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Diets deficient in selenium and vitamin E affect plasma lipoprotein and apolipoprotein concentrations in the rat

  • A Mazur (a1), F Nassir (a1), E Gueux (a1), C Moundras (a1), J Bellanger (a1), P Grolier (a1), E Rock (a1) and Y Rayssiguier (a1)...
Abstract

The present study examined the effects of Se, vitamin E and combined Se and vitamin E deficiencies in rats on plasma lipid, Lipoprotein and apolipoprotein (apo) concentrations. Deficiencies were induced by feeding rats the respective diets for 6 weeks. The study shows that Se deficiency results in increased concentrations of plasma cholesterol and apo E. Both could be explained by an increase in the HDL1 fraction. Vitamin E deficiency alone had no significant effect on plasma lipid, lipoprotein and apo concentrations. Se deficiency in combination with vitamin E deficiency leads to an increase in plasma LDL and apo B concentrations. These results point to the need for further investigations on the mechanism by which Se deficiency affects lipoprotein metabolism.

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J. R. Arthur , D. B. McPhail & B. A. Goodman (1988). Spin trapping of free radicals in homogenates of heart from selenium and vitamin E deficient rats. Free Radical Research Communications 4, 311315.

A. K. Dutta-Roy , M. J. Gordon , F. M. Campbell , G. G. Duthie & W. P. T. James (1994). Vitamin E requirements, transport, and metabolism: Role of α-tocopherol-binding proteins. Journal of Nutritional Biochemistry 5, 562570.

C. Felgines , C. Sérougne , D. Mathé , A. Mazur & C. Lutton (1994). Effect of simvastatin treatment on plasma apolipoproteins and hepatic apolipoprotein mRNA levels in the genetically hypercholesterolemic rats (RICO). Life Sciences 54, 361367.

W. C. Fisher & P. D. Whanger (1977). Effects of selenium deficiency on vitamin E metabolism in rats. Journal of Nutritional Sciences and Vitaminology 23, 273280.

L. T. Lusk , L. F. Walker , L. H. Dubien & G. S. Getz (1979). Isolation and characterization of high-density lipoprotein HDLl from rat plasma by gradient centrifugation. Biochemical Journal 183, 8390.

C. Moundras , C. Demigné , A. Mazur & C. Rémésy (1995). The cholesterol lowering effect of steroid sequestrans is modulated by large intestine fermentations. Journal of Nutritional Biochemistry 6, 158162.

F. Nassir , A. Mazur , E. Gueux , C. Sérougne & Y. Rayssiguier (1994). Apolipoprotein A-I, A-IV and E synthesis in the liver of copper-deficient rats. Lipids 29, 727729.

O. Oster & W. Prellwitz (1990). Selenium and cardiovascular disease. Biological Trace Element Research 24, 91103.

J. T. Rotruck , A. L. Pope , H. E. Ganther , A. B. Swanson , D. G. Hafeman & W. G. Hoekstra (1973). Selenium: biochemical role as a component of glutathione peroxidase. Science 179, 588590.

R. L. Scott , A. Kheshti , M. Heimberg , H. G. Wilcox & W. L. Stone (1991). The role of selenium in the secretion of very-low-density lipoprotein in the isolated perfused liver. Biochemical Journal 279, 741745.

W. L. Stone (1988). The effects of cholesterol supplementation on plasma lipoprotein cholesterol levels in rats fed diets deficient in vitamin E and/or selenium. Nutrition Research 8, 10611071.

W. L. Stone , R. L. Scott , E. M. Stewart & A. Kheshti (1994). Lipoprotein alterations in the spontaneously hypertensive rat fed diets deficient in selenium and vitamin E. Proceedings of the Society for Experimental Biology and Medicine 206, 130137.

W. L. Stone , M. E. Stewart , C. Nicholas & S. Pavuluri (1986). Effects of dietary selenium and vitamin E on plasma lipoprotein cholesterol levels in male rats. Annals of Nutrition and Metabolism 30, 94103.

J. Wojcicki , L. Ruzewicka , B. Barcew-Wiszniewska , L. Samochowiec , S. Juzwiak , D. Kadlubowska , S. Tustanowski & Z. Juzyszyn (1991). Effect of selenium and vitamin E on the development of experimental atherosclerosis in rabbits. Atherosclerosis 87, 916.

W. You-Zhen , J. Xi-An , Z. Jun-Yong & X. Guang-Lu (1993). Effect of selenium deficiency on Ca transport function of sarcoplasmic reticulum and lipid peroxidation in rat myocardium. Biological Trace Element Research 36, 159166.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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