Hostname: page-component-848d4c4894-nr4z6 Total loading time: 0 Render date: 2024-05-28T23:31:36.827Z Has data issue: false hasContentIssue false

Emerging diet-related surrogate end points for colorectal cancer: UK Food Standards Agency diet and colonic health workshop report

Published online by Cambridge University Press:  09 March 2007

Peter Sanderson*
Affiliation:
Nutrition Division, Food Standards Agency, London, UK
Ian T. Johnson
Affiliation:
Intestinal Health and Function Group, Institute of Food Research, Norwich, UK
John C. Mathers
Affiliation:
Human Nutrition Research Centre, University of Newcastle, UK
Hilary J. Powers
Affiliation:
The Centre for Human Nutrition, University of Sheffield, UK
C. Stephen Downes
Affiliation:
School of Biomedical Sciences, University of Ulster, Coleraine, UK
Angela P. McGlynn
Affiliation:
School of Biomedical Sciences, University of Ulster, Coleraine, UK
Rae Dare
Affiliation:
School of Biomedical Sciences, University of Ulster, Coleraine, UK
Ellen Kampman
Affiliation:
Division of Human Nutrition and Epidemiology, Wageningen University, The Netherlands
Beatrice L. Pool-Zobel
Affiliation:
Friedrich-Schiller-University of Jena, Institute for Nutrition and Nutritional Toxicology, Jena, Germany
Sheila A. Bingham
Affiliation:
MRC Dunn Human Nutrition Unit, Cambridge, UK
Joseph J. Rafter
Affiliation:
Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
*
*Corresponding author: Dr Peter Sanderson, fax +44 20 7276 8906, email peter.sanderson@foodstandards.gsi.gov.uk
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The UK Food Standards Agency convened a group of expert scientists to review current research investigating emerging diet-related surrogate end points for colorectal cancer (CRC). The workshop aimed to overview current research and establish priorities for future research. The workshop considered that the validation of current putative diet-related surrogate end points for CRC and the development of novel ones, particularly in the emerging fields of proteomics, genomics and epigenomics, should be a high priority for future research.

Type
Research Article
Copyright
Copyright © The Nutrition Society 2004

References

Ahuja, N, Li, Q, Mohan, AL, Baylin, SB & Issa, JP (1998) Aging and DNA methylation in colorectal mucosa and cancer. Cancer Res 58, 54895494.Google ScholarPubMed
Bandaletova, T, Bailey, N, Bingham, S & Loktionov, A (2002) Isolation of exfoliated colonocytes from the human stool as a new technique for colonic cytology. APMIS 110, 239246.CrossRefGoogle ScholarPubMed
Baron, JA (2001) Intermediate effect markers for colorectal cancer. IARC Sci Publ 154, 113129.Google ScholarPubMed
Baylin, SB, Herman, JG, Graff, JR, Vertino, PM & Issa, JP (1998) Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res 72, 141196.CrossRefGoogle ScholarPubMed
Bedi, A, Pasricha, PJ, Akhtar, AJ et al. (1995) Inhibition of apoptosis during development of colorectal cancer. Cancer Res 55, 18111816.Google ScholarPubMed
Bernstein, H, Holubec, H, Warneke, JA et al. (2002) Patchy field defects of apoptosis resistance and dedifferentiation in flat mucosa of colon resections from colon cancer patients. Ann Surg Oncol 9, 505517.CrossRefGoogle ScholarPubMed
Bingham, SA, Hughes, R & Cross, AJ (2002) Effect of white versus red meat on endogenous N -nitrosation in the human colon and further evidence of a dose response. J Nutr 132, 3522S3525S.CrossRefGoogle ScholarPubMed
Bingham, SA, Pignatelli, B, Pollock, JR et al. (1996) Does increased endogenous formation of N -nitroso compounds in the human colon explain the association between red meat and colon cancer? Carcinogenesis 17, 515523.CrossRefGoogle Scholar
Boffa, LC, Lupton, JR, Mariani, MR et al. (1992) Modulation of colonic epithelial cell proliferation, histone acetylation, and luminal short chain fatty acids by variation of dietary fiber (wheat bran) in rats. Cancer Res 52, 59065912.Google ScholarPubMed
Chen, RZ, Pettersson, U, Beard, C, Jackson-Grusby, L & Jaenisch, R (1998) DNA hypomethylation leads to elevated mutation rates. Nature 395, 8993.CrossRefGoogle ScholarPubMed
Cross, AJ, Pollock, JRA & Bingham, SA (2003) Haem, not protein or inorganic iron, is responsible for endogenous intestinal N -nitrosation arising from red meat. Cancer Res 63, 23582360.Google ScholarPubMed
Davies, RJ, Freeman, A, Morris, LS et al. (2002) A novel method for detecting colorectal cancer in stool. Lancet 359, 19171919.CrossRefGoogle ScholarPubMed
Davis, CD, Uthus, EO & Finley, JW (2000) Dietary selenium and arsenic affect DNA methylation in vitro in Caco-2 cells and in vivo in rat liver and colon. J Nutr 130, 29032909.CrossRefGoogle ScholarPubMed
Day, JK, Bauer, AM & DesBordes, C (2002) Genistein alters methylation patterns in mice. J Nutr 132, 2419S2423S.CrossRefGoogle ScholarPubMed
Diergaarde, B, Van Geloof, WL, Van Muijen, GN, Kok, FJ & Kampman, E (2003) Dietary factors and the occurrence of truncating APC mutations in sporadic colon carcinomas: a Dutch population-based study. Carcinogenesis 24, 283290.CrossRefGoogle ScholarPubMed
Ebert, MN, Beyer-Sehlmeyer, G, Liegibel, UM, Kautenburger, T, Becker, TW & Pool-Zobel, BL (2001) Butyrate-induced activation of glutathione S-transferases protects human colon cells from genetic damage by 4-hydroxynonenal. Nutr Canc 41, 156164.CrossRefGoogle Scholar
Ebert, MN, Klinder, A, Peters, WH et al. (2003) Expression of glutathione S-transferases (GSTs) in human colon cells and inducibility of GSTM2 by butyrate. Carcinogenesis 24, 16371644.CrossRefGoogle ScholarPubMed
Esteller, M, Risques, RA, Toyota, M et al. (2001) Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis. Cancer Res 61, 46894692.Google Scholar
Esteller, M, Sparks, A, Toyota, M et al. (2000) Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer. Cancer Res 60, 43664371.Google ScholarPubMed
Gitan, RS, Shi, H, Chen, CM, Yan, PS & Huang, TH (2002) Methylation-specific oligonucleotide microarray: a new potential for high-throughput methylation analysis. Genome Res 12, 158164.CrossRefGoogle ScholarPubMed
Hayes, JD & Strange, RC (1995) Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress. Free Radic Res 22, 193207.CrossRefGoogle ScholarPubMed
Herman, JG, Umar, A, Polyak, K et al. (1998) Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci 95, 68706875.CrossRefGoogle ScholarPubMed
Hinnebusch, BF, Meng, S, Wu, JT, Archer, SY & Hodin, RA (2002) The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation. J Nutr 132, 10121017.CrossRefGoogle ScholarPubMed
Hirst, J & Goodin, DB (2000) Unusual oxidative chemistry of N-hydroxyarginine and H-hydroxyguanidine catalysed at an engineered cavity in heme peroxidase. J Biol Chem 275, 85828591.CrossRefGoogle Scholar
Hughes, R, Cross, AJ, Pollock, JR & Bingham, S (2001) Dose-dependent effect of dietary meat on endogenous colonic N -nitrosation. Carcinogenesis 22, 199202.CrossRefGoogle ScholarPubMed
Hughes, R, Pollock, JR & Bingham, S (2002) Effect of vegetables, tea and soya on endogenous N -nitrosation, faecal ammonia and faecal water genotoxicity during a high red meat diet in humans. Nutr Cancer 42, 7077.CrossRefGoogle ScholarPubMed
Johanning, GL, Heimburger, DC & Piyathilake, CJ (2002) DNA methylation and diet in cancer. J Nutr 132, 3814S3818S.CrossRefGoogle ScholarPubMed
Johnson, IT (2002) Anticarcinogenic effects of diet-related apoptosis in the colorectal mucosa. Food Chem Toxicol 40, 11711178.CrossRefGoogle ScholarPubMed
Jones, PA & Takai, D (2001) The role of DNA methylation in mammalian epigenetics. Science 293, 10681070.CrossRefGoogle ScholarPubMed
Jubb, AM, Bell, SM & Quirke, P (2001) Methylation and colorectal cancer. J Pathol 195, 111134.CrossRefGoogle ScholarPubMed
Keku, TO, Galanko, JA, Murray, SC, Woosley, JT & Sandler, RS (1998) Rectal mucosal proliferation, dietary factors, and the risk of colorectal adenomas. Cancer Epidemiol Biomarkers Prev 7, 993999.Google ScholarPubMed
Kim, YI, Fawaz, K, Knox, T et al. (1998) Colonic mucosal concentrations of folate correlate well with blood measurements in persons with colorectal polyps. Am J Clin Nutr 68, 866872.Google ScholarPubMed
Kim, YI, Fawaz, K, Knox, T et al. (2001) Colonic mucosal concentrations of folate are accurately predicted by blood measurements of folate status among individuals ingesting physiologic concentrations of folate. Cancer Epidemiol Biomarkers Prev 10, 715719.Google ScholarPubMed
Kinzler, KW & Vogelstein, B (1996) Lessons from hereditary colorectal cancer. Cell 87, 159170.CrossRefGoogle ScholarPubMed
Lampe, JW, Chen, C, Li, S et al. (2000) Modulation of human glutathione S-transferases by botanically defined vegetable diets. Cancer Epidemiol Biomarkers Prev 9, 787793.Google ScholarPubMed
Lampe, JW & Peterson, S (2002) Brassica, biotransformation and cancer risk: genetic polymorphisms alter the preventive effects of cruciferous vegetables. J Nutr 132, 29912994.CrossRefGoogle ScholarPubMed
Leslie, A, Carey, FA, Pratt, NR & Steele, RJ (2002) The colorectal adenoma–carcinoma sequence. Br J Surg 89, 845860.CrossRefGoogle ScholarPubMed
Leuratti, C, Watson, MA, Deag, EJ et al. (2002) Detection of a malondialdehyde DNA adduct in human colorectal biopsy DNA: relationship with diet and the presence of adenomatous polyps. Cancer Epidemiol Biomarkers Prev 11, 267273.Google Scholar
Liegibel, UM, Abrahamse, SL, Pool-Zobel, BL & Rechkemmer, G (2000) Application of confocal laser scanning microscopy to detect oxidative stress in human colon cells. Free Radic Res 32, 535547.CrossRefGoogle ScholarPubMed
Martin, C, Connelly, A, Keku, TO et al. (2002) Nonsteroidal anti-inflammatory drugs, apoptosis, and colorectal adenomas. Gastroenterology 123, 17701777.CrossRefGoogle ScholarPubMed
Matullo, G, Peluso, M & Polidoro, S (2003) Combination of DNA repair gene single nucleotide polymorphisms and increased levels of DNA adducts in a population-based study. Cancer Epidemiol Biomarkers Prev 12, 674677.Google ScholarPubMed
Nakagawa, H, Nuovo, GJ & Zervos, EE (2001) Age-related hypermethylation of the 5’ region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development. Cancer Res 61, 69916995.Google ScholarPubMed
Norat, T, Lukanova, A, Ferrari, P & Riboli, E (2002) Meat consumption and colorectal cancer risk: dose–response meta-analysis of epidemiological studies. Int J Cancer 98, 241256.CrossRefGoogle ScholarPubMed
Palli, D, Vineis, P & Russo, A (2000) Diet, metabolic polymorphisms and DNA adducts: the EPIC-Italy cross-sectional study. Int J Cancer 87, 444451.3.0.CO;2-#>CrossRefGoogle ScholarPubMed
Pool-Zobel, BL, Abrahamse, SL & Collins, AR (1999) Analysis of DNA strand breaks, oxidized bases, and glutathione S-transferase P1 in human colon cells from biopsies. Cancer Epidemiol Biomarkers Prev 8, 609614.Google ScholarPubMed
Rashid, A, Shen, L, Morris, JS, Issa, JP & Hamilton, SR (2001) CpG island methylation in colorectal adenomas. Am J Pathol 159, 11291135.CrossRefGoogle ScholarPubMed
Ricciardiello, L, Goel, A & Mantovani, V (2003) Frequent loss of hMLH1 by promoter hypermethylation leads to microsatellite instability in adenomatous polyps of patients with a single first-degree member affected by colon cancer. Cancer Res 63, 787792.Google ScholarPubMed
Roediger, WEW (1989) The utilisation of nutrients by isolated epithelial cells of the rat colon. Gastroenterology 83, 424429.CrossRefGoogle Scholar
Rowling, MJ, McMullen, MH, Chipman, DC & Schalinske, KL (2002 a) Hepatic glycine N-methyltransferase is up-regulated by excess dietary methionine in rats. J Nutr 132, 25452550.CrossRefGoogle ScholarPubMed
Rowling, MJ, McMullen, MH & Schalinske, KL (2002 b) Vitamin A and its derivatives induce hepatic glycine N-methyltransferase and hypomethylation of DNA in rats. J Nutr 132, 365369.CrossRefGoogle ScholarPubMed
Sandler, RS, Baron, JA, Tosteson, TD, Mandel, JS & Haile, RW (2000) Rectal mucosal proliferation and risk of colorectal adenomas: results from a randomized controlled trial. Cancer Epidemiol Biomarkers Prev 9, 653656.Google ScholarPubMed
Sato, F, Shibata, D & Harpaz, N (2002) Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma. Cancer Res 62, 68206822.Google ScholarPubMed
Schäferhenrich, A, Beyer-Sehlmeyer, G & Festag, G (2003 a) Human adenoma cells are highly susceptible to the genotoxic action of 4-hydroxy-2-nonenal. Mutat Res 526, 1932.CrossRefGoogle Scholar
Schäferhenrich, A, Sendt, W & Scheele, J (2003 b) Putative colon cancer risk factors damage global DNA and TP53 in primary human colon cells isolated from surgical samples. Food Chem Toxicol 41, 655664.CrossRefGoogle Scholar
Seow, A, Yuan, JM, Sun, CL, Van Den Berg, D, Lee, HP & Yu, MC (2002) Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study. Carcinogenesis 23, 20552061.CrossRefGoogle ScholarPubMed
Silvester, KR, Bingham, SA, Pollock, JR, Cummings, JH & O'Neill, IK (1997) Effect of meat and resistant starch on fecal excretion of apparent N -nitroso compounds and ammonia from the human large bowel. Nutr Cancer 29, 1323.CrossRefGoogle ScholarPubMed
Slattery, ML, Curtin, K & Anderson, K (2000) Associations between dietary intake and Ki-ras mutations in colon tumors: a population-based study. Cancer Res 60, 69356941.Google ScholarPubMed
Slattery, ML, Curtin, K & Ma, K (2002) Diet activity, and lifestyle associations with p53 mutations in colon tumors. Cancer Epidemiol Biomarkers Prev 11, 541548.Google ScholarPubMed
Smith, G, Carey, FA & Beattie, J (2002) Mutations in APC, Kirsten-ras, and p53 – alternative genetic pathways to colorectal cancer. Proc Natl Acad Sci 99, 94339438.CrossRefGoogle ScholarPubMed
Tiemersma, EW, Kloosterman, J, Bunschoten, A, Kok, FJ & Kampman, E (2002) Role of EPHX genotype in the associations of smoking and diet with colorectal adenoma. IARC Sci Publ 156, 491493.Google Scholar
Tiemersma, EW, Wark, PA & Ocké, MC (2003) Alcohol consumption, alcohol dehydrogenase 3 polymorphism, and colorectal adenomas. Cancer Epidemiol Biomarkers Prev 12, 419425.Google ScholarPubMed
Van den Donk, M, Pellis, EP, Keijer, J, Kok, FJ, Nagengast, FM & Kampman, E (2002) The role of folic acid and vitamin B12 in colorectal carcinogenesis in genetically different individuals – design of a study. IARC Sci Publ 156, 499500.Google ScholarPubMed
Vogelstein, B, Fearon, ER & Hamilton, SR (1988) Genetic alterations during colorectal-tumor development. N Engl J Med 319, 525532.CrossRefGoogle ScholarPubMed
Vogelstein, B, Lane, D & Levine, AJ (2000) Surfing the p53 network. Nature 408, 307310.CrossRefGoogle ScholarPubMed
Williams, EA, Coxhead, JM & Mathers, JC (2003) Anti-cancer effects of butyrate: use of micro-array technology to investigate mechanisms. Proc Nutr Soc 62, 107115.CrossRefGoogle ScholarPubMed
Yan, PS, Efferth, T & Chen, HL (2002) Use of CpG island microarrays to identify colorectal tumors with a high degree of concurrent methylation. Methods 27, 162169.CrossRefGoogle ScholarPubMed