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Lycopene supplementation attenuated xanthine oxidase and myeloperoxidase activities in skeletal muscle tissues of rats after exhaustive exercise

  • Chieh-Chung Liu (a1), Chi-Chang Huang (a2), Wan-Teng Lin (a3) (a4), Chin-Cheng Hsieh (a5), Shih-Yi Huang (a2), Su-Jiun Lin (a6) and Suh-Ching Yang (a2)
  • DOI:
  • Published online: 01 March 2007

Strenuous exercise is known to induce oxidative stress leading to the generation of free radicals. The purpose of the present study was to investigate the effects of lycopene, an antioxidant nutrient, at a relatively low dose (2·6 mg/kg per d) and a relatively high dose (7·8 mg/kg per d) on the antioxidant status of blood and skeletal muscle tissues in rats after exhaustive exercise. Rats were divided into six groups: sedentary control (C); sedentary control with low-dose lycopene (CLL); sedentary control with high-dose lycopene (CHL); exhaustive exercise (E); exhaustive exercise with low-dose lycopene (ELL); exhaustive exercise with high-dose lycopene (EHL). After 30 d, the rats in the three C groups were killed without exercise, but the rats in the three E groups were killed immediately after an exhaustive running test on a motorised treadmill. The results showed that xanthine oxidase (XO) activities of plasma and muscle, and muscular myeloperoxidase (MPO) activity in group E were significantly increased compared with group C. Compared with group E, the elevations of XO and MPO activities of muscle were significantly decreased in group EHL. The malondialdehyde concentrations of plasma and tissues in group E were significantly increased by 72 and 114 %, respectively, compared with those in group C. However, this phenomenon was prevented in rats of the ELL and EHL groups. There was no significant difference in the GSH concentrations of erythrocytes in each group; however, exhaustive exercise resulted in a significant decrease in the GSH content of muscle. In conclusion, these results suggested that lycopene protected muscle tissue from oxidative stress after exhaustive exercise.

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*Corresponding author: Dr Suh-Ching Yang, fax +886 2 2737 3112, email
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M Atalay , DE Laaksonen , S Khanna , E Kaliste-Korhonen , O Hanninen & CK Sen (2000) Vitamin E regulates changes in tissue antioxidants induced by fish oil and acute exercise. Med Sci Sports Exerc 32, 601607.

AK Banerjee , A Mandal , D Chanda & S Chakraborti (2003) Oxidant, antioxidant and physical exercise. Mol Cell Biochem 253, 307312.

P Di Mascio , S Kaiser & H Sies (1989) Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 274, 532538.

SK Gupta , D Trivedi , S Srivastava , S Joshi , N Holder & SD Verma (2003) Lycopene alternates oxidative stress induced experimental cataract development: an in vitro and in vivo study. Nutrition 19, 794799.

K Husain (2003) Interaction of physical training and chronic nitroglycerin treatment on blood pressure, nitric oxide, and oxidants/antioxidants in the rat heart. Pharmacol Res 48, 253261.

H Itoh , T Ohkuwa , Y Yamazaki , T Shimoda , A Wakayama , S Tamura , T Yamamoto , Y Sato & M Miyamura (2000) Vitamin E supplementation attenuates leakage of enzymes following 6 successive days of running training. Int J Sports Med 21, 369374.

CK Jain , S Agarwal & AV Rao (1999) The effect of dietary lycopene on bioavailability, tissue distribution, in vivo antioxidant properties and colonic preneoplasia in rats. Nutr Res 19, 13831391.

K Koyama , M Kaya , T Ishigaki , J Tsujita , S Hori , T Seino & A Kasugai (1999) Role of xanthine oxidase in delayed lipid peroxidation in rat liver induced by acute exhausting exercise. Eur J Appl Physiol Occup Physiol 80, 2833.

CT Kumar , VK Reddy , M Prasad , K Thyagaraju & P Reddanna (1992) Dietary supplementation of vitamin E protects heart tissue from exercise-induced oxidant stress. Mol Cell Biochem 111, 109115.

M Leal , A Shimada , F Ruiz & E Gonzalez de Mejia (1999) Effect of lycopene on lipid peroxidation and glutathione-dependent enzymes induced by T-2 toxin in vivo. Toxicol Lett 109, 110.

R Marquez , G Santangelo , J Sastre , P Goldschmidt , J Luyckx , FV Pallardo & J Vina (2001) Cyanoside chloride and chromocarbe diethylamine are more effective than vitamin C against exercise-induced oxidative stress. Pharmacol Toxicol 89 255258.

A Mastaloudis , JD Morrow , DW Hopkins , S Devaraj & MG Traber (2004) Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners. Free Radic Biol Med 36, 13291341.

VI Morozov , SA Pryatkin , MI Kalinski & VA Rogozkin (2003) Effect of exercise to exhaustion on myeloperoxidase and lysozyme release from blood neutrophils. Eur J Appl Physiol 89, 257262.

KM Mullane , R Kraemer & B Smith (1985) Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Methods 14, 157167.

KV Reddy , TC Kumar , M Prasad & P Reddanna (1998) Pulmonary lipid peroxidation and antioxidant defenses during exhaustive physical exercise: the role of vitamin E and selenium. Nutrition 14, 448451.

R Reifen , A Nissenkorn , Z Matas & Y Bujanover (2004) 5-ASA and lycopene decrease the oxidative stress and inflammation induced by iron in rats with colitis. J Gastroenterol 39, 514519.

C Schierwagen , AC Bylund-Fellenius & C Lundberg (1990) Improved method for quantification of tissue PMN accumulation measured by myeloperoxidase activity. J Pharmacol Methods 23, 179186.

YH Westing , B Ekblom & B Sjodin (1989) The metabolic relation between hypoxanthine and uric acid in man following maximal short-distance running. Acta Physiol Scand 137, 341345.

HJ Wu , KT Chen , BW Shee , HC Chang , YJ Huang & RS Yang (2004) Effects of 24 h ultra-marathon on biochemical and hematological parameters. World J Gastroenterol 10, 27112714.

M Yamada , K Suzuki , S Kudo , M Totsuka , T Simoyama , S Nakaji & K Sugawara (2000) Effect of exhaustive exercise on human neutrophils in athletes. Luminescence 15, 1520.

A Zajac , Z Waskiewicz & W Pilis (2001) Anaerobic power, creatine kinase activity, lactate concentration, and acid-base equilibrium changes following bouts of exhaustive strength exercises. J Strength Cond Res 15, 357361.

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