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Dietary microparticles and their impact on tolerance and immune responsiveness of the gastrointestinal tract

  • Jonathan J Powell (a1), Vinay Thoree (a1) and Laetitia C Pele (a1)
Abstract

Dietary microparticles are non-biological bacterial-sized particles of the gastrointestinal lumen that occur due to endogenous formation (calcium phosphate) or following oral exposure (exogenous microparticle). In the UK, about 40 mg (1012) of exogenous microparticles are ingested per person per day, through exposure to food additives, pharmaceutical/supplement excipients or toothpaste constituents. Once ingested, exogenous microparticles are unlikely to pass through the gastrointestinal tract without adsorbing to their surfaces some ions and molecules of the intestinal lumen. Both entropy and ionic attraction drive such interactions. Calcium ions are especially well adsorbed by dietary microparticles which then provide a positively charged surface for the attraction (adsorption) of other organic molecules such as lipopolysaccharides, peptidoglycans or protein antigen from the diet or commensal flora. The major (but not only) sites of microparticle entry into intestinal tissue are the M-cell rich lymphoid aggregates (termed Peyer's patches in the small bowel). Indeed, it is well established that this is an efficient transport route for non-biological microparticles although it is unclear why. We hypothesise that this pathway exists for “endogenous microparticles” of calcium phosphate, with immunological and physiological benefit, and that “exogenous dietary microparticles”, such as titanium dioxide and the silicates, hijack this route. This overview focuses on what is known of these microparticles and outlines their potential role in immune tolerance of the gut (endogenous microparticles) or immune activation (exogenous microparticles) and inflammation of the gut.

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Corresponding author
*Corresponding author: Jonathan J. Powell, fax 44 (0) 1223 437515, email jonathan.powell@mrc-hnr.cam.ac.uk
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3JJ Powell , CC Ainley , RS Harvey , IM Mason , MD Kendall , EA Sankey , AP Dhillon & RP Thompson (1996) Characterisation of inorganic microparticles in pigment cells of human gut associated lymphoid tissue. Gut 38, 390395.

4JE Ellingsen (1991) A study on the mechanism of protein adsorption to TiO2. Biomaterials 12, 593596.

8JJ Powell , MW Whitehead , CC Ainley , MD Kendall , JK Nicholson & RP Thompson (1999) Dietary minerals in the gastrointestinal tract: hydroxypolymerisation of aluminium is regulated by luminal mucins. J Inorg Biochem 75, 167180.

12TJ Sernka & AB Borle (1969) Calcium in the intestinal contents of rats on different calcium diets. Proc Soc Exp Biol Med 131, 14201423.

14MW Smith , NW Thomas , PG Jenkins , NG Miller , D Cremaschi & C Porta (1995) Selective transport of microparticles across Peyer's patch follicle-associated M cells from mice and rats. Exp Physiol 80, 735743.

17IM Bovee-Oudenhoven , ML Lettink-Wissink , W Van Doesburg , BJ Witteman & R Van Der Meer (2003) Diarrhea caused by enterotoxigenic Escherichia coli infection of humans is inhibited by dietary calcium. Gastroenterology 125, 469476.

18IM Bovee-Oudenhoven , DS Termont , AH Weerkamp , MA Faassen-Peters & R Van der Meer (1997) Dietary calcium inhibits the intestinal colonization and translocation of Salmonella in rats. Gastroenterology 113, 550557.

20RJ Hambly , M Saunders , PJ Rijken & IR Rowland (2002) Influence of dietary components associated with high or low risk of colon cancer on apoptosis in the rat colon. Food Chem Toxicol 40, 801808.

21ID Penman , QL Liang , J Bode , MA Eastwood & MJ Arends (2000) Dietary calcium supplementation increases apoptosis in the distal murine colonic epithelium. J Clin Pathol 53, 302307.

22Y Zhu , BD Mahon , M Froicu & MT Cantorna (2005) Calcium and 1 alpha,25-dihydroxyvitamin D3 target the TNF-alpha pathway to suppress experimental inflammatory bowel disease. Eur J Immunol 35, 217224.

23SM Evans , P Ashwood , A Warley , F Berisha , RP Thompson & JJ Powell (2002) The role of dietary microparticles and calcium in apoptosis and interleukin-1beta release of intestinal macrophages. Gastroenterology 123, 15431553.

24TA Ferguson , J Herndon , B Elzey , TS Griffith , S Schoenberger & DR Green (2002) Uptake of apoptotic antigen-coupled cells by lymphoid dendritic cells and cross-priming of CD8(+) T cells produce active immune unresponsiveness. J Immunol 168, 55895595.

25K Liu , T Iyoda , M Saternus , Y Kimura , K Inaba & RM Steinman (2002) Immune tolerance after delivery of dying cells to dendritic cells in situ. J Exp Med 196, 10911097.

26JM Blander & R Medzhitov (2006) Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature 440, 808812.

27LE Smythies , M Sellers , RH Clements , M Mosteller-Barnum , G Meng , WH Benjamin , JM Orenstein & PD Smith (2005) Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. J Clin Invest 115, 6675.

28NA Shepherd , PR Crocker , AP Smith & DA Levison (1987) Exogenous pigment in Peyer's patches. Hum Pathol 18, 5054.

31JJ Powell , RS Harvey & RP Thompson (1996) Microparticles in Crohn's disease–has the dust settled? Gut 39, 340341.

33JJ Powell , RS Harvey , P Ashwood , R Wolstencroft , ME Gershwin & RP Thompson (2000) Immune potentiation of ultrafine dietary particles in normal subjects and patients with inflammatory bowel disease. J Autoimmun 14, 99–105.

34MG Netea , G Ferwerda , DJ de Jong , (2005) The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists. J Biol Chem 280, 3585935867.

35MC Lomer , RS Harvey , SM Evans , RP Thompson & JJ Powell (2001) Efficacy and tolerability of a low microparticle diet in a double blind, randomized, pilot study in Crohn's disease. Eur J Gastroenterol Hepatol 13, 101–106.

36MC Lomer , SL Grainger , R Ede , (2005) Lack of efficacy of a reduced microparticle diet in a multi-centred trial of patients with active Crohn's disease. Eur J Gastroenterol Hepatol 17, 377384.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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