1Paoletti R, Poli A & Cignarella A (2006) The emerging link between nutrition, inflammation and atherosclerosis. Expert Rev Cardiovasc Ther 4, 385–393.
2Nappo F, Esposito K, Cioffi M, et al. (2002) Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals. J Am Coll Cardiol 39, 1145–1150.
3van Oostrom AJ, Rabelink TJ, Verseyden C, et al. (2004) Activation of leukocytes by postprandial lipemia in healthy volunteers. Atherosclerosis 177, 175–182.
4Blanco-Colio LM, Valderrama M, Alvarez-Sala LA, et al. (2000) Red wine intake prevents nuclear factor-kappaB activation in peripheral blood mononuclear cells of healthy volunteers during postprandial lipemia. Circulation 102, 1020–1026.
5Erridge C, Attina T, Spickett CM, et al. (2007) A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation. Am J Clin Nutr 86, 1286–1292.
6Cani PD, Amar J, Iglesias MA, et al. (2007) Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56, 1761–1772.
7Ghanim H, Abuaysheh S, Sia CL, et al. (2009) Increase in plasma endotoxin concentrations and the expression of toll like receptors and suppressor of cytokine signaling-3 in mononuclear cells following a high fat high carbohydrate meal: Implications for insulin resistance. Diabetes Care 32, 2281–2287.
8Deopurkar R, Ghanim H, Friedman J, et al. (2010) Differential effects of cream, glucose and orange juice on inflammation, endotoxin and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3. Diabetes Care 33, 991–997.
9Ghanim H, Sia CL, Upadhyay M, et al. (2010) Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression. Am J Clin Nutr 91, 940–949.
10Ghoshal S, Witta J, Zhong J, et al. (2009) Chylomicrons promote intestinal absorption of lipopolysaccharides. J Lipid Res 50, 90–97.
11Berg RD (1996) The indigenous gastrointestinal microflora. Trends Microbiol 4, 430–435.
12Mullick AE, Tobias PS & Curtiss LK (2005) Modulation of atherosclerosis in mice by Toll-like receptor 2. J Clin Invest 115, 3149–3156.
13Michelson KS, Wong MH, Shah PK, et al. (2004) Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U S A 101, 10679–10684.
14Madan M & Amar S (2008) Toll-like receptor-2 mediates diet and/or pathogen associated atherosclerosis: proteomic findings. PLoS ONE 3, e3204.
15Shi H, Kokoeva MV, Inouye K, et al. (2006) TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116, 3015–3025.
16Poggi M, Bastelica D, Gual P, et al. (2007) C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet. Diabetologia 50, 1267–1276.
17Kim F, Pham M, Luttrell I, et al. (2007) Toll like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circ Res 100, 1589–1596.
18Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, et al. (2007) Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 56, 1986–1998.
19Himes RW & Smith CW (2010) TLR2 is critical for diet-induced metabolic syndrome in a murine model. FASEB J 24, 731–739.
20Lehr HA, Sagban TA, Ihling C, et al. (2001) Immunopathogenesis of atherosclerosis: endotoxin accelerates atherosclerosis in rabbits on hypercholesterolemic diet. Circulation 104, 914–920.
21Cuaz-Pérolin C, Billiet L, Baugé E, et al. (2008) Antiinflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-beta-boswellic acid in LPS-challenged ApoE− / − mice. Arterioscler Thromb Vasc Biol 28, 272–277.
22Engelmann MG, Redl CV & Nikol S (2004) Recurrent perivascular inflammation induced by lipopolysaccharide (endotoxin) results in the formation of atheromatous lesions in vivo. Lab Invest 84, 425–432.
23Schoneveld AH, Oude Nijhuis MM, van Middelaar B, et al. (2005) Toll-like receptor 2 stimulation induces intimal hyperplasia and atherosclerotic lesion development. Cardiovasc Res 66, 162–169.
24Erridge C, Duncan SH, Bereswill S, et al. (2010) The induction of colitis and ileitis in mice is associated with marked increases in intestinal concentrations of stimulants of TLRs 2, 4 and 5. PLoS ONE 5, e9125.
25Delahooke DM, Barclay GR & Poxton IR (1995) Tumor necrosis factor induction by an aqueous phenol-extracted lipopolysaccharide complex from Bacteroides species. Infect Immun 63, 840–846.
26Erridge C, Kennedy S, Spickett CM, et al. (2008) Oxidised phospholipid inhibition of toll-like receptor (TLR) signalling is restricted to TLR2 and TLR4 – roles for CD14, LPS-binding protein and MD2 as targets for specificity of inhibition. J Biol Chem 283, 24748–24759.
27Walton KA, Cole AL, Yeh M, et al. (2003) Specific phospholipid oxidation products inhibit ligand activation of Toll-like receptors 4 and 2. Arterioscler Thromb Vasc Biol 23, 1197–1203.
28Hardin JA, Kimm MH, Wirasinghe M, et al. (1999) Macromolecular transport across the rabbit proximal and distal colon. Gut 44, 218–225.
29Yamada T, Inui A, Hayashi N, et al. (2003) Serotonin stimulates endotoxin translocation via 5-HT3 receptors in the rat ileum. Am J Physiol Gastrointest Liver Physiol 284, G782–G788.
30Ravin HA, Rowley D, Jenkins C, et al. (1960) On the absorption of bacterial endotoxin from the gastro-intestinal tract of the normal and shocked animal. J Exp Med 112, 783–792.
31Elin R & Wolff S (1973) Nonspecificity of the limulus amebocyte lysate test: Positive reactions with polynucleotides and proteins. J Infect Dis 128, 349–352.
32Erridge C, Spickett CM & Webb DJ (2007) Non-enterobacterial endotoxins stimulate human coronary artery but not venous endothelial cell activation via Toll-like receptor 2. Cardiovasc Res 73, 181–189.
33Rossignol D, Lynn M, Wittek A, et al. (2006) Elevated plasma levels of limulus amoebocyte lysate-reactive material. Authors' reply. J Infect Dis 194, 1340–1341.
34Lee JY, Zhao L, Youn HS, et al. (2004) Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1. J Biol Chem 279, 16971–16979.
35Ohashi K, Burkart V, Flohe S, et al. (2000) Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol 164, 558–561.
36Blankenship LC (1978) Survival of a Salmonella typhimurium experimental contaminant during cooking of beef roasts. Appl Environ Microbiol 35, 1160–1165.
37Erridge C, Bennett-Guerrero E & Poxton IR (2002) Structure and function of lipopolysaccharides. Microbes Infect 4, 837–851.
38Ibrahim GF, Fleet GH, Lyons MJ, et al. (1985) Method for the isolation of highly purified Salmonella flagellins. J Clin Microbiol 22, 1040–1044.
39Fallowfield HJ & Patterson JT (2007) Potential value of the Limulus lysate assay for the measurement of meat spoilage. Int J Food Sci Tech 20, 467–479.
40Gehring U, Spithoven J, Schmid S, et al. (2008) Endotoxin levels in cow's milk samples from farming and non-farming families – the PASTURE study. Environ Int 34, 1132–1136.
41Jay JM, Margitic S, Shereda AL, et al. (1979) Determining endotoxin content of ground beef by the limulus amoebocyte lysate test as a rapid indicator of microbial quality. Appl Environ Microbiol 38, 885–890.
42Jay JM & Margitic S (1979) Comparison of homogenizing, shaking, and blending on the recovery of microorganisms and endotoxins from fresh and frozen ground beef as assessed by plate counts and the limulus amoebocyte lysate test. Appl Environ Microbiol 38, 879–884.
43Erridge C & Samani NJ (2009) Saturated fatty acids do not directly stimulate Toll-like receptor signaling. Arterioscler Thromb Vasc Biol 29, 1944–1949.
44Yoshino S, Sasatomi E, Mori Y, et al. (1999) Oral administration of lipopolysaccharide exacerbates collagen-induced arthritis in mice. J Immunol 163, 3417–3422.
45Youngner JS (1972) Bacterial lipopolysaccharide: oral route for interferon production in mice. Infect Immun 6, 646–647.
46Yoshino S, Yamaki K, Taneda S, et al. (2005) Reactivation of antigen-induced arthritis in mice by oral administration of lipopolysaccharide. Scand J Immunol 62, 117–122.
47van Deventer SJ, Buller HR, ten Cate JW, et al. (1990) Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways. Blood 76, 2520–2526.
48Keller P, Moller K, Krabbe KS, et al. (2003) Circulating adiponectin levels during human endotoxaemia. Clin Exp Immunol 134, 107–110.
49Benmohamed L, Belkaid Y, Loing E, et al. (2002) Systemic immune responses induced by mucosal administration of lipopeptides without adjuvant. Eur J Immunol 32, 2274–2281.