Skip to main content Accessibility help
×
×
Home

The association of maternal vitamin D status with infant birth outcomes, postnatal growth and adiposity in the first 2 years of life in a multi-ethnic Asian population: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort study

  • Yi Lin Ong (a1), Phaik Ling Quah (a1), Mya Thway Tint (a2), Izzuddin M. Aris (a3), Ling Wei Chen (a3), Rob M. van Dam (a4), Denise Heppe (a5), Seang-Mei Saw (a4), Keith M. Godfrey (a6), Peter D. Gluckman (a1) (a7), Yap Seng Chong (a1) (a2), Fabian Yap (a8) (a9), Yung Seng Lee (a1) (a3) (a10) and Mary Foong-Fong Chong (a1) (a3) (a10)...

Abstract

Maternal vitamin D status during pregnancy has been associated with infant birth and postnatal growth outcomes, but reported findings have been inconsistent, especially in relation to postnatal growth and adiposity outcomes. In a mother–offspring cohort in Singapore, maternal plasma vitamin D was measured between 26 and 28 weeks of gestation, and anthropometric measurements were obtained from singleton offspring during the first 2 years of life with 3-month follow-up intervals to examine birth, growth and adiposity outcomes. Associations were analysed using multivariable linear regression. Of a total of 910 mothers, 13·2 % were vitamin D deficient (<50 nmol/l) and 26·5 % were insufficient (50–75 nmol/l). After adjustment for potential confounders and multiple testing, no statistically significant associations were observed between maternal vitamin D status and any of the birth outcomes – small for gestational age (OR 1·00; 95 % CI 0·56, 1·79) and pre-term birth (OR 1·16; 95 % CI 0·64, 2·11) – growth outcomes – weight-for-age z-scores, length-for-age z-scores, circumferences of the head, abdomen and mid-arm at birth or postnatally – and adiposity outcomes – BMI, and skinfold thickness (triceps, biceps and subscapular) at birth or postnatally. Maternal vitamin D status in pregnancy did not influence infant birth outcomes, postnatal growth and adiposity outcomes in this cohort, perhaps due to the low prevalence (1·6 % of the cohort) of severe maternal vitamin D deficiency (defined as of <30·0 nmol/l) in our population.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      The association of maternal vitamin D status with infant birth outcomes, postnatal growth and adiposity in the first 2 years of life in a multi-ethnic Asian population: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort study
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      The association of maternal vitamin D status with infant birth outcomes, postnatal growth and adiposity in the first 2 years of life in a multi-ethnic Asian population: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort study
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      The association of maternal vitamin D status with infant birth outcomes, postnatal growth and adiposity in the first 2 years of life in a multi-ethnic Asian population: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort study
      Available formats
      ×

Copyright

Corresponding author

* Corresponding author: Dr M. F.-F. Chong, fax +65 6776 6840, email mary_chong@sics.a-star.edu.sg

Footnotes

Hide All

Both authors contributed equally to this work.

Footnotes

References

Hide All
1. Barker, DJ & Clark, PM (1997) Fetal undernutrition and disease in later life. Rev Reprod 2, 105112.
2. Principi, N, Bianchini, S, Baggi, E, et al. (2013) Implications of maternal vitamin D deficiency for the fetus, the neonate and the young infant. Eur J Nutr 52, 859867.
3. Walsh, JM, Kilbane, M, McGowan, CA, et al. (2013) Pregnancy in dark winters: implications for fetal bone growth? Fertil Steril 99, 206211.
4. Weinert, LS & Silveiro, SP (2015) Maternal-fetal impact of vitamin D deficiency: a critical review. Matern Child Health J 19, 94101.
5. Leffelaar, ER, Vrijkotte, TG & van Eijsden, M (2010) Maternal early pregnancy vitamin D status in relation to fetal and neonatal growth: results of the multi-ethnic Amsterdam born children and their development cohort. Br J Nutr 104, 108117.
6. Robinson, CJ, Wagner, CL, Hollis, BW, et al. (2011) Maternal vitamin D and fetal growth in early-onset severe preeclampsia. Am J Obstet Gynecol 204, 556.e551e554.
7. Finkelstein, JL, Mehta, S, Duggan, C, et al. (2012) Maternal vitamin D status and child morbidity, anemia, and growth in human immunodeficiency virus-exposed children in Tanzania. Pediatr Infect Dis J 31, 171175.
8. Gernand, AD, Simhan, HN, Caritis, S, et al. (2014) Maternal vitamin D status and small-for-gestational-age offspring in women at high risk for preeclampsia. Obstet Gynecol 123, 4048.
9. Bodnar, LM, Catov, JM, Zmuda, JM, et al. (2010) Maternal serum 25-hydroxyvitamin D concentrations are associated with small-for-gestational age births in white women. J Nutr 140, 9991006.
10. De-Regil, LM, Palacios, C, Ansary, A, et al. (2012) Vitamin D supplementation for women during pregnancy. The Cochrane Database of Systematic Reviews 2012, issue 2, CD008873.
11. Eckhardt, CL, Gernand, AD, Roth, DE, et al. (2015) Maternal vitamin D status and infant anthropometry in a US multi-centre cohort study. Ann Hum Biol 42, 215222.
12. Song, SJ, Si, S, Liu, J, et al. (2013) Vitamin D status in Chinese pregnant women and their newborns in Beijing and their relationships to birth size. Public Health Nutr 16, 687692.
13. Farrant, HJ, Krishnaveni, GV, Hill, JC, et al. (2009) Vitamin D insufficiency is common in Indian mothers but is not associated with gestational diabetes or variation in newborn size. Eur J Clin Nutr 63, 646652.
14. Gale, CR, Robinson, SM, Harvey, NC, et al. (2008) Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr 62, 6877.
15. Prentice, A, Jarjou, LM, Goldberg, GR, et al. (2009) Maternal plasma 25-hydroxyvitamin D concentration and birthweight, growth and bone mineral accretion of Gambian infants. Acta Paediatr 98, 13601362.
16. Rodriguez, A, Garcia-Esteban, R, Basterretxea, M, et al. (2015) Associations of maternal circulating 25-hydroxyvitamin D3 concentration with pregnancy and birth outcomes. BJOG 122, 16951704.
17. Hanieh, S, Ha, TT, Simpson, JA, et al. (2014) Maternal vitamin D status and infant outcomes in rural Vietnam: a prospective cohort study. PLOS ONE 9, e99005.
18. Lee, HA, Kim, YJ, Lee, H, et al. (2013) Association of vitamin D concentrations with adiposity indices among preadolescent children in Korea. J Pediatr Endocrinol Metab 26, 849854.
19. Morales, E, Rodriguez, A, Valvi, D, et al. (2015) Deficit of vitamin D in pregnancy and growth and overweight in the offspring. Int J Obes (Lond) 39, 6168.
20. Crozier, SR, Harvey, NC, Inskip, HM, et al. (2012) Maternal vitamin D status in pregnancy is associated with adiposity in the offspring: findings from the Southampton Women’s Survey. Am J Clin Nutr 96, 5763.
21. Soh, SE, Tint, MT, Gluckman, PD, et al. (2014) Cohort profile: Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort study. Int J Epidemiol 43, 14011409.
22. Goh, SK (2011) Birthweight percentiles by gestational age and maternal factors that affect birthweight in Singapore. Master of Science, National University of Singapore, Singapore.
23. Maunsell, Z, Wright, DJ & Rainbow, SJ (2005) Routine isotope-dilution liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of the 25-hydroxy metabolites of vitamins D2 and D3 . Clin Chem 51, 16831690.
24. Hamilton, CM, Strader, LC, Pratt, JG, et al. (2011) The PhenX Toolkit: get the most from your measures. Am J Epidemiol 174, 253260.
25. Schaefer, F, Georgi, M, Zieger, A, et al. (1994) Usefulness of bioelectric impedance and skinfold measurements in predicting fat-free mass derived from total body potassium in children. Pediatr Res 35, 617624.
26. Holick, MF, Binkley, NC, Bischoff-Ferrari, HA, et al. (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96, 19111930.
27. Bloem, M (2007) The 2006 WHO child growth standards. BMJ 334, 705706.
28. Corvalan, C (2014) Unconditional or conditional change: does it matter? Growth charts for monitoring weight gain during pregnancy. Am J Clin Nutr 99, 245246.
29. Brough, L, Rees, GA, Crawford, MA, et al. (2010) Effect of multiple-micronutrient supplementation on maternal nutrient status, infant birth weight and gestational age at birth in a low-income, multi-ethnic population. Br J Nutr 104, 437445.
30. Gernand, AD, Simhan, HN, Klebanoff, MA, et al. (2013) Maternal serum 25-hydroxyvitamin D and measures of newborn and placental weight in a U.S. multicenter cohort study. J Clin Endocrinol Metab 98, 398404.
31. Sabour, H, Hossein-Nezhad, A, Maghbooli, Z, et al. (2006) Relationship between pregnancy outcomes and maternal vitamin D and calcium intake: a cross-sectional study. Gynecol Endocrinol 22, 585589.
32. Hashemipour, S, Ziaee, A, Javadi, A, et al. (2014) Effect of treatment of vitamin D deficiency and insufficiency during pregnancy on fetal growth indices and maternal weight gain: a randomized clinical trial. Eur J Obstet Gynecol Reprod Biol 172, 1519.
33. Kalra, P, Das, V, Agarwal, A, et al. (2012) Effect of vitamin D supplementation during pregnancy on neonatal mineral homeostasis and anthropometry of the newborn and infant. Br J Nutr 108, 10521058.
34. van Eijsden, M, Snijder, MB, Brouwer, I, et al. (2013) Maternal early-pregnancy vitamin D status in relation to linear growth at the age of 5-6 years: results of the ABCD cohort. Eur J Clin Nutr 67, 972977.
35. Cole, TJ (1995) Conditional reference charts to assess weight gain in British infants. Arch Dis Child 73, 816.
36. Sullivan, MC, McGrath, MM, Hawes, K, et al. (2008) Growth trajectories of preterm infants: birth to 12 years. J Pediatr Health Care 22, 8393.
37. Nimitphong, H & Holick, MF (2013) Vitamin D status and sun exposure in southeast Asia. Dermatoendocrinol 5, 3437.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Type Description Title
WORD
Supplementary materials

Ong supplementary material
Tables S1-S11

 Word (67 KB)
67 KB

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed