nucleus accumbens or the caudate putamen on the rat's ability to ignore an irrelevant stimulus. Biological Psychiatry 17:743–56. [aJAG, RDO]
Solomon P. R., Crider A., Winkelman J. W., Turi A., Kamer R. M. & Kaplan L. J. (1981) Disrupted latent inhibition in the rat with chronic amphetamine or haloperidol–induced supersensitivity: Relationship to schizophrenic attention disorder. Biological Psychiatry 16:519–37. [aJAG, AnC]
Solomon P. R., Kiney C. A. & Scott D. R. (1978) Disruption of latent inhibition following systemic administration of parachlorophenylalanine (PCPA). Physiology and Behaviour 20:265–71. [aJAG]
Solomon P. R., Nichols G. W., Kiernon J. M. III & Kamer R. S. (1980) Differential effects of lesions in medial and dorsal raphe of the rat: Latent inhibition and septohippocampal serotonin levels. Journal of Comparative & Physiological Psychology 94:145–54. [aJAG]
Somogyi, P., Bolam J. P., Totterdell S.& Smith A. D. (1981) Monosynaptic input from the nucleus accumbens–ventral striatum region to retro–gradely labelled ntgrostriatal neurones. Brain Research 217:245–63. [aJAG]
Somogyi, P., Hodgson A. J., Smith A. D., Nunzi M. G., Gorio A. & Wu J.-Y. (1984) Different populations of GABAergic neurons in the visual cortex and hippocampus of the cat contain somatostatin– or cholecystokinin–like immunoreactivity. Journal of Neuroscience 4:25902603. [aJAG]
Sonders M. S., Keana J. F. W. & Weber E. (1988) Phencyclidine and psychotomimetic sigma opiates: Recent insights into their biochemical and physiological sites of action. Trends in Neurosciences 11:3740. [KLRJ]
Sperber D.& Wilson D. (1987) Précis of relevance: Communication and cognition. Behavioral and Brain Sciences 10:697754. [CF]
Spohn H. E. (1984) Discussion in: Theories of schizophrenia and psychosis, ed. Spaulding N. D. & Cole J. K.. University of Nebraska Press. [rJAG]
Spohn H. E. & Coyne L. (1989) Behavioral phenotypes and pathogenic traits in schizophrenia. Presentation at the meetings of the Society for Research in Psychopathology, Coral Gables, FL. [HES]
Spohn H. E. & Patterson T. (1979) Recent studies of psychophysiology in schizophrenia. Schizophrenia Bulletin 5:581611. [GC]
Spohn H. E., Coyne L. & Spray J. (1988) The effect of neuroleptics and tardive dyskinesia on smooth–pursuit eye movement in chronic schizophrenics. Archives of General Psychiatry 45:833–40. [HES]
Spring B. (1985) Distractibility as a marker of vulnerability to schizophrenia. Psychopharmacology Bulletin 21:509–12. [IJE]
Springer J. E. & Isaacson R. L. (1982) Catecholamine alterations in basal ganglia after hippocampal lesions. Brain Research 252:185–88. [aJAG, MP, TSE]
Stein L. & Wise C. D. (1971) Possible etiology of schizophrenia: Progressive damage to the noradrenergic reward system by 6-hydroxydopamine. Science 171:1032–36. [RS]
Steinfels G. F., Tarn S. W. & Cook L. (1989) Electrophysiological effects of selective sigma receptor agonists, antagonists, and selective pliencyclidine receptor agonist MK-801 on midbrain dopamine neurons. Neuropsychopharmacology 2:201–08. [KLRJ]
Steinhauer S. R. & Zubin J. (1982) Vulnerability to schizophrenia: Information processing in the pupil and event-related potential. In: Biological markers in psychiatry and neurology, ed. Usdin E. & Hanin. I.Pergamon Press. [GGD]
Stevens J. R. (1973) An anatomy of schizophrenia. Archives of General Psychiatry 29:177–89. [aJAG]
Stevens J. R. (1982) Neuropathology of schizophrenia. Archives of General Psychiatry 39:1131–39. [RS]
Stevens J. R. & Livermore A. (1978) Kindling of the mesolimbic dopamine system: Animal model of psychosis. Neurology 28:3646. [JRS]
Stevens J. R., Wilson K. & Foote W. (1974) GABA blockade, dopamine and schizophrenia: Experimental studies in the cat. Psychopharmacologia 39:105–19. [JRS]
Straube E. R. & Oades R. D. (1991) Schizophrenia: an empirical perspective of psychology, neuropsychology, risk and outcome. Academic Press. [RDO]
Strauss J. S. (1987) Processes of healing and chronicity in schizophrenia. In: Search for the causes of schizophrenia, ed. Hafher H., Gattaz W. F. & Janzavik W.. Springer–Verlag. [aJAG]
Strecker R. E. & Jacobs B. (1987) Dopaminergic unit activity and behavior. In: Neurophysiology of dopaminergic systems – current status and clinical perspectives, ed. Chiodo L. A. & Freeman. A. S.Lakeshore Publishing. [MP]
Su T.-P., Weissman A. D. & Yeh S.-Y. (1986) Endogenous ligands for sigma opioid receptors in the brain (“sigmaphin”): Evidence from binding assays. Life Sciences 38:21992210. [KLRJ]
Suddath R. L., Christison G. W., Torrey E. F., Casanova M. F. & Weinberger D. R. (1990) Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. New England Journal of Medicine 322:789–94. [PHV]
Sutherland N. S. & Mackinstrosh N. J. (1971) Mechanisms of animal discrimination learning. Academic Press. [rJAG]
Sutherland R. J., McDonald R. J., Hill C. R. & Rudy J. W. (1989) Damage to the hippocampal formation in rats selectively impairs the ability to learn cue relationships. Behavioral Neural Biology 52:331–56. [RDO]
Sutton S., Braren M., Zubin J., & John E. R. (1965) Evoked-potential correlates of stimulus uncertainty. Science 150:1187–88. [PHV]
Sutula T., Cascino G., Cavazos J., Parada I. & Ramirez L. (1989) Mossy fiber synaptic reorganization in the epileptic human temporal lobe. Annals of Neurology 26:321–30. [JRS]
Swerdlow N. R. & Koob G. F. (1984) Substantia innominata: Critical link in the behavioral expression of mesolimbic dopamine stimulation in the rat. Neuroscience Letters 50:1924. [MS]
Swerdlow N. R. & Koob G. F. (1987a) Dopamine, schizophrenia, mania, and depression: Toward a unified hypothesis of cortico–striato– pallidothalamic function. Behavioral and Brain Sciences 10:197245. [arJAG, LJI, NRS]
Swerdlow N. R. & Koob G. F. (1987b) Lesions of the dorsomedial nucleus of the thalamus, medial prefrontal cortex and pedunculopontine nucleus: Effects on locomotor activity mediated by the nucleus accumbens-ventral pallidal circuitry. Brain Research 412:233–43. [NRS]
Swerdlow N. R., Braff D. L. & Geyer M. A. (1990c) GABAergic projection from nucleus accumbens to ventral pallidum mediates dopamine-induced sensorimotor gating deficits of acoustic startle in rats. Brain Research (in press). [NRS]
Swerdlow N. R., Braff D. L., Masten V. L. & Geyer M. A. (1990b) Schizophrenic-like sensorimotor gating abnormalities in rats following dopamine infusion into the nucleus accumbens. Psychopharmacology 102:414–20. [NRS]
Swerdlow N. R., Caine B. & Geyer M. A. (1990e) Deficits in sensorimotor gating of acoustic startle following carbachol infusion into the hippocampus. Abstracts of the Society for Neuroscience 16:754. [NRS]
Swerdlow N. R., Geyer M., Braff D. & Koob G. F. (1986) Central dopamine hyperactivity in rats mimics abnormal acoustic startle in schizophrenics. Biological Psychiatry 21:2333. [NRS]
Swerdlow N. R., Keith V. A., Braff D. L. & Geyer M. A. (1990d) The effects of spiperone, raclopride, SCH 23390 and clozapine on apomorphine-inhibition of sensorimotor gating of the startle response in the rat. Journal of Pharmacology and Experimental Therapeutics (in press). [NRS]
Swerdlow N. R., Koob G. F., Geyer M. A., Mansbach R. & Braff D. L. (1988) A cross-species model of psychosis. In: Animal models of psychiatric disorders, ed. Simon P., Soubrié P., & Widlocher D.. Karger. [NRS]
Swerdlow N. R., Mansbach R. S., Geyer M. A., Pulvirenti L., Koob G. F. & Braff D. L. (1990a) Amphetamine disruption of prepulse inhibition of acoustic startle is reversed by depletion of mesolimbic dopamine. Psychopharmacology 100:413–16. [NRS]
Takasaka Y. (1985) Movement-related cerebral potentials in schizophrenics. Folia Psychiatrica et Neurologica Japonica 39:173–83. [GGD]
Tam S. W. & Cook L. (1984) Sigma opiates and certain antipsychotic drugs mutually inhibit (+) [*3H]SKF10,047 and [*3H] haloperidol binding in guinea pig membranes. Proceedings of the National Academy of Sciences 81:5620–21. [KLRJ]
Tandon R. & Greden J. F. (1989) Cholinergic overactivity and negative schizophrenic symptoms. A model of cholinergic/dopaminergic interactions in schizophrenia. Archives of General Psychiatry 46:745–53. [rJAG, RS, MS]
Tauck D. L. & Nadler J. V. (1985) Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats. Journal of Neuroscience 5:1016–22. [JRS]
Teuber H.-L. (1968) Alteration of perception and memory in man. In: Analysis of behavioral change, ed. Weiskrantz L.. Harper & Row. [EG]
Timsit-Berthier M., Delaunoy J. & Rousseau J. C. (1973) Slow potential changes in psychiatry. II. Motor potential. Electroencephalography and Clinical Neurophysiology 35:363–67. [GGD]
Tomer R. & Flor-Henry P. (1989) Neuroleptics reverse attention asymmetries in schizophrenic patients. Biological Psychiatry 25:852–60. [TSE]
Tonder N., Johansen F. F., Frederickson C. J., Zimmer . & Diemer N. H. (1990) Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat. Neuroscience Letters 109:247–52. [WEC]
Totterdell S. & Smith A. D. (1986) Cholecystokinin-immunoreaetive boutons in synaptic contact with hippocampal pyramidal neurons that project to the nucleus accumbens. Neuroscience 19:181–92. [aJAG]
Totterdell S. & Smith A. D. (1987) Hippocampal and dopaminergic inputs to the nucleus accumbens converge onto the same neurons. British Journal of Pharmacology 92:684 P. [aJAG]
Totterdell S. & Smith A. D. (1989) Convergence of hippocampal and dopaminergic input onto identified neurons in the nucleus accumbens of the rat. Journal of Chemical Neuroanatomy 2:285–98. [aJAG, JRS]
Trend P., Trimble M. R. & Wessley S. (1989) Schizophrenic psychosis associated with benzhexol (artane) therapy. Journal of Neurology, Neurosurgery and Psychiatry 52:115. [JHW]
Trimble M. R. (1990) First rank symptoms of schizophrenia. A new perspective. British Journal of Psychiatry 156:195200. [LP]
Tsaltas E., Preston G. C., Rawlins J. N. P., Winocur G. & Gray J. A. (1984) Dorsal bundle lesions do not affect latent inhibition of conditioned suppression. Psychopharmacology 84:549–55. [arJAG]
Tucker D. M. & Williamson P. A. (1984) Asymmetric neural control systems in human self-regulation. Psychological Review 91:185215. [EG]
Turski W. A., Cavalheiro E. A., Ikonomidou C., Bortolotto Z. A., Klockgether C. & Turski L. (1990) Dopamine control of seizure propagation: Intranigral dopamine Dl agonist SKF-38393 enhances susceptibility to seizures. Synapse 5:113–19. [RDO]
Van Abeelen J. H. F. (1989) Genetic control of hippocampal cholinergic and dynorphinergic mechanisms regulating novelty-induced exploratory behavior in house mice. Experientia 45:839–45. [WEC]
Van Buren J. M. (1975) The question of thalamic participation in speech mechanisms. Brain and Language 2:3144. [AFO]
Van den Bos R. & Cools A. R. (1989) The involvement of the nucleus accumbens in the ability of rats to switch to cue-directed behaviours, Life Science 44:16971704. [ARC]
Van Eerdewegh M. M., van Eerdewegh P., Coryell W., Clayton P. J., Endicott J., Koepke J. & Rochberg N. (1987) Schizo-affective disorders: Bipolar-unipolar subtyping. Natural history variables: A discriminant analysis approach. Journal of Affective Disorders 12:223–32. [WEC]
Van Kammen D. P., van Kammen W. B., Mann L. S., Seppala T. & Linnoila M. (1986) Dopamine metabolism in the cerebrospinal fluid of drug-free schizophrenic patients with and without cortical atrophy. Archives of General Psychiatry 43:978–83. [RS]
Van Putten T. & May P. R. A. (1978) “Akinetic depression” in schizophrenia. Archives of General Psychiatry 35:1101–07. [RS]
Vanderwolf C. H. (1988) Cerebral activity and behavior; Control by central cholinergic and serotonergic systems. International Review of Neurobiology 30:225340. [rJAG, JHW]
Venables P. H. (1960) Periodicity in reaction time. British Journal of Psychology 51:3743. [PHV]
Venables P. H. (1964) Input dysfunction in schizophrenia. In: Progress in experimental personality research, vol. 1, ed. Maher B. A.. Academic Press. [IJE]
Venables P. H. (1973) Input regulation and psychopathology. In: Psychopathology; Contributions from the social, behavioural, and biological sciences, ed. Hammer M., Salzinger M. & Sutton S.. Wiley. [GC]
Venables P. H. (1984) Cerebral mechanisms, autonomic responsiveness and attention to schizophrenia. In: Theories of schizophrenia and psychosis, ed. Spaulding W. D. & Cole. J. K.University of Nebraska Press. [aJAG, IJE]
Verleger R. (1988) Event-related potentials and cognition: A critique of the context-updating hypothesis and an alternative interpretation of P3. Behavioral and Brain Sciences 11:343–56. [PHV]
Vogel F. & Motulsky A. G. (1986) Human genetics: Problems and approaches. Springer–Verlag. [WEC]
Vogel-Sprott M. D. (1967) Partial-reward training for resistance to punishment and to subsequent extinction. Journal of Experimental Psychology 75:138–40. [rJAG]
Wagner A. R. (1976) Priming in STM: An information-processing mechanism for self-generated or retrieval-generated depression of performance. In: Habituation: Perspectives from child development, animal behavior, and neuropsychology, ed. Tighe T. J. & Leighton R. N.. Lawrence Erlbaum. [JG]
Wagner A. R. (1978) Expectancies and the priming of STM. In: Cognitive processes in animal behavior, ed. Hulse S. H., Fowler H. & Honig W. K.. Erlbaum. [rJAG]
Wagner A. R. & Rescorla R. A. (1972) Inhibition in Pavlovian conditioning: Application of a theory. In: Inhibition and learning, ed. Boakes R. A. & Halliday M. S.. Academic Press. [aJAG]
Walker E. & McGuire M. (1982) Intra- and interhemispheric information processing in schizophrenia. Psychological Bulletin 92:701–25. [GC]
Warburton D. M. (1989) Drugs and the processing of information. In: Cognitive neurochemistry, ed. Stahl S. M., Iversen S. D. &: Goodman E. C.. Oxford University Press. [JHW]
Weinberger D. R. (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry 44:660–60. [arJAG, EG, RDO, LP]
Weinberger D. R., Cannon-Spoor E., Potkin S. G., Wyatt R. J. (1980) Poor premorbid adjustment and CT scan abnormalities in chronic schizophrenia. American Journal of Psychiatry 137:1410–13. [LP]
Weinberger D. R., Berman K. F. & Zee R. F. (1986) Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. Archives of General Psychiatry 43:114–24. [AR]
Weiner I. (1990) Neural substrates of latent inhibition: The switching model. Psychological Bulletin 108:442–61. [rJAG, IW, REL]
Weiner I. & Feldon J. (1986) Reversal and nonreversal shifts under amphetamine. Psychopharmacology 89:355–59. [rJAG, IW]
Weiner I. & Feldon J. (1987) Facilitation of latent inhibition by haloperidol in rats. Psychopharmacology 91:248–53. [aJAG]
Weiner I., Ben-Horin E. & Feldon J. (1986a) Amphetamine and the overtraining reversal effect. Pharmacology, Biochemistry, and Behavior 24:1539–42. [rJAG, IW]
Weiner I., Ben-Horin E. & Feldon J. (1986b) Simultaneous brightness discrimination and reversal: The effects of amphetamine administration in the two stages. Pharmacology, Biochemistry and Behavior 25:939–42. [rJAG, IW]
Weiner I., Bercovitz H., Lubow R. E. & Feldon J. (1985) The abolition of the partial reinforcement extinction effect (PREE) by amphetamine. Psychopharmacology 86:318––23. [aJAG]
Weiner I., Feldon J. & Ben-Horin E. (1987a) Facilitation of discrimination transfers under amphetamine: The relative control by S+ and S– and general transfer effects. Psychopharmacology 93:261–67. [rJAG, IW]
Weiner I., Feldon J. & Bercovitz H. (1987b) The abolition of the partial reinforcement extinction effect (PREE) by amphetamine: Disruption of control by non-reinforcement. Pharmacology, Biochemistry and Behavior 27:205–10. [aJAG]
Weiner I., Feldon J. & Katz Y. (1987c) Facilitation of the expression but not the acquisition of latent inhibition by haloperidol in rats. Pharmacology, Biochemistry and Behavior 26:241–46. [aJAG]
Weiner I., Feldon J. & Ziv-Harris D. (1987d) Early handling and latent inhibition in the conditioned suppression paradigm. Developmental Psychobiology 20:233–40. [rJAG]
Weiner I., Halevy C., Alroy C. & Feldon J. (1987e) The effects of early handling on the partial reinforcement extinction effect and the partial punishment effect in male and female rats. Quarterly Journal of Experimental Psychology 39B:245–63. [rJAG]
Weiner I., Izraeli-Telerant A. & Feldon J. (1987f) Latent inhibition is not affected by acute or chronic administration of 6mg/kg dl-amphetamine. Psychopharmacology 91:345–51. [aJAG, IW]
Weiner I., Lubow R. E. & Feldon J. (1981) Chronic amphetamine and latent inhibition. Behavioural Brain Research 2:285–86. [aJAG]
Weiner I., Lubow R. E. & Feldon J. (1984) Abolition of the expression but not the acquisition of latent inhibition by chronic amphetamine in rats. Psychopharmacology 83:194–99. [aJAG]
Weiner I., Lubow R. E. & Feldon J. (1988) Disruption of latent inhibition by acute administration of low doses of amphetamine. Pharmacology, Biochemistry and Behaviour 30:871–78. [arJAG]
Weiner I., Schnabel I., Lubow R. E. & Feldon J. (1985) The effects of early handling on latent inhibition in male and female rats. Developmental Psychology 18:291–97. [rJAG]
Weissman A. D., Su T.-P., Hedreen J. C. & London E. D. (1988) Sigma receptors in postmortem human brains. Journal of Phannacology and Experimental Therapeutics 247:2933. [KLRJ]
Wells D. S. & Leventhal D. (1984) Perceptual grouping in schizophrenia: A replication of Place and Gilmore. Journal of Abnormal Psychology 93:231–34. [RDO]
West L. J. (1975) A clinical and theoretical overview of hallucinatory phenomena. In; Hallucinations: Behaviour, experience, and theory, ed. Siegel R. K. & West. L. J.Wiley. [KLRJ]
Westphal K. P., Grozinger B., Haag C., Scherb W., Diekmann V. & Kornhuber H. H. (1987) The influence of biperidine on the EEG power spectra during the Bereitschaftspotential paradigm. Electroencephalography and Clinical Neurophysiology (Suppl.) 40:556–61. [JHW]
Williams M. N. & Faull R. L. M. (1988) The nicrotectal projection and tectospinal neurons in the rat. A light and electron microscopic study demonstrating a monosynaptic nigral input to identified tectospinal neurons. Neuroscience 25:533–62. [aJAG]
Willick M. S. (1990) Schizophrenia: A parent's perspective. Paper presented at the American Psychopathology Association (APPA) conference, New York, NY. [IJE]
Wilson D. A., Willner J., Kurz E. M. & Nadel L. (1986) Early handling increases hippocampal long–term potentiation in young rats. Behavioral Brain Research 21:223–27. [rJAG]
Winocur G., Rawlins J. N. P. & Gray J. A. (1987) The hippocampus and conditioning to contextual cues. Behavioral Neuroscience 101:617–25. [rJAG]
Wolkin G., Barouche F., Wolf A. P., Rotrosen J., Fowler J. S., Shiue C.-Y., Cooper T. B. & Brodie J. D. (1989) Dopamine blockade and clinical response: Evidence for two biological subgroups of schizophrenia. American Journal of Psychiatry 146:905–08. [GGD]
Wong D. F., Wagner H. N., Tune L. E., Dannals R. F., Pearlson G. D., Links J. M., Tamminga C. A., Brousolle E. P., Ravert H. T., Wilson A. A., Young J. K. T., Malat J.; Williams J. A., O'Tuama L. A., Snyder S. H., Kuhar M. J. & Gjedde A. (1986) Positron emission tomography reveals elevated D2 dopamine receptors in drug–naive schizophrenics. Science 234:1558–63. [aJAG, REH, LP]
Wong E. H. F., Knight A. R. & Woodruff G. N. (1988) [*3H] MK–801 labels at sites on the N-methyl-D-aspartate receptor channel complex in rat brain membranes. Journal of Neurochemistry 50:274–81. [KLRJ]
Woodard J. S. (1962) Concentric hyaline inclusion body formation in mental disease analysis of twenty-seven cases. Journal of Neuropathology and Experimental Neurology 21:442–49. [rJAG, RS]
Wu J. C., Siegel B. V., Haier R. J. & Buchsbaum M. S. (1990) Testing the Swerdlow-Koob model of schizophrenia pathophysiology using positron emission tomography. Behavioral and Brain Sciences 13:169–70. [NRS]
Wurtz R. H. & Albano J. E. (1980) Visual-motor function of the primate superior colliculus. Annual Review of Neuroscience 3:189226. [aJAG]
Yang C. R. & Mogensen G. J. (1987a) Hippocampal signal transmission to the pedunculopontine nucleus and its regulation by dopamine D2 receptors in the nucleus accumbens: An electrophysiological and behavioural study. Neuroscience 23:1041–55. [aJAG, MS]
Yang C. R. & Mogensen G. J. (1987b) Dopamine enhances the terminal excitability of hippocampalnucleus accumbens neurones by D2 receptor. Journal of Neuroscience 6:2470–78. [NAS]
Yang C. R. & Mogensen G. J. (1989) Ventral pallidal neuronal responses to dopamine receptor stimulation in the nucleus accumbens. Brain Research 489:237–46. [MS]
Yarden P. E. & Discipio W. J. (1971) Abnormal movements and prognosis in schizophrenia. American Journal of Psychiatry 128:317–23. [rJAG, AnC]
Zaborsky L., Heimer L., Eckenstein F. & Lernath C. (1986) GABAergic imput to cholinergic forebrain neurons: An ultrastructural study using retrograde tracing of HRP and double immunolabeling. Journal of Comparative Neurology 250:282–95. [MS]
Zahn T. P. (1988) Studies of autonomic psychophysiology and attention in schizophrenia. Schizophrenia Bulletin 14:205–8. [rJAG]
Zahn T., Frith C. D. & Steinhauer S. (in press) Autonomic functioning: Electrodermal activity, heart rate, pupilography. In: Handbook of schizophrenia: Neuropsychology, psychophysiology, and information processing, vol. 4, ed. Aubin J., Steinhauer S. & Gruzelier J. H.. Elsevier. [CF]
Zhou G.-Z., Young D.-W., Lu M.-K., Zhang L.-D., Yao J.-L., Lu-Fel H.-Q., Gao H. & Zhang A.-Z. (1988) Contents of endogenous phencyclidine-like substances in cerebrospinal fluid of schizophrenic patients. Acta Pharmacologica Sinica 9:515–18. [KLRJ]
Zigmond M. J., Acheson A. L., Stachowiak M. K. & Strickerm E. M. (1984) Neurochemical compensation after nigrostriatal bundle injury in an animal model of preclinical Parkinsonism. Archives of Neurology 41:856–61. [RS]
Zubin J. & Spring B. (1977) Vulnerability – a new view of schizophrenia. Journal of Abnormal Psychology 86:103–26. [KHN]
Zuckerman M. (1982) Leaping up the phylogenetic scale in explaining anxiety: Perils and possibilities. Peer commentary on multiple book review of “The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septohippocampal System.” Behavioral and Brain Sciences 5:505–06. [aJAG]
Zuckerman M. (1984) Sensation seeking: A comparative approach to a human trait. Behavioral and Brain Sciences 7:413–71. [GC]