Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 9
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Kotzé, Sebastian Ranzi Zinyama-Gutsire, Rutendo Kallestrup, Per Benn, Christine Stabell Gomo, Exnevia Gerstoft, Jan van Dam, Govert Mortensen, Ole Hartvig Ullum, Henrik and Erikstrup, Christian 2015. HIV and schistosomiasis in rural Zimbabwe: the association of Retinol-binding protein with disease progression, inflammation and mortality. International Journal of Infectious Diseases, Vol. 33, p. 159.


    García-Casal, Maria N 2014. Planning and Implementing Food Fortification Programs to Combat Micronutrient Malnutrition: Iron. Food and Nutrition Sciences, Vol. 05, Issue. 10, p. 880.


    Saraiva, Bárbara C.A. Soares, Michele C.C. Santos, Luana C.dos Pereira, Simone C.L. and Horta, Paula M. 2014. Iron deficiency and anemia are associated with low retinol levels in children aged 1 to 5 years. Jornal de Pediatria, Vol. 90, Issue. 6, p. 593.


    Saraiva, Bárbara C.A. Soares, Michele C.C. Santos, Luana C. dos Pereira, Simone C.L. and Horta, Paula M. 2014. Iron deficiency and anemia are associated with low retinol levels in children aged 1 to 5 years. Jornal de Pediatria (Versão em Português), Vol. 90, Issue. 6, p. 593.


    De-Regil, Luz Maria Jefferds, Maria Elena D Peña-Rosas, Juan Pablo and De-Regil, Luz Maria 2012. Cochrane Database of Systematic Reviews.


    Carter, C. J. 2011. The Fox and the Rabbits—Environmental Variables and Population Genetics (1) Replication Problems in Association Studies and the Untapped Power of GWAS (2) Vitamin A Deficiency, Herpes Simplex Reactivation and Other Causes of Alzheimer's Disease. ISRN Neurology, Vol. 2011, p. 1.


    Fernández-Gaxiola, Ana C De-Regil, Luz Maria Nasser, Mona and De-Regil, Luz Maria 2011. Cochrane Database of Systematic Reviews.


    Fernández-Gaxiola, Ana C De-Regil, Luz Maria Nasser, Mona and De-Regil, Luz Maria 2011. Cochrane Database of Systematic Reviews.


    García-Casal, María Nieves Landaeta-Jiménez, Maritza Puche, Rafael Leets, Irene Carvajal, Zoila Patiño, Elijú and Ibarra, Carlos 2011. A Program of Nutritional Education in Schools Reduced the Prevalence of Iron Deficiency in Students. Anemia, Vol. 2011, p. 1.


    ×

A single dose of vitamin A improves haemoglobin concentration, retinol status and phagocytic function of neutrophils in preschool children

  • Claudia Jimenez (a1), Irene Leets (a1), Rafael Puche (a1), Elsy Anzola (a2), Rosa Montilla (a2), Cesar Parra (a2), Antonia Aguilera (a2) and María N. García-Casal (a1)
  • DOI: http://dx.doi.org/10.1017/S0007114509992765
  • Published online: 15 December 2009
Abstract

Since there is a reported interrelationship between vitamin A and Fe metabolism, and with immunological response, the objective was to evaluate the effect of a single dose of vitamin A administered to preschool children, on Fe and vitamin A nutritional status, anaemia and phagocytic function of neutrophils, 30 d after supplementation. A total of eighty children (sixty-eight supplemented and twelve controls) were supplemented orally with 200 000 IU (60 mg) vitamin A, and evaluated for nutritional, haematological and immunological responses at the beginning of the study and 30 d after supplementation. Parameters studied included Hb, serum ferritin, retinol and Fe concentrations, transferrin saturation, IL-4, interferon-γ and phagocityc capacity of neutrophils using non-fluorescent latex microbeads. After supplementation there was a significant increase in Hb concentration (P = 0·03), mean corpuscular Hb concentration (P = 0·001) and serum retinol (P = 0·0078). Prevalences of anaemia and vitamin A deficiency decreased significantly from 17·6 % to 13·2 % and from 25 % to 13·2 %, respectively. Regarding phagocytic function, there was a significant increase in the number of microbeads engulfed by neutrophils (P < 0·05) and no significant changes in cytokine concentrations at 1 month after treatment. A single dose of 200 000 IU (60 mg) vitamin A administered orally to a group of preschool children with a high prevalence of vitamin A deficiency enhanced serum retinol and Hb concentrations, decreased the prevalence of anaemia and vitamin A deficiency and improved the constitutive phagocytic capacity of neutrophils. Vitamin A supplementation could help to decrease vitamin A deficiency, anaemia prevalence and to improve the innate immunity response in preschool children. The effects were obtained without Fe supplementation.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      A single dose of vitamin A improves haemoglobin concentration, retinol status and phagocytic function of neutrophils in preschool children
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      A single dose of vitamin A improves haemoglobin concentration, retinol status and phagocytic function of neutrophils in preschool children
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      A single dose of vitamin A improves haemoglobin concentration, retinol status and phagocytic function of neutrophils in preschool children
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr Maria N. García-Casal, fax +58 212 504 1086, email mngarcia@ivic.ve
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: