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Influence of the consumption pattern of magnesium from magnesium-rich mineral water on magnesium bioavailability

  • Magalie Sabatier (a1), Antoine Grandvuillemin (a2), Peter Kastenmayer (a1), Jean-Marc Aeschliman (a1), Florilène Bouisset (a1), Maurice J. Arnaud (a3), Gilles Dumoulin (a4) and Alain Berthelot (a2)...
Abstract

It is generally considered that the absorption of Mg is inversely related to the ingested dose. The objective of the present study was to determine if the mode of administration (bolus v. consumption throughout the day) could influence Mg bioavailability from Mg-rich natural mineral water comparing the same nutritional Mg amount (126 mg). Using a 2 d cross-over design, twelve healthy men were asked to drink 1·5 litres Mg-rich mineral water either as 2 × 750 ml or 7 × 212 ml throughout the day. Two stable isotopes (25Mg and 26Mg) were used to label the water in order to distinguish both regimens. Fractional apparent Mg absorption was determined by faecal monitoring and Mg retention was determined by measuring urinary excretion of Mg isotopes. Higher Mg absorption (50·7 (sd 12·7) v. 32·4 (sd 8·1) %; P = 0·0007) and retention (47·5 (sd 12·9) v. 29·0 (sd 7·5) %; P = 0·0008) from Mg-rich mineral water were observed when it was consumed in seven servings compared with larger servings. Thus, regular water consumption throughout the day is an effective way to increase Mg bioavailability from Mg-rich mineral water.

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Corresponding author
*Corresponding author: Magalie Sabatier, fax +41 21 785 85 44, email magalie.sabatier@rdls.nestle.com
References
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12 Schlingmann, KP, Waldegger, S, Konrad, M, et al. (2008) TRPM6 and TRPM7 – gatekeepers of human magnesium metabolism. Biochim Biophys Acta 1772, 813821.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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