Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 32
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Delgado-Lista, Javier Perez-Martinez, Pablo Garcia-Rios, Antonio Perez-Caballero, Ana I. Perez-Jimenez, Francisco and Lopez-Miranda, Jose 2016. Mediterranean Diet and Cardiovascular Risk: Beyond Traditional Risk Factors. Critical Reviews in Food Science and Nutrition, Vol. 56, Issue. 5, p. 788.


    Miller, Michael Sorkin, John D. Mastella, Laura Sutherland, Aimee Rhyne, Jeffrey Donnelly, Patrick Simpson, Kathy and Goldberg, Andrew P. 2016. Poly is more effective than monounsaturated fat for dietary management in the metabolic syndrome: The muffin study. Journal of Clinical Lipidology,


    Carvalho, V.B. Leite, R.F. Almeida, M.T.C. Paschoaloto, J.R. Carvalho, E.B. Lanna, D.P.D. Perez, H.L. Van Cleef, E.H.C.B. Homem Junior, A.C. and Ezequiel, J.M.B. 2015. Carcass characteristics and meat quality of lambs fed high concentrations of crude glycerin in low-starch diets. Meat Science, Vol. 110, p. 285.


    Pieters, Marlien and de Maat, Moniek P.M. 2015. Diet and haemostasis — A comprehensive overview. Blood Reviews, Vol. 29, Issue. 4, p. 231.


    Holub, Bruce Mutch, David M. Pierce, Grant N. Rodriguez-Leyva, Delfin Aliani, Michel Innis, Sheila Yan, William Lamarche, Benoit Couture, Patrick and Ma, David W.L. 2014. Proceedings from the 2013 Canadian Nutrition Society Conference on Advances in Dietary Fats and Nutrition. Applied Physiology, Nutrition, and Metabolism, Vol. 39, Issue. 7, p. 754.


    Schwab, Ursula Lauritzen, Lotte Tholstrup, Tine Haldorssoni, Thorhallur Riserus, Ulf Uusitupa, Matti and Becker, Wulf 2014. Effect of the amount and type of dietary fat on cardiometabolic risk factors and risk of developing type 2 diabetes, cardiovascular diseases, and cancer: a systematic review. Food & Nutrition Research, Vol. 58,


    Marriott, Duncan T. Chevillon, Patrick Spencer-Phillips, Peter T. N. and Doran, Olena 2013. Effect of Breed on Fatty Acid Composition and Lipogenic Enzyme Abundance in the Subcutaneous Adipose Tissue of Pigs. Journal of Food Science, Vol. 78, Issue. 8, p. C1130.


    Martin, Cathie Zhang, Yang Tonelli, Chiara and Petroni, Katia 2013. Plants, Diet, and Health. Annual Review of Plant Biology, Vol. 64, Issue. 1, p. 19.


    Murray, Michael T. 2013. Textbook of Natural Medicine.


    Costa, Carlos Alberto Soares da Carlos, Aluana Santana Gonzalez, Gabrielle de Paula Lopes Reis, Rejane Pontes Gaspar Ribeiro, Mariana dos Santos dos Santos, Aline de Sousa Monteiro, Alexandra Maria Vieira de Moura, Egberto Gaspar and Nascimento-Saba, Celly Cristina Alves do 2012. Diet containing low n-6/n-3 polyunsaturated fatty acids ratio, provided by canola oil, alters body composition and bone quality in young rats. European Journal of Nutrition, Vol. 51, Issue. 2, p. 191.


    Rosa, Antonella Rescigno, Antonio Piras, Alessandra Atzeri, Angela Scano, Paola Porcedda, Silvia Zucca, Paolo and Assunta Dessì, M. 2012. Chemical composition and effect on intestinal Caco-2 cell viability and lipid profile of fixed oil from Cynomorium coccineum L.. Food and Chemical Toxicology, Vol. 50, Issue. 10, p. 3799.


    Sinzinger, Helmut and Berent, Robert 2012. Platelet function in the postprandial period. Thrombosis Journal, Vol. 10, Issue. 1, p. 19.


    de Gaetano, Giovanni di Giuseppe, Romina and Donati, Maria Benedetta 2011. Nutritional and Metabolic Bases of Cardiovascular Disease.


    Øie, E. Ueland, T. Dahl, C. P. Bohov, P. Berge, C. Yndestad, A. Gullestad, L. Aukrust, P. and Berge, R. K. 2011. Fatty acid composition in chronic heart failure: low circulating levels of eicosatetraenoic acid and high levels of vaccenic acid are associated with disease severity and mortality. Journal of Internal Medicine, Vol. 270, Issue. 3, p. 263.


    Bladbjerg, Else-Marie Larsen, Thomas M. Due, Anette Jespersen, Jørgen Stender, Steen and Astrup, Arne 2010. Long-term effects on haemostatic variables of three ad libitum diets differing in type and amount of fat and carbohydrate: a 6-month randomised study in obese individuals. British Journal of Nutrition, Vol. 104, Issue. 12, p. 1824.


    Gigon, F. and Le Jeune, R. 2010. Huile d’olive, Olea europaea L.. Phytothérapie, Vol. 8, Issue. 2, p. 129.


    Shukla, Santosh K. Gupta, Shipra Ojha, Shreesh K. and Sharma, Suman B. 2010. Cardiovascular friendly natural products: a promising approach in the management of CVD. Natural Product Research, Vol. 24, Issue. 9, p. 873.


    Ramsden, Christopher E. Faurot, Keturah R. Carrera-Bastos, Pedro Cordain, Loren De Lorgeril, Michel and Sperling, Laurence S. 2009. Dietary fat quality and coronary heart disease prevention: A unified theory based on evolutionary, historical, global, and modern perspectives. Current Treatment Options in Cardiovascular Medicine, Vol. 11, Issue. 4, p. 289.


    Hodson, Leanne Skeaff, C. Murray and Fielding, Barbara A. 2008. Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. Progress in Lipid Research, Vol. 47, Issue. 5, p. 348.


    Huang, Christina L. and Sumpio, Bauer E. 2008. Olive Oil, the Mediterranean Diet, and Cardiovascular Health. Journal of the American College of Surgeons, Vol. 207, Issue. 3, p. 407.


    ×

Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects

  • Ruth D. Smith (a1), Colette N. M. Kelly (a1), Barbara A. Fielding (a2), David Hauton (a2), K. D. Renuka R. Silva (a1), Margaretha C. Nydahl (a1), George J. Miller (a3) and Christine M. Williams (a1)
  • DOI: http://dx.doi.org/10.1079/BJN2003953
  • Published online: 01 March 2007
Abstract

The aim of the present study was to compare the response of a range of atherogenic and thrombogenic risk markers to two dietary levels of saturated fatty acid (SFA) substitution with monounsaturated fatty acids (MUFA) in students living in a university hall of residence. Although the benefits of such diets have been reported for plasma lipoproteins in high-risk groups, more needs to be known about effects of more modest SFA-MUFA substitutions over the long term and in young healthy adults. In a parallel design over 16 weeks, fifty-one healthy young subjects were randomised to one of two diets: (1) a moderate-MUFA diet in which 16 g dietary SFA/100 g total fatty acids were substituted with MUFA (n 25); (2) a high-MUFA diet in which 33 g dietary SFA/100 g total fatty acids were substituted with MUFA (n 26). All subjects followed an 8-week run-in diet (reference diet), with a fatty acid composition close to the UK average values. There were no differences in plasma lipid responses between the two diets over 16 weeks of the study with similar reductions in total cholesterol (P <0·001) and LDL-cholesterol (P<0·01) in both groups; a small but significant reduction in HDL-cholesterol was also observed in both groups (P<0·01). Platelet responses to ADP (P<0·01) and arachidonic acid (P<0·05) differed with time on the two diets; at 16 weeks, platelet aggregatory response to ADP was significantly lower on the high-MUFA than the moderate-MUFA (P<0·01) diet; ADP responses were also significantly lower within this group at 8 (P<0·05) and 16 (P<0·01) weeks compared with baseline. There were no differences in fasting factor VII activity (factors VIIc and VIIag), fibrinogen concentration or tissue-type plasminogen activator activity between the diets. There were no differences in postprandial factor VIIc responses to a standard meal (area under the curve) between the diets after 16 weeks, but postprandial factor VIIc response was lower than on the high-MUFA diet compared with baseline (P<0·01). In conclusion, a high-MUFA diet sustains potentially beneficial effects on platelet aggregation and postprandial activation of factor VII. Moderate or high substitution of MUFA for SFA achieves similar reductions in fasting blood lipids in young healthy subjects.

    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author:Professor Christine M. Williams, fax +44 118 931 0080, email c.m.williams@reading.ac.uk
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

M Aviram & K Eias (1993) Dietary olive oil reduces low-density lipoprotein uptake by macrophages and decreases the susceptibility of the lipoprotein to undergo lipid peroxidation. Ann Nutr Metab 37, 7584.

J Callow , JS Samra & KN Frayn (1998) Effect of infusion of a triacylglycerol emulsion on low-density lipoprotein composition and oxidizability. Atherosclerosis 137, 115123.

DC Cardinal & RJ Flower (1980) The electronic aggregometer: A novel device for assessing platelet behaviour in blood. J Pharmacol Methods 3, 135158.

BA Griffin , MJ Caslake , BY Yip , GW Tait , CJ Packard & J Shepherd (1990) Rapid isolation of low density lipoprotein subfractions from plasma by density gradient ultracentrifugation. Atherosclerosis 83, 5967.

SM Grundy (1986) Comparison of monounsaturated fatty acids and carbohydrates for lowering plasma cholesterol. N Engl J Med 314, 745748.

F Lopez-Segura , F Velasco , J Lopez-Mirandia , (1996) Monounsaturated fatty acid-enriched diet decreases plasma plasminogen activator inhibitor type 1. Arterioscler Thromb 16, 8288.

IFW McDowell , J McEneny & ER Trimble (1995) A rapid method of measurement of susceptibility to oxidation of low-density lipoprotein. Ann Clin Biochem 32, 167174.

JNS Matthews , DG Altman , MJ Campbell & P Royston (1990) Analysis of serial measurements in medical research. Br Med J 300, 230235.

RP Mensink , M De Groot , Broeke L van den , A Severignen-Nobels , P Demacker & M Katan (1989) Effect of monounsaturated fatty acids vs. complex carbohydrates on serum lipoproteins and apolipoproteins in healthy men and women. Metabolism 38, 172178.

RP Mensink & MB Katan (1992) Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials. Arterioscler Thromb 12, 911919.

A Petroni , M Blasevich , M Salami , N Papini , GF Montedoro & C Galli (1995) Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil. Thromb Res 78, 151160.

KDRR Silva , AE Jones , RD Smith , (2003) Chylomicron particle size and number, factor VII activation and dietary monounsaturated fatty acids. Atherosclerosis 166, 7384.

JM Thompson (1992) Blood collection and preparation: pre-analytical variation. In ECAT Assay Procedures: A Manual of Laboratory Techniques, pp. 1320 [J Jespersen, , BM Bertina and F Haverkate , editors]. Dordrecht, The Netherlands: Kluwer Academic Publishers.

N Volpi & P Tarugi (1999) The protective effect on Cu2+- and AAPH-mediated oxidation of human low-density lipoproteins depends on glycosaminoglycan structure. Biochimie 81, 955963.

A Zampelas , H Roche , JME Knapper , (1998) Differences in postprandial lipaemic response between Northern and Southern Europeans. Atherosclerosis 139, 8393.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: