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Management of clozapine-induced sialorrhoea

  • Sumeet Gupta (a1), Udayan Khastgir (a1), Matthew Croft (a2) and Sefat Roshny (a3)

Summary

Sialorrhoea (hypersalivation) is a common adverse effect of clozapine. If severe, it can affect patients' quality of life and adherence to the treatment. Clinicians therefore need to proactively manage this effect. At present, no drugs are licensed to manage clozapine-induced sialorrhoea, although there are many off-label treatment options, with variable effectiveness. Anticholinergic medications are commonly prescribed for it, but they have limited effect and can worsen constipation. This article gives a brief overview of other practical and pharmacological management options.

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Corresponding author

Correspondence Sumeet Gupta, Valley Gardens Resource Centre, Windsor House, Cornwall Road, Harrogate HG1 2PW, UK. Email: sumeet.gupta@nhs.net

References

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Bird, AM, Smith, TL, Walton, AE (2011) Current treatment strategies for clozapine-induced sialorrhea. Annals of Pharmacotherapy, 45: 667–75.
Citrome, L, McEvoy, JP, Saklad, SR (2016) Guide to the management of clozapine-related tolerability and safety concerns. Clinical Schizophrenia & Related Psychoses, 10: 163–77.
Maher, S, Cunningham, A, Callaghan, NO, et al. (2016) Clozapine-induced hypersalivation: an estimate of prevalence, severity and impact on quality of life. Therapeutic Advances in Psychopharmacology, 16: 178–84.
Syed, R, Au, K, Cahill, C, et al. (2008) Pharmacological interventions for clozapine-induced hypersalivation. Cochrane Database of Systematic Reviews, 3: CD005579.
Yeşilyurt, S, Aras, I, Altınbaş, K, et al. (2010) Pathophysiology of clozapine induced sialorrhea and current treatment choices. Journal of Psychiatry and Neurological Sciences, 23: 275–81.

Keywords

Management of clozapine-induced sialorrhoea

  • Sumeet Gupta (a1), Udayan Khastgir (a1), Matthew Croft (a2) and Sefat Roshny (a3)

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Management of clozapine-induced sialorrhoea

  • Sumeet Gupta (a1), Udayan Khastgir (a1), Matthew Croft (a2) and Sefat Roshny (a3)
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