1Gibson, GR, Scott, KP, Rastall, RA, et al. (2010) Dietary prebiotics: current status and new definition. Food Sci Technol Bull: Funct Foods 7, 1–19.
2Gibson, GR & Fuller, R (2000) Aspects of in vitro and in vivo research approaches directed toward identifying probiotics and prebiotics for human use. J Nutr 130, 391.
3Chung, CH & Day, DF (2002) Glucooligosaccharides from Leuconostoc mesenteroides B-742 (ATCC 13146): a potential prebiotic. J Indus Microbiol Biotechnol 29, 196–199.
4Gibson, GR (2004) Fibre and effects on probiotics (the prebiotic concept). Clin Nutr Suppl 1, 25–31.
5Eckburg, PB, Bik, EM, Bernstein, CN, et al. (2005) Diversity of the human intestinal microbial flora. Science 308, 1635–1638.
6Ley, RE, Bäckhed, F, Turnbaugh, P, et al. (2005) Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A 102, 11070–11075.
7Turnbaugh, PJ, Ley, RE, Mahowald, MA, et al. (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027–1131.
8Bäckhed, F, Manchester, JK, Semenkovich, CF, et al. (2007) Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A 104, 979–984.
9Ley, RE, Turnbaugh, PJ, Klein, S, et al. (2006) Microbial ecology: human gut microbes associated with obesity. Nature 444, 1022–1023.
10Collado, MC, Isolauri, E, Laitinen, K, et al. (2008) Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women. Am J Clin Nutr 88, 894–899.
11Duncan, SH, Lobley, GE, Holtrop, G, et al. (2008) Human colonic microbiota associated with diet, obesity and weight loss. Int J Obes 32, 1720–1724.
12Hildebrandt, MA, Hoffmann, C, Sherrill-Mix, SA, et al. (2009) High-fat diet determines the composition of the murine gut microbiome independently of obesity. Gastroenterology 137, 1716–24e2.
13Murphy, EF, Cotter, PD, Healy, S, et al. (2010) Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models. Gut 59, 1635–1642.
15Jeanes, A, Haynes, WC, Wilham, CA, et al. (1954) Characterization and classification of dextrans from ninety-six strains of bacteria. J Am Chem Soc 76, 5041–5052.
16Franks, AH, Harmsen, HJM, Raangs, GC, et al. (1998) Variations of bacterial populations in human feces measured by fluorescent in situ hybridization with group-specific 16s rRNA-targeted oligonucleotide probes. Appl Environ Microbiol 64, 3336–3345.
17Harmsen, HJM, Elfferich, P, Schut, F, et al. (1999) A 16s rRNA-targeted probe for detection of lactobacilli and enterococci in faecal samples by fluorescent in situ hybridization. Microb Ecol Health Dis 11, 3–12.
18Walker, AW, Duncan, SH, McWilliam Leitch, EC, et al. (2005) pH and peptide supply can radically alter bacterial populations and short-chain fatty acid ratios within microbial communities from the human colon. Appl Environ Microbiol 71, 3692–3700.
19Hold, GL, Schwiertz, A, Aminov, RI, et al. (2003) Oligonucleotide probes that detect quantitatively significant groups of butyrate-producing bacteria in human feces. Appl Environ Microbiol 69, 4320–4324.
20Harmsen, HJM, Raangs, GC, He, T, et al. (2002) Extensive set of 16s rRNA-based probes for detection of bacteria in human feces. Appl Environ Microbiol 68, 2982–2990.
21Manz, W, Amann, R, Ludwig, W, et al. (1996) Application of a suite of 16s rRNA-specific oligonucleotide probes designed to investigate bacteria of the phylum cytophaga–flavobacter–bacteroides in the natural environment. Microbiology 142, 1097–1106.
22Langendijk, P, Schut, F, Jansen, G, et al. (1995) Quantitative fluorescence in situ hybridization of Bifidobacterium spp. with genus-specific 16s rRNA-targeted probes and its application in fecal samples. Appl Environ Microbiol 61, 3069–3075.
23Harmsen, HJM, Wildeboer-Veloo, ACM, Grijpstra, J, et al. (2000) Development of 16s rRNA-based probes for the Coriobacterium group and the Atopobium cluster and their application for enumeration of Coriobacteriaceae in human feces from volunteers of different age groups. Appl Environ Microbiol 66, 4523–4527.
24Cote, GL (2007) Flavorings and other value-added products from sucrose. In Novel Enzyme Technology for Food Applications, pp. 243–269 [Rastall, RA, editor]. Boca Raton, FL: CRC Press.
25Olano-Martin, E, Mountzouris, KC, Gibson, GR, et al. (2000) In vitro fermentability of dextran, oligodextran and maltodextrin by human gut bacteria. Br J Nutr 83, 247–255.
26Kaneko, T, Kohmoto, T, Kikuchi, H, et al. (1994) Effects of isomaltooligosaccharides with different degrees of polymerization on human fecal bifidobacteria. Biosci Biotechnol Biochem 58, 2288–2290.
27van den Broek, LAM, Hinz, SWA, Beldman, G, et al. (2008) Bifidobacterium carbohydrases – their role in breakdown and synthesis of (potential) prebiotics. Mol Nutr Food Res 52, 146–163.
28Rada, V, Vlková, E, Nevoral, J, et al. (2006) Comparison of bacterial flora and enzymatic activity in faeces of infants and calves. FEMS Microbiol Lett 258, 25–28.
29Sarbini, SR, Kolida, S, Naeye, T, et al. (2011) In vitro fermentation of linear and alpha-1,2-branched dextrans by the human fecal microbiota. Appl Environ Microbiol 77, 5307–5315.
30Sanz, ML, Gibson, GR & Rastall, RA (2005) Influence of disaccharide structure on prebiotic selectivity in vitro. J Agric Food Chem 53, 5192–5199.
31Djouzi, Z & Andrieux, C (1997) Compared effects of three oligosaccharides on metabolism of intestinal microflora in rats inoculated with human faecal flora. Br J Nutr 78, 313–324.
32Rowland, IR (1988) Factors affecting metabolic activity of the intestinal microflora. Drug Metab Rev 19, 243–261.
33Macfarlane, GT & Cummings, JH (1991) The colonic flora, fermentation and large bowel digestive function. In The Large Intestine: Physiology, Pathophysiology and Disease, pp. 51–92 [Phillips, SF, Pemberton, JH and Shorter, RG, editors]. New York: Raven Press.
34Pokusaeva, K, O'Connell-Motherway, M, Zomer, A, et al. (2009) Characterization of two novel α-glucosidases from Bifidobacterium breve UCC2003. Appl Environ Microbiol 75, 1135–1143.
35Sanz, ML, Côté, GL, Gibson, GR, et al. (2006) Influence of glycosidic linkages and molecular weight on the fermentation of maltose-based oligosaccharides by human gut bacteria. J Agric Food Chem 54, 9779–9784.
36Jia, W, Whitehead, RN, Griffiths, L, et al. (2010) Is the abundance of Faecalibacterium prausnitzii relevant to Crohn's disease? FEMS Microbiol Lett 310, 138–144.
37Bastard, J-P, Maachi, M, Lagathu, C, et al. (2006) Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 17, 4–12.
38Hotamisligil, GS (2006) Inflammation and metabolic disorders. Nature 444, 860–867.
39Sbarbati, A, Osculati, F, Silvagni, D, et al. (2006) Obesity and inflammation: evidence for an elementary lesion. Pediatrics 117, 220–223.
40Scanlan, PD, Shanahan, F, O'Mahony, C, et al. (2006) Culture-independent analyses of temporal variation of the dominant fecal microbiota and targeted bacterial subgroups in Crohn's disease. J Clin Microbiol 44, 3980–3988.
41Fogarty, AW, Glancy, C, Jones, S, et al. (2008) A prospective study of weight change and systemic inflammation over 9 y. Am J Clin Nutr 87, 30–35.
42Cani, PD, Neyrinck, AM, Fava, F, et al. (2007) Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 50, 2374–2383.
43Bäckhed, F, Ding, H, Wang, T, et al. (2004) The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 101, 15718–15723.
44Turnbaugh, PJ, Hamady, M, Yatsunenko, T, et al. (2009) A core gut microbiome in obese and lean twins. Nature 457, 480–484.
45Falony, G, Lazidou, K, Verschaeren, A, et al. (2009) In vitro kinetic analysis of fermentation of prebiotic inulin-type fructans by Bifidobacterium species reveals four different phenotypes. Appl Environ Microbiol 75, 454–461.
46Al-Lahham, SaH, Peppelenbosch, MP, Roelofsen, H, et al. (2010) Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms. Biochim Biophys Acta – Mol Cell Biol Lip 1801, 1175–1183.
47Kennedy, A, Martinez, K, Chuang, C-C, et al. (2009) Saturated fatty acid-mediated inflammation and insulin resistance in adipose tissue: mechanisms of action and implications. J Nutr 139, 1–4.
48Ruijschop, RMAJ, Boelrijk, AEM & te Giffel, MC (2008) Satiety effects of a dairy beverage fermented with propionic acid bacteria. Int Dairy J 18, 945–950.
49Chen, W, Anderson, J & Jennings, D (1984) Propionate may mediate the hypo-cholesterolemic effects of certain soluble plant fibers in cholesterol-fed rats. Proc Soc Exp Biol Med 175, 215–218.
50Macy, JM, Ljungdahl, LG & Gottschalk, G (1978) Pathway of succinate and propionate formation in Bacteroides fragilis. J Bacteriol 134, 84–91.
51Salminen, S, Bouley, C, Boutron-Ruault, MC, et al. (1998) Functional food science and gastrointestinal physiology and function. Br J Nutr 80, 147–171.
52Zigová, J, SturdIk, E, Vandák, D, et al. (1999) Butyric acid production by Clostridium butyricum with integrated extraction and pertraction. Proc Biochem 34, 835–843.
53Janssen, PH & O'Farrell, KA (1999) Succinispira mobilis gen. Nov., sp. Nov., a succinate-decarboxylating anaerobic bacterium. Int J Syst Evol Microbiol 49, 1009–1013.
54Van Gylswyk, NO (1995) Succiniclasticum ruminis gen. Nov., sp. Nov., a ruminal bacterium converting succinate to propionate as the sole energy-yielding mechanism. Int J Syst Bacteriol 45, 297–300.
55Djouzi, Z, Andrieux, C, Pelenc, V, et al. (1995) Degradation and fermentation of α-gluco-oligosaccharides by bacterial strains from human colon: in vitro and in vivo studies in gnotobiotic rats. J Appl Microbiol 79, 117–127.
56Flickinger, EA, Wolf, BW, Garleb, KA, et al. (2000) Glucose-based oligosaccharides exhibit different in vitro fermentation patterns and affect in vivo apparent nutrient digestibility and microbial populations in dogs. J Nutr 130, 1267–1273.
57Smiricky-Tjardes, MR, Flickinger, EA, Grieshop, CM, et al. (2003) In vitro fermentation characteristics of selected oligosaccharides by swine fecal microflora. J Anim Sci 81, 2505–2514.
58Hartemink, R & Rombouts, FM (1997) Gas formation from oligosaccharides by the intestinal microflora. In Non-digestible Oligosaccharides: Healthy Food for the Colon? Proceedings of the International Symposium, pp. 57–66 [Hartemink, R, editor]. Wageningen: Wageningen Graduate School VLAG.
59Kolida, S & Gibson, GR (2007) Prebiotic capacity of inulin-type fructans. J Nutr 137, 2503S–2506S.
60Bernalier, A, Dore, J & Durand, M (1999) Biochemistry of fermentation. In Colonic Microbiota, Nutrition and Health, pp. 37–53 [Gibson, GR and Roberfroid, MB, editors]. Dordrecht: Kluwer Academic Publishers.
61Falony, G, Calmeyn, T, Leroy, F, et al. (2009) Coculture fermentations of Bifidobacterium species and Bacteroides thetaiotaomicron reveal a mechanistic insight into the prebiotic effect of inulin-type fructans. Appl Environ Microbiol 75, 2312–2319.
62Duncan, SH, Louis, P & Flint, HJ (2004) Lactate-utilizing bacteria, isolated from human feces that produce butyrate as a major fermentation product. Appl Environ Microbiol 70, 5810–5817.
63Duncan, SH, Hold, GL, Harmsen, H, et al. (2002) Growth requirements and fermentation products of Fusobacterium prausnitzii, and a proposal to reclassify it as Faecalibacterium prausnitzii gen. Nov., comb. Nov. Int J Syst Evol Microbiol 52, 2141–2146.
64Valette, P, Pelenc, V, Djouzi, Z, et al. (1993) Bioavailability of new synthesised glucooligosaccharides in the intestinal tract of gnotobiotic rats. J Sci Food Agric 62, 121–127.