3. Bournat, JC & Brown, CW (2010) Mitochondrial dysfunction in obesity. Curr Opin Endocrinol Diabetes Obes 17, 446–452.
4. Brøns, C, Jacobsen, S, Hiscock, N, et al. (2012) Effects of high-fat overfeeding on mitochondrial function, glucose and fat metabolism, and adipokine levels in low-birth-weight subjects. Am J Physiol Endocrinol Metab 302, E43–E51.
5. Giacco, F & Brownlee, M (2010) Oxidative stress and diabetic complications. Circ Res 107, 1058–1070.
6. Nowotny, K, Jung, T, Höhn, A, et al. (2015) Advanced glycation end products and oxidative stress in type 2 diabetes mellitus. Biomolecules 5, 194–222.
7. Siemieniuk, E & Skrzydlewska, E (2005) Coenzyme Q10: its biosynthesis and biological significance in animal organisms and in humans. Postepy Hig Med Dosw 59, 150–159.
8. Ernster, L & Dallner, G (1995) Biochemical, physiological and medical aspects of ubiquinone function. Biochim Biophys Acta 1271, 195–204.
9. Bentinger, M, Tekle, M & Dallner, G (2010) Coenzyme Q – biosynthesis and functions. Biochem Biophys Res Commun 396, 74–79.
10. Lee, BJ, Huang, YC, Chen, SJ, et al. (2012) Coenzyme Q10 supplements reduce oxidative stress and increase activities of antioxidant enzymes in patients with coronary artery disease. Nutrition 28, 250–255.
11. Lee, BJ, Tseng, YF, Yen, CH, et al. (2013) Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial. Nutr J 12, 142.
12. Liu, HT, Huang, YC, Cheng, SB, et al. (2016) Effects of coenzyme Q10 supplementation on antioxidant capacity and inflammation in hepatocellular carcinoma patients after surgery: a randomized, placebo-controlled trial. Nutr J 15, 85.
13. Mae, T, Sakamoto, Y, Morikawa, S, et al. (2001) Pharmacetical compostition comprising coenzyme Q10. United States Patent US 6,184,255 B1, 2001.
14. Bhagavan, HN & Chopra, RK (2007) Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion 7, Suppl. S78–S88.
15. Langsjoen, PH & Langsjoen, AM (2014) Comparison study of plasma coenzyme Q10 levels in healthy subjects supplemented with ubiquinol versus ubiquinone. Clin Pharmacol Drug Dev 3, 13–17.
16. Miles, MV, Horn, P, Miles, L, et al. (2002) Bioequivalence of coenzyme Q10 from over-the counter supplements. Nutr Res 22, 919–929.
17. Watts, GF, Playford, DA, Croft, KD, et al. (2002) Coenzyme Q10 improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus. Diabetologia 45, 420–426.
18. El-ghoroury, EA, Raslan, HM, Badawy, EA, et al. (2009) Malondialdehyde and coenzyme Q10 in platelets and serum in type 2 diabetes mellitus: correlation with glycemic control. Blood Coagul Fibrinolysis 20, 248–251.
19. Shen, Q & Pierce, JD (2015) Supplementation of coenzyme Q10 among patients with type 2 diabetes mellitus. Healthcare (Basel) 3, 296–309.
20. Hodgson, JM, Watts, GF, Playford, DA, et al. (2002) Coenzyme Q10 improves blood pressure and glycaemic control: A controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr 56, 1137–1142.
21. Suksomboon, N, Poolsup, N & Juanak, N (2015) Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther 40, 413–418.
22. Mayer, B, Jeffreys, AS, Olsen, MK, et al. (2014) Two diets with different haemoglobin A1c and antiglycaemic medication effects despite similar weight loss in type 2 diabetes. Diabetes Obes Metab 16, 90–93.
23. Nathan, DM, Buse, JB, Davidson, MB, et al. (2009) Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. Diabetes Care 27, 4–16.
24. Botsoglou, NA (1994) Rapid, sensitive, and specific thiobarbituric acid method for measuring lipid peroxidation in animal tissue, food and feedstuff samples. J Agric Food Chem 42, 1931–1937.
25. Paglia, D & Valentine, W (1967) Studies on the qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70, 159–169.
26. Marklund, S & Marklund, G (1974) Involvement of superoxide anion radical in autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47, 469–474.
27. Aebi, H (1984) Catalase in vitro
. Methods Enzymol 105, 121–126.
28. Littarru, GP, Mosca, F, Fattorini, D, et al. (2007) Method to assay coenzyme Q10 in blood plasma or blood serum. United States Patent 7303921.
29. Shigeta, Y, LIzumi, K & Abe, H (1966) Effect of coenzyme Q7 treatment on blood sugar and ketone bodies of diabetes. J Vitaminol 12, 293–298.
30. Kolahdouz Mohammadi, R, Hosseinzadeh-Attar, MJ, Eshraghian, MR, et al. (2013) The effect of coenzyme Q10 supplementation on metabolic status of type 2 diabetic patients. Minerva Gastroenterol Dietol 59, 231–236.
31. Bonora, E, Targher, G, Alberiche, M, et al. (2000) Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 23, 57–63.
32. Matthews, DR, Hosker, JP, Rudenski, AS, et al. (1985) Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412–419.
33. Amin, MM, Asaad, GF, Salam, RMA, et al. (2014) Novel CoQ10 antidiabetic mechanisms underlie its positive effect: modulation of insulin and adiponectine receptors, tyrosine kinase, PI3K, glucose transporters, sRAGE and visfatin in insulin resistant/diabetic rats. PLOS ONE 9, e89169.
34. Rains, JL & Jain, SK (2011) Oxidative stress, insulin signaling, and diabetes. Free Radic Biol Med 50, 567–575.
35. Mooradian, AD (2009) Dyslipidemia in type 2 diabetes mellitus. Nat Clin Pract Endocrinol Metab 5, 150–159.
36. Barter, PJ (2011) The causes and consequences of low levels of high density lipoproteins in patients with diabetes. Diabetes Metab J 35, 101–106.
37. Singh, RB, Niaz, M, Rastogi, S, et al. (1999) Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens 13, 203–208.
38. Mohr, D, Bowry, VW & Stocker, R (1992) Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta 1126, 247–254.