Skip to main content Accessibility help
×
×
Home

Argan oil improves surrogate markers of CVD in humans

  • Souad Sour (a1), Meriem Belarbi (a1), Darine Khaldi (a1), Nassima Benmansour (a1), Nassima Sari (a1), Abdelhafid Nani (a1), Farid Chemat (a2) and Francesco Visioli (a3)...

Abstract

Limited – though increasing – evidence suggests that argan oil might be endowed with potential healthful properties, mostly in the areas of CVD and prostate cancer. We sought to comprehensively determine the effects of argan oil supplementation on the plasma lipid profile and antioxidant status of a group of healthy Algerian subjects, compared with matched controls. A total of twenty healthy subjects consumed 15 g/d of argan oil – with toasted bread – for breakfast, during 4 weeks (intervention group), whereas twenty matched controls followed their habitual diet, but did not consume argan oil. The study lasted 30 d. At the end of the study, argan oil-supplemented subjects exhibited higher plasma vitamin E concentrations, lower total and LDL-cholesterol, lower TAG and improved plasma and cellular antioxidant profile, when compared with controls. In conclusion, we showed that Algerian argan oil is able to positively modulate some surrogate markers of CVD, through mechanisms which warrant further investigation.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Argan oil improves surrogate markers of CVD in humans
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Argan oil improves surrogate markers of CVD in humans
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Argan oil improves surrogate markers of CVD in humans
      Available formats
      ×

Copyright

Corresponding author

*Corresponding author: F. Visioli, email francesco.visioli@imdea.org

References

Hide All
1 McNaughton, SA, Mishra, GD & Brunner, EJ (2009) Food patterns associated with blood lipids are predictive of coronary heart disease: the Whitehall II study. Br J Nutr 102, 619624.
2 Martinez-Gonzalez, MA, Bes-Rastrollo, M, Serra-Majem, L, et al. (2009) Mediterranean food pattern and the primary prevention of chronic disease: recent developments. Nutr Rev 67, Suppl. 1, S111S116.
3 Bedard, A, Goulet, J, Riverin, M, et al. (2010) Effects of a dietary intervention promoting the adoption of a Mediterranean food pattern on fast-food consumption among healthy French-Canadian women. Br J Nutr 104, 16621665.
4 Bogani, P & Visioli, F (2007) Antioxidants in the Mediterranean diets: an update. World Rev Nutr Diet 97, 162179.
5 Bere, E & Brug, J (2010) Is the term ‘Mediterranean diet’ a misnomer? Public Health Nutr 13, 21272129.
6 Visioli, F & Bernardini, E (2011) Extra Virgin Olive Oil's Polyphenols: biological activities. Curr Pharm Des 17, 786804.
7 Charrouf, Z & Guillaume, D (2010) Should the amazigh diet (regular and moderate argan-oil consumption) have a beneficial impact on human health? Crit Rev Food Sci Nutr 50, 473477.
8 Drissi, A, Girona, J, Cherki, M, et al. (2004) Evidence of hypolipemiant and antioxidant properties of argan oil derived from the argan tree (Argania spinosa). Clin Nutr 23, 11591166.
9 Bennani, H, Drissi, A, Giton, F, et al. (2007) Antiproliferative effect of polyphenols and sterols of virgin argan oil on human prostate cancer cell lines. Cancer Detect Prev 31, 6469.
10 Berrougui, H, Ettaib, A, Herrera, G, et al. (2003) Hypolipidemic and hypocholesterolemic effect of argan oil (Argania spinosa L.) in Meriones shawi rats. J Ethnopharmacol 89, 1518.
11 Khallouki, F, Younos, C, Soulimani, R, et al. (2003) Consumption of argan oil (Morocco) with its unique profile of fatty acids, tocopherols, squalene, sterols and phenolic compounds should confer valuable cancer chemopreventive effects. Eur J Cancer Prev 12, 6775.
12 Cherki, M, Berrougui, H, Drissi, A, et al. (2006) Argan oil: which benefits on cardiovascular diseases? Pharmacol Res 54, 15.
13 Cherki, M, Derouiche, A, Drissi, A, et al. (2005) Consumption of argan oil may have an antiatherogenic effect by improving paraoxonase activities and antioxidant status: intervention study in healthy men. Nutr Metab Cardiovasc Dis 15, 352360.
14 Zaman, Z, Fielden, P & Frost, PG (1993) Simultaneous determination of vitamins A and E and carotenoids in plasma by reversed-phase HPLC in elderly and younger subjects. Clin Chem 39, 22292234.
15 Pirisi, FM, Cabras, P, Cao, CF, et al. (2000) Phenolic compounds in virgin olive oil. 2. Reappraisal of the extraction, HPLC separation, and quantification procedures. J Agric Food Chem 48, 11911196.
16 Kallithraka, S, el-Jazouli, A & Zeghichi, S (2000) Mediterranean diets in the Maghreb. World Rev Nutr Diet 87, 160179.
17 Zeghichi-Hamri, S & Kallithraka, S (2007) Mediterranean diet in the Maghreb: an update. World Rev Nutr Diet 97, 139161.
18 Anonymous (1991) Répertoire général des aliments: technique et documentation (General list of foods: technical documentation). Paris: Lavoisier-INRA-Ciqual-Régal Edit.
19 Nourooz-Zadeh, J, Tajaddini-Sarmadi, J, Ling, KL, et al. (1996) Low-density lipoprotein is the major carrier of lipid hydroperoxides in plasma. Relevance to determination of total plasma lipid hydroperoxide concentrations. Biochem J 313, 781786.
20 Levine, RL, Garland, D, Oliver, CN, et al. (1990) Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 186, 464478.
21 Esterbauer, H, Striegl, G, Puhl, H, et al. (1989) Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic Res Commun 6, 6775.
22 Jagota, SK & Dani, HM (1982) A new colorimetric technique for the estimation of vitamin C using Folin phenol reagent. Anal Biochem 127, 178182.
23 Aebi, H (1974) Catalase. In Methods of Enzymatic Analysis, 2nd ed., pp. 673684 [Bergmeyer, HU, editor]. Veinheim: Verlag Chemie.
24 Blache, D & Post, M (1992) Free radical attack: biological test for human resistance capability. In Proceedings of the College Park on Chemical Evolution, pp. 8298. Washington, DC: Chemical Analysis Laboratory.
25 Berrougui, H, Alvarez, dS, Perez-Guerrero, C, et al. (2004) Argan (Argania spinosa) oil lowers blood pressure and improves endothelial dysfunction in spontaneously hypertensive rats. Br J Nutr 92, 921929.
26 Ramsden, CE, Hibbeln, JR, Majchrzak, SF, et al. (2010) n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials. Br J Nutr 104, 15861600.
27 Calder, PC (2010) The American Heart Association advisory on n-6 fatty acids: evidence based or biased evidence? Br J Nutr 104, 15751576.
28 Berrougui, H, Cloutier, M, Isabelle, M, et al. (2006) Phenolic-extract from argan oil (Argania spinosa L.) inhibits human low-density lipoprotein (LDL) oxidation and enhances cholesterol efflux from human THP-1 macrophages. Atherosclerosis 184, 389396.
29 Marangoni, F & Poli, A (2010) Phytosterols and cardiovascular health. Pharmacol Res 61, 193199.
30 Hassimotto, NM, Pinto, MS & Lajolo, FM (2008) Antioxidant status in humans after consumption of blackberry (Rubus fruticosus L.) juices with and without defatted milk. J Agric Food Chem 56, 1172711733.
31 Benajiba, N, Morel, S, De Leiris, J, et al. (2002) The effect of argan oil on heart function during ischemia and reperfusion. Therapie 57, 246252.
32 Zougagh, M, Salghi, R, Dhair, S, et al. (2011) Nanoparticle-based assay for the detection of virgin argan oil adulteration and its rapid quality evaluation. Anal Bioanal Chem 399, 23952405.
33 Spickett, CM, Wiswedel, I, Siems, W, et al. (2010) Advances in methods for the determination of biologically relevant lipid peroxidation products. Free Radic Res 44, 11721202.
34 Halliwell, B (2000) Lipid peroxidation, antioxidants and cardiovascular disease: how should we move forward? Cardiovasc Res 47, 410418.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed