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Effect of dietary consumption as a modifier on the association between FTO gene variants and excess body weight in children from an admixed population in Brazil: the Social Changes, Asthma and Allergy in Latin America (SCAALA) cohort study

  • Marília Vilella (a1), Gustavo Nunes de Oliveira Costa (a2), Maurício Lima Barreto (a2) (a3), Camila Alexandrina Figueredo (a4), Neuza Maria Alcantara-Neves (a5), Laura Cunha Rodrigues (a6), Sheila Maria Alvim de Matos (a2), Rosemeire Leovigildo Fiaccone (a5), Pablo Oliveira (a2), Aline Rocha (a1) and Rita de Cássia Ribeiro-Silva (a1)...
Abstract
Abstract

Previous studies have shown associations of variants of the FTO gene with body weight, but none of these have involved Latin American populations with a high level of miscegenation, as is seen in the north-eastern Brazilian population. This study evaluated the association between SNP in the FTO gene and excess weight in Salvador, Bahia, Brazil. In addition, the effect of diet as a modifier on this association was also investigated. This cross-sectional study included 1191 participants aged 4–11 years, who were genotyped for 400 variants of the FTO gene. Direct anthropometric measures were made and dietary data were obtained by 24-h food recall. Multivariate logistic regression analyses were used to assess the associations of interest. Overall, 11·2 % of the individuals included in the study were overweight/obese. Interactions were identified between the percentage energy intake from proteins and obesity risk linked to the rs62048379 SNP (P interaction=0·01) and also between fat intake (PUFA:SFA ratio) and obesity risk linked to the rs62048379 SNP (P interaction=0·01). The T allele for the variant rs62048379 was positively associated with overweight/obesity in individuals whose percentage energy intake from protein was above the median (OR 2·00; 95 % CI 1·05, 3·82). The rs62048379 SNP was also associated with overweight/obesity in individuals whose PUFA:SFA ratio was below the median (OR 1·63; 95 % CI 1·05, 2·55). The association between FTO gene variants and excess body weight can be modulated by dietary characteristics, particularly by fatty acid distribution and dietary protein intake in children.

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Corresponding author
* Corresponding author: R. de Cássia Ribeiro-Silva, email rcrsilva@ufba.br
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2. G Kourlaba , DB Panagiotakos , K Mihas , et al. (2009) Dietary patterns in relation to socio-economic and lifestyle characteristics among Greek adolescents: a multivariate analysis. Public Health Nutr 12, 13661372.

3. SI Berndt , S Gustafsson , R Magi , et al. (2013) Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet 45, 501512.

5. EE Snyder , B Walts , L Perusse , et al. (2004) The human obesity gene map: the 2003 update. Obes Res 12, 369439.

6. T Gerken , CA Girard , YC Tung , et al. (2007) The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318, 14691472.

7. A Moleres , MC Ochoa , T Rendo-Urteaga , et al. (2012) Dietary fatty acid distribution modifies obesity risk linked to the rs9939609 polymorphism of the fat mass and obesity-associated gene in a Spanish case-control study of children. Br J Nutr 107, 533538.

9. E Karra , OG O’Daly , AI Choudhury , et al. (2013) A link between FTO, ghrelin, and impaired brain food-cue responsivity. J Clin Invest 123, 35393551.

10. CM Phillips , E Kesse-Guyot , R McManus , et al. (2012) High dietary saturated fat intake accentuates obesity risk associated with the fat mass and obesity-associated gene in adults. J Nutr 142, 824831.

11. D Albuquerque , C Nobrega & L Manco (2013) Association of FTO polymorphisms with obesity and obesity-related outcomes in Portuguese children. PLOS ONE 8, e54370.

12. H Fang , Y Li , S Du , et al. (2010) Variant rs9939609 in the FTO gene is associated with body mass index among Chinese children. BMC Med Genet 11, 136.

14. CF da Silva , MR Zandona , MR Vitolo , et al. (2013) Association between a frequent variant of the FTO gene and anthropometric phenotypes in Brazilian children. BMC Med Genet 14, 34.

15. BH Lourenco , L Qi , WC Willett , et al. (2014) FTO genotype, vitamin D status, and weight gain during childhood. Diabetes 63, 808814.

16. A Mejia-Benitez , M Klunder-Klunder , L Yengo , et al. (2013) Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children. BMC Med Genet 14, 21.

17. RA Scott , ME Bailey , CN Moran , et al. (2010) FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males. Eur J Hum Genet 18, 13391343.

18. M Zhang , X Zhao , H Cheng , et al. (2014) Age- and sex-dependent association between FTO rs9939609 and obesity-related traits in Chinese children and adolescents. PLOS ONE 9, e97545.

19. ML Barreto , SS Cunha , N Alcantara-Neves , et al. (2006) Risk factors and immunological pathways for asthma and other allergic diseases in children: background and methodology of a longitudinal study in a large urban center in Northeastern Brazil (Salvador-SCAALA study). BMC Pulm Med 6, 15.

23. BN Howie , P Donnelly & J Marchini (2009) A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet 5, e1000529.

25. T Thornton , H Tang , TJ Hoffmann , et al. (2012) Estimating kinship in admixed populations. Am J Hum Genet 91, 122138.

26. CC Laurie , KF Doheny , DB Mirel , et al. (2010) Quality control and quality assurance in genotypic data for genome-wide association studies. Genet Epidemiol 34, 591602.

27. AL Price , NJ Patterson , RM Plenge , et al. (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38, 904909.

28. GN Costa , F Dudbridge , RL Fiaccone , et al. (2015) A genome-wide association study of asthma symptoms in Latin American children. BMC Genet 16, 141.

33. Q Qi , MK Downer , TO Kilpelainen , et al. (2015) Dietary intake, FTO genetic variants, and adiposity: a combined analysis of over 16,000 children and adolescents. Diabetes 64, 24672476.

34. M Belmonte & D Yurgelun-Todd (2001) Permutation testing made practical for functional magnetic resonance image analysis. IEEE Trans Med Imaging 20, 243248.

35. AD Skol , LJ Scott , GR Abecasis , et al. (2006) Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat Genet 38, 209213.

36. JC Barrett , B Fry , J Maller , et al. (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263265.

37. RJ Pruim , RP Welch , S Sanna , et al. (2010) LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics 26, 23362337.

38. MF Lima-Costa , LC Rodrigues , ML Barreto , et al. (2015) Genomic ancestry and ethnoracial self-classification based on 5,871 community-dwelling Brazilians (The Epigen Initiative). Sci Rep 5, 9812.

39. S Bollepalli , LM Dolan , R Deka , et al. (2010) Association of FTO gene variants with adiposity in African-American adolescents. Obesity (Silver Spring) 18, 19591963.

40. LJ Tan , H Zhu , H He , et al. (2014) Replication of 6 obesity genes in a meta-analysis of genome-wide association studies from diverse ancestries. PLOS ONE 9, e96149.

41. R Foraita , F Gunther , W Gwozdz , et al. (2015) Does the FTO gene interact with the socioeconomic status on the obesity development among young European children? Results from the IDEFICS study. Int J Obes 39, 16.

42. A Adeyemo , G Chen , J Zhou , et al. (2010) FTO genetic variation and association with obesity in West Africans and African Americans. Diabetes 59, 15491554.

43. FS Kehdy , MH Gouveia , M Machado , et al. (2015) Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations. Proc Natl Acad Sci U S A 112, 86968701.

44. E Sonestedt , C Roos , B Gullberg , et al. (2009) Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity. Am J Clin Nutr 90, 14181425.

45. D Corella , DK Arnett , KL Tucker , et al. (2011) A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI. J Nutr 141, 22192225.

46. T Huang , Q Qi , Y Li , et al. (2014) FTO genotype, dietary protein, and change in appetite: the Preventing Overweight Using Novel Dietary Strategies trial. Am J Clin Nutr 99, 11261130.

47. X Zhang , Q Qi , C Zhang , et al. (2012) FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: the POUNDS LOST Trial. Diabetes 61, 30053011.

48. P Gulati , MK Cheung , R Antrobus , et al. (2013) Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proc Natl Acad Sci U S A 110, 25572562.

49. MK Cheung , P Gulati , S O’Rahilly , et al. (2013) FTO expression is regulated by availability of essential amino acids. Int J Obes (Lond) 37, 744747.

50. A Moleres , T Rendo-Urteaga , MA Zulet , et al. (2012) Obesity susceptibility loci on body mass index and weight loss in Spanish adolescents after a lifestyle intervention. J Pediatr 161, 466470.e462.

51. S Krishnan & JA Cooper (2014) Effect of dietary fatty acid composition on substrate utilization and body weight maintenance in humans. Eur J Nutr 53, 691710.

53. M Claussnitzer , SN Dankel , KH Kim , et al. (2015) FTO obesity variant circuitry and adipocyte browning in humans. N Engl J Med 373, 895907.

54. S Smemo , JJ Tena , KH Kim , et al. (2014) Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature 507, 371375.

55. A Srivastava , B Mittal , J Prakash , et al. (2016) Association of FTO and IRX3 genetic variants to obesity risk in north India. Ann Hum Biol 43, 451456.

56. EJ Bellefroid , A Kobbe , P Gruss , et al. (1998) Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification. EMBO J 17, 191203.

57. W Willett & MJ Stampfer (1986) Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 124, 1727.

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