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The psychosis risk timeline: can we improve our preventive strategies? Part 2: adolescence and adulthood

  • Karen Romain (a1), Alexandra Eriksson (a1), Richard Onyon (a2) and Manoj Kumar (a3)


Current understanding of psychosis development is relevant to patients' clinical outcomes in mental health services as a whole, given that psychotic symptoms can be a feature of many different diagnoses at different stages of life. Understanding the risk factors helps clinicians to contemplate primary, secondary and tertiary preventive strategies that it may be possible to implement. In this second article of a three-part series, the psychosis risk timeline is again considered, here focusing on risk factors more likely to be encountered during later childhood, adolescence and adulthood. These include environmental factors, substance misuse, and social and psychopathological aspects.


After reading this article you will be able to:

  • understanding the range of risk factors for development of psychotic symptoms in young people and adults
  • understand in particular the association between trauma/abuse and subsequent psychosis
  • appreciate current evidence for the nature and strength of the link between substance misuse and psychosis.




Corresponding author

Correspondence Dr Karen Romain, St Michael's Hospital, Warwick CV34 5QW, UK. Email:


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Parts 1 and 3 of this series appear in this issue. For a commentary on the three articles, see this issue.



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The psychosis risk timeline: can we improve our preventive strategies? Part 2: adolescence and adulthood

  • Karen Romain (a1), Alexandra Eriksson (a1), Richard Onyon (a2) and Manoj Kumar (a3)
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