1Hertog, MG, Kromhout, D, Aravanis, C, et al. (1995) Flavonoid intake and long-term risk of coronary heart disease and cancer in the Seven Countries Study. Arch Intern Med 155, 381–386.
2Lampe, JW (1999) Health effects of vegetables and fruit: assessing mechanisms of action in human experimental studies. Am J Clin Nutr 70, Suppl. 3, 475S–490S.
3Gronbaek, M, Becker, U, Johansen, D, et al. (2000) Type of alcohol consumed and mortality from all causes, coronary heart disease, and cancer. Ann Intern Med 133, 411–419.
4Klatsky, AL, Friedman, GD, Armstrong, MA, et al. (2003) Wine, liquor, beer, and mortality. Am J Epidemiol 158, 585–595.
5Szmitko, PE & Verma, S (2005) Antiatherogenic potential of red wine: clinician update. Am J Physiol Heart Circ Physiol 288, H2023–H2030.
6Agewall, S, Wright, S, Doughty, RN, et al. (2000) Does a glass of red wine improve endothelial function? Eur Heart J 21, 74–78.
7Hashimoto, M, Kim, S, Eto, M, et al. (2001) Effect of acute intake of red wine on flow-mediated vasodilatation of the brachial artery. Am J Cardiol 88, 1457–1460.
8Fitzpatrick, DF, Hirschfield, SL & Coffey, RG (1993) Endothelium-dependent vasorelaxing activity of wine and other grape products. Am J Physiol 265, H774–H778.
9Corder, R, Douthwaite, JA, Lees, DM, et al. (2001) Endothelin-1 synthesis reduced by red wine. Nature 414, 863–864.
10Scalbert, A & Williamson, G (2000) Dietary intake and bioavailability of polyphenols. J Nutr 130, Suppl. 8S, 2073S–2085S.
11Spencer, JP, Abd El Mohsen, MM, Minihane, AM, et al. (2008) Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research. Br J Nutr 99, 12–22.
12Loke, WM, Hodgson, JM, Proudfoot, JM, et al. (2008) Pure dietary flavonoids quercetin and ( − )-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men. Am J Clin Nutr 88, 1018–1025.
13Stoclet, JC, Chataigneau, T, Ndiaye, M, et al. (2004) Vascular protection by dietary polyphenols. Eur J Pharmacol 500, 299–313.
14Shimada, K, Watanabe, H, Hosoda, K, et al. (1999) Effect of red wine on coronary flow-velocity reserve. Lancet 354, 1002.
15van Velden, DP, Mansvelt, EP, Fourie, E, et al. (2002) The cardioprotective effect of wine on human blood chemistry. Ann N Y Acad Sci 957, 337–340.
16Cui, J, Tosaki, A, Cordis, GA, et al. (2002) Cardioprotective abilities of white wine. Ann N Y Acad Sci 957, 308–316.
17Dudley, JI, Lekli, I, Mukherjee, S, et al. (2008) Does white wine qualify for French paradox? Comparison of the cardioprotective effects of red and white wines and their constituents: resveratrol, tyrosol, and hydroxytyrosol. J Agric Food Chem 56, 9362–9373.
18Chamkha, M, Cathala, B, Cheynier, V, et al. (2003) Phenolic composition of champagnes from Chardonnay and Pinot Noir vintages. J Agric Food Chem 51, 3179–3184.
19Constant, J (1997) Alcohol, ischemic heart disease, and the French paradox. Clin Cardiol 20, 420–424.
20Boyer, JC, Bancel, E, Fabbro Perray, P, et al. (2004) Effect of Champagne compared to still white wine on peripheral neurotransmitter concentrations. Int J Vitam Nutr Res 74, 264–271.
21Cartron, E, Fouret, G, Carbonneau, MA, et al. (2003) Red-wine beneficial long-term effect on lipids but not on antioxidant characteristics in plasma in a study comparing three types of wine – description of two O-methylated derivatives of gallic acid in humans. Free Radic Res 37, 1021–1035.
22Vauzour, D, Vafeiadou, K, Corona, G, et al. (2007) Champagne wine polyphenols protect primary cortical neurons against peroxynitrite-induced injury. J Agric Food Chem 55, 2854–2860.
23van der Loo, B, Labugger, R, Skepper, JN, et al. (2000) Enhanced peroxynitrite formation is associated with vascular aging. J Exp Med 192, 1731–1744.
24Xu, S, Ying, J, Jiang, B, et al. (2006) Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging. Am J Physiol Heart Circ Physiol 290, H2220–H2227.
25Armah, CK, Jackson, KG, Doman, I, et al. (2008) Fish oil fatty acids improve postprandial vascular reactivity in healthy men. Clin Sci (Lond) 114, 679–686.
26Ferrell, WR, Ramsay, JE, Brooks, N, et al. (2002) Elimination of electrically induced iontophoretic artefacts: implications for non-invasive assessment of peripheral microvascular function. J Vasc Res 39, 447–455.
27Ramsay, JE, Ferrell, WR, Greer, IA, et al. (2002) Factors critical to iontophoretic assessment of vascular reactivity: implications for clinical studies of endothelial dysfunction. J Cardiovasc Pharmacol 39, 9–17.
28Buache, E, Garnotel, R, Aubert, D, et al. (2007) Reduced secretion and expression of gelatinase profile in Toxoplasma gondii-infected human monocytic cells. Biochem Biophys Res Commun 359, 298–303.
29Kampa, M, Nistikaki, A, Tsaousis, V, et al. (2002) A new automated method for the determination of the total antioxidant capacity (TAC) of human plasma, based on the crocin bleaching assay. BMC Clin Pathol 2, 3.
30Malliaraki, N, Mpliamplias, D, Kampa, M, et al. (2003) Total and corrected antioxidant capacity in hemodialyzed patients. BMC Nephrol 4, 4.
31Tatzber, F, Griebenow, S, Wonisch, W, et al. (2003) Dual method for the determination of peroxidase activity and total peroxides-iodide leads to a significant increase of peroxidase activity in human sera. Anal Biochem 316, 147–153.
32Klatsky, AL, Armstrong, MA & Friedman, GD (1992) Alcohol and mortality. Ann Intern Med 117, 646–654.
33Renaud, S & de Lorgeril, M (1992) Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339, 1523–1526.
34St Leger, AS, Cochrane, AL & Moore, F (1979) Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. Lancet i, 1017–1020.
35Dell’ Agli, M, Busciala, A & Bosisio, E (2004) Vascular effects of wine polyphenols. Cardiovasc Res 63, 593–602.
36Andriambeloson, E, Magnier, C, Haan-Archipoff, G, et al. (1998) Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta. J Nutr 128, 2324–2333.
37Flesch, M, Schwarz, A & Bohm, M (1998) Effects of red and white wine on endothelium-dependent vasorelaxation of rat aorta and human coronary arteries. Am J Physiol 275, H1183–H1190.
38Anselm, E, Chataigneau, M, Ndiaye, M, et al. (2007) Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of eNOS. Cardiovasc Res 73, 404–413.
39Matsuo, S, Nakamura, Y, Takahashi, M, et al. (2001) Effect of red wine and ethanol on production of nitric oxide in healthy subjects. Am J Cardiol 87, 1029–1031.
40Vlachopoulos, C, Tsekoura, D, Tsiamis, E, et al. (2003) Effect of alcohol on endothelial function in healthy subjects. Vasc Med 8, 263–265.
41Bau, PF, Bau, CH, Naujorks, AA, et al. (2005) Early and late effects of alcohol ingestion on blood pressure and endothelial function. Alcohol 37, 53–58.
42Natella, F, Nardini, M, Belelli, F, et al. (2008) Effect of coffee drinking on platelets: inhibition of aggregation and phenols incorporation. Br J Nutr 100, 1276–1282.
43Natella, F, Nardini, M, Belelli, F, et al. (2007) Coffee drinking induces incorporation of phenolic acids into LDL and increases the resistance of LDL to ex vivo oxidation in humans. Am J Clin Nutr 86, 604–609.
44Pignatelli, P, Ghiselli, A, Buchetti, B, et al. (2006) Polyphenols synergistically inhibit oxidative stress in subjects given red and white wine. Atherosclerosis 188, 77–83.
45Tawakol, A, Omland, T & Creager, MA (2004) Direct effect of ethanol on human vascular function. Am J Physiol Heart Circ Physiol 286, H2468–H2473.
46Rechner, AR, Spencer, JP, Kuhnle, G, et al. (2001) Novel biomarkers of the metabolism of caffeic acid derivatives in vivo. Free Radic Biol Med 30, 1213–1222.
47Mannisto, PT & Kaakkola, S (1999) Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors. Pharmacol Rev 51, 593–628.
48Rechner, AR, Kuhnle, G, Bremner, P, et al. (2002) The metabolic fate of dietary polyphenols in humans. Free Radic Biol Med 33, 220–235.
49Caccetta, RA, Croft, KD, Beilin, LJ, et al. (2000) Ingestion of red wine significantly increases plasma phenolic acid concentrations but does not acutely affect ex vivo lipoprotein oxidizability. Am J Clin Nutr 71, 67–74.
50Choudhury, R, Srai, SK, Debnam, E, et al. (1999) Urinary excretion of hydroxycinnamates and flavonoids after oral and intravenous administration. Free Radic Biol Med 27, 278–286.
51Olthof, MR, Hollman, PC, Buijsman, MN, et al. (2003) Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans. J Nutr 133, 1806–1814.
52Klotz, LO & Sies, H (2003) Defenses against peroxynitrite: selenocompounds and flavonoids. Toxicol Lett , 125–132.
53Koppenol, WH (1998) The basic chemistry of nitrogen monoxide and peroxynitrite. Free Radic Biol Med 25, 385–391.
54Radi, R, Peluffo, G, Alvarez, MN, et al. (2001) Unraveling peroxynitrite formation in biological systems. Free Radic Biol Med 30, 463–488.
55Halliwell, B (1996) Antioxidants in human health and disease. Annu Rev Nutr 16, 33–50.
56Schewe, T, Steffen, Y & Sies, H (2008) How do dietary flavanols improve vascular function? A position paper. Arch Biochem Biophys 476, 102–106.
57Steffen, Y, Schewe, T & Sies, H (2007) ( − )-Epicatechin elevates nitric oxide in endothelial cells via inhibition of NADPH oxidase. Biochem Biophys Res Commun 359, 828–833.
58Perrot, L, Dukic, S, Charpentier, M, et al. (2003) . In Oenologie, pp. 688–691 [Lonvaud-Funel, A, Revel, G and Darriet, P, editors]. Paris: Tec and Doc.
59Benkhalti, F, Legssyer, A, Gomez, P, et al. (2003) Effects of virgin olive oil phenolic compounds on LDL oxidation and vasorelaxation activity. Therapie 58, 133–137.
60Chen, GP, Ye, Y, Li, L, et al. (2009) Endothelium-independent vasorelaxant effect of sodium ferulate on rat thoracic aorta. Life Sci 84, 81–88.
61Cicala, C, Morello, S, Iorio, C, et al. (2003) Vascular effects of caffeic acid phenethyl ester (CAPE) on isolated rat thoracic aorta. Life Sci 73, 73–80.
62Li, YY, Feldman, AM, Sun, Y, et al. (1998) Differential expression of tissue inhibitors of metalloproteinases in the failing human heart. Circulation 98, 1728–1734.
63Visse, R & Nagase, H (2003) Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res 92, 827–839.
64Galis, ZS, Sukhova, GK, Lark, MW, et al. (1994) Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 94, 2493–2503.
65Libby, P, Schoenbeck, U, Mach, F, et al. (1998) Current concepts in cardiovascular pathology: the role of LDL cholesterol in plaque rupture and stabilization. Am J Med 104, 14S–18S.
66Loftus, IM, Naylor, AR, Bell, PR, et al. (2002) Matrix metalloproteinases and atherosclerotic plaque instability. Br J Surg 89, 680–694.
67Dell'Agli, M, Canavesi, M, Galli, G, et al. (2005) Dietary polyphenols and regulation of gelatinase expression and activity. Thromb Haemost 93, 751–760.
68Asmar, RG, Pannier, B, Santoni, JP, et al. (1988) Reversion of cardiac hypertrophy and reduced arterial compliance after converting enzyme inhibition in essential hypertension. Circulation 78, 941–950.
69Andreassen, AK, Kvernebo, K, Jorgensen, B, et al. (1998) Exercise capacity in heart transplant recipients: relation to impaired endothelium-dependent vasodilation of the peripheral microcirculation. Am Heart J 136, 320–328.