1Hamdy, O, Porramatikul, S & Al-Ozairi, E (2006) Metabolic obesity: the paradox between visceral and subcutaneous fat. Curr Diabetes Rev 2, 367–373.
2WHO (2000) i–xii, .
3Flegal, KM, Carroll, MD, Ogden, CL, et al. (2010) Prevalence and trends in obesity among US adults, 1999–2008. JAMA 303, 235–241.
4James, PT, Leach, R, Kalamara, E, et al. (2001) The worldwide obesity epidemic. Obes Res 9, Suppl. 4, 228S–233S.
5Must, A, Spadano, J, Coakley, EH, et al. (1999) The disease burden associated with overweight and obesity. JAMA 282, 1523–1529.
6Stewart, ST, Cutler, DM & Rosen, AB (2009) Forecasting the effects of obesity and smoking on U.S. life expectancy. N Engl J Med 361, 2252–2260.
7Bray, GA (2004) Medical consequences of obesity. J Clin Endocrinol Metab 89, 2583–2589.
8Kopelman, P (2007) Health risks associated with overweight and obesity. Obes Rev 8, Suppl. 1, 13–17.
9Ali, AT & Crowther, NJ (2005) Body fat distribution and insulin resistance. S Afr Med J 95, 878–880.
10Jensen, MD (2008) Role of body fat distribution and the metabolic complications of obesity. J Clin Endocrinol Metab 93, 11 Suppl. 1, S57–S63.
11Avram, AS, Avram, MM & James, WD (2005) Subcutaneous fat in normal and diseased states: 2. Anatomy and physiology of white and brown adipose tissue. J Am Acad Dermatol 53, 671–683.
12Frontini, A & Cinti, S (2010) Distribution and development of brown adipocytes in the murine and human adipose organ. Cell Metab 11, 253–256.
13Wells, JCK (2006) The evolution of human fatness and susceptibility to obesity: an ethological approach. Biol Rev 81, 183–205.
14Pond, CM (1998) The Fats of Life. Cambridge: Cambridge University Press.
15Bjorntorp, P (1974) Effects of age, sex, and clinical conditions on adipose tissue cellularity in man. Metabolism 23, 1091–1102.
16Hirsch, J & Batchelor, B (1976) Adipose tissue cellularity in human obesity. Clin Endocrinol Metab 5, 299–311.
17Spalding, KL, Arner, E, Westermark, PO, et al. (2008) Dynamics of fat cell turnover in humans. Nature 453, 783–787.
18Ibrahim, MM (2010) Subcutaneous and visceral adipose tissue: structural and functional differences. Obes Rev 11, 11–18.
19Wajchenberg, BL (2000) Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 21, 697–738.
20Golan, R, Shelef, I, Rudich, A, et al. (2012) Abdominal superficial subcutaneous fat: a putative distinct protective fat subdepot in type 2 diabetes. Diabetes Care 35, 640–647.
21Abate, N, Burns, D, Peshock, RM, et al. (1994) Estimation of adipose tissue mass by magnetic resonance imaging: validation against dissection in human cadavers. J Lipid Res 35, 1490–1496.
22Abate, N, Garg, A, Peshock, RM, et al. (1995) Relationships of generalized and regional adiposity to insulin sensitivity in men. J Clin Invest 96, 88–98.
23Bouchard, C, Despres, JP & Mauriege, P (1993) Genetic and nongenetic determinants of regional fat distribution. Endocr Rev 14, 72–93.
24DeNino, WF, Tchernof, A, Dionne, IJ, et al. (2001) Contribution of abdominal adiposity to age-related differences in insulin sensitivity and plasma lipids in healthy nonobese women. Diabetes Care 24, 925–932.
25Kuk, JL, Saunders, TJ, Davidson, LE, et al. (2009) Age-related changes in total and regional fat distribution. Ageing Res Rev 8, 339–348.
26Dixon, AK (1983) Abdominal fat assessed by computed tomography: sex difference in distribution. Clin Radiol 34, 189–191.
27Smith, SR, Lovejoy, JC, Greenway, F, et al. (2001) Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity. Metabolism 50, 425–435.
28Heid, IM, Jackson, AU, Randall, JC, et al. (2010) Meta-analysis identifies 13 new loci associated with waist–hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 42, 949–960.
29Perusse, L, Despres, JP, Lemieux, S, et al. (1996) Familial aggregation of abdominal visceral fat level: results from the Quebec family study. Metabolism 45, 378–382.
30Cypess, AM, Lehman, S, Williams, G, et al. (2009) Identification and importance of brown adipose tissue in adult humans. N Engl J Med 360, 1509–1517.
31Nedergaard, J, Bengtsson, T & Cannon, B (2007) Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 293, E444–E452.
32Seale, P & Lazar, MA (2009) Brown fat in humans: turning up the heat on obesity. Diabetes 58, 1482–1484.
33van Marken Lichtenbelt, WD, Vanhommerig, JW, Smulders, NM, et al. (2009) Cold-activated brown adipose tissue in healthy men. N Engl J Med 360, 1500–1508.
34Votruba, SB, Mattison, RS, Dumesic, DA, et al. (2007) Meal fatty acid uptake in visceral fat in women. Diabetes 56, 2589–2597.
35Nielsen, S, Guo, Z, Johnson, CM, et al. (2004) Splanchnic lipolysis in human obesity. J Clin Invest 113, 1582–1588.
36Klein, S (2004) The case of visceral fat: argument for the defense. J Clin Invest 113, 1530–1532.
37Xu, H, Barnes, GT, Yang, Q, et al. (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112, 1821–1830.
38Harman-Boehm, I, Bluher, M, Redel, H, et al. (2007) Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity. J Clin Endocrinol Metab 92, 2240–2247.
39Bluher, M, Bashan, N, Shai, I, et al. (2009) Activated Ask1-MKK4-p38MAPK/JNK stress signaling pathway in human omental fat tissue may link macrophage infiltration to whole-body insulin sensitivity. J Clin Endocrinol Metab 94, 2507–2515.
40Vague, J (1999) The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. 1956. Nutrition 15, 89–90; .
41Ruderman, N, Chisholm, D, Pi-Sunyer, X, et al. (1998) The metabolically obese, normal-weight individual revisited. Diabetes 47, 699–713.
42Jensen, MD, Haymond, MW, Rizza, RA, et al. (1989) Influence of body fat distribution on free fatty acid metabolism in obesity. J Clin Invest 83, 1168–1173.
43Brochu, M, Starling, RD, Tchernof, A, et al. (2000) Visceral adipose tissue is an independent correlate of glucose disposal in older obese postmenopausal women. J Clin Endocrinol Metab 85, 2378–2384.
44Goodpaster, BH, Kelley, DE, Wing, RR, et al. (1999) Effects of weight loss on regional fat distribution and insulin sensitivity in obesity. Diabetes 48, 839–847.
45Lemieux, S, Prud'homme, D, Nadeau, A, et al. (1996) Seven-year changes in body fat and visceral adipose tissue in women. Association with indexes of plasma glucose–insulin homeostasis. Diabetes Care 19, 983–991.
46Ross, R, Aru, J, Freeman, J, et al. (2002) Abdominal adiposity and insulin resistance in obese men. Am J Physiol Endocrinol Metab 282, E657–E663.
47Goodpaster, BH, Thaete, FL, Simoneau, JA, et al. (1997) Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes 46, 1579–1585.
48Maffeis, C, Manfredi, R, Trombetta, M, et al. (2008) Insulin sensitivity is correlated with subcutaneous but not visceral body fat in overweight and obese prepubertal children. J Clin Endocrinol Metab 93, 2122–2128.
49Wagenknecht, LE, Langefeld, CD, Scherzinger, AL, et al. (2003) Insulin sensitivity, insulin secretion, and abdominal fat: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study. Diabetes 52, 2490–2496.
50Frayn, KN (2000) Visceral fat and insulin resistance – causative or correlative? Br J Nutr 83, Suppl. 1, S71–S77.
51Kelley, DE, Thaete, FL, Troost, F, et al. (2000) Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance. Am J Physiol Endocrinol Metab 278, E941–E948.
52Misra, A, Garg, A, Abate, N, et al. (1997) Relationship of anterior and posterior subcutaneous abdominal fat to insulin sensitivity in nondiabetic men. Obes Res 5, 93–99.
53Monzon, JR, Basile, R, Heneghan, S, et al. (2002) Lipolysis in adipocytes isolated from deep and superficial subcutaneous adipose tissue. Obes Res 10, 266–269.
54Cannon, B & Nedergaard, J (2004) Brown adipose tissue: function and physiological significance. Physiol Rev 84, 277–359.
55Bartelt, A, Bruns, OT, Reimer, R, et al. (2011) Brown adipose tissue activity controls triglyceride clearance. Nat Med 17, 200–205.
56Nedergaard, J, Bengtsson, T & Cannon, B (2011) New powers of brown fat: fighting the metabolic syndrome. Cell Metab 13, 238–240.
57Smith, SR & Zachwieja, JJ (1999) Visceral adipose tissue: a critical review of intervention strategies. Int J Obes Relat Metab Disord 23, 329–335.
58Chaston, TB & Dixon, JB (2008) Factors associated with percent change in visceral versus subcutaneous abdominal fat during weight loss: findings from a systematic review. Int J Obes (Lond) 32, 619–628.
59Hall, KD & Hallgreen, CE (2008) Increasing weight loss attenuates the preferential loss of visceral compared with subcutaneous fat: a predicted result of an allometric model. Int J Obes (Lond) 32, 722.
60Iacobellis, G, Singh, N, Wharton, S, et al. (2008) Substantial changes in epicardial fat thickness after weight loss in severely obese subjects. Obesity (Silver Spring) 16, 1693–1697.
61Miyashita, Y, Koide, N, Ohtsuka, M, et al. (2004) Beneficial effect of low carbohydrate in low calorie diets on visceral fat reduction in type 2 diabetic patients with obesity. Diabetes Res Clin Pract 65, 235–241.
62Paniagua, JA, de la Sacristana, A Gallego, Romero, I, et al. (2007) Monounsaturated fat-rich diet prevents central body fat distribution and decreases postprandial adiponectin expression induced by a carbohydrate-rich diet in insulin-resistant subjects. Diabetes Care 30, 1717–1723.
63Walker, KZ, O'Dea, K, Johnson, L, et al. (1996) Body fat distribution and non-insulin-dependent diabetes: comparison of a fiber-rich, high-carbohydrate, low-fat (23 %) diet and a 35 % fat diet high in monounsaturated fat. Am J Clin Nutr 63, 254–260.
64Hays, NP, Starling, RD, Liu, X, et al. (2004) Effects of an ad libitum low-fat, high-carbohydrate diet on body weight, body composition, and fat distribution in older men and women: a randomized controlled trial. Arch Intern Med 164, 210–217.
65Josse, AR, Atkinson, SA, Tarnopolsky, MA, et al. (2011) Increased consumption of dairy foods and protein during diet- and exercise-induced weight loss promotes fat mass loss and lean mass gain in overweight and obese premenopausal women. J Nutr 141, 1626–1634.
66Clifton, PM, Noakes, M & Keogh, JB (2004) Very low-fat (12 %) and high monounsaturated fat (35 %) diets do not differentially affect abdominal fat loss in overweight, nondiabetic women. J Nutr 134, 1741–1745.
67McKeown, NM, Troy, LM, Jacques, PF, et al. (2010) Whole- and refined-grain intakes are differentially associated with abdominal visceral and subcutaneous adiposity in healthy adults: the Framingham Heart Study. Am J Clin Nutr 92, 1165–1171.
68McKeown, NM, Yoshida, M, Shea, MK, et al. (2009) Whole-grain intake and cereal fiber are associated with lower abdominal adiposity in older adults. J Nutr 139, 1950–1955.
69Maki, KC, Reeves, MS, Farmer, M, et al. (2009) Green tea catechin consumption enhances exercise-induced abdominal fat loss in overweight and obese adults. J Nutr 139, 264–270.
70Crescenzo, R, Bianco, F, Coppola, P, et al. (2014) Adipose tissue remodeling in rats exhibiting fructose-induced obesity. Eur J Nutr 53, 413–419.
71Ronn, M, Lind, PM, Karlsson, H, et al. (2013) Quantification of total and visceral adipose tissue in fructose-fed rats using water-fat separated single echo MRI. Obesity (Silver Spring) 21, E388–E395.
72Cao, L, Liu, X, Cao, H, et al. (2012) Modified high-sucrose diet-induced abdominally obese and normal-weight rats developed high plasma free fatty acid and insulin resistance. Oxid Med Cell Longev. 2012, 374346.
73Stanhope, KL, Schwarz, JM, Keim, NL, et al. (2009) Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 119, 1322–1334.
74Kavanagh, K, Jones, KL, Sawyer, J, et al. (2007) Trans fat diet induces abdominal obesity and changes in insulin sensitivity in monkeys. Obesity (Silver Spring) 15, 1675–1684.
75Kim, JY, Nolte, LA, Hansen, PA, et al. (2000) High-fat diet-induced muscle insulin resistance: relationship to visceral fat mass. Am J Physiol Regul Integr Comp Physiol 279, R2057–R2065.
76Rokling-Andersen, MH, Rustan, AC, Wensaas, AJ, et al. (2009) Marine n-3 fatty acids promote size reduction of visceral adipose depots, without altering body weight and composition, in male Wistar rats fed a high-fat diet. Br J Nutr 102, 995–1006.
77Oi-Kano, Y, Kawada, T, Watanabe, T, et al. (2007) Extra virgin olive oil increases uncoupling protein 1 content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in rats. J Nutr Biochem 18, 685–692.
78Ross, R (1990 s) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362, 801–809.
79Libby, P (2000) Changing concepts of atherogenesis. J Intern Med 247, 349–358.
80Tirosh, A, Shai, I, Afek, A, et al. (2011) Adolescent BMI trajectory and risk of diabetes versus coronary disease. N Engl J Med 364, 1315–1325.
81Tirosh, A, Rudich, A, Shochat, T, et al. (2007) Changes in triglyceride levels and risk for coronary heart disease in young men. Ann Intern Med 147, 377–385.
82Shai, I, Schwarzfuchs, D, Henkin, Y, et al. (2008) Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. N Engl J Med 359, 229–241.
83Schwarzfuchs, D, Golan, R & Shai, I (2012) Four-year follow-up after two-year dietary interventions. N Engl J Med 367, 1373–1374.
84Estruch, R, Ros, E, Salas-Salvadó, J, et al. (2013) Primary prevention of cardiovascular disease with a Mediterranean Diet. N Engl J Med 368, 1279–1290.
85Gattone, M & Giannuzzi, P (2006) Interventional strategies in early atherosclerosis. Monaldi Arch Chest Dis 66, 54–62.
86Hjerkinn, EM, Abdelnoor, M, Breivik, L, et al. (2006) Effect of diet or very long chain omega-3 fatty acids on progression of atherosclerosis, evaluated by carotid plaques, intima–media thickness and by pulse wave propagation in elderly men with hypercholesterolaemia. Eur J Cardiovasc Prev Rehabil 13, 325–333.
87Markus, RA, Mack, WJ, Azen, SP, et al. (1997) Influence of lifestyle modification on atherosclerotic progression determined by ultrasonographic change in the common carotid intima–media thickness. Am J Clin Nutr 65, 1000–1004.
88Wildman, RP, Schott, LL, Brockwell, S, et al. (2004) A dietary and exercise intervention slows menopause-associated progression of subclinical atherosclerosis as measured by intima–media thickness of the carotid arteries. J Am Coll Cardiol 44, 579–585.
89Blüher, M, Rudich, A, Klöting, N, et al. (2012) Two patterns of adipokine and other biomarker dynamics in a long-term weight loss intervention. Diabetes Care 35, 342–349.
90Koopmans, SJ, Dekker, R, Ackermans, MT, et al. (2011) Dietary saturated fat/cholesterol, but not unsaturated fat or starch, induces C-reactive protein associated early atherosclerosis and ectopic fat deposition in diabetic pigs. Cardiovasc Diabetol 10, 64.
91Rizkalla, SW, Prifti, E, Cotillard, A, et al. (2012) Differential effects of macronutrient content in 2 energy-restricted diets on cardiovascular risk factors and adipose tissue cell size in moderately obese individuals: a randomized controlled trial. Am J Clin Nutr 95, 49–63.
92Pedersen, LR, Olsen, RH, Jurs, A, et al. (2014) A randomised trial comparing weight loss with aerobic exercise in overweight individuals with coronary artery disease: The CUT-IT trial. Eur J Prev Cardiol .
93Garcia-Fernandez, E, Rico-Cabanas, L, Rosgaard, N, et al. (2014) Mediterranean diet and cardiodiabesity: a review. Nutrients 6, 3474–3500.