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Coffee consumption and total mortality: a meta-analysis of twenty prospective cohort studies

  • Youjin Je (a1) and Edward Giovannucci (a2)
Abstract

Coffee consumption has been shown to be associated with various health outcomes, but no comprehensive review and meta-analysis of the association between coffee consumption and total mortality has been conducted. To quantitatively assess this association, we conducted a meta-analysis of prospective cohort studies. Eligible studies were identified by searching the PubMed and EMBASE databases for all articles published through June 2013 and reviewing the reference lists of the retrieved articles. Pooled relative risks (RR) with 95 % CI were calculated using a random-effects model. We identified twenty studies of coffee consumption and total mortality, including 129 538 cases of deaths among the 973 904 participants. The RR of total mortality for the high v. low category of coffee consumption was 0·86 (95 % CI 0·80, 0·92). The pooled RR for studies using ≥ 2–4 cups/d as a cut-off for the high category was similar to that for studies using ≥ 5–9 cups/d as the cut-off. By geographical region, the inverse association tended to be stronger for the eight studies conducted in Europe (RR 0·78, 95 % CI 0·70, 0·88) and three studies carried out in Japan (RR 0·82, 95 % CI 0·73, 0·92) than for the nine studies conducted in the USA (RR 0·92, 95 % CI 0·84, 1·00). The inverse association was similar for men (RR 0·81, 95 % CI 0·73, 0·90) and women (RR 0·84, 95 % CI 0·79, 0·89). A weak, but significant, inverse association was found with moderate coffee consumption (1–2 cups/d; RR 0·92, 95 % CI 0·87, 0·98). High decaffeinated coffee consumption was also found to be associated with a lower risk of death, but the data are limited. Our findings indicate that coffee consumption is associated with a reduced risk of total mortality.

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Corresponding author
*Corresponding author: Y. Je, fax +82 2 961 0538, email youjinje@khu.ac.kr
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1JV Higdon & B Frei (2006) Coffee and health: a review of recent human research. Crit Rev Food Sci Nutr 46, 101123.

2M Noordzij , CS Uiterwaal , LR Arends , et al. (2005) Blood pressure response to chronic intake of coffee and caffeine: a meta-analysis of randomized controlled trials. J Hypertens 23, 921928.

3TR Hartley , WR Lovallo & TL Whitsett (2004) Cardiovascular effects of caffeine in men and women. Am J Cardiol 93, 10221026.

4B de Roos & MB Katan (1999) Possible mechanisms underlying the cholesterol-raising effect of the coffee diterpene cafestol. Curr Opin Lipidol 10, 4145.

5 RHuxley , CMLee , FBarzi , et al. (2009) Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysis. Arch Intern Med 169, 20532063.

6JN Wu , SC Ho , C Zhou , et al. (2009) Coffee consumption and risk of coronary heart diseases: a meta-analysis of 21 prospective cohort studies. Int J Cardiol 137, 216225.

7X Yu , Z Bao , J Zou , et al. (2011) Coffee consumption and risk of cancers: a meta-analysis of cohort studies. BMC Cancer 11, 96.

8 MLucas , EJO'Reilly , APan , et al. (2013) Coffee, caffeine, and risk of completed suicide: results from three prospective cohorts of American adults. World J Biol Psychiatry (Epublication ahead of print version 2 July 2013) .

9 KSääksjärvi , PKnekt , HRissanen , et al. (2008) Prospective study of coffee consumption and risk of Parkinson's disease. Eur J Clin Nutr 62, 908915.

10JL Barranco Quintana , MF Allam , A Serrano Del Castillo , et al. (2007) Alzheimer's disease and coffee: a quantitative review. Neurol Res 29, 9195.

11MF Leitzmann , WC Willett , EB Rimm , et al. (1999) A prospective study of coffee consumption and the risk of symptomatic gallstone disease in men. JAMA 281, 21062112.

12MF Leitzmann , MJ Stampfer , WC Willett , et al. (2002) Coffee intake is associated with lower risk of symptomatic gallstone disease in women. Gastroenterology 123, 18231830.

13JA Gómez-Ruiz , DS Leake & JM Ames (2007) In vitro antioxidant activity of coffee compounds and their metabolites. J Agric Food Chem 55, 69626969.

14RM van Dam (2006) Coffee and type 2 diabetes: from beans to beta-cells. Nutr Metab Cardiovasc Dis 16, 6977.

15WW Huber , G Scharf , G Nagel , et al. (2003) Coffee and its chemopreventive components kahweol and cafestol increase the activity of O6-methylguanine-DNA methyltransferase in rat liver – comparison with phase II xenobiotic metabolism. Mutat Res 522, 5768.

17BK Jacobsen , E Bjelke , G Kvale , et al. (1986) Coffee drinking, mortality and cancer incidence: results from a Norwegian prospective study. J Natl Cancer Inst 76, 823831.

19D LeGrady , AR Dyer , RB Shekelle , et al. (1987) Coffee consumption and mortality in the Chicago Western Electric Company Study. Am J Epidemiol 126, 803812.

20A Rosengren & L Wilhelmsen (1991) Coffee, coronary heart disease and mortality in middle-aged Swedish men: findings from the Primary Prevention Study. J Intern Med 230, 6771.

21 ALKlatsky , MAArmstrong & GDFriedman (1993) Coffee, tea, and mortality. Ann Epidemiol 3, 375381.

22M Woodward & H Tunstall-Pedoe (1999) Coffee and tea consumption in the Scottish Heart Health Study follow up: conflicting relations with coronary risk factors, coronary disease, and all-cause mortality. J Epidemiol Community Health 53, 481487.

23P Kleemola , P Jousilahti , P Pietinen , et al. (2000) Coffee consumption and the risk of coronary heart disease and death. Arch Intern Med 160, 33933400.

24 NIwai , HOhshiro , YKurozawa , et al. (2002) Relationship between coffee and green tea consumption and all-cause mortality in a cohort of a rural Japanese population. J Epidemiol 12, 191198.

25A Jazbec , D Simić , N Corović , et al. (2003) Impact of coffee and other selected factors on general mortality and mortality due to cardiovascular disease in Croatia. J Health Popul Nutr 21, 332340.

27 PHapponen , ELäärä , LHiltunen , et al. (2008) Coffee consumption and mortality in a 14-year follow-up of an elderly northern Finnish population. Br J Nutr 99, 13541361.

28A Paganini-Hill , CH Kawas & MM Corrada (2007) Non-alcoholic beverage and caffeine consumption and mortality: the Leisure World Cohort Study. Prev Med 44, 305310.

29E Lopez-Garcia , RM van Dam , TY Li , et al. (2008) The relationship of coffee consumption with mortality. Ann Intern Med 148, 904914.

30 KSugiyama , SKuriyama , MAkhter , et al. (2010) Coffee consumption and mortality due to all causes, cardiovascular disease, and cancer in Japanese women. J Nutr 140, 10071013.

31 JMde Koning Gans , CSUiterwaal , YTvan der Schouw , et al. (2010) Tea and coffee consumption and cardiovascular morbidity and mortality. Arterioscler Thromb Vasc Biol 30, 16651671.

32A Tamakoshi , Y Lin , M Kawado , et al. (2011) Effect of coffee consumption on all-cause and total cancer mortality: findings from the JACC study. Eur J Epidemiol 26, 285293.

33 NDFreedman , YPark , CCAbnet , et al. (2012) Association of coffee drinking with total and cause-specific mortality. N Engl J Med 366, 18911904.

34 HGardener , TRundek , CBWright , et al. (2013) Coffee and tea consumption are inversely associated with mortality in a multi-ethnic urban population. J Nutr 143, 12991308.

35KD Lindsted , JW Kuzma & JL Anderson (1992) Coffee consumption and cause-specific mortality. Association with age at death and compression of mortality. J Clin Epidemiol 45, 733742.

36 DFStroup , JABerlin , SCMorton , et al. (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA 283, 20082012.

37R DerSimonian & N Laird (1986) Meta-analysis in clinical trials. Control Clin Trials 7, 177188.

38WG Cochran (1954) The combination of estimates from different experiments. Biometrics 10, 101129.

39JP Higgins , SG Thompson , JJ Deeks , et al. (2003) Measuring inconsistency in meta-analyses. BMJ 327, 557560.

40JA Berlin , MP Longnecker & S Greenland (1993) Meta-analysis of epidemiologic dose–response data. Epidemiology 4, 218228.

43Y Je & E Giovannucci (2012) Coffee consumption and risk of endometrial cancer: findings from a large up-to-date meta-analysis. Int J Cancer 131, 17001710.

44CB Begg & M Mazumdar (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50, 10881101.

45 MEgger , GDavey Smith , MSchneider , et al. (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315, 629663.

46Y Je , W Liu & E Giovannucci (2009) Coffee consumption and risk of colorectal cancer: a systematic review and meta-analysis of prospective cohort studies. Int J Cancer 124, 16621668.

47A Svilaas , AK Sakhi , LF Andersen , et al. (2004) Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans. J Nutr 134, 562567.

49T Watanabe , Y Arai , Y Mitsui , et al. (2006) The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension. Clin Exp Hypertens 28, 439449.

50RM van Dam & FB Hu (2005) Coffee consumption and risk of type 2 diabetes: a systematic review. JAMA 294, 97104.

51J Arnlov , B Vessby & U Riserus (2004) Coffee consumption and insulin sensitivity. JAMA 291, 11991201.

52JM Tunnicliffe & J Shearer (2008) Coffee, glucose homeostasis, and insulin resistance: physiological mechanisms and mediators. Appl Physiol Nutr Metab 33, 12901300.

53 EGiovannucci , DMHarlan , MCArcher , et al. (2010) Diabetes and cancer: a consensus report. Diabetes Care 33, 16741685.

54M Inoue & S Tsugane (2012) Insulin resistance and cancer: epidemiological evidence. Endocr Relat Cancer 19, F1F8.

55 LXSang , BChang , XHLi , et al. (2013) Consumption of coffee associated with reduced risk of liver cancer: a meta-analysis. BMC Gastroenterol 13, 34.

56C Tian , W Wang , Z Hong , et al. (2013) Coffee consumption and risk of colorectal cancer: a dose–response analysis of observational studies. Cancer Causes Control 24, 12651268.

57XJ Li , ZJ Ren , JW Qin , et al. (2013) Coffee consumption and risk of breast cancer: an up-to-date meta-analysis. PLOS ONE 8, e52681.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
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