Skip to main content
×
×
Home

Inulin and oligofructose: effects on lipid metabolism from human studies

  • C. M. Williams (a1) and K. G. Jackson (a1)
Abstract

Although convincing lipid-lowering effects of the fructo-oligosaccharide, inulin, have been demonstrated in animals, attempts to reproduce similar effects in man have produced conflicting findings. This may be because of the much lower doses which can be used due to the adverse gastrointestinal symptoms exhibited by most subjects consuming in excess of 15 g/d. There are nine studies reported in the literature which have investigated the response of blood lipids (usually total and LDL-cholesterol and triacylglycerol) to inulin or oligofructose supplementation in human volunteers. Three have observed no effects of inulin or oligofructose on blood levels of cholesterol or triacylglycerol, three have shown significant reductions in triacylglycerol, whilst four have shown modest reductions in total and LDL-cholesterol. Studies have been conducted in both normo- and moderately hyperlipidaemic subjects. Differences in study outcomes do not appear to be due to differences in the type or dose of oligosaccharides used nor the duration of the studies. Because animal studies have identified inhibition of hepatic fatty acid synthesis as the major site of action for the triacylglycerol lowering effects of inulin and oligofructose, and because this pathway is relatively inactive in man unless a high carbohydrate diet is fed, variability in response may be a reflection of differences in background diet or the experimental foods used.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Inulin and oligofructose: effects on lipid metabolism from human studies
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Inulin and oligofructose: effects on lipid metabolism from human studies
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Inulin and oligofructose: effects on lipid metabolism from human studies
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Professor C M Williams, tel +44 0118 9318706, fax +44 0118 9310080, email c.m.williams@reading.ac.uk
References
Hide All
Aarsland, A, Chinkes, D & Wolfe, RR (1996) Contributions of de novo synthesis of fatty acids to total VLDL-triacylglycerol secretion during prolonged hyperglycemial hyperinsulinemia in normal man. Journal of Clinical Investigation 98, 20082017.
Alles, MA, de Roos, NM, Bakz, JC, van de Lisdonk, E, Zock, PL & Hautvast, JGAJ (1999) Consumption of fructo-oligosaccharides does not favorably affect blood glucose and serum lipid concentrations in patients with type 2 diabetes. American Journal of Clinical Nutrition 69, 6469.
Brighenti, F, Casiraghi, MC, Canzi, E & Ferrari, A (1999) Effect of consumption of a ready-to-eat breakfast cereal containing inulin on the intestinal milieu and blood lipids in healthy male volunteers. European Journal of Clinical Nutrition 53, 726733.
Causey, JL, Feirtag, JM, Gallaher, DD, Tungland, BC & Slavin, JL (2000) Effects of dietary inulin on serum lipids, blood glucose and the gastrointestinal environment in hypercholesterolemic men. Nutrition Research 20, 191201.
Davidson, MH, Synecki, C, Maki, KC & Drennan, KB (1998) Effects of dietary inulin in serum lipids in men and women with hypercholesterolemia. Nutrition Research 3, 503517.
Delzenne, N, Kok, N, Fiordaliso, M, Deboyser, D, Goethals, F & Roberfroid, M (1993) Dietary fructo-oligosaecharides modifies lipid metabolism in rats. American Journal of Clinical Nutrition 57, 8205.
Fiordaliso, MF, Kok, N, Desager, JP, Goethals, F, Deboyser, D, Roberfroid, M & Delzenne, N (1995) Dietary oligofructose lowers triacylglycerols, phospholipids and cholesterol in serum and very low density lipoproteins of rats. Lipids 30, 163167.
Griffin, BA, Freeman, DJ, Tait, GW, Thomson, J, Caslake, MJ, Packard, CJ & Shepherd, J (1994) Role of plasma triglyceride in the regulation of plasma LDL subfractions: relative contribution of small dense LDL to coronary heart disease risk. Atherosclerosis 106, 241253.
Hidaka, H, Tashiro, Y & Eida, T (1991) Proliferation of bifidobacteria by oligosaccharides and their useful effect on human health. Bifidobacteria Microflora 10, 6579.
Jackson, KG, Taylor, GRJ, Clohessy, AM & Williams, CM (1999) The effect of the daily intake of inulin on fasting lipid, insulin and glucose concentrations in middle-aged men and women. British Journal of Nutrition 82, 2330.
Kok, N, Roberfroid, M & Delzenne, N (1996 a) Involvement of lipogenesis in the lower VLDL secretion induced by oligofructose in rats. British Journal of Nutrition 76, 881890.
Kok, N, Roberfroid, M & Deizenne, N (1996 b) Dietary oligofructose modifies the impact of fructose on hepatic triacylglycerol metabolism. Metabolism 45, 15471550.
Luo, J, Rizkalla, SW, Alamowitch, C, Boussairi, A, Blayo, A, Barry, J-L, Laffifle, A, Ouyon, F, Bornet, FRJ & Slama, VS (1996) Chronic consumption of short-chain fructooligosaccharides by healthy subjects decreased basal hepatic glucose production but had no effect on insulin-stimulated glucose metabolism. American Journal of Clinical Nutrition 63, 939945.
Parks, E (2002) Dietary carbohydrate's effects on lipogenesis and the relationship of lipogenesis to blood insulin and glucose concentration. British Journal of Nutrition 87, S247S253, this issue.
Pedersen, A, Sandstrom, B & Van Amelsvobrt, JMM (1997) The effect of ingestion of inulin on blood lipids and gastrointestinal symptoms in healthy females. British Journal of Nutrition 78, 215222.
Roberfroid, M (1993) Dietary fiber, inulin and oligofructose: a review comparing their physiological effects. Critical Reviews in Food Science and Nutrition 33, 102148.
Todesco, T, Rao, AV, Bosello, O & Jenkins, DJA (1991) Propionate lowers blood glucose and alters lipid metabolism in healthy subjects. American Journal of Clinical Nutrition 54, 860865.
Wolever, TMS, Spadafora, PJ, Cunnane, SC & Pencharz, PB (1995) Propionate inhibits incorporation of colonic [1,2-13C] acetate into plasma lipids in humans. American Journal of Clinical Nutrition 61, 12411247.
Williams, CM (1997) Postprandial lipid metabolism: effects of dietary fatty acids. Proceedings of the Nutrition Society 6, 679692.
Yamashita, K, Kawai, K & Itakura, M (1984) Effectsof fructo-oligosaccharides on blood glucose and serum lipids in diabetic subjects. Nutrition Research 4, 961966.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed