Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 1
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Sundrani, D. Chavan-Gautam, P. Pisal, H. Mehendale, S. and Joshi, S. 2013. Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases-1, -2 in placentas from preterm pregnancies and their association with one-carbon metabolites. Reproduction, Vol. 145, Issue. 4, p. 401.


    ×

Cystatin C levels in plasma and peripheral blood mononuclear cells among hyperhomocysteinaemic subjects: effect of treatment with B-vitamins

  • Kari Anne R. Tobin (a1) (a2), Kirsten B. Holven (a3), Kjetil Retterstøl (a1), Ellen Strøm (a1), Leiv Ose (a1), Pål Aukrust (a2) (a4) and Marit S. Nenseter (a1) (a2)
  • DOI: http://dx.doi.org/10.1017/S0007114509991048
  • Published online: 17 August 2009
Abstract

Homocysteine has been related to increased risk of CVD. Matrix degradation and inflammation may be involved in this link between hyperhomocysteinaemia and CVD. Recent studies suggest that cystatin C can modulate matrix degradation and inflammation. The present study measured cystatin C at protein (plasma) and mRNA levels (peripheral blood mononuclear cells (PBMC)) in hyperhomocysteinaemic individuals (n 37, female seven and male thirty, aged 20–70 years) before and after B-vitamin supplementation for 3 months in a randomised, placebo-controlled double-blind trial. In a cross-sectional study, seventeen of the hyperhomocysteinaemic subjects were age- and sex-matched to healthy controls (n 17). Our main findings were: (i) as compared with controls, hyperhomocysteinaemic subjects tended to have higher plasma concentrations of cystatin C and lower mRNA levels of cystatin C in PBMC; (ii) compared with placebo, treatment of hyperhomocysteinaemic individuals with B-vitamins significantly increased plasma levels of cystatin C and mRNA levels of cystatin C in PBMC; (iii) while plasma levels of cystatin C were positively correlated with plasma levels of TNF receptor-1, mRNA levels of cystatin C in PBMC were inversely correlated with this TNF parameter. Taken together, our findings suggest that disturbed cystatin C levels may be a characteristic of hyperhomocysteinaemic individuals, potentially related to low-grade systemic inflammation in hyperhomocysteinaemic subjects, and that B-vitamins may modulate cystatin C levels in these individuals.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Cystatin C levels in plasma and peripheral blood mononuclear cells among hyperhomocysteinaemic subjects: effect of treatment with B-vitamins
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Cystatin C levels in plasma and peripheral blood mononuclear cells among hyperhomocysteinaemic subjects: effect of treatment with B-vitamins
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Cystatin C levels in plasma and peripheral blood mononuclear cells among hyperhomocysteinaemic subjects: effect of treatment with B-vitamins
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Marit S. Nenseter, fax +47 23073630, email marit.s.nenseter@rr-research.no
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1DS Wald , M Law & JK Morris (2002) Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ 325, 12021206.

2Homocysteine Studies Collaboration (2002) Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 288, 20152022.

3LE Bautista , IA Arenas , A Penuela , (2002) Total plasma homocysteine level and risk of cardiovascular disease: a meta-analysis of prospective cohort studies. J Clin Epidemiol 55, 882887.

4S Dayal & SR Lentz (2008) Murine models of hyperhomocysteinemia and their vascular phenotypes. Arterioscler Thromb Vasc Biol 28, 15961605.

5JF Toole , MR Malinow , LE Chambless , (2004) Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA 291, 565575.

6KH Bønaa , I Njølstad , PM Ueland , (2006) Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med 354, 15781588.

8Q Yang , LD Botto , JD Erickson , (2006) Improvement in stroke mortality in Canada and the United States, 1990 to 2002. Circulation 113, 13351343.

9X Wang , X Qin , H Demirtas , (2007) Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Lancet 369, 18761882.

10JD Spence (2006) Homocysteine. Call off the funeral. Stroke 37, 282283.

11KB Holven , P Aukrust , T Holm , (2002) Folic acid treatment reduces chemokine release from peripheral blood mononuclear cells in hyperhomocysteinemic subjects. Arterioscler Thromb Vasc Biol 22, 699703.

12KB Holven , P Aukrust , K Retterstøl , (2006) Increased levels of high-sensitivity C-reactive protein and interleukin-6 in hyperhomocysteinemic subjects. Scand J Clin Lab Invest 66, 4554.

13KB Holven , B Halvorsen , V Bjerkeli , (2006) Impaired inhibitory effect of interleukin-10 on the balance between matrix metalloproteinase-9 and its inhibitor in mononuclear cells from hyperhomocysteinemic subjects. Stroke 37, 17311736.

14M Arnadottir , B Hultberg , P Nilsson-Ehle , (1996) The effect of reduced glomerular filtration rate on plasma total homocysteine concentration. Scand J Clin Lab Invest 56, 4146.

15C Lewerin , S Ljungman & H Nilsson-Ehle (2007) Glomerular filtration rate as measured by serum cystatin C is an important determinant of plasma homocysteine and serum methylmalonic acid in the elderly. J Intern Med 261, 6567.

16J Liu , GK Sukhova , JS Sun , (2004) Lysosomal cysteine proteases in atherosclerosis. Arterioscler Thromb Vasc Biol 24, 13591366.

17GK Sukhova , B Wang , P Libby , (2005) Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice. Circ Res 96, 368375.

19GP Shi , GK Sukhova , A Grubb , (1999) Cystatin C deficiency in human atherosclerosis and aortic aneurysms. J Clin Invest 104, 11911197.

20MA Albert , N Rifai & PM Ridker (2001) Plasma levels of cystatin-C and mannose binding protein are not associated with risk of developing systemic atherosclerosis. Vasc Med 6, 145149.

21L Djoussé , T Kurth & JM Gaziano (2008) Cystatin C and risk of heart failure in the Physicians' Health Study (PHS). Am Heart J 155, 8286.

22W Koenig , D Twardella , H Brenner , (2005) Plasma concentrations of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rate. Clin Chem 51, 321327.

23L Ni , J , LB Hou , (2007) Cystatin C, associated with hemorrhagic and ischemic stroke, is a strong predictor of the risk of cardiovascular events and death in Chinese. Stroke 38, 32873288.

24DM Maahs , LG Ogden , A Kretowski , (2007) Serum cystatin C predicts progression of subclinical coronary atherosclerosis in individuals with type 1 diabetes. Diabetes 56, 27742779.

25J Arpegård , J Ostergren , U de Faire , (2008) Cystatin C – a marker of peripheral atherosclerotic disease? Atherosclerosis 199, 397401.

26A Bökenkamp , S Herget-Rosenthal & R Bökenkamp (2008) Cystatin C, kidney function and cardiovascular disease. Pediatr Nephrol 21, 12231230.

27MS Nenseter , T Ueland , K Retterstøl , (2009) Dysregulated RANK ligand/RANK axis in hyperhomocysteinemic subjects. Effect of treatment with B-vitamins. Stroke 40, 241247.

28KB Holven , B Halvorsen , H Schulz , (2003) Expression of matrix metalloproteinase-9 in mononuclear cells of hyperhomocysteinaemic subjects. Eur J Clin Invest 33, 555560.

29E Bengtsson , F To , A Grubb , (2005) Absence of the protease inhibitor cystatin C in inflammatory cells results in larger plaque area in plaque regression of apoE-deficient mice. Atherosclerosis 180, 4553.

30S Yap , GH Boers , B Wilcken , (2001) Vascular outcome in patients with homocystinuria due to cystathionine beta-synthase deficiency treated chronically: a multicenter observational study. Arterioscler Thromb Vasc Biol 21, 20802085.

31C Keller , R Katz , M Cushman , (2008) Association of kidney function with inflammatory and procoagulant markers in a diverse cohort: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis (MESA). BMC Nephrol 9, 9.

32CR Keller , MC Odden , LF Fried , (2007) Kidney function and markers of inflammation in elderly persons without chronic kidney disease: the health, aging, and body composition study. Kidney Int 71, 239244.

33D Singh , MA Whooley , JH Ix , (2007) Association of cystatin C and estimated GFR with inflammatory biomarkers: the Heart and Soul Study. Nephrol Dial Transplant 22, 10871092.

34K Potter , GJ Hankey , DJ Green , (2008) Homocysteine or renal impairment: which is the real cardiovascular risk factor? Arterioscler Thromb Vasc Biol 28, 11581164.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: