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Evaluation of the effect of wheat aleurone-rich foods on markers of antioxidant status, inflammation and endothelial function in apparently healthy men and women

  • Ruth K. Price (a1), Julie M. W. Wallace (a1), Lesley L. Hamill (a1), Edel M. Keaveney (a1), J. J. Strain (a1), Michael J. Parker (a2) and Robert W. Welch (a1)
  • DOI:
  • Published online: 16 January 2012

Observational data show an inverse association between the consumption of wholegrain foods, and inflammation and related diseases. Although the underlying mechanisms are unclear, wholegrains, and in particular the aleurone layer, contain a wide range of components with putative antioxidant and anti-inflammatory effects. We evaluated the effects of a diet high in wheat aleurone on plasma antioxidants status, markers of inflammation and endothelial function. In this parallel, participant-blinded intervention, seventy-nine healthy, older, overweight participants (45–65 years, BMI>25 kg/m2) incorporated either aleurone-rich cereal products (27 g aleurone/d), or control products balanced for fibre and macronutrients, into their habitual diets for 4 weeks. Fasting blood samples were taken at baseline and on day 29. Results showed that, compared to control, consumption of aleurone-rich products provided substantial amounts of micronutrients and phytochemicals which may function as antioxidants. Additionally, incorporating these products into a habitual diet resulted in significantly lower plasma concentrations of the inflammatory marker, C-reactive protein (P = 0·035), which is an independent risk factor for CVD. However, no changes were observed in other markers of inflammation, antioxidant status or endothelial function. These results provide a possible mechanism underlying the beneficial effects of longer-term wholegrain intake. However, it is unclear whether this effect is owing to a specific component, or a combination of components in wheat aleurone.

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*Corresponding author: R. W. Welch, fax +44 28 7032 3023, email
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1SAM Kelly , CD Summerbell , A Brynes , et al. (2007) Wholegrain cereals for coronary heart disease. The Cochrane Database of Systematic Reviews 2007 issue 18, CD005051.

5RC Masters , AD Liese , SM Haffner , et al. (2010) Whole and refined grain intakes are related to inflammatory protein concentrations in human plasma. J Nutr 140, 587594.

6AJ Gaskins , SL Mumford , AJ Rovner , et al. (2010) Whole grains are associated with serum concentrations of high sensitivity C-reactive protein among premenopausal women. J Nutr 140, 16691676.

8L Qi , RM Van Dam , SM Liu , et al. (2006) Whole-grain, bran, and cereal fiber intakes and markers of systemic inflammation in diabetic women. Diabetes Care 29, 207211.

10R Estruch , E Sacanella , E Badia , et al. (2004) Different effects of red wine and gin consumption on inflammatory biomarkers of atherosclerosis: a prospective randomized crossover trial – effects of wine on inflammatory markers. Atherosclerosis 175, 117123.

11K Esposito , R Marfella , M Ciotola , et al. (2004) Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome – a randomized trial. JAMA 292, 14401446.

13AM Lampi , T Nurmi , V Ollilainen , et al. (2008) Tocopherols and tocotrienols in wheat genotypes in the HEALTHGRAIN diversity screen. J Agric Food Chem 56, 97169721.

17NM Anson , R van den Berg , R Havenaar , et al. (2008) Ferulic acid from aleurone determines the antioxidant potency of wheat grain (Triticum aestivum L.). J Agric Food Chem 56, 55895594.

18LP Liu , L Zubik , FW Collins , et al. (2004) The antiatherogenic potential of oat phenolic compounds. Atherosclerosis 175, 3949.

20L Enright & J Slavin (2010) No effect of 14 day consumption of whole grain diet compared to refined grain diet on antioxidant measures in healthy, young subjects: a pilot study. Nutr J 9, 1219.

23P Tighe , G Duthie , N Vaughan , et al. (2010) Effect of increased consumption of whole-grain foods on blood pressure and other cardiovascular risk markers in healthy middle-aged persons: a randomized controlled trial. Am J Clin Nutr 92, 733740.

25RK Price , EM Keaveney , LL Hamill , et al. (2010) Consumption of wheat aleurone-rich foods increases fasting plasma betaine and modestly decreases fasting homocysteine and LDL-cholesterol in adults. J Nutr 140, 21532157.

26FJ Zhao , YH Su , SJ Dunham , et al. (2009) Variation in mineral micronutrient concentrations in grain of wheat lines of diverse origin. J Cereal Sci 49, 290295.

27JL Stroud , FJ Zhao , P Buchner , et al. (2010) Impacts of sulphur nutrition on selenium and molybdenum concentrations in wheat grain. J Cereal Sci 52, 111113.

28JR Howarth , S Parmar , J Jones , et al. (2008) Co-ordinated expression of amino acid metabolism in response to N and S deficiency during wheat grain filling. J Exp Bot 59, 36753689.

29L Li , PR Shewry & JL Ward (2008) Phenolic acids in wheat varieties in the HEALTHGRAIN diversity screen. J Agric Food Chem 56, 97329739.

30RK Price , RW Welch , AM Lee-Manion , et al. (2008) Total phenolics and antioxidant potential in plasma and urine of humans after consumption of wheat bran. Cereal Chem 85, 152157.

31IFF Benzie & JJ Strain (1996) The ferric reducing ability of plasma (FRAP) as a measure of ‘antioxidant power’: the FRAP assay. Anal Biochem 239, 7076.

33Y Matsui , S Nakamura , N Kondou , et al. (2007) Liquid chromatography-electrospray ionization-tandem mass spectrometry for simultaneous analysis of chlorogenic acids and their metabolites in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci 858, 96105.

34Y Konishi , ZH Zhao & M Shimizu (2006) Phenolic acids are absorbed from the rat stomach with different absorption rates. J Agric Food Chem 54, 75397543.

35PM Ridker (2003) Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation 107, 363369.

36SS Bassuk , N Rifai & PM Ridker (2004) High-sensitivity C-reactive protein: clinical importance. Curr Probl Cardiol 29, 439493.

37PM Ridker , J MacFadyen , P Libby , et al. (2010) Relation of baseline high-sensitivity C-reactive protein level to cardiovascular outcomes with rosuvastatin in the justification for use of statins in prevention: an intervention trial evaluating rosuvastatin (JUPITER). Am J Cardiol 106, 204209.

38LP He , XY Tang , WH Ling , et al. (2010) Early C-reactive protein in the prediction of long-term outcomes after acute coronary syndromes: a meta-analysis of longitudinal studies. Heart 96, 339346.

40J Danesh , JG Wheeler , GM Hirschfield , et al. (2004) C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med 350, 13871397.

41PM Ridker , JE Buring , J Shih , et al. (1998) Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation 98, 731733.

42M Hanefeld , N Marx , A Pfutzner , et al. (2007) Anti-inflammatory effects of pioglitazone and/or sinivastatin in high cardiovascular risk patients with elevated high sensitivity C-reactive protein – the PIOSTAT study. J Am Coll Cardiol 49, 290297.

44S Kinlay (2007) Low-density lipoprotein-dependent and -independent effects of cholesterol-lowering therapies on C-reactive protein – a meta-analysis. J Am Coll Cardiol 49, 20032009.

45E Zakynthinos & N Pappa (2009) Inflammatory biomarkers in coronary artery disease. J Cardiol 53, 317333.

46L Papatheodorou & N Weiss (2007) Vascular oxidant stress and inflammation in hyperhomocysteinemia. Antioxid Redox Signal 9, 19411958.

47MF Abdelmalek , SO Sanderson , P Angulo , et al. (2009) Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. Hepatology 50, 18181826.

48G Targher (2006) Relationship between high-sensitivity C-reactive protein levels and liver histology in subjects with non-alcoholic fatty liver disease. J Hepatol 45, 879881.

49NM Anson , R van den Berg , R Havenaar , et al. (2009) Bioavailability of ferulic acid is determined by its bioaccessibility. J Cereal Sci 49, 296300.

50SM Kern , RN Bennett , FA Mellon , et al. (2003) Absorption of hydroxycinnamates in humans after high-bran cereal consumption. J Agric Food Chem 51, 60506055.

51P Vitaglione , A Napolitano & V Fogliano (2008) Cereal dietary fibre: a natural functional ingredient to deliver phenolic compounds into the gut. Trends Food Sci Technol 19, 451463.

52A Costabile , A Klinder , F Fava , et al. (2008) Whole-grain wheat breakfast cereal has a prebiotic effect on the human gut microbiota: a double-blind, placebo-controlled, crossover study. Br J Nutr 99, 110120.

55R Giacco , G Clemente , D Cipriano , et al. (2010) Effects of the regular consumption of wholemeal wheat foods on cardiovascular risk factors in healthy people. Nutr Metab Cardiovasc Dis 20, 186194.

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