1. Zhang, S, Li, T-S, Soyama, A, et al. (2016) Up-regulated extracellular matrix components and inflammatory chemokines may impair the regeneration of cholestatic liver. Sci Rep 6, 26540.
2. Colares, JR, Schemitt, EG, Hartmann, RM, et al. (2016) Antioxidant and anti-inflammatory action of melatonin in an experimental model of secondary biliary cirrhosis induced by bile duct ligation. World J Gastroenterol 22, 8918.
3. Kabirifar, R, Safari, F, Karimollah, A, et al. (2017) Quercetin protects liver injury induced by bile duct ligation via attenuation of Rac1 and NADPH oxidase1 expression in rats. Hepatobiliary Pancreat Dis Int 16, 88–95.
4. Saxena, NK, Ikeda, K, Rockey, DC, et al. (2002) Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice. Hepatology 35, 762–771.
5. García-Ruiz, I, Gómez-Izquierdo, E, Díaz-Sanjuán, T, et al. (2012) Sp1 and Sp3 transcription factors mediate leptin-induced collagen α1 (I) gene expression in primary culture of male rat hepatic stellate cells. Endocrinology 153, 5845–5856.
6. Kabirifar, R, Safari, F, Karimollah, A, et al. (2017) Hepatoprotective effects of curcumin in rats after bile duct ligation via downregulation of Rac1 and NOX1. Nutrition 36, 72–78.
7. Brandes, RP, Weissmann, N & Schröder, K (2014) Nox family NADPH oxidases: molecular mechanisms of activation. Free Radic Biol Med 76, 208–226.
8. Zhao, Y, Ma, X, Wang, J, et al. (2014) Curcumin protects against CCl4-induced liver fibrosis in rats by inhibiting HIF-1α through an ERK-dependent pathway. Molecules 19, 18767–18780.
9. Toriumi, K, Horikoshi, Y, Osamura, RY, et al. (2013) Carbon tetrachloride-induced hepatic injury through formation of oxidized diacylglycerol and activation of the PKC/NF-[kappa] B pathway. Lab Invest 93, 218.
10. Meshkani, R & Adeli, K (2009) Hepatic insulin resistance, metabolic syndrome and cardiovascular disease. Clin Biochem 42, 1331–1346.
11. O’Shea, JJ, Schwartz, DM, Villarino, AV, et al. (2015) The JAK-STAT pathway: impact on human disease and therapeutic intervention. Annu Rev Med 66, 311–328.
12. Elliott, J & Johnston, JA (2004) SOCS: role in inflammation, allergy and homeostasis. Trends Immunol 25, 434–440.
13. Croker, BA, Kiu, H & Nicholson, SE (2008) SOCS regulation of the JAK/STAT signalling pathway. Semin Cell Dev Biol 19, 414–422.
14. Taniguchi, CM, Ueki, K & Kahn, CR (2005) Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism. J Clin Invest 115, 718.
15. Rui, L, Yuan, M, Frantz, D, et al. (2002) SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J Biol Chem 277, 42394–42398.
16. Tilg, H & Moschen, AR (2008) Insulin resistance, inflammation, and non-alcoholic fatty liver disease. Trends Endocrinol Metab 19, 371–379.
17. Kawaguchi, T, Taniguchi, E, Itou, M, et al. (2011) Insulin resistance and chronic liver disease. World J Hepatol 3, 99.
18. Leclercq, IA, Morais, ADS, Schroyen, B, et al. (2007) Insulin resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequences. J Hepatol 47, 142–156.
19. Gual, P, Le Marchand-Brustel, Y & Tanti, J-F (2005) Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie 87, 99–109.
20. El Swefy, S, Hasan, RA, Ibrahim, A, et al. (2016) Curcumin and hemopressin treatment attenuates cholestasis-induced liver fibrosis in rats: role of CB1 receptors. Naunyn Schmiedebergs Arch Pharmacol 389, 103–116.
21. Wang, M-E, Chen, Y-C, Chen, I-S, et al. (2012) Curcumin protects against thioacetamide-induced hepatic fibrosis by attenuating the inflammatory response and inducing apoptosis of damaged hepatocytes. J Nutr Biochem 23, 1352–1366.
22. Park, EJ, Jeon, CH, Ko, G, et al. (2000) Protective effect of curcumin in rat liver injury induced by carbon tetrachloride. J Pharm Pharmacol 52, 437–440.
23. Reyes-Gordillo, K, Segovia, J, Shibayama, M, et al. (2008) Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress. Fundam Clin Pharmacol 22, 417–427.
24. Afrin, MR, Arumugam, S, Rahman, MA, et al. (2017) Curcumin reduces the risk of chronic kidney damage in mice with nonalcoholic steatohepatitis by modulating endoplasmic reticulum stress and MAPK signaling. Int Immunopharmacol 49, 161–167.
25. Gupta, A, Singh, VK, Kumar, D, et al. (2017) Curcumin-3,4-Dichloro Phenyl Pyrazole (CDPP) overcomes curcumin’s low bioavailability, inhibits adipogenesis and ameliorates dyslipidemia by activating reverse cholesterol transport. Metabolism 73, 109–124.
26. Jaiswal, SK, Sharma, A, Gupta, VK, et al. (2016) Curcumin mediated attenuation of carbofuran induced oxidative stress in rat brain. Biochem Res Int 2016, 7637931.
27. Haddadian, Z, Eftekhari, G, Mazloom, R, et al. (2013) Effect of endotoxin on heart rate dynamics in rats with cirrhosis. Auton Neurosci 177, 104–113.
28. Ma, Z, Zhang, Y, Huet, P-M, et al. (1999) Differential effects of jaundice and cirrhosis on β-adrenoceptor signaling in three rat models of cirrhotic cardiomyopathy. J Hepatol 30, 485–491.
29. Yagi, K (1984)  Assay for blood plasma or serum. Methods Enzymol 105, 328–331.
30. Gülçin, İ (2006) Antioxidant activity of caffeic acid (3, 4-dihydroxycinnamic acid). Toxicology 217, 213–220.
31. Tahir, I, Khan, MR, Shah, NA, et al. (2016) Evaluation of phytochemicals, antioxidant activity and amelioration of pulmonary fibrosis with Phyllanthus emblica leaves. BMC Complement Altern Med 16, 406.
32. Matthews, D, Hosker, J, Rudenski, A, et al. (1985) Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412–419.
33. Vivoli, E, Maira, G & Marra, F (2016) Liver fibrosis and leptin. Curr Pathobiol Rep 4, 69–76.
34. García-Compeán, D, González-González, JA, Lavalle-González, FJ, et al. (2016) Hepatogenous diabetes: Is it a neglected condition in chronic liver disease? World J Gastroenterol 22, 2869.
35. Karadeniz, G, Acikgoz, S, Tekin, IO, et al. (2008) Oxidized low-density-lipoprotein accumulation is associated with liver fibrosis in experimental cholestasis. Clinics 63, 531–540.
36. Tahan, G, Akin, H, Aydogan, F, et al. (2010) Melatonin ameliorates liver fibrosis induced by bile-duct ligation in rats. Can J Surg 53, 313–318.
37. Svegliati Baroni, G, D’Ambrosio, L, Ferretti, G, et al. (1998) Fibrogenic effect of oxidative stress on rat hepatic stellate cells. Hepatology 27, 720–726.
38. Qiao, Q, Le Manach, S, Sotton, B, et al. (2016) Deep sexual dimorphism in adult medaka fish liver highlighted by multi-omic approach. Sci Rep 6, 32459.
39. George, J (2003) Ascorbic acid concentrations in dimethylnitrosamine-induced hepatic fibrosis in rats. Clin Chim Acta 335, 39–47.
40. Trebicka, J, Hennenberg, M, Odenthal, M, et al. (2010) Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells. J Hepatol 53, 702–712.
41. Reyes-Gordillo, K, Segovia, J, Shibayama, M, et al. (2007) Curcumin protects against acute liver damage in the rat by inhibiting NF-κB, proinflammatory cytokines production and oxidative stress. Biochim Biophys Acta 1770, 989–996.
42. Bahçecıoğlu, İH, Yalniz, M, Ataseven, H, et al. (2004) TNF‐α and leptin in experimental liver fibrosis models induced by carbon tetrachloride and by common bile duct ligation. Cell Biochem Funct 22, 359–363.
43. Choi, SS, Sicklick, JK, Ma, Q, et al. (2006) Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice. Hepatology 44, 1267–1277.
44. Li, J, Zhu, H, Shen, E, et al. (2010) Deficiency of rac1 blocks NADPH oxidase activation, inhibits endoplasmic reticulum stress, and reduces myocardial remodeling in a mouse model of type 1 diabetes. Diabetes 59, 2033–2042.
45. Hafez, MM, Al-Harbi, NO, Al-Hoshani, AR, et al. (2015) Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl 4-induced hepatotoxicity in rats. Biol Res 48, 30.
46. Kim, Y, Kim, Y, Cho, Y, et al. (2012) Metformin ameliorates IL-6-induced hepatic insulin resistance via induction of orphan nuclear receptor small heterodimer partner (SHP) in mouse models. Diabetologia 55, 1482–1494.
47. El-Zayadi, A-R (2010) Insulin resistance. Arab J Gastroenterol 11, 66–69.
48. Sadek, K, Beltagy, D, Saleh, E, et al. (2016) Camel milk and bee honey regulate profibrotic cytokine gene transcripts in liver cirrhosis induced by carbon tetrachloride. Can J Physiol Pharmacol 94, 1141–1150.