Skip to main content



  • Access


      • Send article to Kindle

        To send this article to your Kindle, first ensure is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

        Note you can select to send to either the or variations. ‘’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

        Find out more about the Kindle Personal Document Service.

        Exploring genomes in agriculture and food science
        Available formats
        Send article to Dropbox

        To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

        Exploring genomes in agriculture and food science
        Available formats
        Send article to Google Drive

        To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

        Exploring genomes in agriculture and food science
        Available formats
Export citation

The way in which food is produced, processed and delivered to the consumer is the concern of farming and industry worldwide. The desire to produce nutritious food more efficiently has led to the increasing use of advanced molecular technologies in nutritional sciences (van der Werf et al. 2001). This area of research can be considered to fall within the emerging science of nutritional genomics. Whilst the focus of nutritional genomics has been human health (Stover, 2004), its utility is now beginning to extend beyond the study of human systems to include agriculture and food science.

The significant advances made within the field of nutritional genomics have been underpinned by the advent of genome sequencing projects, which has led to an explosion of available genetic information. Genomics involves the study of genes and their functions in an organism. It aims to understand the structure of the genome, including the mapping of genes and the sequencing of DNA. However, the realisation that the genome sequence fails to explain the fundamental nature of many biological processes has led to the development of post-genomic strategies (transcriptomics, proteomics and metabolomics) aimed at relating gene expression to phenotypic outcome.

Transcriptomics monitors the expression levels of thousands of genes simultaneously at a specific time and set of conditions and permits the characterisation of mRNA populations. This ability to determine gene expression on a global scale has been facilitated by the development of high-throughput platforms such as DNA microarrays and related technologies. Proteomics complements and extends the study of genomes and transcript data, reflecting the true biochemical outcome of genetic information. Proteomics may be defined as the study of the protein component of a cell, tissue or organism at a given time under given conditions (Wilkins et al. 1995) and has progressed from the simple identification of proteins to studies that are concerned with protein quantification and proteome dynamics. Proteomic analyses require a combination of efficient and stringent separation technologies and high-resolution MS.

Metabolomics is focused on the analysis of low-molecular-weight metabolites, which are the endproducts of gene expression and are regarded as important indicators, and indeed, integrators, of phenotype (Whitfield et al. 2004). Metabolomics represents a radical shift from single metabolite monitoring to complex metabolite profiling and pattern recognition. A major goal of modern metabolomic strategies is to measure each individual metabolite within a biological sample. The wide range of low-molecular-weight metabolites in complex biological systems demands a variety of analytical platforms for detection, identification and quantification of molecules with diverse chemical and physical properties. Suitable techniques that are sensitive, robust and have the capacity to acquire data on large populations of metabolites include MS and NMR spectroscopy.

Since nutrition plays a crucial role in the development of human diseases the focus of many nutritional genomic studies to date has been the investigation of the relationship between genes and diet and how these interactions may impact on human health (Ordovas & Mooser, 2004). The manifestation of nutritional deficiencies or disorders such as diabetes, CVD and obesity is known to be influenced by diet. Therefore determining the composition of foods and understanding how food components can modulate health may prove important in the management of these diseases. Nutritional genomic strategies will be useful in providing molecular biomarkers of health and disease and in understanding gene expression changes induced by whole diets or individual dietary constituents (Kussmann et al. 2006). This has evolved into the concept of personalised nutrition, which offers the possibility of tailoring dietary recommendations and more effective management of diseases (Watkins et al. 2001).

In the present issue of the British Journal of Nutrition, Brown & van der Ouderaa (2007) discuss the applications of nutritional genomics to agriculture and the food industry. The review outlines how investigators are now using nutritional genomics to identify crops with desired genetic characteristics and to enhance the nutritional quality of plants (DellaPenna, 1999). These approaches have previously been employed to produce GM crops and to profile their molecular composition (Kuiper et al. 2003; Cellini et al. 2004). The authors also describe the use of these technologies as part of selective breeding programmes of livestock (Georges, 1999). The focus of these studies is an understanding of the genetic basis of commercially important traits of farm animals such as reproductive health, disease resistance, growth, fat deposition and milk production. The ability to predict such traits is of immense value to agriculture and food production and there is a clear role for nutritional genomics in developing the knowledge obtained from these studies.

Nutritional genomics has also influenced the monitoring of food composition, authenticity and safety, a key area for the food industry. Nutritional genomic strategies are increasingly being employed to confirm the origin and source of food ingredients (Popping, 2002) and feed products (Fernandez Ocana et al. 2004). These technologies are powerful tools with which to detect food allergens and evaluate changes in plant- and meat-based foods upon processing (Carbonaro, 2004). They can also be used to evaluate meat quality (Bendixen, 2005; Mullen et al. 2006), and provide a means of identifying markers of food spoilage in fruits, vegetables, meats and dairy products (Brul et al. 2006).

Genomic, transcriptomic, proteomic and metabolomic strategies are making a significant impact on the landscape of agriculture and food technology. The genome sequences of a number of agriculturally important plant species such as rice and farm animals including the pig, cow and chicken have been obtained or are well advanced. Further, public resources such as ARKdb (Hu et al. 2001) and AgBase (McCarthy et al. 2006) now exist for the functional analysis of genes and their products in numerous animal and plant species. The genetic manipulation of plants and animals for higher nutritional quality through nutritional genomics may benefit crop and livestock management, leading to more efficient production methods and improvements in diet and health.

Whilst this technology is advancing rapidly, challenges remain and nutritional genomics will be best addressed by integrative studies that include measurements of mRNA, proteins and low-molecular-weight metabolites over time and under varied conditions. Understanding these complex networks will require bioinformatics to obtain additional insights and provide the opportunities for greater exploitation of this information. Whilst this goal may currently be elusive, the umbrella discipline of nutritional genomics has the potential to make a significant impact in the way that we view the availability, production and, ultimately, personalisation of our dietary needs.


Bendixen, E (2005) The use of proteomics in meat science. Meat Sci 71, 138149.
Brown, L & van der Ouderaa, F (2007) Nutritional genomics: food industry applications from farm to fork. Br J Nutr. DOI: 10.1017/S0007114507691983.
Brul, S, Schuren, F, Montijn, R, Keijser, BJ, van der Spek, H & Oomes, SJ (2006) The impact of functional genomics on microbiological food quality and safety. Int J Food Microbiol 112, 195199.
Carbonaro, M (2004) Proteomics: present and future in food quality evaluation. Trends Food Sci Technol 15, 209216.
Cellini, F, Chesson, A, Colquhoun, I, et al. (2004) Unintended effects and their detection in genetically modified crops. Food Chem Toxicol 42, 10891125.
DellaPenna, D (1999) Nutritional genomics: manipulating plant micronutrients to improve human health. Science 285, 375379.
Fernandez Ocana, M, Neubert, H, Przyborowska, A, Parker, R, Bramley, P, Halket, J & Patel, R (2004) BSE control: detection of gelatine-derived peptides in animal feed by mass spectrometry. Analyst 129, 111115.
Georges, M (1999) Towards marker assisted selection in livestock. Reprod Nutr Dev 39, 555561.
Hu, J, Mungall, C, Law, A, et al. (2001) The ARKdb: genome databases for farmed and other animals. Nucleic Acids Res 29, 106110.
Kuiper, HA, Kok, EJ & Engel, KH (2003) Exploitation of molecular profiling techniques for GM food safety assessement. Curr Opin Biotechnol 14, 238243.
Kussmann, M, Raymond, F & Affolter, M (2006) OMICS-driven biomarker discovery in nutrition and health. J Biotechnol 124, 758787.
McCarthy, FM, Wang, N, Magee, GB, et al. (2006) AgBase: a functional genomics resource for agriculture. BMC Genomics 7, 229.
Mullen, AM, Stapleton, PC, Corcoran, D, Hamill, RM & White, A (2006) Understanding meat quality through the application of genomic and proteomic approaches. Meat Sci 74, 3–16.
Ordovas, JM & Mooser, V (2004) Nutrigenomics and nutrigenetics. Curr Opin Lipidol 15, 101108.
Popping, B (2002) The application of biotechnological methods in authenticity testing. J Biotechnol 98, 107112.
Stover, PJ (2004) Nutritional genomics. Physiol Genomics 16, 161165.
van der Werf, MJ, Schuren, FHJ, Bijlsma, S, Tas, AC & van Ommen, B (2001) Nutrigenomics: application of genomics technologies in nutritional sciences and food technology. J Food Sci 66, 772780.
Watkins, SM, Hammock, BD, Newman, JW & German, JB (2001) Individual metabolism should guide agriculture towards foods for improved health and nutrition. Am J Clin Nutr 74, 283–286.
Whitfield, PD, German, AJ & Noble, PJ (2004) Metabolomics: an emerging post-genomic tool for nutrition. Br J Nutr 92, 549555.
Wilkins, MR, Sanchez, JC, Gooley, AA, Appel, RD, Humphery-Smith, I, Hochstrasser, DF & Williams, KL (1995) Progress with proteome projects: why all proteins expressed by a genome should be identified and how to do it. Biotechnol Genet Eng Rev 13, 19–50.