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Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: a double-blind, placebo-controlled study

  • Raakel Luoto (a1) (a2), Kirsi Laitinen (a3) (a4), Merja Nermes (a1) and Erika Isolauri (a1) (a2)
  • DOI: http://dx.doi.org/10.1017/S0007114509993898
  • Published online: 04 February 2010
Abstract

The perinatal nutritional environment impacts upon the health and well-being of mother and child also in the long term. The aim of the present study was to determine the safety and efficacy of perinatal probiotic-supplemented dietary counselling by evaluating pregnancy outcome and fetal and infant growth during the 24 months' follow-up. Altogether, 256 women were randomised at their first trimester of pregnancy into a control and a dietary intervention group. The intervention group received intensive dietary counselling provided by a nutritionist and were further randomised, double-blind to receive probiotics (Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12; diet/probiotics) or placebo (diet/placebo). Firstly, probiotic intervention reduced the frequency of gestational diabetes mellitus (GDM); 13 % (diet/probiotics) v. 36 % (diet/placebo) and 34 % (control); P = 0·003. Secondly, the safety of this approach was attested by normal duration of pregnancies with no adverse events in mothers or children. No significant differences in prenatal or postnatal growth rates among the study groups were detected. Thirdly, distinctive effects of the two interventions were detected; probiotic intervention reduced the risk of GDM and dietary intervention diminished the risk of larger birth size in affected cases; P = 0·035 for birth weight and P = 0·028 for birth length. The results of the present study show that probiotic-supplemented perinatal dietary counselling could be a safe and cost-effective tool in addressing the metabolic epidemic. In view of the fact that birth size is a risk marker for later obesity, the present results are of significance for public health in demonstrating that this risk is modifiable.

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*Corresponding author: Raakel Luoto, fax +358 2 313 1460, email raakel.luoto@utu.fi
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2HT Sorensen , S Sabroe , KJ Rothman , (1997) Relation between weight and length at birth and body mass index in young adulthood: cohort study. BMJ 315, 1137.

3TJ Parsons , C Power & O Manor (2001) Foetal and early life growth and body mass index from birth to early adulthood in 1958 British cohort: longitudinal study. BMJ 323, 13311335.

4W Palinski , T Yamashita , S Freigang , (2007) Developmental programming: maternal hypercholesterolemia and immunity influence susceptibility to atherosclerosis. Nutr Rev 65, 12 Pt 2, S182S187.

6PW Howie , JS Forsyth , SA Ogston , (1990) Protective effect of breast feeding against infection. BMJ 300, 1116.

7PJ Surkan , CC Hsieh , AL Johansson , (2004) Reasons for increasing trends in large for gestational age births. Obstet Gynecol 104, 720726.

8P Damm (2009) Future risk of diabetes in mother and child after gestational diabetes mellitus. Int J Gynaecol Obstet 104, Suppl. 1, 525526.

9F Bäckhed , H Ding , T Wang , (2004) The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci USA 101, 1571815723.

10PD Cani & NM Delzenne (2007) Gut microflora as a target for energy and metabolic homeostasis. Curr Opin Clin Nutr Metab Care 10, 729734.

11RE Ley , PJ Turnbaugh , S Klein , (2006) Microbial ecology: human gut microbes associated with obesity. Nature 444, 10221023.

13M Kalliomäki , P Kirjavainen , E Eerola , (2001) Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J Allergy Clin Immunol 107, 129134.


16J Aaltonen , T Ojala , K Laitinen , (2008) Evidence of infant blood pressure programming by maternal nutrition during pregnancy: a prospective randomized controlled intervention study. J Pediatr 152, 7984.

17W Becker , N Lyhne , AN Pedersen , (2004) Nordic nutrition recommendations 2004 – integrating nutrition and physical activity. Scand J Nutr 48, 178187.

20J Schwager , MH Mohajeri , A Fowler , (2008) Challenges in discovering bioactives for the food industry. Curr Opin Biotechnol 19, 6672.

21LC Douglas & ME Sanders (2008) Probiotics and prebiotics in dietetics practice. J Am Diet Assoc 108, 510521.

22F He , H Morita , AC Ouwehand , (2002) Stimulation of the secretion of pro-inflammatory cytokines by Bifidobacterium strains. Microbial Immunol 46, 781785.

23HR Christensen , H Frøkiær & JJ Pestka (2002) Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells. J Immunol 168, 171178.

24MP Piccini , L Beloni , C Livi , (1998) Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions. Nat Med 4, 10201024.

25SL Prescott , C Macauba , T Smallacombe , (1999) Development of allergen-specific T-cell memory in atopic and normal children. Lancet 353, 196200.

26K Godfrey , S Robinson , DJ Barker , (1996) Maternal nutrition in early and late pregnancy in relation to placental and foetal growth. BMJ 312, 410414.

27DJ Barker (2004) The developmental origins of adult disease. J Am Coll Nutr 23, Suppl. 6, 588S595S.

28P Catalano (2002) The diabetogenic state of maternal metabolism in pregnancy. NeoReviews 3, e165e171.

29J Baird , D Fisher , P Lucas , (2005) Being big or growing fast: systematic review of size and growth in infancy and later obesity. BMJ 331, 929934.

30C Druet & KK Ong (2008) Early childhood predictors of adult body composition. Best Pract Res Clin Endocrinol Metab 22, 489502.

31CM Boney , A Verma , R Tucker , (2005) Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics 115, e290e296.

33PJ Turnbaugh , RE Ley , MA Mahovald , (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 10271031.

34PD Cani , J Amar , MA Iglesias , (2007) Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56, 17611772.

35E Isolauri (1999) Probiotics and gut inflammation. Curr Opin Gastroenterol 15, 534537.

36PD Cani , S Possemiers , T Van de Wiele , (2009) Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 58, 10911103.

37PC Calder (2006) Polyunsaturated fatty acids and inflammation. Prostaglandins Leukot Essent Fatty Acids 75, 197202.

38H Shi , MV Kokoeva , K Inouye , (2006) TLR4 links innate immunity and fatty acid induced insulin resistance. J Clin Invest 116, 30153025.

39Y Yogev , BE Metzger & M Hod (2009) Establishing diagnosis of gestational diabetes mellitus: Impact of the hyperglycemia and adverse pregnancy outcome study. Semin Foetal Neonatal Med 14, 94100.

41ST Weiss (2005) Obesity: insight into the origins of asthma. Nat Immunol 6, 537539.

42SA Shore (2008) Obesity and asthma: possible mechanism. J Allergy Clin Immunol 121, 10871093.

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