Skip to main content Accessibility help
×
×
Home

Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins

  • I. Stuart Wood (a1) and Paul Trayhurn (a1)

Abstract

The number of known glucose transporters has expanded considerably over the past 2 years. At least three, and up to six, Na+-dependent glucose transporters (SGLT1–SGLT6; gene name SLC5A) have been identified. Similarly, thirteen members of the family of facilitative sugar transporters (GLUT1–GLUT12 and HMIT; gene name SLC2A) are now recognised. These various transporters exhibit different substrate specificities, kinetic properties and tissue expression profiles. The number of distinct gene products, together with the presence of several different transporters in certain tissues and cells (for example, GLUT1, GLUT4, GLUT5, GLUT8, GLUT12 and HMIT in white adipose tissue), indicates that glucose delivery into cells is a process of considerable complexity.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins
      Available formats
      ×

Copyright

Corresponding author

*Corresponding author: Dr I. S. Wood, fax +44 151 706 5802, email iswood@liverpool.ac.uk

References

Hide All
Abel, ED, Peroni, O, Kim, JK, Kim, YB, Boss, O, Hadro, E, Minne-mann, T, Shulman, GI & Kahn, BB (2001) Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 409, 729733.
Asano, T, Katagiri, H, Takata, K, Lin, JL, Ishihara, H, Inukai, K, Tsu-kuda, K, Kikuchi, M, Hirano, H, Yazaki, Y et al. , (1991) The role of N-glycosylation of GLUT 1 for glucose transport activity. Journal of Biological Chemistry 266, 2463224636.
Astrup, A & Finer, N (2000) Redefining type 2 diabetes: 'diabesity' or 'obesity dependent diabetes mellitus'? Obesity Reviews 1, 5759.
Bryant, NJ, Govers, R & James, DE (2002) Regulated transport of the glucose transporter GLUT4. Nature Reviews Molecular Cell Biology 3, 267277.
Burchell, A (1998) A re-evaluation of GLUT7. Biochemical Journal 331, 973.
Carayannopoulos, MO, Chi, MM, Cui, Y, Pingsterhaus, JM, McKnight, RA, Mueckler, M, Devaskar, SU & Moley, KH (2000) GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst. Proceedings of the National Academy of Sciences USA 97, 73137318.
Davidson, NO, Hausman, AM, Ifkovits, CA, Buse, JB, Gould, GW, Burant, CF & Bell, GI (1992) Human intestinal glucose transporter expression and localization of GLUT5. American Journal of Physiology 262, C795C800.
Dawson, PA, Mychaleckyj, JC, Fossey, SC, Mihic, SJ, Craddock, AL & Bowden, DW (2001) Sequence and functional analysis of GLUT 10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1. Molecular Genetics and Metabolism 74, 186199.
Diabetes, UK (2000) Fact Sheet no. 2. Diabetes: The Figures. http://www.diabetes.org.uk/infocentre/fact/fact2.htm
Doege, H, Bocianski, A, Joost, HG & Schurmann, A (2000a) Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes. Biochemical Journal 350, 771776.
Doege, H, Bocianski, A, Scheepers, A, Axer, H, Eckel, J, Joost, HG & Schurmann, A (2001) Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle. Biochemical Journal 359, 443449.
Doege, H, Schurmann, A, Bahrenberg, G, Brauers, A & Joost, HG (2000b) GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity. Journal of Biological Chemistry 275, 1627516280.
Felsenstein, J (1989) PHYLIP – Phylogeny Inference Package (Version 3.2). Cladistics 5, 164166.
Froesch, ER (1972) Fructose metabolism in adipose tissue. Acta Medica Scandinavica 542, Suppl., 3746.
Fukumoto, H, Kayano, T, Buse, JB, Edwards, Y, Pilch, PF, Bell, GI & Seino, S (1989) Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues. Journal of Biological Chemistry 264, 77767779.
Fukumoto, H, Seino, S, Imura, H, Seino, Y, Eddy, RL, Fukushima, Y, Byers, MG, Shows, TB & Bell, GI (1988) Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein. Proceedings of the National Academy of Sciences USA 85, 54345438.
Gould, GW, Thomas, HM, Jess, TJ & Bell, GI (1991) Expression of human glucose transporters in Xenopus oocytes: kinetic characterization and substrate specificities of the erythrocyte, liver, and brain isoforms. Biochemistry 30, 51395145.
Hajduch, E, Darakhshan, F & Hundal, HS (1998) Fructose uptake in rat adipocytes: GLUT5 expression and the effects of streptozotocin-induced diabetes. Diabetologia 41, 821828.
Halperin, ML & Cheema-Dhadli, S (1982) Comparison of glucose and fructose transport into adipocytes of the rat. Biochemical Journal 202, 717721.
Hediger, MA, Coady, MJ, Ikeda, TS & Wright, EM (1987) Expression cloning and cDNA sequencing of the Na+/glucose co-transporter. Nature 330, 379381.
Hediger, MA, Turk, E & Wright, EM (1989) Homology of the human intestinal Na+/glucose and Escherichia coli Na+/proline cotran-sporters. Proceedings of the National Academy of Sciences USA 86, 57485752.
Hediger, MA, Kanai, Y, You, G & Nussberger, S (1995) Mammalian ion-coupled solute transporters. Journal of Physiology 482, 7S17S.
Ibberson, M, Uldry, M & Thorens, B (2000) GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. Journal of Biological Chemistry 275, 46074612.
James, DE, Strube, M & Mueckler, M (1989) Molecular cloning and characterization of an insulin-regulatable glucose transporter. Nature 338, 8387.
Joost, HG, Bell, GI, Best, JD, Birnbaum, MJ, Charron, MJ, Chen, YT, Doege, H, James, DE, Lodish, HF, Moley, KH, Moley, JF, Mueckler, M, Rogers, S, Schurmann, A, Seino, S & Thorens, B (2002) Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators. American Journal of Physiology 282, E974E976.
Joost, HG & Thorens, B (2001) The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review). Molecular Membrane Biology 18, 247256.
Kanai, Y, Lee, WS, You, G, Brown, D & Hediger, MA (1994) The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose. Journal of Clinical Investigation 93, 397404.
Katz, EB, Burcelin, R, Tsao, TS, Stenbit, AE & Charron, MJ (1996) The metabolic consequences of altered glucose transporter expression in transgenic mice. Journal of Molecular Medicine 74, 639652.
Katz, EB, Stenbit, AE, Hatton, K, DePinho, R & Charron, MJ (1995) Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4. Nature 377, 151155.
Kayano, T, Burant, CF, Fukumoto, H, Gould, GW, Fan, YS, Eddy, RL, Byers, MG, Shows, TB, Seino, S & Bell, GI (1990) Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6). Journal of Biological Chemistry 265, 1327613282.
Kayano, T, Fukumoto, H, Eddy, RL, Fan, YS, Byers, MG, Shows, TB & Bell, GI (1988) Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues. Journal of Biological Chemistry 263, 1524515248.
Kong, CT, Yet, SF & Lever, JE (1993) Cloning and expression of a mammalian Na+/amino acid cotransporter with sequence similarity to Na+/glucose cotransporters. Journal of Biological Chemistry 268, 15091512.
Lisinski, I, Schurmann, A, Joost, HG, Cushman, SW & Al-Hasani, H (2001) Targeting of GLUT6 (formerly GLUT9) and GLUT8 in rat adipose cells. Biochemical Journal 358, 517522.
Mackenzie, B, Panayotova-Heiermann, M, Loo, DD, Lever, JE & Wright, EM (1994) SAAT1 is a low affinity Na+/glucose cotransporter and not an amino acid transporter. A reinterpretation. Journal of Biological Chemistry 269, 2248822491.
McVie-Wylie, AJ, Lamson, DR & Chen, YT (2001) Molecular cloning of a novel member of the GLUT family of transporters, SLC2a10 (GLUT 10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility. Genomics 72, 113117.
Mueckler, M (1994) Facilitative glucose transporters. European Journal of Biochemistry 219, 713725.
Mueckler, M, Caruso, C, Baldwin, SA, Panico, M, Blench, I, Morris, HR, Allard, WJ, Lienhard, GE & Lodish, HF (1985) Sequence and structure of a human glucose transporter. Science 229, 941945.
Phay, JE, Hussain, HB & Moley, JF (2000) Strategy for identification of novel glucose transporter family members by using internet-based genomic databases. Surgery 128, 946951.
Rayner, DV, Thomas, ME & Trayhurn, P (1994) Glucose transporters (GLUTs 1–4) and their mRNAs in regions of the rat brain: insulin-sensitive transporter expression in the cerebellum. Canadian Journal of Physiology and Pharmacology 72, 476479.
Rogers, S, Macheda, ML, Docherty, SE, Carty, MD, Henderson, MA, Soeller, WC, Gibbs, EM, James, DE & Best, JD (2002) Identification of a novel glucose transporter-like protein-GLUT-12. American Journal of Physiology 282, E733E738.
Sasaki, T, Minoshima, S, Shiohama, A, Shintani, A, Shimizu, A, Asakawa, S, Kawasaki, K & Shimizu, N (2001) Molecular cloning of a member of the facilitative glucose transporter gene family GLUT 11 (SLC2A11) and identification of transcription variants. Biochemical and Biophysical Research Communications 289, 12181224.
Shepherd, PR, Gibbs, EM, Wesslau, C, Gould, GW & Kahn, BB (1992) Human small intestine facilitative fructose/glucose transporter (GLUT5) is also present in insulin-responsive tissues and brain. Investigation of biochemical characteristics and translocation. Diabetes 41, 13601365.
Shepherd, PR & Kahn, BB (1999) Glucose transporters and insulin action – implications for insulin resistance and diabetes mellitus. New England Journal of Medicine 341, 248257.
Stenbit, AE, Tsao, TS, Li, J, Burcelin, R, Geenen, DL, Factor, SM, Houseknecht, K, Katz, EB & Charron, MJ (1997) GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes. Nature Medicine 3, 10961101.
Turk, E & Wright, EM (1997) Membrane topology motifs in the SGLT cotransporter family. Journal of Membrane Biology 159, 120.
Turk, E, Zabel, B, Mundlos, S, Dyer, J & Wright, EM (1991) Glucose galactose malabsorption caused by a defect In the Na+/glucose cotransporter. Nature 350, 354356.
Uldry, M, Ibberson, M, Horisberger, J-D, Chatton, J-Y, Riederer, BM & Thorens, B (2001) Identification of a mammalian H+-myo-inositol symporter expressed predominantly in the brain. EMBO Journal 20, 44674477.
Wells, RG, Pajor, AM, Kanai, Y, Turk, E, Wright, EM & Hediger, MA (1992) Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter. American Journal of Physiology 263, F459F465.
Wright, EM (2001) Renal Na+-glucose cotransporters. American Journal of Physiology 280, F10F18.
Wu, X, Li, W, Sharma, V, Godzik, A & Freeze, HH (2002) Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues. Molecular Genetics and Metabolism 76, 3745.
Zisman, A, Peroni, OD, Abel, ED, Michael, MD, Mauvais-Jarvis, F, Lowell, BB, Wojtaszewski, JF, Hirshman, MF, Virkamaki, A, Goodyear, LJ, Kahn, CR & Kahn, BB (2000) Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nature Medicine 6, 924928.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed