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Dietary acetic acid reduces serum cholesterol and triacylglycerols in rats fed a cholesterol-rich diet

  • Takashi Fushimi (a1), Kazuhito Suruga (a2), Yoshifumi Oshima (a1), Momoko Fukiharu (a1), Yoshinori Tsukamoto (a1) and Toshinao Goda (a2)
  • DOI:
  • Published online: 01 March 2007

To investigate the efficacy of the intake of vinegar for prevention of hyperlipidaemia, we examined the effect of dietary acetic acid, the main component of vinegar, on serum lipid values in rats fed a diet containing 1% (w/w) cholesterol. Animals were allowed free access to a diet containing no cholesterol, a diet containing 1% cholesterol without acetic acid, or a diet containing 1% cholesterol with 0·3% (w/w) acetic acid for 19 d. Then, they were killed after food deprivation for 7 h. Cholesterol feeding increased serum total cholesterol and triacylglycerol levels. Compared with the cholesterol-fed group, the cholesterol and acetic acid-fed group had significantly lower values for serum total cholesterol and triacylglycerols, liver ATP citrate lyase (ATP-CL) activity, and liver 3-hydroxy-3-methylglutaryl-CoA content as well as liver mRNA levels of sterol regulatory element binding protein-1, ATP-CL and fatty acid synthase (P<,0·05). Further, the serum secretin level, liver acyl-CoA oxidase expression, and faecal bile acid content were significantly higher in the cholesterol and acetic acid-fed group than in the cholesterol-fed group (P<0·05). However, acetic acid feeding affected neither the mRNA level nor activity of cholesterol 7a-hydroxylase. In conclusion, dietary acetic acid reduced serum total cholesterol and triacylglycerol: first due to the inhibition of lipogenesis in liver; second due to the increment in faecal bile acid excretion in rats fed a diet containing cholesterol.

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*Corresponding author: Dr. Takashi Fushimi, fax +81 56924 5028, email
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R Apfel , D Benbrook , E Lernhardt , MA Ortiz , G Salbert & M Pfahl (1994) A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Mol Cell Biol. 14 70257035

T Aritsuka , K Tanaka & S Kiriyama (1989) Effect of beet fiber on lipid metabolism in rats fed a cholesterol-free diet in comparison with pectin and cellulose. J Jpn Soc Nutr Food Sci 42 295304

MK Bennett , JM Lopez , HB Sanchez & TF Osborne (1995) Sterol regulation of fatty acid synthase promotor. J Biol Chem. 270 2557825583

C Chang , T Ohshima & C Koizumi (1994) Changes in the composition of free amino acids, organic acids and lipids during processing and ripening of ‘Hatahata-zushi’, a fermented fish product of sandfish (Arctoscopus japonicus). J Sci Food Agric. 66 7582

B Crabtree , M Gordon & SL Christie (1990) Measurement of the rates of acetyl-CoA hydrolysis and synthesis from acetate in rat hepatocytes and the role of these fluxes in substrate cycling. Biochem J. 270 219225

MS DeBuysere & MS Olson (1983) The analysis of acetyl-coenzyme A derivatives by reverse-phase high-performance liquid chromatography. Anal Biochem. 133 373379

F Foufelle & P Ferré (2002) New perspective in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem J. 366 377391

T Fujii , T Sasaki & M Okuzumi (1992) Chemical composition and microbial flora of saba-narezushi (fermented mackerel with rice) (in Japanese). Bull Jap Soc Fish Sci. 58 891894

T Fushimi & Y Sato (2005) Effect of acetic acid feeding on the circadian changes in glycogen and metabolites of glucose and lipid in liver and skeletal muscle of rats. Br J Nutr. 94 714719

T Fushimi , K Tayama , M Fukaya , K Kitakoshi , N Nakai , Y Tsukamoto & Y Sato (2002) The efficacy of acetic acid for glycogen repletion in rat skeletal muscle after exercise. Int J Sports Med. 23 218222

T Goda , H Yasutake & S Takase (1994) Dietary fat regulates cellular retinol-binding protein II gene expression in rat jejunum. Biochim Biophys Acta. 1200 3440

DG Hardie (2003) The AMP-activated protein kinase cascade: the key sensors of cellular energy status. Endocrinology. 144 51795183

DG Hardie , D Carling & M Carlson (1998) The AMP-activated/SNF 1 protein kinase subfamily: metabolic sensors of the eukaryotic cell Ann Rev Biochem. 67 821855

JD Horton , Y Bashimakov , I Shimomura & H Shimano (1998) Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc Natl Acad Sci U S A. 95 59875992

T Kawaguchi , K Osatomi , H Yamashita , T Kabashima & K Uyeda (2002) Mechanism for fatty acid 'sparing' effect on glucose-induced transcription. J Biol Chem. 277 38293835

M Kishi , M Fukaya , Y Tsukamoto , T Nagasawa , K Kakehana & N Nishizawa (1999) Enhancing effect of dietary vinegar on the intestinal absorption of calcium in ovariectomized rats. Biosci Biotechnol Biochem. 63 905910

H Liljeberg & I Björck (1998) Delayed gastric emptying rate may explain improved glycaemia in healthy subjects to a starchy meal with added vinegar. Eur J Clin Nutr 52 368371

JM Lopez , MK Bennett , HB Sanchez , JM Rosenfeld & TF Osborne (1996) Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipid. Proc Natl Acad Sci U S A. 93 10491053

K Mochizuki , K Suruga , M Kitagawa , S Takase & T Goda (2001) Modulation of the expression of peroxisome proliferator-activated receptor-dependent genes through disproportional expression of two subtypes in the small intestine. Arch Biochem Biophys. 389 4148

K Mochizuki , K Suruga , N Sakaguchi , S Takase & T Goda (2002) Major intestinal coactivator p300 strongly activates peroxisome proliferator-activated receptor in intestinal cell line. Caco-2. Gene. 291 271277

M Noshiro , M Nishimoto , K Morohashi & K Okuda (1989) Molecular cloning of cDNA for cholesterol 7 alpha-hydroxylase from rat liver microsomes. Nucleotide sequence and expression. FEBS Lett 257 97100

NJ Pearce , JW Yates & TA Berkhout (1998) The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Biochem J. 334 113119

CM Ross & JJ Poluhowich (1984) The effect of apple cider vinegar on adjuvant arthritic rats. Nutr Res 4 737741

AK Saha & NB Ruderman (2003) Malonyl-CoA and AMP-activated proteinkinase: an expanding partnership. Mol Cell Biochem. 253 6570

C Sanchez-Vincente , F Rondriguez-Nodal , A Minguela , LJ Garcia , JI San Roman , JJ Calvo & MA Lopez (1995) Cholinergic pathways are involved in secretin and VIP release and the exocrine pancreatic response after intraduodenally perfused acetic and lactic acids in the rat. Pancreas. 10. 9399

R Sato , A Okamoto , J Inoue , W Miyamoto , Y Sakai , N Emoto , H Shimano & M Maeda (2000) Transcriptional regulation of the ATP citrate-lyase gene by sterol regulatory element-binding proteins. J Biol Chem. 275 1249712502

O Spydevold , EJ Davis & J Bremer (1976) Replenishment and depletion of citric acid cycle intermediates in skeletal muscle. Eur J Biochem 71 155165

Y Takeda , F Suzuki & H Inoue (1969) ATP-citrate lyase (citrate-cleavege enzyme) Methods Enzymol 13 153160

G Zhou , R Myers & Y Li (2001) Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 108 11671174

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