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Influence of a combination of Lactobacillus acidophilus NCFM and lactitol on healthy elderly: intestinal and immune parameters

  • Arthur C. Ouwehand (a1), Kirsti Tiihonen (a1), Markku Saarinen (a1), Heli Putaala (a1) and Nina Rautonen (a1)
  • DOI: http://dx.doi.org/10.1017/S0007114508003097
  • Published online: 18 July 2008
Abstract

With increasing age, a number of physiological changes take place which are reflected in immune and bowel function. These changes may relate to the commonly assumed age-related changes in intestinal microbiota; most noticeably a reduction in bifidobacteria. The current study aimed at modifying the intestinal microbiota with a potential synbiotic on selected immune and microbiota markers. Healthy elderly subjects were randomised to consume during 2 weeks either a placebo (sucrose) or a combination of lactitol and Lactobacillus acidophilus NCFM twice daily in a double-blind parallel trial. After the intervention, stool frequency was higher in the synbiotic group than in the placebo group and a significant increase in faecal L. acidophilus NCFM levels was observed in the synbiotic group, after baseline correction. In contrast to the generally held opinion, the study subjects had faecal Bifidobacterium levels that were similar to those reported in healthy young adults. These levels were, nevertheless, significantly increased by the intervention. Levels of SCFA were not changed significantly. Of the measured immune markers, PGE2 levels were different between treatments and IgA levels changed over time. These changes were modest which may relate to the fact that the volunteers were healthy. Spermidine levels changed over time which may suggest an improved mucosal integrity and intestinal motility. The results suggest that consumption of lactitol combined with L. acidophilus NCFM twice daily may improve some markers of the intestinal microbiota composition and mucosal functions.

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*Corresponding author: Dr Arthur Ouwehand, fax +358 9 2982203, email arthur.ouwehand@danisco.com
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1M Blaut , P Marteau & GD Miller (2006) Probiotics and the intestinal microflora. What impact on the immune system, infections and ageing? Curr Nutr Food Sci 2, 7995.

2T He , HJM Harmsen , GC Raangs & GW Welling (2003) Composition of faecal microbiota of elderly people. Microb Ecol Health Dis 15, 153159.

3I Bjarnason , J Hayllar , AJ MacPherson & AS Russell (1993) Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology 104, 18321847.

4L Laine (2003) Gastrointestinal effects of NSAIDs and coxibs. J Pain Symptom Manage 25, Suppl. 2, S32S40.

5S Hartikainen , P Mantyselka , K Louhivuori-Laako , H Enlund & R Sulkava (2005) Concomitant use of analgesics and psychotropics in home-dwelling elderly people – Kuopio 75+ study. Br J Clin Pharmacol 60, 306310.

6K Tiihonen , S Tynkkynen , AC Ouwehand , T Ahlroos & N Rautonen (2008) The effect of ageing with and without non-steroidal anti-inflammatory drugs on gastrointestinal microbiology and immunology. Br J Nutr (epublication ahead of print version 18 February 2008).

7EJ Woodmansey (2007) Intestinal bacteria and ageing. J Appl Microbiol 102, 11781186.

8S Mueller , K Saunier , C Hanisch , (2006) Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study. Appl Environ Microbiol 72, 10271033.

12P Marteau , E Cuillerier , S Meance , (2002) Bifidobacterium animalis strain DN-173 010 shortens the colonic transit time in healthy women: a double-blind, randomized, controlled study. Aliment Pharmacol Ther 16, 587593.

13H Gill , KJ Rutherfurd & ML Cross (2001) Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related immunological changes. J Clin Immunol 21, 264271.

14SR Dunn , ML Simenhoff , KE Ahmed , (1998) Effect of oral administration of freeze-dried Lactobacillus acidophilus on small bowel bacterial overgrowth in patients with end stage kidney disease. Reducing uremic toxins and improving nutrition. Int Dairy J 8, 545553.

15B Foligné , S Nutten , C Grangette , (2007) Correlation between in vitro and in vivo immune modulatory properties of lactic acid bacteria. World J Gastroenterol 13, 236243.

16J Varcoe , C Zook , J Sui , S Leighton , F Busta & L Brady (2002) Variable response to exogenous Lactobacillus acidophilus NCFM® consumed in different delivery vehicles. J Appl Microbiol 93, 900906.

17J Ballongue , C Schumann & P Quignon (1997) Effects of lactulose and lactitol on colonic microflora and enzymatic activity. Scand J Gastroenterol 32, Suppl. 222, 4144.

19P Kontula , ML Suihko , A von Wright & T Mattila-Sandholm (1999) The effect of lactose derivatives on intestinal lactic acid bacteria. J Dairy Sci 82, 249256.

20M Saarinen (2002) Determination of biogenic amines as dansyl derivatives in intestinal digesta and feces by reversed phase HPLC. Chromatographia 55, 297300.

21JHA Apajalahti , H Kettunen , A Kettunen , (2002) Culture-independent microbial community analysis reveals that inulin in the diet primarily affects previously unknown bacteria in the mouse cecum. Appl Environ Microbiol 68, 49864995.

23H Mäkivuokko , J Nurmi , P Nurminen , J Stowell & N Rautonen (2005) In vitro effects on polydextrose by colonic bacteria and caco-2 cell cyclooxygenase gene expression. Nutr Cancer 52, 94104.

24J-P Furet , P Quénée & P Taolliez (2004) Molecular quantification of lactic acid bacteria in fermented milk products using real-time PCR. Int J Food Microbiol 97, 197207.

25E Altermann , WM Russell , MA Azcarate-Peril , (2005) Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM. Proc Natl Acad Sci U S A 102, 39063912.

27MY Morgan , M Alonso & LC Stanger (1989) Lactitol and lactulose for the treatment of subclinical hepatic encephalopathy in cirrhotic patients. A randomised, cross-over study. J Hepatol 8, 208217.

28MJ Hopkins & GT Macfarlane (2002) Changes in predominant bacterial populations in human faeces with age and with Clostridium difficile infection. J Med Microbiol 51, 448454.

29P Hotten , F Marotta , Y Naito , (2003) Effects of probiotics, lactitol and rifaximin on intestinal flora and fecal excretion of organic acids in cirrhotic patients. Chin J Digest Dis 4, 1318.

30M Matsumoto & Y Benno (2006) Anti-inflammatory metabolite production in the gut from the consumption of probiotic yogurt containing Bifidobacterium animalis subsp. lactis LKM512. Biosci Biotechnol Biochem 70, 12871292.

31M Matsumoto & Y Benno (2004) Consumption of Bifidobacterium lactis LKM512 yogurt reduces gut mutagenicity by increasing gut polyamine contents in healthy adult subjects. Mutat Res 568, 147153.

33Y Guigoz , J Dore & EJ Schiffrin (2008) The inflammatory status of old age can be nurtured from the intestinal environment. Curr Opin Clin Nutr Metab Care 11, 1320.

34E Arranz , S O'Mahony , JR Barton & A Ferguson (1992) Immunosenescence and mucosal immunity: significant effects of old age on secretory IgA concentrations and intraepithelial lymphocyte counts. Gut 33, 882886.

35L Maiden , B Thjodleifsson , A Theodors , J Gonzalez & I Bjarnason (2005) A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy. Gastroenterology 128, 11721178.

36I Dey , M Lejeune & K Chadee (2006) Prostaglandin E2 receptor distribution and function in the gastrointestinal tract. Br J Pharmacol 149, 611623.

37JL Madsen & J Graff (2004) Effects of ageing on gastrointestinal motor function. Age Ageing 33, 154159.

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