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Do long-chain n-3 fatty acids reduce arterial stiffness? A meta-analysis of randomised controlled trials

  • Matthew P. Pase (a1) (a2), Natalie A. Grima (a3) and Jerome Sarris (a1) (a2) (a4)
  • DOI:
  • Published online: 06 July 2011

Fish oils, rich in long-chain n-3 PUFA, are known to reduce various risk factors for CVD. However, conclusive evidence regarding the benefits of n-3 on arterial stiffness, a risk factor for CVD, has not yet been established. Consequently, we conducted the first study aimed to quantify the effects of n-3 supplementation on arterial stiffness through meta-analysis. Multiple databases and clinical trial registries were systematically searched up until September 2010 for randomised and controlled adult human clinical trials to investigate the effects of long-chain n-3 fatty acids on arterial stiffness. No limits were set on dosage sizes or sample characteristics. A total of ten n-3 trials met the final inclusion criteria; four using pulse wave velocity (PWV) and six using arterial compliance, measured as capacitive compliance or systemic arterial compliance, as respective outcome measures. Meta-analysis revealed that n-3 was statistically significant in effectively improving both PWV (g = 0·33; 95 % CI 0·12, 0·56; P < 0·01) and arterial compliance (g = 0·48; 95 % CI 0·24, 0·72; P < 0·001). There was no evidence of heterogeneity or publication bias. Results were not influenced by changes in blood pressure, heart rate or BMI. The findings of the present study reveal that supplementation with n-3 offers a scientifically supported means of reducing arterial stiffness. Reduction in arterial stiffness by n-3 may account for some of its purported cardioprotective effects.

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*Corresponding author: M. P. Pase, fax +613 9214 5525, email
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1C Vlachopoulos , K Aznaouridis & C Stefanadis (2010) Prediction of cardiovascular events and all-cause mortality with arterial stiffness. A systematic review and meta-analysis. J Am Coll Cardiol 55, 13181327.

2MF O'Rourke & ME Safar (2005) Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy. Hypertension 46, 200204.

4MC Morris , F Sacks & B Rosner (1993) Does fish oil lower blood pressure? A meta-analysis of controlled trials. Circulation 88, 523533.

5D Mozaffarian , A Geelen , IA Brouwer , (2005) Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials. Circulation 112, 19451952.

6A Leaf , CM Albert , M Josephson , (2005) Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake. Circulation 112, 27622768.

7HC Bucher , P Hengstler & C Schindler (2002) n-3 Polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. Am J Med 112, 298304.

8JN Cohn , S Finkelstein , G McVeigh , (1995) Noninvasive pulse wave analysis for the early detection of vascular disease. Hypertension 26, 503508.

9MP Pase , NA Grima & J Sarris (2011) The effects of dietary and nutrient interventions on arterial stiffness: a systematic review. Am J Clin Nutr 93, 446454.

10C Vlachopoulos , K Aznaouridis , MF O'Rourke , (2010) Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis. Eur Heart J 31, 18651871.

11RH Marcus , C Korcarz , G McCray , (1994) Noninvasive method for determination of arterial compliance using Doppler echocardiography and subclavian pulse tracings: validation and clinical application of a physiological model of the circulation. Circulation 89, 26882699.

13A Yamashina , H Tomiyama , K Takeda , (2002) Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens Res 25, 359364.

15GE McVeigh , GM Brennan , JN Cohn , (1994) Fish oil improves arterial compliance in non-insulin-dependent diabetes mellitus. Arterioscler Thromb 14, 14251429.

16AR Jadad , RA Moore , D Carroll , (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17, 112.

17J Sarris & GJ Byrne (2011) A systematic review of insomnia and complementary medicine. Sleep Med Rev 15, 99106.

18JPT Higgins & SG Thompson (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21, 15391558.

20BJ Meyer , T Hammervold , AC Rustan , (2007) Dose-dependent effects of docosahexaenoic acid supplementation on blood lipids in statin-treated hyperlipidaemic subjects. Lipids 42, 109115.

22S Wang , AQ Ma , SW Song , (2008) Fish oil supplementation improves large arterial elasticity in overweight hypertensive patients. Eur J Clin Nutr 62, 14261431.

24 N Satoh , A Shimatsu , K Kotani , (2009) Highly purified eicosapentaenoic acid reduces cardio-ankle vascular index in association with decreased serum amyloid A-LDL in metabolic syndrome. Hypertens Res 32, 10041008.

25H Tomiyama , K Takazawa , SI Osa , (2005) Do eicosapentaenoic acid supplements attenuate age-related increases in arterial stiffness in patients with dyslipidemia?: a preliminary study. Hypertens Res 28, 651655.

26T Mita , H Watada , T Ogihara , (2007) Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes. Atherosclerosis 191, 162167.

28TA Mori & RJ Woodman (2006) The independent effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors in humans. Curr Opin Clin Nutr Metab Care 9, 95104.

30PM Kris-Etherton , WS Harris & LJ Appel (2002) Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 106, 27472757.

31Yasmin, CM McEniery , S Wallace , (2004) C-reactive protein is associated with arterial stiffness in apparently healthy individuals. Arterioscler Thromb Vasc Biol 24, 969974.

32S Laurent , P Boutouyrie & P Lacolley (2005) Structural and genetic bases of arterial stiffness. Hypertension 45, 10501055.

33IB Wilkinson , A Qasem , CM McEniery , (2002) Nitric oxide regulates local arterial distensibility in vivo. Circulation 105, 213217.

34S Laurent , J Cockcroft , L Van Bortel , (2006) Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 27, 25882605.

35H Tomiyama , Y Koji , M Yambe , (2005) Brachial-ankle pulse wave velocity is a simple and independent predictor of prognosis in patients with acute coronary syndrome. Circulation J 69, 815822.

36TC Turin , Y Kita , N Rumana , (2010) Brachial-ankle pulse wave velocity predicts all-cause mortality in the general population: findings from the Takashima study, Japan. Hypertens Res 33, 922925.

37TK Waddell , AM Dart , TL Medley , (2001) Carotid pressure is a better predictor of coronary artery disease severity than brachial pressure. Hypertension 38, 927931.

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