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    Schmidt, Lisa D Blank, Gregory Boros, Danuta and Slominski, Bogdan A 2007. The nutritive value of egg by-products and their potential bactericidal activity:in vitro andin vivo studies. Journal of the Science of Food and Agriculture, Vol. 87, Issue. 3, p. 378.


    Osuga, David T. and Feeney, Robert E. 1974. Toxic Constituents of Animal Foodstuffs.


    Dewar, W. A. and Siller, W. G. 1971. Sodium toxicity resulting from feeding hen egg albumen powder to turkey poults. British Poultry Science, Vol. 12, Issue. 4, p. 535.


    Boyd, Eldon M. 1970. The Cardiac Toxicity of Noncardiac Drugs and Other Agents in Toxicity Tests on Laboratory Animals at Queen's University between 1958 and 1968. Clinical Toxicology, Vol. 3, Issue. 2, p. 221.


    Boyd, Eldon M. Dobos, Ilona and Krijnen, Catharina J. 1970. Endosulfan Toxicity and Dietary Protein. Archives of Environmental Health: An International Journal, Vol. 21, Issue. 1, p. 15.


    Krijnen, C.J. and Boyd, E.M. 1970. Susceptibility to captan pesticide of albino rats fed from weaning on diets containing various levels of protein. Food and Cosmetics Toxicology, Vol. 8, Issue. 1, p. 35.


    Boyd, Eldon M. Chen, C.P. and Krijnen, C.J. 1969. Lindane and dietary protein. Pharmacological Research Communications, Vol. 1, Issue. 4, p. 403.


    Boyd, Eldon M. 1969. Diet and Drug Toxicity. Clinical Toxicology, Vol. 2, Issue. 4, p. 423.


    Boyd, Eldon M. and Boulanger, M.Andrée 1969. Acute oral toxicity of cottonseed oil. Toxicology and Applied Pharmacology, Vol. 14, Issue. 3, p. 432.


    Boyd, Eldon M. and Krijnen, C. J. 1969. Dietary protein and DDT toxicity. Bulletin of Environmental Contamination and Toxicology, Vol. 4, Issue. 5, p. 256.


    Boyd, E. M. Carsky, E. and Krijnen, C. J. 1969. The Effects of Diets Containing from 0 to 81 Per Cent Casein on the Acute Oral Toxicity of Diazinon. Clinical Toxicology, Vol. 2, Issue. 3, p. 295.


    Peters, J.M. and Boyd, E.M. 1969. Toxic effects from a rancid diet containing large amountsof raw egg-white powder. Food and Cosmetics Toxicology, Vol. 7, p. 197.


    BOYD, ELDON M. 1968. Food and Drug Toxicity A Summary of Recent Studies. The Journal of Clinical Pharmacology and The Journal of New Drugs, Vol. 8, Issue. 5, p. 281.


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A separation of the direct toxic effects of dietary raw egg white powder from its action in producing biotin deficiency

  • J. M. Peters (a1)
  • DOI: http://dx.doi.org/10.1079/BJN19670082
  • Published online: 01 March 2007
Abstract

1. Young adult female albino rats were given 20, 40, 60, 80, and 100% raw egg white powder in their diet; controls were fed on laboratory chow. Daily clinical measurements were made for 2 weeks. The rats were then killed, and the weights and water contents of various organs were determined.

2. The experiment was repeated with groups of young male albino rats fed for 2 and 4 weeks.

3. Toxic signs caused by increasing intake of dried raw egg white powder were: decreased food intake, weight loss, soft stool, diarrhoea, glycosuria and death. Water intake and urine output rose with increasing raw egg white powder in the diet. In all groups the urine was alkaline and the urinary output of protein increased. At autopsy there was a decrease in the absolute weight and in the water content of most body organs with increasing amounts of raw egg white powder in the diet.

4. The toxicity syndrome was not prevented by a biotin supplement, but was largely prevented by heat denaturation of the egg white powder; 80% of denatured egg white was well tolerated, as was 80% of casein in the diet.

5. The syndrome was due to the direct toxic effects of large amounts of dietary raw egg white powder and not to biotin deficiency.

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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

M. A. Boas (1927). Biochem. J. 21, 712.

E. M. Boyd & E. J. Sargeant (1962). J. New Drugs 2, 283.

J. M. Peters & E. M. Boyd (1966). Toxic. appl. Pharmac. 8, 350.

S. H. Rubin , L. Drekter & E. H. Moyer (1945). Proc. Soc. exp. Biol. Med. 58, 352.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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