Skip to main content Accessibility help
×
Home

Effects of dietary strawberry powder on blood lipids and inflammatory markers in obese human subjects

  • Susan J. Zunino (a1), Mardi A. Parelman (a2), Tammy L. Freytag (a1), Charles B. Stephensen (a1), Darshan S. Kelley (a1), Bruce E. Mackey (a3), Leslie R. Woodhouse (a1) and Ellen L. Bonnel (a2)...

Abstract

Obesity is a strong risk factor for the development of CVD, hypertension and type 2 diabetes. The overall goal of the present pilot study was to feed strawberries, in the form of freeze-dried powder, to obese subjects to determine whether dietary strawberries beneficially altered lipid profiles and reduced blood markers of inflammation compared with a control intervention. A total of twenty healthy subjects (thirteen females and seven males) aged between 20 and 50 years with a BMI between 30 and 40 kg/m2 completed the present 7-week double-blind, randomised, cross-over trial. Each subject received a prepared diet 7 d/week for 7 weeks consisting of approximately 35 % of energy from fat, 20 % protein, 45 % carbohydrate and 14 g fibre. Blood was collected on days 1 and 8 for baseline information. After the first week, subjects were randomly assigned to the strawberry powder (equivalent to four servings of frozen strawberries) or control (strawberry-flavoured) intervention for 3 weeks. For the remaining 3 weeks, subjects crossed over to the opposite intervention. Blood was collected again at the end of weeks 3, 4, 6 and 7. A comprehensive chemistry panel, lipid profile analyses and measurement of inflammatory mediators were performed for each blood draw. A 3-week dietary intervention with strawberry powder reduced plasma concentrations of cholesterol and small HDL-cholesterol particles, and increased LDL particle size in obese subjects (P < 0·05). Dietary strawberry powder reduced risk factors for CVD, stroke and diabetes in obese volunteers, suggesting a potential role for strawberries as a dietary means to decrease obesity-related disease.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Effects of dietary strawberry powder on blood lipids and inflammatory markers in obese human subjects
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Effects of dietary strawberry powder on blood lipids and inflammatory markers in obese human subjects
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Effects of dietary strawberry powder on blood lipids and inflammatory markers in obese human subjects
      Available formats
      ×

Copyright

Corresponding author

*Corresponding author: Dr S. J. Zunino, fax +1 530 752 5271, email susan.zunino@ars.usda.gov

References

Hide All
1Flegal, KM, Carroll, MD, Ogden, CL, et al. (2010) Prevalence and trends in obesity among US adults, 1999–2008. JAMA 303, 235241.
2Nguyen, DM & El-Serag, HB (2010) The epidemiology of obesity. Gastroenterol Clin North Am 39, 17.
3Finkelstein, EA, Trogdon, JG, Cohen, JW, et al. (2009) Annual medical spending attributable to obesity: payer- and service-specific estimates. Health Aff (Millwood) 28, w822w831.
4Samartin, S & Chandra, RK (2001) Obesity, overnutrition and the immune system. Nutr Res 21, 243262.
5Libby, P (2002) Inflammation in atherosclerosis. Nature 420, 868872.
6Hotamisligil, GS, Arner, P, Caro, JF, et al. (1995) Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 95, 24092415.
7Mohamed-Ali, V, Goodrick, S, Rawesh, A, et al. (1997) Human subcutaneous adipose tissue releases IL6 but not TNF-alpha in vivo. J Clin Endocrinol Metab 82, 41964200.
8O'Brien, KD & Chait, A (2006) Serum amyloid A; the “other” inflammatory protein. Curr Atheroscler Rep 8, 6268.
9Faber, DR, de Groot, PG & Visseren, FL (2009) Role of adipose tissue in haemostasis, coagulation and fibrinolysis. Obesity Res 10, 554563.
10Rosenson, RS & Koenig, W (2003) Utility of inflammatory markers in the management of coronary artery disease. Am J Cardiol 92, 1018.
11Fain, JN (2006) Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells. Vitam Horm 74, 443477.
12Pickup, JC (2004) Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 27, 813823.
13Straczkowski, M, Lewczuk, P, Dzienis-Straczkowski, S, et al. (2002) Elevated soluble intercellular adhesion molecule-1 levels in obesity: relationship to insulin resistance and tumor necrosis factor-alpha system activity. Metabolism 51, 7578.
14Shai, I, Pischon, T, Hu, FB, et al. (2006) Soluble intercellular adhesion molecules, soluble vascular cell adhesion molecules, and risk of coronary heart disease. Obesity 14, 20992106.
15Kim, C-S, Park, H-S, Kawada, T, et al. (2006) Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters. Int J Obes 30, 13471355.
16Otero, M, Lago, R, Lago, F, et al. (2005) Leptin, from fat to inflammation: old question and new insights. FEBS Lett 579, 295301.
17Lago, R, Gómez, R, Lago, F, et al. (2008) Leptin beyond body weight regulation – current concepts concerning its role in immune function and inflammation. Cell Immunol 252, 139145.
18Basu, A, Rhone, M & Lyons, TJ (2010) Berries: emerging impact on cardiovascular health. Nutr Rev 68, 168177.
19Hannum, SM (2004) Potential impact of strawberries on human health: a review of the science. Crit Rev Food Sci Nutr 44, 117.
20United States Department of Agriculture, Agricultural Research Service (2009) National nutrient database for standard reference, release 22. http://www.ars.usda.gov/main/site_main.htm?modecode = 12-35-45-00 (accessed 24 September 2010).
21Erkkilä, AT & Lichtenstein, AH (2006) Fiber and cardiovascular disease risk: how strong is the evidence? J Cardiovasc Nurs 21, 38.
22Bao, B, Prasad, AS, Beck, FWJ, et al. (2010) Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent. Am J Clin Nutr 91, 16341641.
23Costarelli, L, Muti, E, Malavolta, M, et al. (2010) Distinctive modulation of inflammatory and metabolic parameters in relation to zinc nutritional status in adult overweight/obese subjects. J Nutr Biochem 21, 432437.
24Yang, YJ, Choi, BY, Chun, BY, et al. (2010) Dietary zinc intake is inversely related to subclinical atherosclerosis measured by carotid intima–media thickness. Br J Nutr 104, 12021211.
25Mifflin, MD, St Jeor, ST, Hill, LA, et al. (1990) A new predictive equation for resting energy expenditure in healthy individuals. Am J Clin Nutr 51, 241247.
26Centers for Disease Control and Prevention (1994) Daily dietary fat and total food-energy intakes – Third National Health and Nutrition Examination Survey, Phase 1, 1988–91. MMWR Morb Mortal Wkly Rep 43, 116117, 123–125.
27 United States Department of Health and Human Services, National Center for Health Statistics (1996) The Third National Health and Nutrition Examination Survey (NHANES III, 1988–94) Reference Manuals and Reports. NCHS CD-ROM. Hyattsville, MD: Centers for Disease Control and Prevention.
28Jeyarajah, EJ, Cromwell, WC & Otvos, JD (2006) Lipoprotein particle analysis by nuclear magnetic resonance spectroscopy. Clin Lab Med 26, 847870.
29Prior, RL, Hoang, H, Gu, L, et al. (2003) Assays for hydrophilic and lipophilic antioxidant capacity (oxygen radical absorbance capacity (ORAC(FL)) of plasma and other biological and food samples. J Agric Food Chem 51, 32733279.
30Basu, A, Wilkinson, M, Penugonda, K, et al. (2009) Freeze-dried strawberry powder improves lipid profile and lipid peroxidation in women with metabolic syndrome: baseline and post intervention effects. Nutr J 8, 4349.
31Basu, A, Fu, DX, Wilkinson, M, et al. (2010) Strawberries decrease atherosclerotic markers in subjects with metabolic syndrome. Nutr Res 30, 462469.
32Jenkins, DJA, Nguyen, TH, Kendall, CWC, et al. (2008) The effect of strawberries in a cholesterol-lowering dietary portfolio. Metabolism 57, 16361644.
33Cheung, MC, Brown, BG, Wolf, AC, et al. (1991) Altered particle size distribution of apolipoprotein A-I-containing lipoproteins in subjects with coronary artery disease. J Lipid Res 32, 383394.
34Bhalodkar, NC, Blum, S, Rana, T, et al. (2004) Comparison of levels of large and small high-density lipoprotein cholesterol in Asian Indian men compared with Caucasian men in the Framington Offspring Study. Am J Cardiol 94, 15611563.
35Zeljkovic, A, Vekic, J, Spasojevic-Kalimanovska, V, et al. (2010) LDL and HDL subclasses in acute ischemic stroke: prediction of risk and short-term mortality. Atherosclerosis 210, 548554.
36Rivellese, AA, Patti, L, Kaufman, D, et al. (2008) Lipoprotein particle distribution and size, insulin resistance, and metabolic syndrome in Alaska Eskimos: The GOCADAN Study. Atherosclerosis 200, 350358.
37Festa, A, Williams, K, Hanley, AJG, et al. (2005) Nuclear magnetic resonance lipoprotein abnormalities in prediabetic subjects in the Insulin Resistance Atherosclerosis Study. Circulation 111, 34653472.
38Koba, S, Yokota, Y, Hirano, T, et al. (2008) Small LDL-cholesterol is superior to LDL-cholesterol for determining severe coronary atherosclerosis. J Atherosclerosis Thromb 15, 250260.
39Garvey, WT, Kwon, S, Zheng, D, et al. (2003) Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonance. Diabetes 52, 453462.
40Rizzo, M, Pernice, V, Frasheri, A, et al. (2009) Small, dense low-density lipoproteins (LDL) are predictors of cardio- and cerebro-vascular events in subjects with the metabolic syndrome. Clin Endocrinol 70, 870875.
41Lyons, TJ, Jenkins, AJ, Zheng, D, et al. (2006) Nuclear magnetic resonance-determined lipoprotein subclass profile in the DCCT/EDIC cohort: associations with carotid intima–media thickness. Diabet Med 23, 955966.
42Arsenault, BJ, Lemieux, I, Despres, JP, et al. (2009) HDL particle size and the risk of coronary heart disease in apparently healthy men and women: the EPIC-Norfolk prospective population study. Atherosclerosis 206, 276281.
43Sesso, HD, Gaziano, JM, Jenkins, DJ, et al. (2007) Strawberry intake, lipids, C-reactive protein, and the risk of cardiovascular disease in women. J Am Coll Nutr 26, 303310.
44Ruel, G, Pomerleau, S, Couture, P, et al. (2008) Low-calorie cranberry juice supplementation reduces plasma oxidized LDL and cell adhesion molecule concentrations in men. Br J Nutr 99, 352359.
45Erlund, I, Koli, R, Alfthan, G, et al. (2008) Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 87, 323331.
46Edirisinghe, I, Banaszewski, K, Cappozzo, J, et al. (2011) Strawberry anthocyanin and its association with postprandial inflammation and insulin. Br J Nutr 106, 913922.
47Burton-Freeman, B, Linares, A, Hyson, D, et al. (2010) Strawberry modulates LDL oxidation and postprandial lipemia in response to high-fat meal in overweight hyperlipidemic men and women. J Am Coll Nutr 29, 4654.
48Henning, SM, Seeram, NP, Zhang, Y, et al. (2010) Strawberry consumption is associated with increased antioxidant capacity in serum. J Med Food 13, 116122.
49Wojdyło, A, Figiel, A & Oszmiański, J (2009) Effect of drying methods with the application of vacuum microwaves on the bioactive compounds, color, and antioxidant activity of strawberry fruits. J Agric Food Chem 57, 13371343.

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed