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    Lafiandra, Domenico Riccardi, Gabriele and Shewry, Peter R. 2014. Improving cereal grain carbohydrates for diet and health. Journal of Cereal Science, Vol. 59, Issue. 3, p. 312.


    Ludwig, David S. Astrup, Arne and Willett, Walter C. 2015. The glycemic index: Reports of its demise have been exaggerated. Obesity, Vol. 23, Issue. 7, p. 1327.


    Haywood, Cilla J. and Proietto, Joseph 2012. Wholegrains: Emerging Concepts, Controversies and Alternatives. Food and Nutrition Sciences, Vol. 03, Issue. 08, p. 1156.


    Seal, C.J. 2013. Encyclopedia of Human Nutrition.


    Pan, A. and Hu, F. B. 2011. Effets satiétogènes des sucres : différences entre boissons et aliments solides. Obésité, Vol. 6, Issue. 4, p. 206.


    Gentzel, Joseph B 2013. Does contemporary canine diet causes cancer? ; A review. Veterinary World, p. 632.


    Gélinas, Pierre 2013. Preventing constipation: a review of the laxative potential of food ingredients. International Journal of Food Science & Technology, Vol. 48, Issue. 3, p. 445.


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    Brand-Miller, Jennie and Colagiuri, Stephen 2012. Present Knowledge in Nutrition.


    Buttriss, Judith 2012. Phytonutrients.


    Lefevre, Michael and Jonnalagadda, Satya 2012. Effect of whole grains on markers of subclinical inflammation. Nutrition Reviews, Vol. 70, Issue. 7, p. 387.


    de Punder, Karin and Pruimboom, Leo 2013. The Dietary Intake of Wheat and other Cereal Grains and Their Role in Inflammation. Nutrients, Vol. 5, Issue. 3, p. 771.


    Hornick, Betsy Liska, DeAnn Dolven, Cheryl and Wrick, Kathie L. 2011. The Fiber Deficit, Part I. Nutrition Today, Vol. 46, Issue. 6, p. 293.


    Lichtenstein, Alice H. 2014. Managing Cardiovascular Complications in Diabetes.


    Brownlee, Iain 2014. The impact of dietary fibre intake on the physiology and health of the stomach and upper gastrointestinal tract. Bioactive Carbohydrates and Dietary Fibre, Vol. 4, Issue. 2, p. 155.


    Kim, Yoona Keogh, Jennifer and Clifton, Peter 2016. Polyphenols and Glycemic Control. Nutrients, Vol. 8, Issue. 1, p. 17.


    Watzl, B. 2013. Diet, Immunity and Inflammation.


    Pan, An and Hu, Frank B 2011. Effects of carbohydrates on satiety: differences between liquid and solid food. Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 14, Issue. 4, p. 385.


    Wolever, T M S 2013. Is glycaemic index (GI) a valid measure of carbohydrate quality?. European Journal of Clinical Nutrition, Vol. 67, Issue. 5, p. 522.


    Frølich, Wenche Åman, Per and Tetens, Inge 2013. Whole grain foods and health – a Scandinavian perspective. Food & Nutrition Research, Vol. 57,


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Markers of cardiovascular risk are not changed by increased whole-grain intake: the WHOLEheart study, a randomised, controlled dietary intervention

  • Iain A. Brownlee (a1), Carmel Moore (a2), Mark Chatfield (a2), David P. Richardson (a3), Peter Ashby (a4), Sharron A. Kuznesof (a1), Susan A. Jebb (a2) and Chris J. Seal (a1)
  • DOI: http://dx.doi.org/10.1017/S0007114510000644
  • Published online: 23 March 2010
Abstract

Recommendations for whole-grain (WG) intake are based on observational studies showing that higher WG consumption is associated with reduced CVD risk. No large-scale, randomised, controlled dietary intervention studies have investigated the effects on CVD risk markers of substituting WG in place of refined grains in the diets of non-WG consumers. A total of 316 participants (aged 18–65 years; BMI>25 kg/m2) consuming < 30 g WG/d were randomly assigned to three groups: control (no dietary change), intervention 1 (60 g WG/d for 16 weeks) and intervention 2 (60 g WG/d for 8 weeks followed by 120 g WG/d for 8 weeks). Markers of CVD risk, measured at 0 (baseline), 8 and 16 weeks, were: BMI, percentage body fat, waist circumference; fasting plasma lipid profile, glucose and insulin; and indicators of inflammatory, coagulation, and endothelial function. Differences between study groups were compared using a random intercepts model with time and WG intake as factors. Although reported WG intake was significantly increased among intervention groups, and demonstrated good participant compliance, there were no significant differences in any markers of CVD risk between groups. A period of 4 months may be insufficient to change the lifelong disease trajectory associated with CVD. The lack of impact of increasing WG consumption on CVD risk markers implies that public health messages may need to be clarified to consider the source of WG and/or other diet and lifestyle factors linked to the benefits of whole-grain consumption seen in observational studies.

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Corresponding author
*Corresponding author: Professor Chris Seal, fax +44 191 222 6720, email chris.seal@ncl.ac.uk
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1JW Anderson (2003) Whole grains protect against atherosclerotic cardiovascular disease. Proc Nutr Soc 62, 135142.

4SM Liu , JE Manson , MJ Stampfer , (2000) Whole grain consumption and risk of ischemic stroke in women – a prospective study. JAMA 284, 15341540.

12AS Truswell (2002) Cereal grains and coronary heart disease. Eur J Clin Nutr 56, 114.

15KM Behall , DJ Scholfield & J Hallfrisch (2006) Whole-grain diets reduce blood pressure in mildly hypercholesterolemic men and women. J Am Diet Assoc 106, 14451449.



24AFG Cicero , S Nascetti , MC Lopez-Sabater , (2008) Changes in LDL fatty acid composition as a response to olive oil treatment are inversely related to lipid oxidative damage: The EUROLIVE study. J Am Coll Nutr 27, 314320.

25MB Madsen , AM Jensen & EB Schmidt (2007) The effect of a combination of plant sterol-enriched foods in mildly hypercholesterolemic subjects. Clin Nutr 26, 792798.

29DJA Jenkins , V Wesson , TMS Wolever , (1988) Wholemeal versus wholegrain breads – proportion of whole or cracked grain and the glycemic response. BMJ 297, 958960.

31H Nandeesha , BC Koner , LN Dorairajan , (2006) Hyperinsulinemia and dyslipidemia in non-diabetic benign prostatic hyperplasia. Clin Chim Acta 370, 8993.

33S Shimizu , Y Tani , H Yamada , (1980) Enzymatic determination of serum-free fatty-acids – a colorimetric method. Anal Biochem 107, 193198.

34R Savoca , B Jaworek & AR Huber (2006) New ‘plasma referenced’ POCT glucose monitoring systems – are they suitable for glucose monitoring and diagnosis of diabetes? Clin Chim Acta 372, 199201.

36A Katz , SS Nambi , K Mather , (2000) Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85, 24022410.

37R Rabasa-Lhoret , JP Bastard , V Jan , (2003) Modified quantitative insulin sensitivity check index is better correlated to hyperinsulinemic glucose clamp than other fasting-based index of insulin sensitivity in different insulin-resistant states. J Clin Endocrinol Metab 88, 49174923.

38TC Register , KP Burdon , L Lenchik , (2004) Variability of serum soluble intercellular adhesion molecule-1 measurements attributable to a common polymorphism. Clin Chem 50, 21852187.

39KJ Garton , PJ Gough , J Philalay , (2003) Stimulated shedding of vascular cell adhesion molecule 1 (VCAM-1) is mediated by tumor necrosis factor-α-converting enzyme (ADAM 17). J Biol Chem 278, 3745937464.

40MH Ruchaud-Sparagano , EM Drost , SC Donnelly , (1998) Potential pro-inflammatory effects of soluble E-selectin upon neutrophil function. Eur J Immunol 28, 8089.

41D Webber , CM Radcliffe , L Royle , (2006) Sialylation of urinary prothrombin fragment 1 is implicated as a contributory factor in the risk of calcium oxalate kidney stone formation. FEBS J 273, 30243037.

43L Wehlin , J Vedin , J Vaage , (2004) Activation of complement and leukocyte receptors during on- and off pump coronary artery bypass surgery. Eur J Cardiothorac Surg 25, 3542.

44HS Al-Barjas , R Ariens , P Grant , (2006) Raised plasma fibrinogen concentration in patients with abdominal aortic aneurysm. Angiology 57, 607614.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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