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Histidine and arginine are associated with inflammation and oxidative stress in obese women

  • Yu-Cun Niu (a1), Ren-Nan Feng (a1), Yan Hou (a2), Kang Li (a2), Zhen Kang (a3), Jian Wang (a3), Chang-Hao Sun (a1) and Ying Li (a1)...

Abstract

The aims of the present study were to examine the serum amino acid profiles in obese and non-obese women and investigate the relationships between the serum amino acids and inflammation and oxidative stress in a human case–control study. Serum amino acids, inflammatory biomarkers (C-reactive protein and IL-6) and oxidative biomarkers (superoxide dismutase, malondialdehyde and glutathione peroxidase) were measured and compared in 235 obese women and 217 non-obese controls. The relationships between serum amino acids and inflammatory and oxidative biomarkers were examined using multiple linear regression. Among the amino acids determined, serum histidine, arginine, threonine, glycine, lysine and serine were found to be significantly lower in obese women as compared to non-obese controls (P < 0·001). The difference was the greatest for histidine (P < 0·001). In obese women, both histidine and arginine were negatively associated with inflammation and oxidative stress. In non-obese controls, histidine was negatively associated with oxidative stress. The findings in this study indicate that the metabolism of amino acids is abnormal in obese women in whom histidine and arginine have close relationships with inflammation and oxidative stress.

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Copyright

Corresponding author

*Corresponding authors: Chang-Hao Sun, fax +86 451 87502885, email sun2002changhao@yahoo.com; Ying Li, fax +86 451 87502885, email liying2002helen@gmail.com

References

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
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Keywords

Type Description Title
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Supplementary Table

Li Supplementary Table
Table S1. Multiple linear regression between serum amino acids and inflammatory, oxidative stress biomarkers in non-obese controls and obese women, adjusted by age, smoking, alcohol use, menopause and physical activity at work and leisure (standardized coefficients, β)

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