Skip to main content
    • Aa
    • Aa
  • Access
  • Cited by 32
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Baadkar, Shruti V. Mukherjee, Manjari S. and Lele, Smita S. 2014. Study on influence of age, gender and genetic variants on lactose intolerance and its impact on milk intake in adult Asian Indians. Annals of Human Biology, Vol. 41, Issue. 6, p. 548.

    Hertzler, Steve Savaiano, Dennis A. Jackson, Karry A. Bhriain, Sinead Ni and Suarez, Fabrizis L. 2013. Nutrition in the Prevention and Treatment of Disease.

    Medeiros, Lilian C. da Silva Lederman, Henrique M. and de Morais, Mauro B. 2012. Lactose Malabsorption, Calcium Intake, and Bone Mass in Children and Adolescents. Journal of Pediatric Gastroenterology and Nutrition, Vol. 54, Issue. 2, p. 204.

    Tomba, C. Baldassarri, A. Coletta, M. Cesana, B. M. and Basilisco, G. 2012. Is the subjective perception of lactose intolerance influenced by the psychological profile?. Alimentary Pharmacology & Therapeutics, Vol. 36, Issue. 7, p. 660.

    Agueda, Lídia Urreizti, Roser Bustamante, Mariona Jurado, Susana Garcia-Giralt, Natàlia Díez-Pérez, Adolfo Nogués, Xavier Mellibovsky, Leonardo Grinberg, Daniel and Balcells, Susana 2010. Analysis of Three Functional Polymorphisms in Relation to Osteoporosis Phenotypes: Replication in a Spanish Cohort. Calcified Tissue International, Vol. 87, Issue. 1, p. 14.

    Buchowski, M S Aslam, M Dossett, C Dorminy, C Choi, L and Acra, S 2010. Effect of dairy and non-dairy calcium on fecal fat excretion in lactose digester and maldigester obese adults. International Journal of Obesity, Vol. 34, Issue. 1, p. 127.

    Kull, Mart Kallikorm, Riina and Lember, Margus 2009. Impact of molecularly defined hypolactasia, self-perceived milk intolerance and milk consumption on bone mineral density in a population sample in Northern Europe. Scandinavian Journal of Gastroenterology, Vol. 44, Issue. 4, p. 415.

    Lee, Ming-Fen and Krasinski, Stephen D. 2009. Human Adult-Onset Lactase Decline: An Update. Nutrition Reviews, Vol. 56, Issue. 1, p. 1.

    Smith, George Davey Lawlor, Debbie A Timpson, Nic J Baban, Jamil Kiessling, Matt Day, Ian N M and Ebrahim, Shah 2009. Lactase persistence-related genetic variant: population substructure and health outcomes. European Journal of Human Genetics, Vol. 17, Issue. 3, p. 357.

    Agarwal, Mayank mohan Rana, Satyavati V. Mandal, Arup kumar Malhotra, Sunita Khandelwal, Niranjan Kumar, Santosh Acharya, Naveen chandra and Singh, Shrawan kumar 2008. Lactose intolerance in prostate cancer patients: Incidence and associated factors. Scandinavian Journal of Gastroenterology, Vol. 43, Issue. 3, p. 270.

    Ebrahim, Shah and Davey Smith, George 2008. Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology?. Human Genetics, Vol. 123, Issue. 1, p. 15.

    Portincasa, P. Di Ciaula, A. Vacca, M. Montelli, R. Wang, D. Q.-H. and Palasciano, G. 2008. Beneficial effects of oral tilactase on patients with hypolactasia. European Journal of Clinical Investigation, Vol. 38, Issue. 11, p. 835.

    Gugatschka, M. Hoeller, A. Fahrleitner-Pammer, A. Dobnig, H. Pietschmann, P. Kudlacek, S. and Obermayer-Pietsch, B. 2007. Calcium supply, bone mineral density and genetically defined lactose maldigestion in a cohort of elderly men. Journal of Endocrinological Investigation, Vol. 30, Issue. 1, p. 46.

    Sabikhi, Latha 2007.

    2006. Handbook of Dairy Foods and Nutrition, Third Edition.

    Enattah, N Pekkarinen, T Välimäki, M J Löyttyniemi, E and Järvelä, I 2005. Genetically defined adult-type hypolactasia and self-reported lactose intolerance as risk factors of osteoporosis in Finnish postmenopausal women. European Journal of Clinical Nutrition, Vol. 59, Issue. 10, p. 1105.

    Janner, M. and Mullis, P. E. 2005. Osteopenie und pathologische Frakturen bei einem Jugendlichen mit Laktoseintoleranz und hohem Oxalatkonsum. Monatsschrift Kinderheilkunde, Vol. 153, Issue. 4, p. 360.

    Järvelä, Irma E. 2005. Molecular genetics of adult‐type hypolactasia. Annals of Medicine, Vol. 37, Issue. 3, p. 179.

    MCKINLEY, MICHELLE C 2005. The nutrition and health benefits of yoghurt. International Journal of Dairy Technology, Vol. 58, Issue. 1, p. 1.

    Bernstein, C. N. and Leslie, W. D. 2004. Osteoporosis and inflammatory bowel disease. Alimentary Pharmacology and Therapeutics, Vol. 19, Issue. 9, p. 941.


Lactose intolerance and bone mass in postmenopausal Italian women

  • Gino R. Corazza (a1), Giuseppe Benati (a2), Antonio Di Sario (a2), Carlo Tarozzi (a3), Alessandra Strocchi (a2), Mario Passeri (a4) and Giovanni Gasbarrini (a2)
  • DOI:
  • Published online: 01 March 2007

Previous studies on the role of lactose malabsorption in the pathogenesis of postmenopausal osteoporosis have yielded conflicting results and further information is needed. To date, all studies have been carried out on populations with a low prevalence of lactose malabsorption and the lactose intestinal absorptive capacity was tested using a non-physiological dose of lactose. In fifty-eight Italian postmenopausal women (mean age 57 (SD 7) years), bone mineral density (BMD) at lumbar spine, H2 breath response after ingestion of 20 g lactose, intensity of symptoms of intolerance after a lactose load and daily Ca intake were evaluated. No differences were found between women with or without a positive H2, breath test with regard to BMD (−1·2 (SD 0·9) ν −0·9 (SD 0·8)) and Ca intake (509 (SD 266) ν 511 (SD 313) mg/d). On the contrary, both BMD and Ca intake were significantly lower in women with lactose malabsorption and symptoms of intolerance (−1·5 (SD 0·7) and 378 (SD 220) mg/d) than in those with malabsorption without symptoms (−0·9 (SD 0·9) and 624 (SD 254) mg/d). Moreover, in lactose malabsorbers Ca intake was correlated inversely with symptom score (rs −0·31, P<0·05) and positively with BMD (rs 0·42, P<0·005). Our results show that in Italian postmenopausal women Ca intake and BMD are not influenced directly by lactose malabsorption; the appearance of symptoms of intolerance seems to influence BMD unfavourably through a reduced Ca intake.

    • Send article to Kindle

      To send this article to your Kindle, first ensure is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the or variations. ‘’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Lactose intolerance and bone mass in postmenopausal Italian women
      Available formats
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Lactose intolerance and bone mass in postmenopausal Italian women
      Available formats
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Lactose intolerance and bone mass in postmenopausal Italian women
      Available formats
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

E. M. Alhava , J. Jussila , P. Karjalainen & P. Vuojolahti (1977) Lactose malabsorption and bone mineral content. Acta Medica Scandinavica 201, 281283.

N. H. Bell , A. Greene , S. Epstein , M. J. Oexmann , S. Show & J. Shary (1985) Evidence for alteration of the vitamin D-endocrine system in Blacks. Journal of Clinical Investigation 76, 470473.

S. J. Birge , H. T. Keutmann , P. Cuatrecasas & G. D. Whedon (1967) Osteoporosis, intestinal lactase deficiency and low dietary calcium intake. New England Journal of Medicine 276, 445448.

A. Bozzani , R. Penagini , G. Velio , G. Camboni , A. Corbellini , M. Quatrini , D. Conte & P. A. Bianchi (1986) Lactose malabsorption and intolerance in Italians. Clinical implications. Digestive Diseases and Sciences 31, 13131316.

S. H. Cohn , C Abesamis , S. Yasumara , J. F. Aloia , I. Zanzi & K. J. Ellis (1977) Comparative skeletal mass and radial bone mineral content in black and white women. Metabolism 26, 171178.

G. R. Corazza , G. Benati , M. Sorge , A. Strocchi , G. Calza & G. Gasbarrini (1992) β-Galactosidase from Aspergillus niger in adult lactose malabsorption: a double-blind crossover study. Alimentary Pharmacology & Therapeutics 6, 6166.

D. W. Dempster & R. Lindsay (1993) Pathogenesis of osteoporosis. Lancet 341, 797801.

J. A. Di Palma & R. M. Narvaez (1988) Prediction of lactose malabsorption in referral patients. Digestive Diseases and Sciences 33, 303307.

G. Finkenstedt , F. Skrabal , R. W. Gasser & H. Braunsteiner (1986) Lactose malabsorption, milk consumption, and fasting blood glucose concentrations in women with idiopathic osteoporosis. British Medical Journal 292, 161162.

E. Gudmand-Höyer & K. Simony (1977) Individual sensitivity to lactose in lactose malabsorption. Digestive Diseases 22, 177181.

M. Horowitz , J. Wishart , L. Mundy & B. E. C. Nordin (1987) Lactose and calcium absorption in postmenopausal osteoporosis. Archives of Internal Medicine 147, 534536.

J. C Kolars , M. D. Levitt , M. Aouji & D. A. Savaiano (1984) Yogurt-an autodigesting source of lactose. New England Journal of Medicine 310, 13.

A. D. Newcomer , S. F. Hodgson , D. B. McGill & P. J. Thomas (1978 a) Lactase deficiency: prevalence in osteoporosis. Annals of Internal Medicine 89, 218220.

J. A. Perman , S. Modler & A. C. Obson (1981) Role of pH in production of hydrogen from carbohydrate bycolonic bacterial flora. Journal of Clinical Investigation 67, 643650.

L. S. Richelson , H. W. Wahner , L. J. Melton & B. L. Riggs (1984) Relative contributions of aging and estrogen deficiency to postmenopausal bone loss. New England Journal of Medicine 311, 12731275.

B. L. Riggs , H. W. Wahner , J. Melton , L. S. Richelson , H. L. Judd & W. M. O'Fallon (1987) Dietary calcium intake and rates of bone loss in women. Journal of Clinical Investigation 80, 979982.

B. L. Riggs & L.J. Melton (1990) Clinical heterogeneity of involutional osteoporosis: implications for preventive therapy. Journal of Clinical Endocrinology and Metabolism 70, 12291232.

J. M. Saavedra & J. A. Perman (1989) Current concepts in lactose malabsorption and intolerance. Annual Review of Nutrition 9, 475502.

E. Seeman , H. W. Wahner , K. P. Offord , R. Kumar , W. J. Johnson & B. L. Riggs (1982) Differencial effectsof endocrine dysfunction on the axial and appendicular skeleton. Journal of Clinical Investigation 69, 13021309.

C. W. Slemenda , J. C Christian , S. Hui , J. Fitzgerald & C. Johnston (1991) No evidence for an effect of lactase deficiency on bone mass in pre- or postmenopausal women. Journal of Bone and Mineral Research 6, 13671371.

A. Strocchi & M. D. Levitt (1992) Factors affecting hydrogen production and consumption by human fecal flora: the critical role of hydrogen tension and methanogenesis. Journal of Clinical Investigation 89, 13041311.

R. S. Weinstein & N. H. Bell (1988) Diminished rates of bone formation in normal Black adults. New England Journal of Medicine 319, 16981701.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *