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Effect of capsinoids on energy metabolism in human subjects

  • Jose E. Galgani (a1), Donna H. Ryan (a1) and Eric Ravussin (a1)

Capsinoids are non-pungent compounds with molecular structures similar to capsaicin, which has accepted thermogenic properties. To assess the acute effect of a plant-derived preparation of capsinoids on energy metabolism, we determined RMR and non-protein respiratory quotient (NPRQ) after ingestion of different doses of the capsinoids. Thirteen healthy subjects received four doses of the capsinoids (1, 3, 6 and 12 mg) and placebo using a crossover, randomised, double-blind trial. After a 10 h overnight fast as inpatients, RMR was measured by indirect calorimetry for 45 min before and 120 min after ingesting capsinoids or placebo. Blood pressure and axillary temperature were measured before ( − 55 and − 5 min) and after (60 and 120 min) dosing. Before dosing, mean RMR was 6247 (se 92) kJ/d and NPRQ was 0·86 (se 0·01). At 120 min after dosing, metabolic rate and NPRQ remained similar across the four capsinoids and placebo doses. Capsinoids also had no influence on blood pressure or axillary temperature. Capsinoids provided in four doses did not affect metabolic rate and fuel partitioning in human subjects when measured 2 h after exposure. Longer exposure and higher capsinoids doses may be required to cause meaningful acute effects on energy metabolism.

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*Corresponding author: Dr Eric Ravussin, fax +1 225 763 2525, email
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1 Nishida, C, Uauy, R, Kumanyika, S, et al. (2004) The joint WHO/FAO expert consultation on diet, nutrition and the prevention of chronic diseases: process, product and policy implications. Public Health Nutr 7, 245250.
2 Watanabe, T, Kawada, T, Kurosawa, M, et al. (1988) Adrenal sympathetic efferent nerve and catecholamine secretion excitation caused by capsaicin in rats. Am J Physiol 255, E23E27.
3 Kawada, T, Sakabe, S, Watanabe, T, et al. (1988) Some pungent principles of spices cause the adrenal medulla to secrete catecholamine in anesthetized rats. Proc Soc Exp Biol Med 188, 229233.
4 Kawada, T, Watanabe, T, Takaishi, T, et al. (1986) Capsaicin-induced beta-adrenergic action on energy metabolism in rats: influence of capsaicin on oxygen consumption, the respiratory quotient, and substrate utilization. Proc Soc Exp Biol Med 183, 250256.
5 Watanabe, T, Kawada, T, Yamamoto, M, et al. (1987) Capsaicin, a pungent principle of hot red pepper, evokes catecholamine secretion from the adrenal medulla of anesthetized rats. Biochem Biophys Res Commun 142, 259264.
6 Yoshioka, M, Lim, K, Kikuzato, S, et al. (1995) Effects of red-pepper diet on the energy metabolism in men. J Nutr Sci Vitaminol (Tokyo) 41, 647656.
7 Yoshioka, M, St-Pierre, S, Suzuki, M, et al. (1998) Effects of red pepper added to high-fat and high-carbohydrate meals on energy metabolism and substrate utilization in Japanese women. Br J Nutr 80, 503510.
8 Lejeune, MP, Kovacs, EM & Westerterp-Plantenga, MS (2003) Effect of capsaicin on substrate oxidation and weight maintenance after modest body-weight loss in human subjects. Br J Nutr 90, 651659.
9 Kobata, K, Sutoh, K, Todo, T, et al. (1999) Nordihydrocapsiate, a new capsinoid from the fruits of a nonpungent pepper, Capsicum annuum. J Nat Prod 62, 335336.
10 Iida, T, Moriyama, T, Kobata, K, et al. (2003) TRPV1 activation and induction of nociceptive response by a non-pungent capsaicin-like compound, capsiate. Neuropharmacology 44, 958967.
11 Ohnuki, K, Haramizu, S, Oki, K, et al. (2001) Administration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in mice. Biosci Biotechnol Biochem 65, 27352740.
12 Masuda, Y, Haramizu, S, Oki, K, et al. (2003) Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog. J Appl Physiol 95, 24082415.
13 Ohnuki, K, Niwa, S, Maeda, S, et al. (2001) CH-19 sweet, a non-pungent cultivar of red pepper, increased body temperature and oxygen consumption in humans. Biosci Biotechnol Biochem 65, 20332036.
14 Inoue, N, Matsunaga, Y, Satoh, H, et al. (2007) Enhanced energy expenditure and fat oxidation in humans with high BMI scores by the ingestion of novel and non-pungent capsaicin analogues (capsinoids). Biosci Biotechnol Biochem 71, 380389.
15 Snitker, S, Fujishima, Y, Shen, H, et al. (2009) Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am J Clin Nutr 89, 4550.
16 Human energy requirements. Scientific background papers from the Joint FAO/WHO/UNU Expert Consultation (2005) October 17–24, 2001, Rome, Italy. Public Health Nutr 8, 9291228.
17 Wadden, TA, Stunkard, AJ, Day, SC, et al. (1987) Less food, less hunger: reports of appetite and symptoms in a controlled study of a protein-sparing modified fast. Int J Obes 11, 239249.
18 Jequier, E, Acheson, K & Schutz, Y (1987) Assessment of energy expenditure and fuel utilization in man. Annu Rev Nutr 7, 187208.
19 Gannon, MC, Nuttall, FQ, Westphal, SA, et al. (1989) Effects of dose of ingested glucose on plasma metabolite and hormone responses in type II diabetic subjects. Diabetes Care 12, 544552.
20 Hill, JO (2006) Understanding and addressing the epidemic of obesity: an energy balance perspective. Endocr Rev 27, 750761.
21 Butte, NF & Ellis, KJ (2003) Comment on ‘Obesity and the environment: where do we go from here?’ author reply. Science 301, 598.
22 Swinburn, BA, Jolley, D, Kremer, PJ, et al. (2006) Estimating the effects of energy imbalance on changes in body weight in children. Am J Clin Nutr 83, 859863.
23 Weinsier, RL, Bracco, D & Schutz, Y (1993) Predicted effects of small decreases in energy expenditure on weight gain in adult women. Int J Obes Relat Metab Disord 17, 693700.
24 Ravussin, E (1995) Obesity in Britain. Rising trend may be due to ‘pathoenvironment’. BMJ 311, 1569.
25 Seagle, HM, Bessesen, DH & Hill, JO (1998) Effects of sibutramine on resting metabolic rate and weight loss in overweight women. Obes Res 6, 115121.
26 Hansen, DL, Toubro, S, Stock, MJ, et al. (1998) Thermogenic effects of sibutramine in humans. Am J Clin Nutr 68, 11801186.
27 Yoshioka, M, Doucet, E, Drapeau, V, et al. (2001) Combined effects of red pepper and caffeine consumption on 24 h energy balance in subjects given free access to foods. Br J Nutr 85, 203211.
28 Yoshioka, M, St-Pierre, S, Drapeau, V, et al. (1999) Effects of red pepper on appetite and energy intake. Br J Nutr 82, 115123.
29 Reinbach, HC, Smeets, A, Martinussen, T, et al. (2009) Effects of capsaicin, green tea and CH-19 sweet pepper on appetite and energy intake in humans in negative and positive energy balance. Clin Nutr 28, 260265.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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